Skip to main content
Erschienen in: European Journal of Applied Physiology 5/2008

01.11.2008 | Original Article

Metabolic and cardiovascular responses during sub-maximal exercise in humans after 14 days of head-down tilt bed rest and inactivity

verfasst von: C. Capelli, G. Antonutto, M. Cautero, E. Tam, G. Ferretti

Erschienen in: European Journal of Applied Physiology | Ausgabe 5/2008

Einloggen, um Zugang zu erhalten

Abstract

\( {{\dot{V}O}}_{2} , \) f H, \( \dot{Q}, \) SV, [Hb], CaO2, \( {{\dot{Q}}}_{\text{a}} \)O2, MAP and R P were measured in 10 young subjects at rest and during exercise at 50, 100 and 150 W before and after 14 days of head-down tilt bed rest (HDTBR) and of ambulatory (AMB) control period. f H was 18 and 8% higher after HDTBR and AMB, respectively. SV dropped by 15% both after HDTBR and AMB, whereas \( \dot{Q} \) did not change. After HDTBR, CaO2 decreased at rest (−8%) and at 50 W (−5%), whereas \( {{\dot{Q}}}_{\text{a}} \)O2 did not change; MAP was 14 and 6% lower at rest and at 100 W and R P decreased by 23% only at rest. Changes in f H and SV were larger after HDTBR than after AMB. These results show that, notwhistanding the drop of SV, moderate-intensity dynamic exercise elicited a normal pressure response after 14 days of HDTBR.
Literatur
Zurück zum Zitat Åstrand PO, Rodahl K, Dahl HA, Strømme SB (2003) Physical training. In: Textbook of Work Physiology, 4th edn, Human Kinetics, Champaign, pp 347–352 Åstrand PO, Rodahl K, Dahl HA, Strømme SB (2003) Physical training. In: Textbook of Work Physiology, 4th edn, Human Kinetics, Champaign, pp 347–352
Zurück zum Zitat Barker RC, Hopkins SR, Kellogg N, Olfert IM, Brutsaert TD, Gavin TP et al (1999) Measurement of cardiac output during exercise by open circuit acetylene uptake. J Appl Physiol 87:1506–1512PubMed Barker RC, Hopkins SR, Kellogg N, Olfert IM, Brutsaert TD, Gavin TP et al (1999) Measurement of cardiac output during exercise by open circuit acetylene uptake. J Appl Physiol 87:1506–1512PubMed
Zurück zum Zitat Biolo G, Ciocchi B, Lebenstedt M, Barazzoni R, Zanetti M, Platen P, Heer M, Guarnieri G (2004) Short-term bed rest impairs amino acid-induced protein anabolism in humans. J Physiol 558:381–388 Biolo G, Ciocchi B, Lebenstedt M, Barazzoni R, Zanetti M, Platen P, Heer M, Guarnieri G (2004) Short-term bed rest impairs amino acid-induced protein anabolism in humans. J Physiol 558:381–388
Zurück zum Zitat Box GEP, Hunter WG, Hunter JS (1978) Statistics for experimenters. An introduction to design, data analysis and model building. Wiley, New York, pp 453–462 Box GEP, Hunter WG, Hunter JS (1978) Statistics for experimenters. An introduction to design, data analysis and model building. Wiley, New York, pp 453–462
Zurück zum Zitat Capelli C, Antonutto G, Azabji Kenfack M, Cautero M, Lador F, Moia C, Tam e, Ferretti G (2006) Factors determining the time course of \( {{\dot{V}O}}_{2\max } \) decay during bed rest: implications for \( {{\dot{V}O}}_{2\max } \) limitation. Eur J Appl Physiol 98:152–160 Capelli C, Antonutto G, Azabji Kenfack M, Cautero M, Lador F, Moia C, Tam e, Ferretti G (2006) Factors determining the time course of \( {{\dot{V}O}}_{2\max } \) decay during bed rest: implications for \( {{\dot{V}O}}_{2\max } \) limitation. Eur J Appl Physiol 98:152–160
Zurück zum Zitat Convertino V, Hung J, Goldwater D, DeBusk RF (1982) Cardiovascular responses to exercise in middle-aged men after 10 days of bed rest. Circulation 65:134–140PubMed Convertino V, Hung J, Goldwater D, DeBusk RF (1982) Cardiovascular responses to exercise in middle-aged men after 10 days of bed rest. Circulation 65:134–140PubMed
Zurück zum Zitat Convertino VA, Doerr DF, Eckberg DL, Fritsch JM, Vernikos-Danellis J (1990) Head-down bed rest impairs vagal baroreflex responses and provokes orthostatic hypotension. J Appl Physiol 68:1458–1464PubMed Convertino VA, Doerr DF, Eckberg DL, Fritsch JM, Vernikos-Danellis J (1990) Head-down bed rest impairs vagal baroreflex responses and provokes orthostatic hypotension. J Appl Physiol 68:1458–1464PubMed
