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01.07.2006 | Original Article

Body fat and blood lipids in postmenopausal women are related to resting autonomic nervous system activity

verfasst von: Tetsuya Kimura, Tamaki Matsumoto, Mihoko Akiyoshi, Yoko Owa, Naoyuki Miyasaka, Takeshi Aso, Toshio Moritani

Erschienen in: European Journal of Applied Physiology | Ausgabe 5/2006

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Abstract

The present study investigated the activity of the autonomic nervous system (ANS), a major influence in normal physiological function, and its association with unfavorable postmenopausal states in body composition, lipid and/or glucose metabolism, or cardiovascular profiles. Body composition, blood pressure, and blood profiles of lipid and glucose of 175 postmenopausal women were measured. Resting ANS activity was assessed by heart rate variability (HRV) power spectral analysis. To scrutinize the influence of ANS activity levels on postmenopausal obesity-related factors, we divided the subjects into a low group ( < 220 ms²) and a high group ( > 220 ms²), based on the total power of HRV. Low-frequency (P < 0.01) and high-frequency power (P < 0.01) were both significantly lower in the low group. No significant difference was found in age, age at menopause, or years after menopause between the two groups. In contrast, body mass index (P < 0.05), percentages of body fat (P < 0.01), and systolic (P < 0.01) and diastolic (P < 0.01) blood pressure were significantly greater in the low group. As to blood lipid profiles, triglycerides (P < 0.05), total cholesterol (P < 0.05), and low-density lipoprotein cholesterol (P < 0.05) were significantly higher in the low group. Our findings indicate that reduced sympatho-vagal activity is associated with higher postmenopausal body fat content, blood pressure, and blood lipid concentrations. This study further implies that such autonomic depression could be a crucial risk factor in undermining the health and, ultimately, the quality of life, of postmenopausal women.

Akselrod S, Gordon D, Ubel FA, Shannon DC, Barger AC, Cohen RJ (1981) Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science 213:220–222PubMedCrossRef

Amano M, Kanda T, Ue H, Moritani T (2001) Exercise training and autonomic nervous system activity in obese individuals. Med Sci Sports Exerc 33:1287–1291PubMedCrossRef

Bray GA (1991) Obesity, a disorder of nutrient partitioning: The MONA LISA hypothesis. J Nutr 121:1146–1162PubMed

Brockbank CL, Chatterjee F, Bruce SA, Woledge RC (2000) Heart rate and its variability change after the menopause. Exp Physiol 85:327–330PubMedCrossRef

Carr MC (2003) The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab 88:2404–2411PubMedCrossRef

Conny MA, Louis AA, Jeroen CW, Gerard BA, Herman P (1993) Heart rate variability. Ann Intern Med 118:436–447

Danev S, Nikolova R, Kerekovska M, Svetoslavov S (1997) Relationship between heart rate variability and hypercholesterolaemia. Cent Eur J Public Health 5:143–146PubMed

Davy KP, DeSouza CA, Jones PP, Seals DR (1998) Elevated heart rate variability in physically active young and older adult women. Clin Sci (Lond) 94:579–584

Doncheva NI, Nikolova RI, Danev SG (2003) Overweight, dyslipoproteinemia, and heart rate variability measures. Folia Med (Plovdiv) 45:8–12

Eckberg DL (1997) Sympathovagal balance: A critical appraisal. Circulation 96:3224–3232PubMed

Ferrara CM, Lynch NA, Nicklas BJ, Ryan AS, Berman DM (2002) Differences in adipose tissue metabolism between postmenopausal and perimenopausal women. J Clin Endocrinol Metab 87:4166–4170PubMedCrossRef

Hayano J, Sakakibara Y, Yamada M, Ohte N, Fujinami T, Yokoyama K, Watanabe Y, Takata K (1990) Decreased magnitude of heart rate spectral components in coronary artery disease. Its relation to angiographic severity. Circulation 81:1217–1224PubMed

Hayashi T, Masuda I, Shinohara M, Moritani T, Nakao K (1994) Autonomic nerve activity during physical exercise and postural change: investigations by power spectral analysis of heart rate variability. Jpn J Biochem Exerc 6:30–37

Hirsch J, Leibel RL, Mackintosh R, Aguirre A (1991) Heart rate variability as a measure of autonomic function during weight change in humans. Am J Physiol 261:R1418–R1423PubMed

Jones PP, Snitker S, Skinner JS, Ravussin E (1996) Gender differences in muscle sympathetic nerve activity: effect of body fat distribution. Am J Physiol 270 (Endocrinol Metabo 33) E363–E366

Laederach-Hofmann K, Mussgay L, Ruddel H (2000) Autonomic cardiovascular regulation in obesity. J Endocrinol 164:59–66PubMedCrossRef

Liao D, Sloan RP, Cascio WE, Folsom AR, Liese AD, Evans GW, Cai J, Sharrett AR (1998) Multiple metabolic syndrome is associated with lower heart rate variability. The Atherosclerosis Risk in Communities Study. Diabetes Care 21:2116–2122PubMedCrossRef

Liu CC, Kuo TB, Yang CC (2003) Effects of estrogen on gender-related autonomic differences in humans. Am J Physiol Heart Circ Physiol 285:H2188–H2193PubMed

Lynch NA, Ryan AS, Berman DM, Sorkin JD, Nicklas BJ (2002) Comparison of VO₂max and disease risk factors between perimenopausal and postmenopausal women. Menopause 9:456–462PubMedCrossRef

