Skip to main content
Erschienen in: International Journal of Clinical Oncology 4/2015

01.08.2015 | Original Article

Transoral robotic surgery in management of oropharyngeal cancers: a preliminary experience at a tertiary cancer centre in India

verfasst von: Surender Dabas, Abhinav Dewan, Reetesh Ranjan, Ajay Kumar Dewan, Anoop Puri, Swati H. Shah, Rupal Sinha

Erschienen in: International Journal of Clinical Oncology | Ausgabe 4/2015

Einloggen, um Zugang zu erhalten

Abstract

Background

The aim of this observational prospective study was to determine the technical feasibility, safety and adequacy of surgical margins for transoral robotic surgery (TORS) in oropharyngeal cancers.

Methods

From March 2013 to May 2014, 60 patients with oropharyngeal lesions underwent TORS with or without neck dissection using the ‘DaVinci’ robot. Patients were observed and data recorded on surgical time, blood loss, complications and functional outcome of patients.

Results

All 60 patients underwent TORS, with neck dissection performed in 45 of the patients. A positive margin was seen in two patients (3.3 %). Intent to treatment was radical in 42 patients and salvage in 18 patients. None of the patients required tracheostomy, and one patient (1.66 %) died postoperatively. Postoperative complications in the form of primary haemorrhage required active intervention in three patients. Average estimated blood loss was 26.5 ± 31.1 ml. Postoperatively, all patients had adequate swallowing and speech function with nasal twang reported in three patients on long-term follow up. Patients started tolerating oral feeds within a week of procedure (mean 3.96 days), with the nasogastric tube removed on the ninth postoperative day (mean 9.19 days). No long-term gastrostomy tube dependency was reported.