Zurück zum Zitat Convertino DA (1996) Exercise and adaptation to microgravity environments. In: Fregley MJ, Blatteis CM (eds) Handbook of physiology, Sect. 4, Environmental physiology, vol II. Oxford University Press, New York, pp 815–853 Convertino DA (1996) Exercise and adaptation to microgravity environments. In: Fregley MJ, Blatteis CM (eds) Handbook of physiology, Sect. 4, Environmental physiology, vol II. Oxford University Press, New York, pp 815–853
Zurück zum Zitat Convertino VA, Jill LP, Engelke KA, Hoffler GW, Lane LD, Blomqvist CG (1997) Evidence for increased β-adrenoreceptor responsiveness induced by 14 days of simulated microgravity in humans. Am J Physiol 273:R93–R99PubMed Convertino VA, Jill LP, Engelke KA, Hoffler GW, Lane LD, Blomqvist CG (1997) Evidence for increased β-adrenoreceptor responsiveness induced by 14 days of simulated microgravity in humans. Am J Physiol 273:R93–R99PubMed
Zurück zum Zitat de Chantemele EB, Blanc S, Pellet N, Duvareille M, Ferretti G, Gauquelin-Koch G et al (2004) Does resistance exercise prevent body fluid changes after a 90-day bed rest? Eur J Appl Physiol 92:555–564. doi:10.1007/s00421-004-1121-6 CrossRef de Chantemele EB, Blanc S, Pellet N, Duvareille M, Ferretti G, Gauquelin-Koch G et al (2004) Does resistance exercise prevent body fluid changes after a 90-day bed rest? Eur J Appl Physiol 92:555–564. doi:10.​1007/​s00421-004-1121-6 CrossRef
Zurück zum Zitat Delp MD, Hagbarth KE, Hongell A, Wallin BG (1972) Vasoconstrictor properties of rat aorta are dimished by hind limb unweighting. J Appl Physiol 75:2620–2628 Delp MD, Hagbarth KE, Hongell A, Wallin BG (1972) Vasoconstrictor properties of rat aorta are dimished by hind limb unweighting. J Appl Physiol 75:2620–2628
Zurück zum Zitat Drummer C, Gerzer R, Baisch F, Heer M (2000) Body fluid regulation in μ-gravity differs from that on earth: an overview. Pflugers Arch 441(Suppl):R66–R72PubMed Drummer C, Gerzer R, Baisch F, Heer M (2000) Body fluid regulation in μ-gravity differs from that on earth: an overview. Pflugers Arch 441(Suppl):R66–R72PubMed
Zurück zum Zitat Ferretti G, Girardis M, Moia C, Antonutto G (1998) Effects of prolonged bed rest on cardiovascular oxygen transport during submaximal exercise in humans. Eur J Appl Physiol 78:398–402. doi:10.1007/s004210050437 CrossRef Ferretti G, Girardis M, Moia C, Antonutto G (1998) Effects of prolonged bed rest on cardiovascular oxygen transport during submaximal exercise in humans. Eur J Appl Physiol 78:398–402. doi:10.​1007/​s004210050437 CrossRef
Zurück zum Zitat Fortney SM, Hyatt KH, Davis JE, Vogel JM (1991) Changes in body fluid compartments during a 28-day bed rest. Aviat Space Environ Med 62:97–104PubMed Fortney SM, Hyatt KH, Davis JE, Vogel JM (1991) Changes in body fluid compartments during a 28-day bed rest. Aviat Space Environ Med 62:97–104PubMed
Zurück zum Zitat Fortney SM, Schneider VS, Greenleaf JE (1996) The physiology of bed rest. In: Handbook of Physiology. Environmental Physiology, Sect. 4, vol I, Chap. 39. American Physiological Society, Bethesda, pp 889–939 Fortney SM, Schneider VS, Greenleaf JE (1996) The physiology of bed rest. In: Handbook of Physiology. Environmental Physiology, Sect. 4, vol I, Chap. 39. American Physiological Society, Bethesda, pp 889–939
Zurück zum Zitat Fritsch-Yelle JM, Whitson PA, Bondar RL, Brown TE (1996) Subnormal norepinephrine release relates to presyncope in astronauts after spaceflight. J Appl Physiol 81:2134–2141PubMed Fritsch-Yelle JM, Whitson PA, Bondar RL, Brown TE (1996) Subnormal norepinephrine release relates to presyncope in astronauts after spaceflight. J Appl Physiol 81:2134–2141PubMed
Zurück zum Zitat Fu Q, Levine BD, Pawelczyk JA, Ertl AC, Diedrich A, Cox JF et al (2002) Cardiovascular and sympathetic neural responses to handgrip and cold pressure stimuli in humans before, during and after spaceflight. J Physiol 544:653–664. doi:10.1113/jphysiol.2002.025098 PubMedCrossRef Fu Q, Levine BD, Pawelczyk JA, Ertl AC, Diedrich A, Cox JF et al (2002) Cardiovascular and sympathetic neural responses to handgrip and cold pressure stimuli in humans before, during and after spaceflight. J Physiol 544:653–664. doi:10.​1113/​jphysiol.​2002.​025098 PubMedCrossRef
