nach oben

Erschienen in:

01.04.2014 | Original Paper

Effectiveness of Mindfulness-Based Cognitive Therapy on the Quality of Life, Emotional Status, and CD4 Cell Count of Patients Aging with HIV Infection

verfasst von: Marian Gonzalez-Garcia, Maria Jose Ferrer, Xavier Borras, Jose A. Muñoz-Moreno, Cristina Miranda, Jordi Puig, Nuria Perez-Alvarez, Joaquim Soler, Albert Feliu-Soler, Bonaventura Clotet, Carmina R. Fumaz

Erschienen in: AIDS and Behavior | Ausgabe 4/2014

Einloggen, um Zugang zu erhalten

Abstract

Long-term diagnosed and treated HIV-infected patients have to cope with a wide range of challenges that threaten their ability to age successfully. We report the results of a randomized controlled trial testing the effects of a mindfulness-based cognitive therapy (MBCT) program on quality of life (QoL), emotional status, and immune status over a 3-month period. Forty HIV-infected patients diagnosed prior to 1996 and on cART for a minimum of 5 years were randomized to follow an MBCT program (n = 20) or remain as controls (routine follow-up) (n = 20). A regression analysis was performed, and the measurement of effect size was estimated using Cohen’s d. QoL, psychological stress, depressive symptoms, and anxiety symptoms improved in the MBCT group compared with the control group. During follow-up, patients in the MBCT group had a significantly increased CD4 cell count. Effect sizes for MBCT on the variables assessed were large (d = 0.8). The findings suggest that this program may help to promote successful aging in these patients.

Mrus JM, Leonard AC, Yi MS, et al. Health-related quality of life in veterans and non-veterans with HIV/AIDS. J Gen Intern Med. 2006;21(Suppl 5):S39–47.PubMedCentralPubMedCrossRef

Lohse N, Hansen AB, Pedersen G, et al. Survival of persons with and without HIV infection in Denmark, 1995–2005. Ann Intern Med. 2007;146(2):87–95.PubMedCrossRef

Antiretroviral Therapy Cohort Collaboration. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet. 2008;372(9635):293–9.CrossRef

May M, Gompels M, Delpech V, et al. Impact of late diagnosis and treatment on life-expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study. BMJ. 2011;343:d6016.PubMedCentralPubMedCrossRef

Effros RB, Fletcher CV, Gebo K, et al. Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions. Clin Infect Dis. 2008;47(4):542–53.PubMedCentralPubMedCrossRef

Deeks SG. HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med. 2011;62:141–55.PubMedCentralPubMedCrossRef

Bhatia R, Ryscavage P, Taiwo B. Accelerated aging and human immunodeficiency virus infection: emerging challenges of growing older in the era of successful antiretroviral therapy. J Neurovirol. 2012;18(4):247–55.PubMedCrossRef

Guaraldi G, Orlando G, Zona S, et al. Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin Infect Dis. 2011;53(11):1120–6.PubMedCrossRef

Capeau J. Premature aging and premature age-related comorbidities in HIV-infected patients: facts and hypotheses. Clin Infect Dis. 2011;53(11):1127–9.PubMedCrossRef

10.

Justice AC. HIV and aging: time for a new paradigm. Curr HIV/AIDS Rep. 2010;7(2):69–76.PubMedCrossRef

11.

Bing EG, Hays RD, Jacobson LP, et al. Health-related quality of life among people with HIV disease: results from the Multicenter AIDS Cohort Study. Qual Life Res. 2000;9(1):55–63.PubMedCrossRef

12.

Davis S. Clinical sequelae affecting quality of life in the HIV-infected patient. J Assoc Nurses AIDS Care. 2004;15(Suppl 5):28S–33S.PubMedCrossRef

13.

Silverman GK, Jacobs SC, Kasl SV, et al. Quality of life impairments associated with diagnostic criteria for traumatic grief. Psychol Med. 2000;30(4):857–62.PubMedCrossRef

14.

Liu C, Johnson L, Ostrow D, Silvestre A, Vusscher B, Jacobson LP. Predictors for lower quality of life in the HAART era among HIV-infected men. J Acquir Immune Defic Syndr. 2006;42(4):470–7.PubMedCrossRef

15.

