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International Journal of Clinical Oncology

Erschienen in:

01.01.2019 | Review Article

Diagnostic accuracy of magnetic resonance imaging and computed tomography for lateral lymph node metastasis in rectal cancer: a systematic review and meta-analysis

verfasst von: Nobuaki Hoshino, Katsuhiro Murakami, Koya Hida, Takashi Sakamoto, Yoshiharu Sakai

Erschienen in: International Journal of Clinical Oncology | Ausgabe 1/2019

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Abstract

Purpose

Accurate diagnosis of lateral lymph node metastasis is a major concern in rectal cancer. Metastasis is not only a poor prognostic factor, but it can also affect decisions about treatment options, such as preoperative chemoradiotherapy and lateral lymph node dissection. The purpose of this review was to assess the diagnostic performance of magnetic resonance imaging and computed tomography for lateral lymph node metastasis in rectal cancer.

Methods

A literature search was systematically performed using PubMed, Scopus, and the Cochrane Central Register of Controlled Trials. All studies in which preoperative magnetic resonance imaging or computed tomography findings involving the lateral lymph nodes were compared with pathologic findings were included. Two authors independently assessed the literature and extracted the data, and any disagreement was resolved by discussion. Pooled sensitivity, specificity, and diagnostic odds ratios were estimated using hierarchical summary receiver-operating characteristic curve analysis. The methodologic quality of the included studies was assessed using the QUADAS-2 tool.

Results

Nine studies were included in the meta-analysis of magnetic resonance imaging. The pooled sensitivity, specificity, and diagnostic odds ratio for magnetic resonance imaging were 0.72 [95% confidence interval (CI) 0.66–0.78], 0.80 (95% CI 0.73–0.85), and 10.2 (95% CI 6.4–16.3), respectively. Pooled analyses were not conducted for computed tomography because of the small number of studies (only three could be identified) and the wide range in diagnostic performance between these studies.

Conclusions

Magnetic resonance imaging was useful to diagnose lateral lymph node metastasis in rectal cancer, especially due to high specificity.

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Titel: Diagnostic accuracy of magnetic resonance imaging and computed tomography for lateral lymph node metastasis in rectal cancer: a systematic review and meta-analysis
verfasst von: Nobuaki Hoshino
Katsuhiro Murakami
Koya Hida
Takashi Sakamoto
Yoshiharu Sakai
Publikationsdatum: 01.01.2019
Verlag: Springer Japan
Erschienen in: International Journal of Clinical Oncology / Ausgabe 1/2019
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-018-1349-5

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