Zurück zum Zitat Geigy Scientific Tables (1982) Lentner C (ed) Ciba-Geigy, Basel, pp 210–213 Geigy Scientific Tables (1982) Lentner C (ed) Ciba-Geigy, Basel, pp 210–213
Zurück zum Zitat Grigoriev AI, Kozlovskaya IB (1987) Man in space: 25 years of manned space flights in the Soviet Union. Biomedical aspects, biological science in space. In: Watanabe S, Mitarai G, Mori S (eds) Proceedings of the international symposium on biological sciences in space. My Research, Tokyo, pp 9–16 Grigoriev AI, Kozlovskaya IB (1987) Man in space: 25 years of manned space flights in the Soviet Union. Biomedical aspects, biological science in space. In: Watanabe S, Mitarai G, Mori S (eds) Proceedings of the international symposium on biological sciences in space. My Research, Tokyo, pp 9–16
Zurück zum Zitat Grenon SM, Sheynberg N, Hurwitz S, Xiao G, Ramsdell CD, Ehrman MD et al (2004) Renal, endocrine, and cardiovascular responses to bed rest in male subjects on a constant diet. J Investig Med 52:117–128. doi:10.2310/6650.2004.17862 PubMedCrossRef Grenon SM, Sheynberg N, Hurwitz S, Xiao G, Ramsdell CD, Ehrman MD et al (2004) Renal, endocrine, and cardiovascular responses to bed rest in male subjects on a constant diet. J Investig Med 52:117–128. doi:10.​2310/​6650.​2004.​17862 PubMedCrossRef
Zurück zum Zitat Gunga HC, Kirsch K, Baartz F, Maillet A, Gharib C, Nalishiti W et al (1996) Erythropoietin under real and simulated microgravity conditions in humans. J Appl Physiol 81:761–773PubMed Gunga HC, Kirsch K, Baartz F, Maillet A, Gharib C, Nalishiti W et al (1996) Erythropoietin under real and simulated microgravity conditions in humans. J Appl Physiol 81:761–773PubMed
Zurück zum Zitat Iellamo F, Di Rienzo M, Lucini D, Legramante JM, Pizzinelli P, Castiglioni P, Pigozzi F, Pagani M, Parati G (2006) Muscle metaboreflex contribution to cardiovascular regulation during dynamic exercise in microgravity: insights from mission STS-107 of the space shuttle Columbia. J Physiol 572:829–838PubMed Iellamo F, Di Rienzo M, Lucini D, Legramante JM, Pizzinelli P, Castiglioni P, Pigozzi F, Pagani M, Parati G (2006) Muscle metaboreflex contribution to cardiovascular regulation during dynamic exercise in microgravity: insights from mission STS-107 of the space shuttle Columbia. J Physiol 572:829–838PubMed
Zurück zum Zitat Infanger M, Ulbrich C, Baatout S, Wehland M, Kreutz R, Bauer J et al. (2007) Modelled gravitational unloading induced downregulation of endothelin-1 in human endothelial cells. J Cell Biochem. doi:10.1002/jcb.21261 Infanger M, Ulbrich C, Baatout S, Wehland M, Kreutz R, Bauer J et al. (2007) Modelled gravitational unloading induced downregulation of endothelin-1 in human endothelial cells. J Cell Biochem. doi:10.​1002/​jcb.​21261
Zurück zum Zitat Kamiya A, Michikami D, Iwase S, Hayano J, Kawada T, Sugimachi M et al (2004) α-Adrenergic vascular responsiveness to sympathetic nerve activity is intact after head-down bed rest in humans. Am J Physiol Regul Integr Comp Physiol 286:R151–R157. doi:10.1152/ajpregu.00685.2002 PubMed Kamiya A, Michikami D, Iwase S, Hayano J, Kawada T, Sugimachi M et al (2004) α-Adrenergic vascular responsiveness to sympathetic nerve activity is intact after head-down bed rest in humans. Am J Physiol Regul Integr Comp Physiol 286:R151–R157. doi:10.​1152/​ajpregu.​00685.​2002 PubMed
Zurück zum Zitat Krasney JA (1996) Head-water immersion: animal studies. In: Fregley MJ, Blatteis CM (eds) Handbook of physiology, Sect. 4, environmental physiology, vol II. Oxford University Press, New York, pp 855–887 Krasney JA (1996) Head-water immersion: animal studies. In: Fregley MJ, Blatteis CM (eds) Handbook of physiology, Sect. 4, environmental physiology, vol II. Oxford University Press, New York, pp 855–887
Zurück zum Zitat Meyer M, Scheid P (1980) Solubility of acetylene in human blood determined by mass spectrometry. J Appl Physiol 48:1035–1037PubMed Meyer M, Scheid P (1980) Solubility of acetylene in human blood determined by mass spectrometry. J Appl Physiol 48:1035–1037PubMed