Burgess AP, Carretero M, Elkington A, Pasqual-Marsettin E, Lobaccaro C, Catalán J. The role of personality, coping style and social support in health-related quality of life in HIV infection. Qual Life Res. 2000;9(4):423–37.PubMedCrossRef

16.

Vance DE, Struzick T, Childs G. Challenges of depression and suicidal ideation associated with aging with HIV/AIDS: implications for social work. J Gerontol Soc Work. 2010;53(2):159–75.PubMedCrossRef

17.

Owen G, Catalan J. ‘We never expected this to happen’: narratives of ageing with HIV among gay men living in London, UK. Cult Health Sex. 2012;14(1):59–72.PubMedCrossRef

18.

Fumaz CR, Muñoz-Moreno JA, Ferrer MJ, et al. Emotional impact of premature aging symptoms in long-term treated HIV-infected subjects. J Acquir Immune Defic Syndr. 2012;59(1):e5–8.PubMedCrossRef

19.

Irwin MR. Human psychoneuroimmunology: 20 years of discovery. Brain Behav Immun. 2008;22(2):129–39.PubMedCrossRef

20.

Leserman J. Role of depression, stress, and trauma in HIV disease progression. Psychosom Med. 2008;70(5):539–45.PubMedCrossRef

21.

Bottonari KA, Safren SA, McQuaid JR, Hsiao C-B, Roberts JE. A longitudinal investigation of the impact of life stress on HIV treatment adherence. J Behav Med. 2010;33(6):486–95.PubMedCentralPubMedCrossRef

22.

Campos LN, Guimaraes MD, Remien RH. Anxiety and depression symptoms as risk factors for non-adherence to antiretroviral therapy in Brazil. AIDS Behav. 2010;14(2):289–99.PubMedCentralPubMedCrossRef

23.

Kacanek D, Jacobson DL, Spiegelman D, Wanke C, Isaac R, Wilson IB. Incident depression symptoms are associated with poorer HAART adherence: a longitudinal analysis from the nutrition for healthy living study. J Acquir Immune Defic Syndr. 2010;53(2):266–72.PubMedCentralPubMedCrossRef

24.

Logsdon-Conradsen S. Using mindfulness meditation to promote holistic health in individuals with HIV/AIDS. Cogn Behav Pract. 2002;9(1):67–72.CrossRef

25.

High KP, Brennan-Ing M, Clifford DB, et al. HIV and aging: state of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group. J Acquir Immune Defic Syndr. 2012;60(Suppl 1):S1–18.PubMedCrossRef

26.

Carlson LE. Mindfulness-based interventions for physical conditions: a narrative review evaluating levels of evidence. ISRN Psychiatry. 2012;2012:651583.PubMedCentralPubMedCrossRef

27.

Segal ZV, Williams JMG, Teasdale JD. Mindfulness-based cognitive therapy for depression: a new approach to preventing relapse. New York: Guilford Press; 2002.

28.

Kabat-Zinn J. Full catastrophe living: using the wisdom of your body and mind to face stress, pain, and illness. New York: Delta; 1990.

29.

Beck AT, Rush AJ, Shaw BF, Emery G. Cognitive therapy of depression. New York: Guilford Press; 1979.

30.

Foley E, Baillie A, Huxter M, Price M, Sinclair E. Mindfulness-based cognitive therapy for individuals whose lives have been affected by cancer: a randomized controlled trial. J Consult Clin Psychol. 2010;78(1):72–9.PubMedCrossRef

31.

Moustgaard AK. Mindfulness-based cognitive therapy (MBCT) for stroke survivors: an application of a novel intervention. Doctoral dissertation, Lakehead University, Canada; 2005.

32.

Sibinga EM, Stewart M, Magyari T, Welsh CK, Hutton N, Ellen JM. Mindfulness-based stress reduction for HIV-infected youth: a pilot study. Explore (NY). 2008;4(1):36–7.PubMedCrossRef

33.

