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Supportive Care in Cancer

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02.02.2022 | Review Article

Effectiveness of exercise training on cancer-related fatigue in colorectal cancer survivors: a systematic review and meta-analysis of randomized controlled trials

verfasst von: Pedro Machado, Miguel Morgado, João Raposo, Marco Mendes, Cândida G. Silva, Nuno Morais

Erschienen in: Supportive Care in Cancer | Ausgabe 7/2022

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Abstract

Purpose

To investigate the effects of exercise training on cancer-related fatigue (CRF) in colorectal cancer survivors.

Methods

Randomized controlled trials published between 1 January 2010 and 19 October 2020, selected through online search conducted in PubMed, Scopus, Web of Science, SPORTDiscus and PEDro databases, were included. Eligible trials compared the effect of exercise training interventions, versus non-exercise controls on CRF, in colorectal cancer survivors, during or after treatment. The methodological quality of individual studies was analysed using the Physiotherapy Evidence Database (PEDro) scale. Standardized mean differences (SMD) that were pooled using random-effects models were included as the effect size. In addition, 95% prediction intervals (PI) were calculated.

Results

Six trials involving 330 colorectal cancer patients met the inclusion criteria and presented reasonable to good methodological quality. An overall small-to-moderate effect of exercise training on CRF was found (SMD = − 0.29: 95% CI: [− 0.53; − 0.06]; p = 0.01; PI: [− 0.63; 0.04]; low-quality evidence). Subgroup analysis revealed moderate effects of exercise interventions performed during chemotherapy (SMD = − 0.63; 95% CI: [− 1.06; − 0.21]; p = 0.003) and small, non-significant effects, when exercise training was performed after cancer treatment (SMD = − 0.14; 95% CI: [− 0.43; 0.14]; p = 0.32). Steady improvements were achieved when a combination of aerobic plus resistance exercise was used, in interventions lasting 12 to 24 weeks.

Conclusion

Exercise training could be regarded as a supportive therapy for the clinical management of CRF in colorectal cancer patients undergoing chemotherapy, but further studies are necessary to clarify the effects of exercise interventions on CRF after cancer treatment.

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Titel: Effectiveness of exercise training on cancer-related fatigue in colorectal cancer survivors: a systematic review and meta-analysis of randomized controlled trials
verfasst von: Pedro Machado
Miguel Morgado
João Raposo
Marco Mendes
Cândida G. Silva
Nuno Morais
Publikationsdatum: 02.02.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 7/2022
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-022-06856-3

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Effectiveness of exercise training on cancer-related fatigue in colorectal cancer survivors: a systematic review and meta-analysis of randomized controlled trials

Abstract

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Methods

Results

Conclusion

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