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Angiogenesis

Erschienen in:

01.03.2008 | Original Paper

Wnt/Frizzled signaling in angiogenesis

verfasst von: Marielba Zerlin, Martin A. Julius, Jan Kitajewski

Erschienen in: Angiogenesis | Ausgabe 1/2008

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Abstract

The roles of growth factors such as angiopoietin (Ang) and vascular endothelial growth factor (VEGF) in angiogenesis have been known for some time, yet we have just an incipient appreciation for the contribution of Wnts to this process. Cellular proliferation and polarity, apoptosis, branching morphogenesis, inductive processes, and the maintenance of stem cells in an undifferentiated, proliferative state are all regulated by Wnt signaling. The development and maintenance of vascular structures are dependent on all these processes, and their orchestration has, to some extent, been revealed in studies of VEGF and Ang receptors. Recent evidence links the Wnt/Frizzled signaling pathway to proper vascular growth in mammals but our knowledge of Wnt function in the vasculature is rudimentary. Further insight into vascular development and the process of angiogenesis depends on evaluating the function of novel endothelial regulatory pathways such as Wnt/Frizzled signaling.

Wodarz A, Nusse R (1998) Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 14:59–88PubMedCrossRef

Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, Hintz L, Nusse R, Weissman IL (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423(6938):409–414PubMedCrossRef

Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR III, Nusse R (2003) Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423(6938):448–452PubMedCrossRef

Hanahan D (1997) Signaling vascular morphogenesis and maintenance. Science 277(5322):48–50PubMedCrossRef

Carmeliet P, Storkebaum E (2002) Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders. Semin Cell Dev Biol 13(1):39–53PubMedCrossRef

Holash J, Wiegand SJ, Yancopoulos GD (1999) New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 18(38):5356–5362PubMedCrossRef

Rossant J, Howard L (2002) Signaling pathways in vascular development. Annu Rev Cell Dev Biol 18:541–573PubMedCrossRef

Darland DC, D’Amore PA (2001) Cell-cell interactions in vascular development. Curr Top Dev Biol 52:107–149PubMedCrossRef

Conway EM, Collen D, Carmeliet P (2001) Molecular mechanisms of blood vessel growth. Cardiovasc Res 49(3):507–521PubMedCrossRef

10.

Bhanot P, Brink M, Samos CH, Hsieh JC, Wang Y, Macke JP, Andrew D, Nathans J, Nusse R (1996) A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382(6588):225–230PubMedCrossRef

11.

Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X (2000) LDL-receptor-related proteins in Wnt signal transduction. Nature 407(6803):530–535PubMedCrossRef

12.

Wehrli M, Dougan ST, Caldwell K, O’Keefe L, Schwartz S, Vaizel-Ohayon D, Schejter E, Tomlinson A, DiNardo S (2000) arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 407(6803):527–530PubMedCrossRef

13.

Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 407(6803):535–538PubMedCrossRef

14.

Bafico A, Liu G, Yaniv A, Gazit A, Aaronson SA (2001) Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol 3(7):683–686PubMedCrossRef

15.

Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S, He X (2001) Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol 11(12):951–961PubMedCrossRef

16.

Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411(6835):321–325PubMedCrossRef

17.

Slusarski DC, Corces VG, Moon RT (1997) Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 390(6658):410–413PubMedCrossRef

18.

Liu T, DeCostanzo AJ, Liu X, Wang H, Hallagan S, Moon RT, Malbon CC (2001) G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway. Science 292(5522):1718–1722PubMedCrossRef

19.

Peifer M, Polakis P (2000) Wnt signaling in oncogenesis and embryogenesis—a look outside the nucleus. Science 287(5458):1606–1609PubMedCrossRef

20.

Polakis P (2000) Wnt signaling and cancer. Genes Dev 14(15):1837–1851PubMed

21.

Zeng L, Fagotto F, Zhang T, Hsu W, Vasicek TJ, Perry WL III, Lee JJ, Tilghman SM, Gumbiner BM, Costantini F (1997) The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell 90(1):181–192PubMedCrossRef

22.

Latres E, Chiaur DS, Pagano M (1999) The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. Oncogene 18(4):849–854PubMedCrossRef

23.

Klingensmith J, Nusse R, Perrimon N (1994) The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev 8(1):118–130PubMedCrossRef

24.

Li L, Yuan H, Weaver CD, Mao J, Farr GH III, Sussman DJ, Jonkers J, Kimelman D, Wu D (1999) Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J 18(15):4233–4240PubMedCrossRef

25.