Conclusion

TORS is a safe, feasible, minimally invasive procedure in patients with oropharyngeal cancers. It has the least morbidity and offers benefits in terms of avoidance of tracheostomy tube, prolonged Ryle’s tube and gastrostomy dependency.
Literatur
1.
Zurück zum Zitat National Cancer Registry Programme (ICMR) (2008). Consolidated report of population based cancer registries: 2004-05. ICMR, Bangalore National Cancer Registry Programme (ICMR) (2008). Consolidated report of population based cancer registries: 2004-05. ICMR, Bangalore
2.
Zurück zum Zitat Warnakulasuriya S (2009) Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 45:309–316PubMedCrossRef Warnakulasuriya S (2009) Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 45:309–316PubMedCrossRef
3.
Zurück zum Zitat Gourin CG, Johnson JT (2001) Surgical treatment of squamous cell carcinoma of the base of tongue. Head Neck 23:653–660PubMedCrossRef Gourin CG, Johnson JT (2001) Surgical treatment of squamous cell carcinoma of the base of tongue. Head Neck 23:653–660PubMedCrossRef
4.
Zurück zum Zitat Goguen LA, Posner MR, Norris CM et al (2006) Dysphagia after sequential chemoradiation therapy for advanced head and neck cancer. Otolaryngol Head Neck Surg 134:916–922PubMedCrossRef Goguen LA, Posner MR, Norris CM et al (2006) Dysphagia after sequential chemoradiation therapy for advanced head and neck cancer. Otolaryngol Head Neck Surg 134:916–922PubMedCrossRef
5.
Zurück zum Zitat Gillespie MB, Brodsky MB, Day TA et al (2004) Swallowing-related quality of life after head and neck cancer treatment. Laryngoscope 114:1362–1367PubMedCrossRef Gillespie MB, Brodsky MB, Day TA et al (2004) Swallowing-related quality of life after head and neck cancer treatment. Laryngoscope 114:1362–1367PubMedCrossRef
6.
Zurück zum Zitat Weinstein GS, O’Malley BW Jr, Hockstein NG (2005) Transoral robotic surgery: supraglottic laryngectomy in a canine model. Laryngoscope 115:1315–1319PubMedCrossRef Weinstein GS, O’Malley BW Jr, Hockstein NG (2005) Transoral robotic surgery: supraglottic laryngectomy in a canine model. Laryngoscope 115:1315–1319PubMedCrossRef
7.
Zurück zum Zitat Weinstein GS, O’Malley BW Jr, Desai SC et al (2009) Transoral robotic surgery: does the ends justify the means? Curr Opin Otolaryngol Head Neck Surg 17:126–131PubMedCrossRef Weinstein GS, O’Malley BW Jr, Desai SC et al (2009) Transoral robotic surgery: does the ends justify the means? Curr Opin Otolaryngol Head Neck Surg 17:126–131PubMedCrossRef
8.
Zurück zum Zitat Genden EM, Desai S, Sung CK (2009) Transoral robotic surgery for the management of head and neck cancer: a preliminary experience. Head Neck 31:283–289PubMedCrossRef Genden EM, Desai S, Sung CK (2009) Transoral robotic surgery for the management of head and neck cancer: a preliminary experience. Head Neck 31:283–289PubMedCrossRef
9.
Zurück zum Zitat Moore EJ, Olsen KD, Kasperbauer JL (2009) Transoral robotic surgery for oropharyngeal squamous cell carcinoma: a prospective study of feasibility and functional outcomes. Laryngoscope 119:2156–2164PubMedCrossRef Moore EJ, Olsen KD, Kasperbauer JL (2009) Transoral robotic surgery for oropharyngeal squamous cell carcinoma: a prospective study of feasibility and functional outcomes. Laryngoscope 119:2156–2164PubMedCrossRef
10.
Zurück zum Zitat Boudreaux BA, Rosenthal EL, Magnuson JS et al (2009) Robot-assisted surgery for upper aerodigestive tract neoplasms. Arch Otolaryngol Head Neck Surg 135:397–401PubMedCrossRef Boudreaux BA, Rosenthal EL, Magnuson JS et al (2009) Robot-assisted surgery for upper aerodigestive tract neoplasms. Arch Otolaryngol Head Neck Surg 135:397–401PubMedCrossRef
11.
Zurück zum Zitat Parsons JT, Mendenhall WM, Stringer SP et al (2002) Squamous cell carcinoma of the oropharynx: surgery, radiation therapy, or both. Cancer 94:2967–2980PubMedCrossRef Parsons JT, Mendenhall WM, Stringer SP et al (2002) Squamous cell carcinoma of the oropharynx: surgery, radiation therapy, or both. Cancer 94:2967–2980PubMedCrossRef
12.
Zurück zum Zitat Machtay M, Perch S, Markiewicz D et al (1997) Combined surgery and postoperative radiotherapy for carcinoma of the base of radiotherapy for carcinoma of the base of tongue: analysis of treatment outcome and prognostic value of margin status. Head Neck 19:494–499PubMedCrossRef Machtay M, Perch S, Markiewicz D et al (1997) Combined surgery and postoperative radiotherapy for carcinoma of the base of radiotherapy for carcinoma of the base of tongue: analysis of treatment outcome and prognostic value of margin status. Head Neck 19:494–499PubMedCrossRef