Zurück zum Zitat Moffitt JA, Foley CM, Schadt JC, Laughlin MH, Hasser EM (1998) Attenuated baroreflex control of sympathetic nerve activity after cardiovascular deconditioning in rats. Am J Physiol 274:R1397–R1405PubMed Moffitt JA, Foley CM, Schadt JC, Laughlin MH, Hasser EM (1998) Attenuated baroreflex control of sympathetic nerve activity after cardiovascular deconditioning in rats. Am J Physiol 274:R1397–R1405PubMed
Zurück zum Zitat Norsk P (2000) Renal adjustments to microgravity. Eur J Appl Physiol 441(Suppl):R62–R65 Norsk P (2000) Renal adjustments to microgravity. Eur J Appl Physiol 441(Suppl):R62–R65
Zurück zum Zitat Pawelczyk JA, Zuckerman JH, Blomqvist CG, Levine BD (2001) Regulation of muscle sympathetic nerve activity after bed rest deconditioning. Am J Physiol Heart Circ Physiol 280:H2230–H2239PubMed Pawelczyk JA, Zuckerman JH, Blomqvist CG, Levine BD (2001) Regulation of muscle sympathetic nerve activity after bed rest deconditioning. Am J Physiol Heart Circ Physiol 280:H2230–H2239PubMed
Zurück zum Zitat Perhonen MA, Franco F, lane LD, Buckey JC, Blomqvist CG, Zerweckh JE, Peshock RM, Weatherall PT, Levine BD (2001a) Cardiac atrophy after bed rest and space flight. J Appl Physiol 91:645–653PubMed Perhonen MA, Franco F, lane LD, Buckey JC, Blomqvist CG, Zerweckh JE, Peshock RM, Weatherall PT, Levine BD (2001a) Cardiac atrophy after bed rest and space flight. J Appl Physiol 91:645–653PubMed
Zurück zum Zitat Perhonen MA, Zuckerman JH, Levine BD (2001b) Deterioration of left ventricular chamber performance after bed rest: “cardiovascular deconditioning” or hypovolemia? Circulation 103:1851–1857PubMed Perhonen MA, Zuckerman JH, Levine BD (2001b) Deterioration of left ventricular chamber performance after bed rest: “cardiovascular deconditioning” or hypovolemia? Circulation 103:1851–1857PubMed
Zurück zum Zitat Saltin B, Blomqvist G, Mitchell JH, Johnson RL JR Wildenthal K, Chapman CB, Frenkel E M.D.1; Norton W, Siperstein, Suki W, Vastagh G, Prengler A (1968) A longitudinal study of adaptive changes in oxygen transport and body composition. Circulation 30(Suppl 7):1–78. doi:10.1016/S0079-6123(08)61433-8 Saltin B, Blomqvist G, Mitchell JH, Johnson RL JR Wildenthal K, Chapman CB, Frenkel E M.D.1; Norton W, Siperstein, Suki W, Vastagh G, Prengler A (1968) A longitudinal study of adaptive changes in oxygen transport and body composition. Circulation 30(Suppl 7):1–78. doi:10.​1016/​S0079-6123(08)61433-8
Zurück zum Zitat Shoemaker JK, Hogeman CS, Sinoway LI (1999) Contributions of MSNA and stroke volume to orthostatic intolerance following bed rest. Am J Physiol 277:R1084–R1090PubMed Shoemaker JK, Hogeman CS, Sinoway LI (1999) Contributions of MSNA and stroke volume to orthostatic intolerance following bed rest. Am J Physiol 277:R1084–R1090PubMed
Zurück zum Zitat Shykoff BE, Farhi LE, Olszowka AJ, Pendergast DR, Rokitka MA, Eisenhardt CG et al (1996) Cardiovascular response to submaximal exercise in sustained microgravity. J Appl Physiol 81:26–32PubMed Shykoff BE, Farhi LE, Olszowka AJ, Pendergast DR, Rokitka MA, Eisenhardt CG et al (1996) Cardiovascular response to submaximal exercise in sustained microgravity. J Appl Physiol 81:26–32PubMed
Zurück zum Zitat Smorawínski J, Nazar K, Kaciuba-Uscilisko H, Kamínska E, Cybulski G, Kodrzycka A et al (2001) J Appl Physiol 91:249–257PubMed Smorawínski J, Nazar K, Kaciuba-Uscilisko H, Kamínska E, Cybulski G, Kodrzycka A et al (2001) J Appl Physiol 91:249–257PubMed
Zurück zum Zitat Sundblad P, Spaak J, Linnarsson D (2000) Cardiovascular responses to upright and supine exercise in humans after 6 weeks of head-down tilt (−6°). Eur J Appl Physiol 83:303–309. doi:10.1007/s004210000258 PubMedCrossRef Sundblad P, Spaak J, Linnarsson D (2000) Cardiovascular responses to upright and supine exercise in humans after 6 weeks of head-down tilt (−6°). Eur J Appl Physiol 83:303–309. doi:10.​1007/​s004210000258 PubMedCrossRef
Metadaten
Titel
Metabolic and cardiovascular responses during sub-maximal exercise in humans after 14 days of head-down tilt bed rest and inactivity
verfasst von
C. Capelli
G. Antonutto
M. Cautero
E. Tam
G. Ferretti
Publikationsdatum
01.11.2008
Verlag
Springer-Verlag
Erschienen in
European Journal of Applied Physiology / Ausgabe 5/2008
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-008-0848-x