Matsumoto T, Miyawaki T, Ue H, Kanda T, Zenji C, Moritani T (1999) Autonomic responsiveness to acute cold exposure in obese and non-obese young women. Int J Obes Relat Metab Disord 23:793–800PubMedCrossRef

Matsumoto T, Miyawaki C, Ue H, Yuasa T, Miyatsuji A, Moritani T (2000) Effects of capsaicin-containing yellow curry sauce on sympathetic nervous system activity and diet-induced thermogenesis in lean and obese young women. J Nutr Sci Vitaminol 46:309–315PubMed

Matsumoto T, Miyawaki C, Ue T, Kanda T, Yoshitake Y, Moritani T (2001) Comparison of thermogenic sympathetic response to food intake between obese and non-obese young women. Obes Res 9:78–85PubMedCrossRef

Ministry of Health, Labor and Welfare, Japan (2004) The national nutrition survey in Japan, 2002. Dai-ichi shuppan publishing, Co Ltd. Tokyo, Japan, pp 52

Ministry of Health, Labor, and Welfare (2005) Part 3 Investigation of the physical characteristics. The National Health and Nutrition Survey in Japan, 2003. http://www.mhlw.go.jp/bunya/kenkou/eiyou-chosa2–01/pdf/05a.pdf, pp 15

Moritani T, Hayashi T, Shinohara M, Mimasa F, Masuda I, Nakao K (1995) Sympatho-vagal activities of NIDDM patients during exercise as determined by heart rate spectral analysis. In: Kawamori R, Vranic M, Horton ES, Kubota M (eds) Glucose fluxes, exercise and diabetes. Smith-Gordon: Great Britain pp 91–96

Nagai N, Moritani T (2004) Effect of physical activity on autonomic nervous system function in lean and obese children. Int J Obes Relat Metab Disord 28:27–33PubMedCrossRef

Novak V, Novak P, de Champlain J, Nadeau R (1994) Altered cardiorespiratory transfer in hypertension. Hypertension 23:104–113PubMed

Oida E, Moritani T, Yamori Y (1997) Tone-entropy analysis on cardiac recovery after dynamic exercise. J Appl Physiol 82:1794–1801PubMed

Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell’Orto S, Piccaluga E, Turiel M, Baselli G, Cerutti S, Malliani A (1986) Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res 59:178–193PubMed

Peterson HR, Rothschild M, Weinberg CR, Fell RD, McLeish KR, Pfeifer MA (1988) Body fat and the activity of the autonomic nervous system. N Engl J Med 318:1077–1083PubMedCrossRef

Petretta M, Bonaduce D, de Filippo E, Mureddu GF, Scalfi L, Marciano F, Bianchi V, Salemme L, de Simone G, Contaldo F (1995) Assessment of cardiac autonomic control by heart period variability in patients with early-onset familial obesity. Eur J Clin Invest 25:826–832PubMedCrossRef

Poehlman ET, Toth MJ, Gardner AW (1995) Changes in energy balance and body composition at menopause: a controlled longitudinal study. Ann Intern Med 123:673–675PubMed

Poehlman ET, Toth MJ, Ades PA, Rosen CJ (1997) Menopause-associated changes in plasma lipids, insulin-like growth factor I and blood pressure: a longitudinal study. Eur J Clin Invest 27:322–326PubMedCrossRef

Rompelman O, Coenen AJR, Kitney RI (1977) Measurement of heart-rate variability: part 1 - comparative study of heart-rate variability analysis methods. Med Biol Eng Comput 15:233–239PubMedCrossRef

Scherrer U, Randin D, Tappy L, Vollenweider P, Jequier E, Nicod P (1994) Body fat and sympathetic nerve activity in healthy subjects. Circulation 89:2634–2640PubMed

Singh JP, Larson MG, Tsuji H, Evans JC, O’Donnell CJ, Levy D (1998) Reduced heart rate variability and new-onset hypertension: insights into pathogenesis of hypertension: the Framingham Heart Study. Hypertension 32:293–297PubMed

Singh JP, Larson MG, O’Donnell CJ, Wilson PF, Tsuji H, Lloyd-Jones DM, Levy D (2000) Association of hyperglycemia with reduced heart rate variability (The Framingham Heart Study). Am J Cardiol 86:309–312PubMedCrossRef

Task force of the European Society of Cardiology, the North American Society of Pacing and Electrophysiology (1996) Heart rate variability. Standard of measurements, physiological interpretation and clinical use. Circulation 93:1043–1065

Tataranni PA, Young JB, Bogardus C, Ravussin E (1997) A low sympathoadrenal activity is associated with body weight gain and development of central adiposity in Pima Indian men. Obes Res 5:341–347PubMed

Wise PM, Krajnak KM, Kashon ML (1996) Menopause: the aging of multiple pacemakers. Science 273:67–70PubMedCrossRef

Titel: Body fat and blood lipids in postmenopausal women are related to resting autonomic nervous system activity
verfasst von: Tetsuya Kimura
Tamaki Matsumoto
Mihoko Akiyoshi
Yoko Owa
Naoyuki Miyasaka
Takeshi Aso
Toshio Moritani
Publikationsdatum: 01.07.2006
Verlag: Springer-Verlag
Erschienen in: European Journal of Applied Physiology / Ausgabe 5/2006
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-006-0207-8

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