13.
Zurück zum Zitat Denittis AS, Machtay M, Rosenthal DI et al (2001) Advanced oropharyngeal carcinoma treated with surgery and radiotherapy: oncologic outcome and functional assessment. Am J Otolaryngol 22:329–335PubMedCrossRef Denittis AS, Machtay M, Rosenthal DI et al (2001) Advanced oropharyngeal carcinoma treated with surgery and radiotherapy: oncologic outcome and functional assessment. Am J Otolaryngol 22:329–335PubMedCrossRef
14.
Zurück zum Zitat Machtay M, Rosenthal DI, Hershock D et al (2002) Organ preservation therapy using induction plus concurrent chemoradiation for advanced resectable oropharyngeal carcinoma: a University of Pennsylvania phase II trial. J Clin Oncol 20:3964–3971PubMedCrossRef Machtay M, Rosenthal DI, Hershock D et al (2002) Organ preservation therapy using induction plus concurrent chemoradiation for advanced resectable oropharyngeal carcinoma: a University of Pennsylvania phase II trial. J Clin Oncol 20:3964–3971PubMedCrossRef
15.
Zurück zum Zitat Koch WM (2000) Head and neck surgery in the era of organ preservation therapy. Semin Oncol 27[Suppl 8]:5–12PubMed Koch WM (2000) Head and neck surgery in the era of organ preservation therapy. Semin Oncol 27[Suppl 8]:5–12PubMed
16.
Zurück zum Zitat Nguyen NP, Moltz CC, Frank C et al (2004) Dysphagia following chemoradiation for locally advanced head and neck cancer. Ann Oncol 15(3):383–388PubMedCrossRef Nguyen NP, Moltz CC, Frank C et al (2004) Dysphagia following chemoradiation for locally advanced head and neck cancer. Ann Oncol 15(3):383–388PubMedCrossRef
17.
Zurück zum Zitat Forastiere AA, Goepfert H, Maor M et al (2003) Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 349:2091–2098PubMedCrossRef Forastiere AA, Goepfert H, Maor M et al (2003) Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 349:2091–2098PubMedCrossRef
18.
Zurück zum Zitat Laccourreye O, Hans S, Menard M et al (2005) Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region. Arch Otolaryngol Head Neck Surg 131:592–599PubMedCrossRef Laccourreye O, Hans S, Menard M et al (2005) Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region. Arch Otolaryngol Head Neck Surg 131:592–599PubMedCrossRef
19.
Zurück zum Zitat Steiner W, Fierek O, Ambrosch P et al (2003) Transoral laser microsurgery for squamous cell carcinoma of the base of tongue. Arch Otolaryngol Head Neck Surg 129:36–43PubMedCrossRef Steiner W, Fierek O, Ambrosch P et al (2003) Transoral laser microsurgery for squamous cell carcinoma of the base of tongue. Arch Otolaryngol Head Neck Surg 129:36–43PubMedCrossRef
20.
Zurück zum Zitat Grant DG, Salassa JR, Hinni ML et al (2006) Carcinoma of the tongue base treated by transoral laser microsurgery, Part 1: a prospective analysis of oncologic and functional outcomes. Laryngoscope 116:2150–2155PubMedCrossRef Grant DG, Salassa JR, Hinni ML et al (2006) Carcinoma of the tongue base treated by transoral laser microsurgery, Part 1: a prospective analysis of oncologic and functional outcomes. Laryngoscope 116:2150–2155PubMedCrossRef
21.
Zurück zum Zitat Iseli TA, Kulbersh BD, Iseli CE et al (2009) Functional outcomes after transoral robotic surgery for head and neck cancer. Otolaryngol Head Neck Surg 141:166–171PubMedCrossRef Iseli TA, Kulbersh BD, Iseli CE et al (2009) Functional outcomes after transoral robotic surgery for head and neck cancer. Otolaryngol Head Neck Surg 141:166–171PubMedCrossRef
22.
Zurück zum Zitat Weinstein GS, O’Malley BW, Snyder W et al (2007) Transoral robotic surgery: radical tonsillectomy. Arch Otolaryngol Head Neck Surg 133:1220–1226PubMedCrossRef Weinstein GS, O’Malley BW, Snyder W et al (2007) Transoral robotic surgery: radical tonsillectomy. Arch Otolaryngol Head Neck Surg 133:1220–1226PubMedCrossRef
23.
Zurück zum Zitat Moore EJ, Henstrom DK, Olsen KD et al (2009) Transoral resection of tonsillar squamous cell carcinoma. Laryngoscope 119:508–515PubMedCrossRef Moore EJ, Henstrom DK, Olsen KD et al (2009) Transoral resection of tonsillar squamous cell carcinoma. Laryngoscope 119:508–515PubMedCrossRef
24.
