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Pediatric Nephrology
Erschienen in: Pediatric Nephrology 10/2003

01.10.2003 | Editorial Commentary

Calciphylaxis and vascular calcification: a continuum of extra-skeletal osteogenesis

verfasst von: Sharon M. Moe, Neal X. Chen

Erschienen in: Pediatric Nephrology | Ausgabe 10/2003

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Abstract

Calciphylaxis, more appropriately termed calcific uremic arteriolopathy, is a clinical syndrome of skin necrosis due to medial calcification of the small arterioles. While this disease has been described as a distinct entity, we believe it is but a single manifestation of a complicated systemic process that leads to vascular calcification in both the intimal and medial layers of all forms of arteries in patients with chronic kidney disease. The pathophysiology of vascular calcification includes injury leading to vascular smooth muscle cell de-differentiation to osteoblast-like cells, a nidus "formation" of matrix proteins with and without apoptotic bodies, initiation and extension of mineralization, and a balance of pro-calcification factors and inhibitory calcification factors. The clinical manifestations depend upon the location of the affected artery. The rationale behind this hypothesis is discussed in this review.
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Metadaten
Titel
Calciphylaxis and vascular calcification: a continuum of extra-skeletal osteogenesis
verfasst von
Sharon M. Moe
Neal X. Chen
Publikationsdatum
01.10.2003
Verlag
Springer-Verlag
Erschienen in
Pediatric Nephrology / Ausgabe 10/2003
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-003-1276-0

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