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Neurosurgical Review
Erschienen in: Neurosurgical Review 3/2014

01.07.2014 | Review

Treatment of epileptic seizures in brain tumors: a critical review

verfasst von: R. Bauer, M. Ortler, M. Seiz-Rosenhagen, R. Maier, J. V. Anton, I. Unterberger

Erschienen in: Neurosurgical Review | Ausgabe 3/2014

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Abstract

Epileptic seizures represent a common signal of intracranial tumors, frequently the presenting symptom and the main factor influencing quality of life. Treatment of tumors concentrates on survival; antiepileptic drug (AED) treatment frequently is prescribed in a stereotyped way. A differentiated approach according to epileptic syndromes can improve seizure control and minimize unwarranted AED effects. Prophylactic use of AEDs is to be discouraged in patients without seizures. Acutely provoked seizures do not need long-term medication except for patients with high recurrence risk indicated by distinct EEG patterns, auras, and several other parameters. With chronically repeated seizures (epilepsies), long-term AED treatment is indicated. Non-enzyme-inducing AEDs might be preferred. Valproic acid exerts effects against progression of gliomatous tumors. In low-grade astrocytomas with epilepsy, a comprehensive presurgical epilepsy work-up including EEG-video monitoring is advisable; in static non-progressive tumors, it is mandatory. In these cases, the neurosurgical approach has to include the removal of the seizure-onset zone frequently located outside the lesion.
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Metadaten
Titel
Treatment of epileptic seizures in brain tumors: a critical review
verfasst von
R. Bauer
M. Ortler
M. Seiz-Rosenhagen
R. Maier
J. V. Anton
I. Unterberger
Publikationsdatum
01.07.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Neurosurgical Review / Ausgabe 3/2014
Print ISSN: 0344-5607
Elektronische ISSN: 1437-2320
DOI
https://doi.org/10.1007/s10143-014-0538-6

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