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Lasers in Medical Science

Erschienen in:

17.05.2022 | Original Article

Morphological parameters predicting subthreshold micropulse laser effectiveness in central serous chorioretinopathy

verfasst von: Peter Kiraly, Jaka Smrekar, Polona Jaki Mekjavić

Erschienen in: Lasers in Medical Science | Ausgabe 8/2022

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Abstract

Purpose

The purpose of this prospective study was to predict the effectiveness of subthreshold micropulse laser (SML) based on morphological parameters in patients with central serous chorioretinopathy (CSC).

Methods

Thirty-one patients were examined at presentation, 3 months, and 6 months after the disease onset. In patients with persistent subretinal fluid (SRF) at 3 months, SML was performed. The following morphological parameters were observed just before treatment: central retinal thickness (CRT), maximal SRF, choroidal thickness (CT), pigment epithelial detachment (PED) height and width, number of hyperreflective foci (HF) at fovea and leakage site, secondary choroidal neovascularization (CNV), and severity of retinal pigment epithelium (RPE) alterations using multimodal imaging.

Results

Good response was associated with lower SRF (p = 0.038), narrower PED (p = 0.078), and decreasing number of HF at fovea (difHFf) (p = 0 .016) just before the treatment. From a bivariate and multivariate point of view, the two groups differed significantly in the pair (SRF, PED width) (p = 0.048) and in the triple (SRF, PED width, difHFf) (p = 0.026).

Conclusion

Lower SRF, narrower PED, and decreasing HF could be associated with good response to SML in CSC patients.

The p value of 0.048 was obtained using the spatial-rank-based test. Hotelling’s T² test gives p = 0.055.

The p value of 0.026 was obtained using the spatial-rank-based test. Hotelling’s T² test gives p = 0.008.

Wang M, Munch IC, Hasler PW, Prünte C, Larsen M (2008) Central serous chorioretinopathy. Acta Ophthalmol 86(2):126–145CrossRef

Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N, Jaisser F, Behar-Cohen F (2015) Central serous chorioretinopathy: recent findings and new physiopathology hypothesis. Prog Retin Eye Res 48:82–118CrossRef

Lourthai P, Bhurayanontachai P (2017) Pattern of contrast sensitivity changes in acute central serous chorioretinopathy. J Ophthalmol 2017:9053932PubMedPubMedCentral

Roisman L, Ribeiro JC, Fechine FV, Lavinsky D, Moraes N, Campos M, Farah ME (2014) Does microperimetry have a prognostic value in central serous chorioretinopathy? Retina 34(4):713–718CrossRef

Maaranen TH, Tuppurainen KT, Mäntyjärvi MI (2000) Color vision defects after central serous chorioretinopathy. Retina 20(6):633–637CrossRef

Chappelow AV, Marmor MF (2000) Multifocal electroretinogram abnormalities persist following resolution of central serous chorioretinopathy. Arch Ophthalmol 118(9):1211–1215CrossRef

Kitzmann AS, Pulido JS, Diehl NN, Hodge DO, Burke JP (2008) The incidence of central serous chorioretinopathy in Olmsted County, Minnesota, 1980–2002. Ophthalmology 115(1):169–173CrossRef

Liu B, Deng T, Zhang J (2016) Risk factors for central serous chorioretinopathy: a systematic review and meta-analysis. Retina 36(1):9–19CrossRef

Daruich A, Matet A, Marchionno L, De Azevedo JD, Ambresin A, Mantel I, Behar-Cohen F (2017) Acute central serous chorioretinopathy: factors influencing episode duration. Retina 37(10):1905–1915CrossRef

10.

Bousquet E, Zhao M, Daruich A, Behar-Cohen F (2019) Mineralocorticoid antagonists in the treatment of central serous chorioetinopathy: review of the pre-clinical and clinical evidence. Exp Eye Res 187:107754CrossRef

11.

van Dijk EHC, Fauser S, Breukink MB, Blanco-Garavito R, Groenewoud JMM, Keunen JEE, Peters PJH, Dijkman G, Souied EH, MacLaren RE et al (2018) Half-dose photodynamic therapy versus high-density subthreshold micropulse laser treatment in patients with chronic central serous chorioretinopathy: the place trial. Ophthalmology 125(10):1547–1555CrossRef

12.

