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Magnetic Resonance Materials in Physics, Biology and Medicine

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01.02.2016 | Research Article

Investigating the state-of-the-art in whole-body MR-based attenuation correction: an intra-individual, inter-system, inventory study on three clinical PET/MR systems

verfasst von: Thomas Beyer, Martin L. Lassen, Ronald Boellaard, Gaspar Delso, Maqsood Yaqub, Bernhard Sattler, Harald H. Quick

Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine | Ausgabe 1/2016

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Abstract

Objective

We assess inter- and intra-subject variability of magnetic resonance (MR)-based attenuation maps (MRμMaps) of human subjects for state-of-the-art positron emission tomography (PET)/MR imaging systems.

Materials and methods

Four healthy male subjects underwent repeated MR imaging with a Siemens Biograph mMR, Philips Ingenuity TF and GE SIGNA PET/MR system using product-specific MR sequences and image processing algorithms for generating MRμMaps. Total lung volumes and mean attenuation values in nine thoracic reference regions were calculated. Linear regression was used for comparing lung volumes on MRμMaps. Intra- and inter-system variability was investigated using a mixed effects model.

Results

Intra-system variability was seen for the lung volume of some subjects, (p = 0.29). Mean attenuation values across subjects were significantly different (p < 0.001) due to different segmentations of the trachea. Differences in the attenuation values caused noticeable intra-individual and inter-system differences that translated into a subsequent bias of the corrected PET activity values, as verified by independent simulations.

Conclusion

Significant differences of MRμMaps generated for the same subjects but different PET/MR systems resulted in differences in attenuation correction factors, particularly in the thorax. These differences currently limit the quantitative use of PET/MR in multi-center imaging studies.

Schmand M, Burbar Z, Corbeil JL et al (2007) BrainPET: first human tomograph for simultaneous (functional) PET and MR imaging. J Nucl Med 48:45

Delso G, Fürst S, Jakoby B et al (2011) Performance measurements of the Siemens mMR integrated whole-body PET/MR scanner. J Nucl Med 52:1914–1922CrossRefPubMed

Zaidi H, Ojha N, Morich M et al (2011) Design and performance evaluation of a whole-body Ingenuity TF PET-MRI system. Phys Med Biol 56:3091–3106PubMedCentralCrossRefPubMed

Bailey DL, Barthel H, Beyer T et al (2013) Summary report of the First International Workshop on PET/MR imaging, March 19–23, 2012, Tübingen, Germany. Mol Imaging Biol 15:361–371PubMedCentralCrossRefPubMed

Bezrukov I, Mantlik F, Schmidt H et al (2013) MR-Based PET attenuation correction for PET/MR imaging. Semin Nucl Med 43:45–59CrossRefPubMed

Bailey DL, Barthel H, Beuthien-Baumann B et al (2014) Combined PET/MR: Where are we now? Summary report of the second international workshop on PET/MR imaging April 8–12, 2013, Tubingen, Germany. Mol Imaging Biol 16:295–310PubMed

Keereman V, Fierens Y, Vanhove C et al (2012) Magnetic resonance-based attenuation correction for micro-single-photon emission computed tomography. Mol Imaging 12:155–165

Samarin A, Burger C, Wollenweber SD et al (2012) PET/MR imaging of bone lesions: implications for PET quantification from imperfect attenuation correction. Eur J Nucl Med Mol Imaging 39:1154–1160CrossRefPubMed

Keller SH, Holm S, Hansen AE et al (2013) Image artifacts from MR-based attenuation correction in clinical, whole-body PET/MRI. Magn Reson Mater Phy 26:173–181CrossRef

10.

Aznar MC, Sersar R, Saabye J et al (2014) Whole-body PET/MRI: the effect of bone attenuation during MR-based attenuation correction in oncology imaging. Eur J Radiol 83:1177–1183CrossRefPubMed

11.

National Electrical Manufacturers Association. NEMA Standards Publication NU 2-2007 (2007) Performance measurements of positron emission tomographs. Rosslyn, VA 26–33

12.

EANM Physics Committee, Busemann Sokole E, Płachcínska A et al (2010) Routine quality control recommendations for nuclear medicine instrumentation. Eur J Nucl Med Mol Imaging 37:662–671CrossRef

13.

Boellaard R, O’Doherty MJ, Weber WA et al (2000) FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0. Eur J Nucl Med Mol Imaging 37:181–200CrossRef

14.

Ziegler S, Braun H, Ritt P et al (2013) Systematic evaluation of phantom fluids for simultaneous PET/MR hybrid imaging. J Nucl Med 54:1464–1471CrossRefPubMed

15.

Deller T, Delso G, Grant A, et al (2014) PET NEMA Performance Measurements for a SiPM-Based Time-of-Flight PET/MR System” IEEE Medical Imaging Conference, Seattle #1618

16.

Martinez-Möller A, Souvatzoglou M, Delso G et al (2009) Tissue classification as a potential approach for attenuation correction in whole-body PET/MRI: evaluation with PET/CT data. J Nucl Med 50:520–526CrossRefPubMed

17.