Duncan LG, Moskowitz JT, Neilands TB, Dilworth SE, Hecht FM, Johnson MO. Mindfulness-based stress reduction for HIV treatment side effects: a randomized, wait-list controlled trial. J Pain Symptom Manage. 2012;43(2):161–71.PubMedCentralPubMedCrossRef

34.

Gayner B, Esplen MJ, Deroche P, et al. A randomized controlled trial of mindfulness-based stress reduction to manage affective symptoms and improve quality of life in gay men living with HIV. J Behav Med. 2012;35(3):272–85.PubMedCrossRef

35.

Robinson FP, Mathews HL, Witek-Janusez L. Psycho-endocrine-immune response to mindfulness-based stress reduction in individuals infected with the human immunodeficiency virus: a quasiexperimental study. J Altern Complement Med. 2003;9(5):683–94.PubMedCrossRef

36.

Creswell JD, Myers HF, Cole SW, Irwin MR. Mindfulness meditation training effects on CD4+ T lymphocytes in HIV-1 infected adults: a small randomized controlled trial. Brain Behav Immun. 2009;23(2):184–8.PubMedCentralPubMedCrossRef

37.

Jam S, Imani AH, Foroughi M, SeyedAlinaghi S, Koochak HE, Mohraz M. The effects of mindfulness-based stress reduction (MBSR) program in Iranian HIV/AIDS patients: a pilot study. Acta Med Iran. 2010;48(2):101–6.PubMed

38.

SeyedAlinaghi S, Jam S, Foroughi M, et al. Randomized controlled trial of mindfulness-based stress reduction delivered to human immunodeficiency virus-positive patients in Iran: effects on CD4⁺ T lymphocyte count and medical and psychological symptoms. Psychosom Med. 2012;74(6):620–7.PubMedCentralPubMedCrossRef

39.

Weston E, Moran P, Acree M, et al. Effect of MBSR and psychological state on inflammatory markers in HIV positive adults. BMC Complement Altern Med. 2012;12(Suppl 1):O6.PubMedCentralCrossRef

40.

Wood NA. Mindfulness-based cognitive therapy for the symptoms of depression in a community-based HIV/AIDS Clinic: outcomes and feasibility. Chester: Widener University; 2008.

41.

Teasdale JD, Segal ZV, Williams JMG, Ridgeway VA, Soulsby JM, Lau MA. Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. J Consult Clin Psychol. 2000;68(4):615–23.PubMedCrossRef

42.

Tuldrà A, Fumaz CR, Ferrer MJ, et al. Prospective randomized two-arm controlled study to determine the efficacy of a specific intervention to improve long-term adherence to highly active antiretroviral therapy. J Acquir Inmune Defic Syndr. 2000;25(3):221–8.CrossRef

43.

Fumaz CR, Muñoz-Moreno JA, Moltó J, et al. Sustained antiretroviral treatment adherence in survivors of the pre-HAART era: attitudes and beliefs. AIDS Care. 2008;20(7):796–805.PubMedCrossRef

44.

Paterson DL, Swindells S, Mohr J, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med. 2000;133(1):21–30.PubMedCrossRef

45.

Hendricks K, Tang A, Spiegelman D, Skinner S, Woods M. Dietary intake in human immunodeficiency virus-infected adults: a comparison of dietary assessment methods. J Am Diet Assoc. 2005;105(4):532–40.PubMedCrossRef

46.

Mitrou PN, Kipnis V, Thiébaut AC, et al. Mediterranean dietary pattern and prediction of all-cause mortality in a US population: results from the NIH-AARP Diet and Health Study. Arch Intern Med. 2007;167(22):2461–8.PubMedCrossRef

47.

Wilson PW, D’Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97(18):1837–47.PubMedCrossRef

48.

Hunt SM, McKenna SP, McEwen J, Williams J, Papp E. The Nottingham Health Profile: subjective health status and medical consultations. Soc Sci Med A. 1981;15(3 Pt 1):221–9.PubMed

49.

Alonso J, Anto JM, Moreno C. Spanish version of the Nottingham Health Profile: translation and preliminary validity. Am J Public Health. 1990;80(6):704–8.PubMedCentralPubMedCrossRef

50.