Julius MA, Schelbert B, Hsu W, Fitzpatrick E, Jho E, Fagotto F, Costantini F, Kitajewski J (2000) Domains of axin and disheveled required for interaction and function in Wnt signaling. Biochem Biophys Res Commun 276(3):1162–1169PubMedCrossRef

26.

Behrens J, von Kries JP, Kuhl M, Bruhn L, Wedlich D, Grosschedl R, Birchmeier W (1996) Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 382(6592):638–642PubMedCrossRef

27.

Molenaar M, van de Wetering M, Oosterwegel M, Peterson-Maduro J, Godsave S, Korinek V, Roose J, Destree O, Clevers H (1996) XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell 86(3):391–399PubMedCrossRef

28.

He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW (1998) Identification of c-MYC as a target of the APC pathway. Science 281(5382):1509–1512PubMedCrossRef

29.

Tetsu O, McCormick F (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398(6726):422–426PubMedCrossRef

30.

You Z, Saims D, Chen S, Zhang Z, Guttridge DC, Guan KL, MacDougald OA, Brown AM, Evan G, Kitajewski J, Wang CY (2002) Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol 157(3):429–440PubMedCrossRef

31.

Kuhl M, Sheldahl LC, Park M, Miller JR, Moon RT (2000) The Wnt/Ca²⁺ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet 16(7):279–283PubMedCrossRef

32.

Sheldahl LC, Park M, Malbon CC, Moon RT (1999) Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr Biol 9(13):695–698PubMedCrossRef

33.

Kuhl M, Sheldahl LC, Malbon CC, Moon RT (2000) Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J Biol Chem 275(17):12701–12711PubMedCrossRef

34.

Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K (2003) The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol 23(1):131–139PubMedCrossRef

35.

Ishitani T, Ninomiya-Tsuji J, Nagai S, Nishita M, Meneghini M, Barker N, Waterman M, Bowerman B, Clevers H, Shibuya H, Matsumoto K (1999) The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature 399(6738):798–802PubMedCrossRef

36.

Saneyoshi T, Kume S, Amasaki Y, Mikoshiba K (2002) The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature 417(6886):295–299PubMedCrossRef

37.

Buchholz M, Schatz A, Wagner M, Michl P, Linhart T, Adler G, Gress TM, Ellenrieder V (2006) Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. EMBO J 25(15):3714–3724PubMedCrossRef

38.

Hesser BA, Liang XH, Camenisch G, Yang S, Lewin DA, Scheller R, Ferrara N, Gerber HP (2004) Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells. Blood 104(1):149–158PubMedCrossRef

39.

Theisen H, Purcell J, Bennett M, Kansagara D, Syed A, Marsh JL (1994) Dishevelled is required during wingless signaling to establish both cell polarity and cell identity. Development 120:347–360PubMed

40.

Eaton S (1977) Planar polarization of Drosophilla and vertebrate epithelia. Curr Opin Cell Biol 9:860–866CrossRef

41.

Mlodzik M (2002) Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet 18:564–571PubMedCrossRef

42.

Monkley SJ, Delaney SJ, Pennisi DJ, Christiansen JH, Wainwright BJ (1996) Targeted disruption of the Wnt2 gene results in placentation defects. Development 122(11):3343–3353PubMed

43.

Shimizu H, Julius MA, Giarre M, Zheng Z, Brown AM, Kitajewski J (1997) Transformation by Wnt family proteins correlates with regulation of beta-catenin. Cell Growth Differ 8(12):1349–1358PubMed

44.

Jeays-Ward K, Hoyle C, Brennan J, Dandonneau M, Alldus G, Capel B, Swain A (2003) Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development 130(16):3663–3670PubMedCrossRef

45.

Shu W, Jiang YQ, Lu MM, Morrisey EE (2002) Wnt7b regulates mesenchymal proliferation and vascular development in the lung. Development 129(20):4831–4842PubMed

46.

Ishikawa T, Tamai Y, Zorn AM, Yoshida H, Seldin MF, Nishikawa S, Taketo MM (2001) Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development 128(1):25–33PubMed

47.

He X, Saint-Jeannet JP, Wang Y, Nathans J, Dawid I, Varmus H (1997) A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 275(5306):1652–1654PubMedCrossRef

48.

Robitaille J, MacDonald ML, Kaykas A, Sheldahl LC, Zeisler J, Dube MP, Zhang LH, Singaraja RR, Guernsey DL, Zheng B, Siebert LF, Hoskin-Mott A, Trese MT, Pimstone SN, Shastry BS, Moon RT, Hayden MR, Goldberg YP, Samuels ME (2002) Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nat Genet 32(2):326–330PubMedCrossRef

49.