Boellaard R, Hofman MBM, Hoekstra OS, Lammertsma AA (2014) Accurate PET/MR quantification using time of flight MLAA image reconstruction. Mol Imaging Biol 16(4):469–477CrossRefPubMed

18.

Ladefoged CN, Hansen AE, Keller SH (2014) Impact of incorrect tissue classification in Dixon-based MR-AC: fat-water tissue inversion. EJNMMI Phys 1(1):101PubMedCentralCrossRefPubMed

19.

Schramm G, Langner J, Hofheinz F et al (2013) Quantitative accuracy of attenuation correction in the Philips Ingenuity TF whole-body PET/MR system: a direct comparison with transmission-based attenuation correction. Magn Reson Mater Phy 26(1):115–126CrossRef

20.

Conti M (2011) Why is TOF PET reconstruction a more robust method in the presence of inconsistent data? Phys Med Biol 56(1):155–168CrossRefPubMed

21.

Nuyts, J. Michel, M. Fenchel, et al. (2010) Completion of a truncated attenuation image from the attenuated PET emission data. In: IEEE nuclear science symposium conference record 2123–2127

22.

Salomon A, Goedicke A, Schweizer B et al (2011) Simultaneous reconstruction of activity and attenuation for PET/MR. IEEE Trans Med Imaging 30:804–813CrossRefPubMed

23.

Nuyts J, Bal G, Kehren F et al (2013) Completion of a truncated attenuation image from the attenuated PET emission data. IEEE Trans Med Imaging 32:237–246CrossRefPubMed

24.

Blumhagen JO, Ladebeck R, Fenchel M, Scheffler K (2013) MR-based field-of-view extension in MR/PET: B0 homogenization using gradient enhancement (HUGE). Magn Reson Med 70:1047–1057CrossRefPubMed

25.

Blumhagen JO, Braun H, Ladebeck R et al (2014) Field of view extension and truncation correction for MR-based human attenuation correction in simultaneous MR/PET imaging. Med Phys. doi:10.1118/1.4861097 PubMed

26.

Hofmann M, Steinke F, Scheel V et al (2008) MRI-based attenuation correction for PET/MRI: a novel approach combining pattern recognition and atlas registration. J Nucl Med 49:1875–1883CrossRefPubMed

27.

Hofmann M, Bezrukov I, Mantlik F et al (2011) MRI-based attenuation correction for whole-body PET/MRI: quantitative evaluation of segmentation and atlas based methods. J Nucl Med 52:1392–1399CrossRefPubMed

28.

Johansson A, Karlsson M, Nyholm T (2011) CT substitute derived from MRI sequences with ultrashort echo time. Med Phys 38:2708–2714CrossRefPubMed

29.

Navalpakkam BK, Braun H, Kuwert T, Quick HH (2013) Magnetic Resonance-based attenuation correction for PET/MR hybrid imaging using continuous valued attenuation maps. Invest Radiol 48:323–332CrossRefPubMed

30.

Paulus DH, Quick HH, Geppert C et al (2015) Whole-body PET/MR imaging: quantitative evaluation of a novel model-based MR attenuation correction method including bone. J Nucl Med 56:1061–1066CrossRefPubMed

31.

Tellmann L, Quick HH, Bockisch A et al (2011) The effect of MR surface coils on PET quantification in whole-body PET/MR: results from a pseudo-PET/MR phantom study. Med Phys 38:2795–2805CrossRefPubMed

32.

Paulus D, Braun H, Aklan B, Quick HH (2011) Simultaneous PET/MR imaging: MR-based attenuation correction of local radiofrequency surface coils. Med Phys 39:4306–4315CrossRef

33.

Kartmann R, Paulus DH, Braun H, Aklan B, Ziegler S, Navalpakkam BK, Lentschig M, Quick HH (2013) Integrated PET/MR imaging: automatic attenuation correction of flexible RF coils. Med Phys. doi:10.1118/1.4812685 PubMed

34.

Wollenweber SD, Delso G, Deller T, Goldhaber D, Hüllner M, Veit-Haibach P (2014) Characterization of the impact to PET quantification and image quality of an anterior array surface coil for PET/MR imaging. Magn Reson Mater Phy 27:149–159CrossRef

35.

Dixon AK (1983) Abdominal fat assessed by computed tomography: sex difference in distribution. Clin Radiol 34:189–191CrossRefPubMed

36.

Schramm G, Langner J, Hofheinz F et al (2013) Influence and compensation of truncation artifacts in MR-based attenuation correction in PET/MR. IEEE Trans Med Imaging 32:2056–2063CrossRefPubMed

Titel: Investigating the state-of-the-art in whole-body MR-based attenuation correction: an intra-individual, inter-system, inventory study on three clinical PET/MR systems
verfasst von: Thomas Beyer
Martin L. Lassen
Ronald Boellaard
Gaspar Delso
Maqsood Yaqub
Bernhard Sattler
Harald H. Quick
Publikationsdatum: 01.02.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine / Ausgabe 1/2016
Print ISSN: 0968-5243
Elektronische ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-015-0505-4

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Investigating the state-of-the-art in whole-body MR-based attenuation correction: an intra-individual, inter-system, inventory study on three clinical PET/MR systems