Burumcek E, Mudun A, Karacorlu S, Arslan MO (1997) Laser photocoagulation for persistent central serous retinopathy: results of long-term follow-up. Ophthalmology 104(4):616–622CrossRef

13.

Gawęcki M (2019) Micropulse laser treatment of retinal diseases. J Clin Med 8(2):242CrossRef

14.

Inagaki K, Shuo T, Katakura K, Ebihara N, Murakami A, Ohkoshi K (2015) Sublethal photothermal stimulation with a micropulse laser induces heat shock protein expression in Arpe-19 cells. J Ophthalmol 2015:729792PubMedPubMedCentral

15.

Li Z, Song Y, Chen X, Chen Z, Ding Q (2015) Biological modulation of mouse Rpe cells in response to subthreshold diode micropulse laser treatment. Cell Biochem Biophys 73(2):545–552CrossRef

16.

Midena E, Bini S, Martini F, Enrica C, Pilotto E, Micera A, Esposito G, Vujosevic S (2020) Changes of aqueous humor müller cells’ biomarkers in human patients affected by diabetic macular edema after subthreshold micropulse laser treatment. Retina 40(1):126–134CrossRef

17.

Scholz P, Altay L, Fauser S (2017) A review of subthreshold micropulse laser for treatment of macular disorders. Adv Ther 34(7):1528–1555CrossRef

18.

Abd Elhamid AH (2015) Subthreshold micropulse yellow laser treatment for nonresolving central serous chorioretinopathy. Clin Ophthalmol 9:2277–2283CrossRef

19.

Sousa K, Calvão-Santos G, João M, Gomes N, Falcão M (2020) 532-Nm subthreshold micropulse laser for the treatment of chronic central serous retinopathy. Clin Ophthalmol 14:525–531CrossRef

20.

Altınel MG, Acikalin B, Gunes H, Demir G (2021) Optical coherence tomography parameters as predictors of treatment response to a 577-nm subthreshold micropulse laser in chronic central serous chorioretinopathy. Lasers Med Sci 36(7):1505–1514CrossRef

21.

Lee H, Lee J, Chung H, Kim HC (2016) Baseline spectral domain optical coherence tomographic hyperreflective foci as a predictor of visual outcome and recurrence for central serous chorioretinopathy. Retina 36(7):1372–1380CrossRef

22.

Chen SN, Hwang JF, Tseng LF, Lin CJ (2008) Subthreshold diode micropulse photocoagulation for the treatment of chronic central serous chorioretinopathy with juxtafoveal leakage. Ophthalmology 115(12):2229–2234CrossRef

23.

Mohabati D, Schellevis RL, van Dijk EHC, Fauser S, den Hollander AI, Hoyng CB, De Jong EK, Yzer S, Boon CJF (2019) Genetic Risk Factors in Severe, Nonsevere and Acute Phenotypes of Central Serous Chorioretinopathy. Retina 40(9):1734–1741CrossRef

24.

Mrejen S, Balaratnasingam C, Kaden TR, Bottini A, Dansingani K, Bhavsar KV, Yannuzzi NA, Patel S, Chen KC, Yu S et al (2019) Long-term visual outcomes and causes of vision loss in chronic central serous chorioretinopathy. Ophthalmology 126(4):576–588CrossRef

25.

Lainscak M, Pelliccia F, Rosano G, Vitale C, Schiariti M, Greco C, Speziale G, Gaudio C (2015) Safety profile of mineralocorticoid receptor antagonists: spironolactone and eplerenone. Int J Cardiol 200:25–29CrossRef

26.