Weitere Artikel der Ausgabe 5/2008

European Journal of Applied Physiology 5/2008 Zur Ausgabe

Neu im Fachgebiet Arbeitsmedizin

Das Geschlechterparadoxon in der gesundheitlich beeinträchtigten Lebenszeit – Ende eines Mythos?

Beginnend mit den 1920er-Jahren hat sich eine Vorstellung über die Geschlechterdifferenzen in Gesundheit und Mortalität etabliert, die von Lorber und Moore in dem einprägsamen Satz: „Women get sicker, but men die quicker“, zusammengefasst wurde [ 1 …, S. 13]. Tatsächlich erscheinen vor dem Hintergrund der höheren Lebenserwartung der Frauen die Studienergebnisse zu den Geschlechterdifferenzen in der Morbidität überraschend, wonach Frauen im Durchschnitt einen schlechteren Gesundheitszustand aufweisen als Männer [

Gesunde Lebenserwartung: Ein kritischer Blick auf Nutzen und Potenziale des demographischen Gesundheitsindikators

Open Access Leitthema

Die demographische Alterung hat vielfältige gesellschaftliche Konsequenzen, deren Ausmaß wesentlich vom Gesundheitszustand der Bevölkerung abhängt. Um diesen analysieren und bewerten zu können, wurden spezielle Kennziffern entwickelt, die in …

Wie hat sich die Lebenserwartung ohne funktionelle Einschränkungen in Deutschland entwickelt? Eine Analyse mit Daten des Deutschen Alterssurveys (DEAS)

Deutschland erfährt, wie andere Hocheinkommensstaaten, aufgrund kontinuierlich rückläufiger Mortalität und niedriger Geburtenraten tiefgreifende demografische Veränderungen. Der demografische Wandel führt in Deutschland zu einem zunehmend höheren …

Hitzeschutz im Fokus der hessischen Betreuungs- und Pflegeaufsicht

Open Access Klimawandel Übersichtsartikel

Im Sommer 2023 kündigte das Bundesministerium für Gesundheit (BMG) einen nationalen Hitzeschutzplan an und forderte die Länder auf, zu prüfen, „ob die Warnstufen des [Deutschen Wetterdienstes] DWD mit der Durchführung von Akutmaßnahmen …