Alonso J, Prieto L, Antó JM. The Spanish version of the Nottingham Health Profile: a review of adaptation and instrument characteristics. Qual Life Res. 1994;3(6):385–93.PubMedCrossRef

51.

Badia X, Alonso J, Brosa M, Lock P. Reliability of the Spanish version of the Nottingham Health Profile in patients with stable end-stage renal disease. Soc Sci Med. 1994;38(1):153–8.PubMedCrossRef

52.

Permanyer-Miralda G, Alonso J, Antó JM, Alijarde-Guimerá M, Soler–Soler J. Comparison of perceived health status and conventional functional evaluation in stable patients with coronary artery disease. J Clin Epidemiol. 1991;44(8):779–86.PubMedCrossRef

53.

Cohen S, Williamson G. Perceived stress in a probability sample of the United States. In: Spacapan S, Oskamp S, editors. The social psychology of health: Claremont symposium on applied social psychology. Newbury Park: Sage; 1988. p. 31–67.

54.

Remor E. Psychometric properties of a European Spanish version of the Perceived Stress Scale (PSS). Span J Psychol. 2006;9(1):86–93.PubMed

55.

Beck AT, Steer R, Brown GK. BDI-II: Beck Depression Inventory. 2nd ed. San Antonio: The Psychological Corporation; 1996.

56.

Sanz J, García MP, Espinosa R, et al. Adaptación española del Inventario para la Depresión de Beck-II (BDI-II): 3. Propiedades psicométricas en pacientes con trastornos psicológicos. Clínica y Salud. 2005;16(2):121–42.

57.

Beck AT, Brown G, Epstein N, et al. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988;56(6):893–7.PubMedCrossRef

58.

Sanz J, Navarro ME. Propiedades psicométricas de una versión española del Inventario de Ansiedad de Beck (BAI) en estudiantes universitarios. Ansiedad y Estrés. 2003;9(1):59–84.

59.

Sanz J, Garcia-Vera MP, Fortun M. El “inventario de ansiedad de beck” (BAI): propiedades psicométricas de la versión española en pacientes con trastornos psicológicos. The Free Library (2012, September 1). http://www.thefreelibrary.com/El “inventario de ansiedad de beck” (BAI): propiedades psicometricas…-a0314254361. Accessed 2 July 2013.

60.

Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale: Lawrence Erlbaum Associates; 1988.

61.

Casado JM, González N, Moraleda S, Orueta R, Carmona J, Gomez-Calcerrada RM. Calidad de vida relacionada con la salud en pacientes ancianos en atención primaria. Atención Primaria. 2001;28(3):167–73.PubMedCrossRef

62.

Ozturk A, Simşek T, Yümin ET, Sertel M, Yümin M. The relationship between physical, functional capacity and quality of life (QoL) among elderly people with a chronic disease. Arch Gerontol Geriatr. 2011;53(3):278–83.PubMedCrossRef

63.

Kuyken W, Byford S, Taylor RS, et al. Mindfulness-based cognitive therapy to prevent relapse in recurrent depression. J Consult Clin Psychol. 2008;76(6):966–78.PubMedCrossRef

64.

Godfrin KA, van Heeringen C. The effects of mindfulness-based cognitive therapy on recurrence of depressive episodes, mental health and quality of life: a randomized controlled study. Behav Res Ther. 2010;48(8):738–46.PubMedCrossRef

65.

Splevins K, Smith A, Simpson J. Do improvements in emotional distress correlate with becoming more mindful? A study of older adults. Aging Ment Health. 2009;13(3):328–35.PubMedCrossRef

66.

Baer RA. Mindfulness training as a clinical intervention: a conceptual and empirical review. Clin Psychol Sci Pract. 2003;10(2):125–43.CrossRef

67.

Finucane A, Mercer SW. An exploratory mixed methods study of the acceptability and effectiveness of mindfulness-based cognitive therapy for patients with active depression and anxiety in primary care. BMC Psychiatry. 2006;6:14.PubMedCentralPubMedCrossRef

68.

Kenny M, Williams JM. Treatment-resistant depressed patients show a good response to mindfulness-based cognitive therapy. Behav Res Ther. 2007;45(3):617–25.PubMedCentralPubMedCrossRef

69.