Zurück zum Zitat Preuss SF, Cramer K, Klussmann JP et al (2009) Transoral laser surgery for laryngeal cancer: outcome, complications and prognostic factors in 275 patients. Eur J Surg Oncol 35:235–240PubMedCrossRef Preuss SF, Cramer K, Klussmann JP et al (2009) Transoral laser surgery for laryngeal cancer: outcome, complications and prognostic factors in 275 patients. Eur J Surg Oncol 35:235–240PubMedCrossRef
25.
Zurück zum Zitat Grant DG, Salassa JR, Hinni ML et al (2006) Carcinoma of the tongue base treated by transoral laser microsurgery, part 2: persistent, recurrent and second primary tumors. Laryngoscope 116:2156–2161PubMedCrossRef Grant DG, Salassa JR, Hinni ML et al (2006) Carcinoma of the tongue base treated by transoral laser microsurgery, part 2: persistent, recurrent and second primary tumors. Laryngoscope 116:2156–2161PubMedCrossRef
26.
Zurück zum Zitat Weinstein GS, O’Malley BW, Cohen MA et al (2010) Transoral robotic surgery for advanced oropharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 136(11):1079–1085PubMedCrossRef Weinstein GS, O’Malley BW, Cohen MA et al (2010) Transoral robotic surgery for advanced oropharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 136(11):1079–1085PubMedCrossRef
27.
Zurück zum Zitat Langendijk JA, Doornaert P, Rietveld DH et al (2009) A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer. Radiother Oncol 90(2):189–195PubMedCrossRef Langendijk JA, Doornaert P, Rietveld DH et al (2009) A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer. Radiother Oncol 90(2):189–195PubMedCrossRef
28.
Zurück zum Zitat Machtay M, Moughan J, Trotti A et al (2008) Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol 26:3582–3589PubMedCrossRef Machtay M, Moughan J, Trotti A et al (2008) Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol 26:3582–3589PubMedCrossRef
29.
Zurück zum Zitat Weinstein GS, Quon H, O’Malley BW Jr et al (2010) Selective neck dissection and deintensified postoperative radiation and chemotherapy for oropharyngeal cancer: a subset analysis of the University of Pennsylvania transoral robotic surgery trial. Laryngoscope 120:1749–1755PubMedCrossRef Weinstein GS, Quon H, O’Malley BW Jr et al (2010) Selective neck dissection and deintensified postoperative radiation and chemotherapy for oropharyngeal cancer: a subset analysis of the University of Pennsylvania transoral robotic surgery trial. Laryngoscope 120:1749–1755PubMedCrossRef
30.
Zurück zum Zitat Weinstein GS, Quon H, Newman HJ et al (2012) Transoral robotic surgery alone for oropharyngeal cancer: an analysis of local control. Arch Otolaryngol Head Neck Surg 138(7):628–634PubMedCrossRef Weinstein GS, Quon H, Newman HJ et al (2012) Transoral robotic surgery alone for oropharyngeal cancer: an analysis of local control. Arch Otolaryngol Head Neck Surg 138(7):628–634PubMedCrossRef
31.
Zurück zum Zitat More YI, Tsue TT, Girod DA et al (2013) Functional swallowing outcome following transoral robotic surgery vs primary chemoradiotherapy in patients with advanced-stage oropharynx and supraglottic cancers. JAMA Otolaryngol Head Neck Surg 139(1):43–48PubMedCrossRef More YI, Tsue TT, Girod DA et al (2013) Functional swallowing outcome following transoral robotic surgery vs primary chemoradiotherapy in patients with advanced-stage oropharynx and supraglottic cancers. JAMA Otolaryngol Head Neck Surg 139(1):43–48PubMedCrossRef
32.
Zurück zum Zitat White HN, Moore EJ, Rosenthal EL et al (2010) Transoral robotic-assisted surgery for head and neck squamous cell carcinoma: one- and 2-year survival analysis. Arch Otolaryngol Head Neck Surg 136(12):1248–1252PubMedCrossRef White HN, Moore EJ, Rosenthal EL et al (2010) Transoral robotic-assisted surgery for head and neck squamous cell carcinoma: one- and 2-year survival analysis. Arch Otolaryngol Head Neck Surg 136(12):1248–1252PubMedCrossRef
33.
Zurück zum Zitat Greven KM, White DR, Browne JD et al (2008) Swallowing dysfunction is a common sequelae after chemoradiation therapy for oropharynx carcinoma. Am J Clin Oncol 31:209–212PubMedCrossRef Greven KM, White DR, Browne JD et al (2008) Swallowing dysfunction is a common sequelae after chemoradiation therapy for oropharynx carcinoma. Am J Clin Oncol 31:209–212PubMedCrossRef
34.
Zurück zum Zitat Lawson JD, Otto K, Chen A et al (2008) Concurrent platinum based chemotherapy and simultaneous modulated accelerated radiation therapy for locally advanced squamous cell carcinoma of the tongue base. Head Neck 30(3):327–335PubMedCrossRef Lawson JD, Otto K, Chen A et al (2008) Concurrent platinum based chemotherapy and simultaneous modulated accelerated radiation therapy for locally advanced squamous cell carcinoma of the tongue base. Head Neck 30(3):327–335PubMedCrossRef