Kaykas A, Yang-Snyder J, Heroux M, Shah KV, Bouvier M, Moon RT (2004) Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization. Nat Cell Biol 6(1):52–58PubMedCrossRef

50.

Wang Y, Huso D, Cahill H, Ryugo D, Nathans J (2001) Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene. J Neurosci 21(13):4761–4771PubMed

51.

Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, Kelley MW, Jiang L, Tasman W, Zhang K, Nathans J (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116(6):883–895PubMedCrossRef

52.

MacDonald IM, Sasi R (1994) Molecular genetics of inherited eye disorders. Clin Invest Med 17(5):474–498PubMed

53.

Meitinger T, Meindl A, Bork P, Rost B, Sander C, Haasemann M, Murken J (1993) Molecular modelling of the Norrie disease protein predicts a cystine knot growth factor tertiary structure. Nat Genet 5(4):376–380PubMedCrossRef

54.

Mechoulam H, Pierce EA (2003) Retinopathy of prematurity: molecular pathology and therapeutic strategies. Am J Pharmacogenomics 3(4):261–277PubMedCrossRef

55.

Black GC, Perveen R, Bonshek R, Cahill M, Clayton-Smith J, Lloyd IC, McLeod D (1999) Coats’ disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis. Hum Mol Genet 8(11):2031–2035PubMedCrossRef

56.

Jones JH, Kroll AJ, Lou PL, Ryan EA (2001) Coats’ disease. Int Ophthalmol Clin 41(4):189–198PubMedCrossRef

57.

Baron R, Rawadi G, Roman-Roman S (2006) Wnt signaling: a key regulator of bone mass. Curr Top Dev Biol 76:103–127PubMedCrossRef

58.

Kato M, Patel MS, Levasseur R, Lobov I, Chang BH, Glass DA II, Hartmann C, Li L, Hwang TH, Brayton CF, Lang RA, Karsenty G, Chan L (2002) Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol 157(2):303–314PubMedCrossRef

59.

Wright M, Aikawa M, Szeto W, Papkoff J (1999) Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells. Biochem Biophys Res Commun 263(2):384–388PubMedCrossRef

60.

Masckauchan TN, Shawber CJ, Funahashi Y, Li CM, Kitajewski J (2005) Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells. Angiogenesis 8(1):43–51PubMedCrossRef

61.

Cheng CW, Smith SK, Charnock-Jones DS (2003) Wnt-1 signaling inhibits human umbilical vein endothelial cell proliferation and alters cell morphology. Exp Cell Res 291(2):415–425PubMedCrossRef

62.

Sala CF, Formenti E, Terstappen GC, Caricasole A (2000) Identification, gene structure, and expression of human frizzled-3 (FZD3). Biochem Biophys Res Commun 273(1):27–34PubMedCrossRef

63.

Chan SD, Karpf DB, Fowlkes ME, Hooks M, Bradley MS, Vuong V, Bambino T, Liu MY, Arnaud CD, Strewler GJ et al (1992) Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues. J Biol Chem 267(35):25202–25207PubMed

64.

Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (1996) A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem 271(8):4468–4476PubMedCrossRef

65.

van Gijn ME, Daemen MJ, Smits JF, Blankesteijn WM (2002) The Wnt-Frizzled cascade in cardiovascular disease. Cardiovasc Res 55(1):16–24PubMedCrossRef

66.

Goodwin AM, D’Amore PA (2002) Wnt signaling in the vasculature. Angiogenesis 5(1–2):1–9PubMedCrossRef

67.

Wu WB, Peng HC, Huang TF (2003) Disintegrin causes proteolysis of beta-catenin and apoptosis of endothelial cells. Involvement of cell-cell and cell-ECM interactions in regulating cell viability. Exp Cell Res 286(1):115–127PubMedCrossRef

68.

Masckauchan TN, Agalliu D, Vorontchikhina M, Ahn A, Parmalee NL, Li CM, Khoo A, Tycko B, Brown AM, Kitajewski J (2006) Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol Biol Cell 17(12):5163–5172PubMedCrossRef

69.

Holnthoner W, Pillinger M, Groger M, Wolff K, Ashton AW, Albanese C, Neumeister P, Pestell RG, Petzelbauer P (2002) Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells. J Biol Chem 277(48):45847–45853PubMedCrossRef

70.

