Erschienen in:
01.06.2009 | Case Report
A case of “refractory” lupus erythematosus profundus responsive to rituximab [case report]
verfasst von:
Adrian McArdle, Joshua F. Baker
Erschienen in:
Clinical Rheumatology
|
Ausgabe 6/2009
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Abstract
Lupus erythematosus profundus is a rare complication of systemic lupus erythematosus characterized by the presence of deep, tender subcutaneous nodules. A 22-year-old African-American female with extensive lupus profundus resistant to conventional therapies was treated with two infusions of the anti-CD20 monoclonal antibody, rituximab, at a dosage of 1,000 mg each. The patient demonstrated a remarkable clinical response as indicated by the disappearance of the nodules. B-cell depletion therapy with rituximab used alone or in combination with other therapies may be a viable option in patients with lupus profundus refractory to current therapies.