35.
Zurück zum Zitat De Arruda FF, Puri DR, Zhung J et al (2006) Intensity-modulated radiation therapy for the treatment of oropharyngeal carcinoma: the Memorial Sloan-Kettering Cancer Center experience. Int J Radiat Oncol Biol Phys 64(2):363–373PubMedCrossRef De Arruda FF, Puri DR, Zhung J et al (2006) Intensity-modulated radiation therapy for the treatment of oropharyngeal carcinoma: the Memorial Sloan-Kettering Cancer Center experience. Int J Radiat Oncol Biol Phys 64(2):363–373PubMedCrossRef
36.
Zurück zum Zitat Rusthoven KE, Raben D, Ballonoff A et al (2008) Effect of radiation techniques in treatment of oropharynx cancer. Laryngoscope 118(4):635–639PubMedCrossRef Rusthoven KE, Raben D, Ballonoff A et al (2008) Effect of radiation techniques in treatment of oropharynx cancer. Laryngoscope 118(4):635–639PubMedCrossRef
37.
Zurück zum Zitat Leonhardt FD, Quon H, Abrahão M et al (2012) Transoral robotic surgery for oropharyngeal carcinoma and its impact on patient-reported quality of life and function. Head Neck 34(2):146–154PubMedCrossRef Leonhardt FD, Quon H, Abrahão M et al (2012) Transoral robotic surgery for oropharyngeal carcinoma and its impact on patient-reported quality of life and function. Head Neck 34(2):146–154PubMedCrossRef
38.
Zurück zum Zitat Sobol SM, Freeman R, Thawley S et al (1982) Management of inadvertent injury to the carotid artery during head and neck surgery. Head Neck Surg 4:475–482PubMedCrossRef Sobol SM, Freeman R, Thawley S et al (1982) Management of inadvertent injury to the carotid artery during head and neck surgery. Head Neck Surg 4:475–482PubMedCrossRef
39.
Zurück zum Zitat Ketcham AS, Hoye RC (1965) Spontaneous carotid artery hemorrhage after head and neck surgery. Am J Surg 110:649–655PubMedCrossRef Ketcham AS, Hoye RC (1965) Spontaneous carotid artery hemorrhage after head and neck surgery. Am J Surg 110:649–655PubMedCrossRef
41.
Zurück zum Zitat Joseph DL, Shumrick DL (1973) Risks of head and neck surgery in previously irradiated patients. Arch Otolaryngol 97:381–384PubMedCrossRef Joseph DL, Shumrick DL (1973) Risks of head and neck surgery in previously irradiated patients. Arch Otolaryngol 97:381–384PubMedCrossRef
42.
Zurück zum Zitat O’Brien CJ, Nettle WJ, Lee KK (1993) Changing trends in the management of carcinoma of the oral cavity and oropharynx. Aust N Z J Surg 63:270–274PubMedCrossRef O’Brien CJ, Nettle WJ, Lee KK (1993) Changing trends in the management of carcinoma of the oral cavity and oropharynx. Aust N Z J Surg 63:270–274PubMedCrossRef
43.
Zurück zum Zitat Weber RS, Berkey BA, Forastiere A et al (2003) Outcome of salvage total laryngectomy following organ preservation therapy: the Radiation Therapy Oncology Group trial 91-11. Arch Otolaryngol Head Neck Surg 129:44–49PubMedCrossRef Weber RS, Berkey BA, Forastiere A et al (2003) Outcome of salvage total laryngectomy following organ preservation therapy: the Radiation Therapy Oncology Group trial 91-11. Arch Otolaryngol Head Neck Surg 129:44–49PubMedCrossRef
44.
Zurück zum Zitat Aubry K, Yachine M, Perez AF et al (2011) Transoral robotic surgery for head and neck cancer: a series of 17 cases. Eur Ann Otorhinolaryngol Head Neck Dis 128(6):290–296PubMedCrossRef Aubry K, Yachine M, Perez AF et al (2011) Transoral robotic surgery for head and neck cancer: a series of 17 cases. Eur Ann Otorhinolaryngol Head Neck Dis 128(6):290–296PubMedCrossRef
45.
Zurück zum Zitat Moore EJ, Olsen KD, Martin EJ (2011) Concurrent neck dissection and transoral robotic surgery. Laryngoscope 121:541–544PubMedCrossRef Moore EJ, Olsen KD, Martin EJ (2011) Concurrent neck dissection and transoral robotic surgery. Laryngoscope 121:541–544PubMedCrossRef
Metadaten
Titel
Transoral robotic surgery in management of oropharyngeal cancers: a preliminary experience at a tertiary cancer centre in India
verfasst von
Surender Dabas
Abhinav Dewan
Reetesh Ranjan
Ajay Kumar Dewan
Anoop Puri
Swati H. Shah
Rupal Sinha
Publikationsdatum
01.08.2015
Verlag
Springer Japan
Erschienen in
International Journal of Clinical Oncology / Ausgabe 4/2015
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI
https://doi.org/10.1007/s10147-014-0774-3