Hanai J, Gloy J, Karumanchi SA, Kale S, Tang J, Hu G, Chan B, Ramchandran R, Jha V, Sukhatme VP, Sokol S (2002) Endostatin is a potential inhibitor of Wnt signaling. J Cell Biol 158(3):529–539PubMedCrossRef

71.

Biswas P, Canosa S, Schoenfeld J, Schoenfeld D, Tucker A, Madri JA (2003) PECAM-1 promotes beta-catenin accumulation and stimulates endothelial cell proliferation. Biochem Biophys Res Commun 303(1):212–218PubMedCrossRef

72.

Blankesteijn WM, van Gijn ME, Essers-Janssen YP, Daemen MJ, Smits JF (2000) Beta-catenin, an inducer of uncontrolled cell proliferation and migration in malignancies, is localized in the cytoplasm of vascular endothelium during neovascularization after myocardial infarction. Am J Pathol 157(3):877–883PubMed

73.

Yeh JR, Ju R, Brdlik CM, Zhang W, Zhang Y, Matyskiela ME, Shotwell JD, Crews CM (2006) Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci USA 103(27):10379–10384PubMedCrossRef

74.

Maier JA, Delia D, Thorpe PE, Gasparini G (1997) In vitro inhibition of endothelial cell growth by the antiangiogenic drug AGM-1470 (TNP-470) and the anti-endoglin antibody TEC-11. Anticancer drugs 8(3):238–244PubMedCrossRef

75.

Zhang Y, Yeh JR, Mara A, Ju R, Hines JF, Cirone P, Griesbach HL, Schneider I, Slusarski DC, Holley SA, Crews CM (2006) A chemical and genetic approach to the mode of action of fumagillin. Chem Biol 13(9):1001–1009PubMedCrossRef

76.

Duplaa C, Jaspard B, Moreau C, D’Amore PA (1999) Identification and cloning of a secreted protein related to the cysteine-rich domain of frizzled. Evidence for a role in endothelial cell growth control. Circ Res 84(12):1433–1445PubMed

77.

Dufourcq P, Leroux L, Ezan J, Descamps B, Lamaziere J-MD, Costet P, Basoni C, Moreau C, Deutsch U, Couffinhal T, Duplaa C (2008) Regulation of endothelial cell cytoskeletal reorganization by a secreted Frizzled-related protein-1 and Frizzled 4- and Frizzled-7 dependent pathway. Am J Pathol 172:37–49PubMedCrossRef

78.

Maretto S, Cordenonsi M, Dupont S, Braghetta P, Broccoli V, Hassan AB, Volpin D, Bressan GM, Piccolo S (2003) Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci USA 100(6):3299–3304PubMedCrossRef

79.

Zhang X, Gaspard JP, Chung DC (2001) Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res 61(16):6050–6054PubMed

80.

Easwaran V, Lee SH, Inge L, Guo L, Goldbeck C, Garrett E, Wiesmann M, Garcia PD, Fuller JH, Chan V, Randazzo F, Gundel R, Warren RS, Escobedo J, Aukerman SL, Taylor RN, Fantl WJ (2003) beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res 63(12):3145–3153PubMed

81.

Strieter RM, Kunkel SL, Elner VM, Martonyi CL, Koch AE, Polverini PJ, Elner SG (1992) Interleukin-8. A corneal factor that induces neovascularization. Am J Pathol 141(6):1279–1284PubMed

82.

Koch AE, Polverini PJ, Kunkel SL, Harlow LA, DiPietro LA, Elner VM, Elner SG, Strieter RM (1992) Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258(5089):1798–1801PubMedCrossRef

83.

Li A, Dubey S, Varney ML, Dave BJ, Singh RK (2003) IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 170(6):3369–3376PubMed

84.

Levy L, Neuveut C, Renard CA, Charneau P, Branchereau S, Gauthier F, Van Nhieu JT, Cherqui D, Petit-Bertron AF, Mathieu D, Buendia MA (2002) Transcriptional activation of interleukin-8 by beta-catenin-Tcf4. J Biol Chem 277(44):42386–42393PubMedCrossRef

85.

Visse R, Nagase H (2003) Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 92(8):827–839PubMedCrossRef

Titel: Wnt/Frizzled signaling in angiogenesis
verfasst von: Marielba Zerlin
Martin A. Julius
Jan Kitajewski
Publikationsdatum: 01.03.2008
Verlag: Springer Netherlands
Erschienen in: Angiogenesis / Ausgabe 1/2008
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-008-9095-3

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