Lotery A, Sivaprasad S, O’Connell A, Harris RA, Culliford L, Ellis L, Cree A, Madhusudhan S, Behar-Cohen F, Chakravarthy U et al (2020) Eplerenone for chronic central serous chorioretinopathy in patients with active, previously untreated disease for more than 4 months (Vici): a randomised, double-blind, placebo-controlled trial. Lancet 395(10220):294–303CrossRef

27.

Iwase T, Yokouchi H, Kitahashi M, Kubota-Taniai M, Baba T, Yamamoto S (2020) Long-term effects of half-time photodynamic therapy on retinal sensitivity in eyes with chronic central serous chorioretinopathy. Biomed Res Int 2020:3190136CrossRef

28.

van Rijssen TJ, van Dijk EHC, Yzer S, Ohno-Matsui K, Keunen JEE, Schlingemann RO, Sivaprasad S, Querques G, Downes SM, Fauser S et al (2019) Central serous chorioretinopathy: towards an evidence-based treatment guideline. Prog Retin Eye Res 73:100770CrossRef

29.

Donati MC, Murro V, Mucciolo DP, Giorgio D, Cinotti G, Virgili G, Rizzo S (2021) Subthreshold yellow micropulse laser for treatment of diabetic macular edema: comparison between fixed and variable treatment regimen. Eur J Ophthalmol 31(3):1254–1260CrossRef

30.

Keunen JEE, Battaglia-Parodi M, Vujosevic S, Luttrull JK (2020) International retinal laser society guidelines for subthreshold laser treatment. Transl Vis Sci Technol 9(9):15CrossRef

31.

Ludwig K, Lasser T, Sakowski H, Abramowski H, Wörz G (1994) Photocoagulation in the edematous and non-edematous retina with the Cw-laser of different wavelengths. Ophthalmologe 91(6):783–788PubMed

32.

Mansouri A, Sampat KM, Malik KJ, Steiner JN, Glaser BM (2014) Efficacy of subthreshold micropulse laser in the treatment of diabetic macular edema is influenced by pre-treatment central foveal thickness. Eye (Lond) 28(12):1418–1424CrossRef

33.

Rizzolo LJ, Peng S, Luo Y, Xiao W (2011) Integration of tight junctions and Claudins with the barrier functions of the retinal pigment epithelium. Prog Retin Eye Res 30(5):296–323CrossRef

34.

Plateroti AM, Witmer MT, Kiss S, D’Amico DJ (2014) Characteristics of intraretinal deposits in acute central serous chorioretinopathy. Clin Ophthalmol 8:673–676CrossRef

35.

Wang M, Sander B, la Cour M, Larsen M (2005) Clinical characteristics of subretinal deposits in central serous chorioretinopathy. Acta Ophthalmol Scand 83(6):691–696CrossRef

36.

Landa G, Barnett JA, Garcia PM, Tai KW, Rosen RB (2013) Quantitative and qualitative spectral domain optical coherence tomography analysis of subretinal deposits in patients with acute central serous retinopathy. Ophthalmologica 230(2):62–68CrossRef

37.

Yalcinbayir O, Gelisken O, Akova-Budak B, Ozkaya G, Gorkem Cevik S, Yucel AA (2014) Correlation of spectral domain optical coherence tomography findings and visual acuity in central serous chorioretinopathy. Retina 34(4):705–712CrossRef

38.

Borrelli E, Zuccaro B, Zucchiatti I, Parravano M, Querques L, Costanzo E, Sacconi R, Prascina F, Scarinci F, Bandello F et al (2019) Optical coherence tomography parameters as predictors of treatment response to eplerenone in central serous chorioretinopathy. J Clin Med. 8(9):1271CrossRef

Titel: Morphological parameters predicting subthreshold micropulse laser effectiveness in central serous chorioretinopathy
verfasst von: Peter Kiraly
Jaka Smrekar
Polona Jaki Mekjavić
Publikationsdatum: 17.05.2022
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 8/2022
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-022-03574-4

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Morphological parameters predicting subthreshold micropulse laser effectiveness in central serous chorioretinopathy

Abstract

Purpose

Methods

Results

Conclusion

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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