Weitere Artikel der Ausgabe 4/2015

International Journal of Clinical Oncology 4/2015 Zur Ausgabe

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

29.05.2024 Larynxkarzinom Nachrichten

Fast ein Viertel der Personen mit mäßig dysplastischen Stimmlippenläsionen entwickelt einen Kehlkopftumor. Solche Personen benötigen daher eine besonders enge ärztliche Überwachung.

15% bedauern gewählte Blasenkrebs-Therapie

29.05.2024 Urothelkarzinom Nachrichten

Ob Patienten und Patientinnen mit neu diagnostiziertem Blasenkrebs ein Jahr später Bedauern über die Therapieentscheidung empfinden, wird einer Studie aus England zufolge von der Radikalität und dem Erfolg des Eingriffs beeinflusst.

Erhöhtes Risiko fürs Herz unter Checkpointhemmer-Therapie

28.05.2024 Nebenwirkungen der Krebstherapie Nachrichten

Kardiotoxische Nebenwirkungen einer Therapie mit Immuncheckpointhemmern mögen selten sein – wenn sie aber auftreten, wird es für Patienten oft lebensgefährlich. Voruntersuchung und Monitoring sind daher obligat.

Costims – das nächste heiße Ding in der Krebstherapie?

28.05.2024 Onkologische Immuntherapie Nachrichten

„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.