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European Journal of Applied Physiology

Erschienen in:

01.01.2006 | Original Article

Baroreflex impairment during rapid posture changes at rest and exercise after 120 days of bed rest

verfasst von: D. Linnarsson, J. Spaak, P. Sundblad

Erschienen in: European Journal of Applied Physiology | Ausgabe 1/2006

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Abstract

Orthostatic intolerance is common after space flight and head-down tilt (HDT) bed rest. We hypothesized that HDT-induced impairments of arterial blood pressure (AP) control would be more marked during exercise and that recovery of baroreflex function after very long-term HDT would be delayed. Six subjects were studied before (BDC) during (day 60, D60; D113) and after (recovery day 0, R0; R3; R15) 120 days of HDT. Supine resting subjects were exposed to repeated 1 min passive tilts to upright at 3-min interval. During 50 W steady-state exercise corresponding tilt had a 2-min duration at 4-min interval. The amplitudes of the tilt-induced transient beat-by-beat deviations in AP and rate (HR) were determined during the gravity transients. At rest these deviations did not change over time, but during exercise the total peak-to-nadir range of deviations in systolic AP (SAP) at up-tilt and down-tilt increased to 168±16% (mean±SEM) of BDC at D113 with no clear recovery upto and including R15. Counter-regulatory HR responses were not increased proportionally and especially not tachycardic responses to up-tilt, resulting in a reduction of baroreflex sensitivity (ΔRR-interval/ΔSAP) by 55±9% of BDC at D113 with no recovery upto and including R15. We conclude that prolonged bed rest cause long-lasting impairments in AP control and baroreflex function in exercising humans.

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Titel: Baroreflex impairment during rapid posture changes at rest and exercise after 120 days of bed rest
verfasst von: D. Linnarsson
J. Spaak
P. Sundblad
Publikationsdatum: 01.01.2006
Verlag: Springer-Verlag
Erschienen in: European Journal of Applied Physiology / Ausgabe 1/2006
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-005-0062-z

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Baroreflex impairment during rapid posture changes at rest and exercise after 120 days of bed rest

Abstract

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