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Erschienen in:

30.03.2017 | Brief Report

Self-Report and Dry Blood Spot Measurement of Antiretroviral Medications as Markers of Adherence in Pregnant Women in Rural South Africa

verfasst von: Maria L. Alcaide, Shandir Ramlagan, Violeta J. Rodriguez, Ryan Cook, Karl Peltzer, Stephen M. Weiss, Sibusiso Sifunda, Deborah L. Jones

Erschienen in: AIDS and Behavior | Ausgabe 7/2017

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Abstract

Antiretroviral (ARV) adherence is essential to prevent mother-to-child transmission of HIV. This study compared self-reported adherence versus ARV detection in dried blood spots (DBS) among N = 392 HIV-infected pregnant women in South Africa (SA). Women completed two self-reported adherence measures [visual analog scale (VAS), AIDS Clinical Trials Group Adherence (ACTG)]. Adherence was 89% (VAS), 80% (ACTG), and 74% (DBS). Self-report measures marginally agreed with DBS (VAS: Kappa = 0.101, Area under the ROC curve (AUROC) = 0.543; ACTG: Kappa = 0.081, AUROC = 0.538). Self-reported adherence was overestimated and agreement with DBS was poor. Validation of self-reported ARV adherence among pregnant HIV+ women in SA is needed.

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Titel: Self-Report and Dry Blood Spot Measurement of Antiretroviral Medications as Markers of Adherence in Pregnant Women in Rural South Africa
verfasst von: Maria L. Alcaide
Shandir Ramlagan
Violeta J. Rodriguez
Ryan Cook
Karl Peltzer
Stephen M. Weiss
Sibusiso Sifunda
Deborah L. Jones
Publikationsdatum: 30.03.2017
Verlag: Springer US
Erschienen in: AIDS and Behavior / Ausgabe 7/2017
Print ISSN: 1090-7165
Elektronische ISSN: 1573-3254
DOI: https://doi.org/10.1007/s10461-017-1760-3

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Self-Report and Dry Blood Spot Measurement of Antiretroviral Medications as Markers of Adherence in Pregnant Women in Rural South Africa

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