Neuromonitoring of the language pathways using cortico-cortical evoked potentials: a systematic review and meta-analysis

Cortico-cortical evoked potentials (CCEPs) are a surge in activity of one cortical zone caused by stimulation of another cortical zone. Recording of CCEP may be a useful method of intraoperative monitoring of the brain pathways, particularly of the language-related tracts. We aimed to conduct a systematic review and meta-analysis, dedicated to the clinical question: Does the CCEP recording effectively predict the postoperative speech deficits in neurosurgical patients? We conducted language-restricted PubMed, Google Scholar, Scopus, and Cochrane database search for eligible studies of CCEP published until March 2021. There were 4 articles (3 case series and 1 case report), which met our inclusion/exclusion criteria. A total of 32 patients (30 cases of tumors and 2 cavernomas) included in the analysis were divided into two cohorts — quantitative and qualitative, in accordance with the method of evaluating changes in the amplitude of CCEP after the lesion resection and postoperative alterations in speech function. Quantitative variables were studied using the Spearman rank correlation coefficient. Categorical variables were compared in groups by Fisher’s exact test. We found a strong positive correlation between the decrease in the N1 wave amplitude and the severity of postoperative speech deficits (quantitative cohort: r = 0.57, p = 0.01; qualitative cohort: p = 0.02). Thus, the CCEP method using the N1 wave amplitude as a marker enables to effectively predict postoperative speech outcomes. Nevertheless, the low level of evidence for the included works indicated the necessity for additional research on this issue.