Fumaz CR, Gonzalez-Garcia M, Borras X, et al. Psychological stress is associated with high levels of IL-6 in HIV-1 infected individuals on effective combined antiretroviral treatment. Brain Behav Immun. 2012;26(4):568–72.PubMedCrossRef

70.

Witek-Janusek L, Albuquerque K, Chroniak KR, Chroniak C, Durazo-Arvizu R, Mathews HL. Effect of mindfulness based stress reduction on immune function, quality of life and coping in women newly diagnosed with early stage breast cancer. Brain Behav Immun. 2008;22(6):969–81.PubMedCentralPubMedCrossRef

71.

Brewer JA, Mallik S, Babuscio TA, et al. Mindfulness training for smoking cessation: results from a randomized controlled trial. Drug Alcohol Depend. 2011;119(1–2):72–80.PubMedCentralPubMedCrossRef

Titel: Effectiveness of Mindfulness-Based Cognitive Therapy on the Quality of Life, Emotional Status, and CD4 Cell Count of Patients Aging with HIV Infection
verfasst von: Marian Gonzalez-Garcia
Maria Jose Ferrer
Xavier Borras
Jose A. Muñoz-Moreno
Cristina Miranda
Jordi Puig
Nuria Perez-Alvarez
Joaquim Soler
Albert Feliu-Soler
Bonaventura Clotet
Carmina R. Fumaz
Publikationsdatum: 01.04.2014
Verlag: Springer US
Erschienen in: AIDS and Behavior / Ausgabe 4/2014
Print ISSN: 1090-7165
Elektronische ISSN: 1573-3254
DOI: https://doi.org/10.1007/s10461-013-0612-z

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

„Überwältigende“ Evidenz für Tripeltherapie beim metastasierten Prostata-Ca.

22.05.2024 Prostatakarzinom Nachrichten

Patienten mit metastasiertem hormonsensitivem Prostatakarzinom sollten nicht mehr mit einer alleinigen Androgendeprivationstherapie (ADT) behandelt werden, mahnt ein US-Team nach Sichtung der aktuellen Datenlage. Mit einer Tripeltherapie haben die Betroffenen offenbar die besten Überlebenschancen.

So sicher sind Tattoos: Neue Daten zur Risikobewertung

22.05.2024 Melanom Nachrichten

Das größte medizinische Problem bei Tattoos bleiben allergische Reaktionen. Melanome werden dadurch offensichtlich nicht gefördert, die Farbpigmente könnten aber andere Tumoren begünstigen.

CAR-M-Zellen: Warten auf das große Fressen

22.05.2024 Onkologische Immuntherapie Nachrichten

Auch myeloide Immunzellen lassen sich mit chimären Antigenrezeptoren gegen Tumoren ausstatten. Solche CAR-Fresszell-Therapien werden jetzt für solide Tumoren entwickelt. Künftig soll dieser Prozess nicht mehr ex vivo, sondern per mRNA im Körper der Betroffenen erfolgen.

Frühzeitige HbA1c-Kontrolle macht sich lebenslang bemerkbar

22.05.2024 Typ-2-Diabetes Nachrichten

Menschen mit Typ-2-Diabetes von Anfang an intensiv BZ-senkend zu behandeln, wirkt sich positiv auf Komplikationen und Mortalität aus – und das offenbar lebenslang, wie eine weitere Nachfolgeuntersuchung der UKPD-Studie nahelegt.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2014

Marital Concurrency and HIV Risk in 16 African Countries

Examining the Authors’ Choice of Secondary Data in Determining What Factors Affect HIV Prevalence in WMSM, BMSM and Transgender Populations

Prevalence and Correlates of Sexual Partner Concurrency Among Australian Gay Men Aged 18–39 Years

Identification of Evidence-Based Interventions for Promoting HIV Medication Adherence: Findings from a Systematic Review of U.S.-Based Studies, 1996–2011

Methadone Maintenance Therapy Decreases the Rate of Antiretroviral Therapy Discontinuation Among HIV-Positive Illicit Drug Users