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Breast Cancer Research and Treatment
Erschienen in: Breast Cancer Research and Treatment 1/2008

01.05.2008 | Epidemiology

Epidemiology of basal-like breast cancer

verfasst von: Robert C. Millikan, Beth Newman, Chiu-Kit Tse, Patricia G. Moorman, Kathleen Conway, Lisa V. Smith, Miriam H. Labbok, Joseph Geradts, Jeannette T. Bensen, Susan Jackson, Sarah Nyante, Chad Livasy, Lisa Carey, H. Shelton Earp, Charles M. Perou

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 1/2008

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Abstract

Risk factors for the newly identified “intrinsic” breast cancer subtypes (luminal A, luminal B, basal-like and human epidermal growth factor receptor 2-positive/estrogen receptor-negative) were determined in the Carolina Breast Cancer Study, a population-based, case–control study of African-American and white women. Immunohistochemical markers were used to subtype 1,424 cases of invasive and in situ breast cancer, and case subtypes were compared to 2,022 controls. Luminal A, the most common subtype, exhibited risk factors typically reported for breast cancer in previous studies, including inverse associations for increased parity and younger age at first full-term pregnancy. Basal-like cases exhibited several associations that were opposite to those observed for luminal A, including increased risk for parity and younger age at first term full-term pregnancy. Longer duration breastfeeding, increasing number of children breastfed, and increasing number of months breastfeeding per child were each associated with reduced risk of basal-like breast cancer, but not luminal A. Women with multiple live births who did not breastfeed and women who used medications to suppress lactation were at increased risk of basal-like, but not luminal A, breast cancer. Elevated waist-hip ratio was associated with increased risk of luminal A in postmenopausal women, and increased risk of basal-like breast cancer in pre- and postmenopausal women. The prevalence of basal-like breast cancer was highest among premenopausal African-American women, who also showed the highest prevalence of basal-like risk factors. Among younger African-American women, we estimate that up to 68% of basal-like breast cancer could be prevented by promoting breastfeeding and reducing abdominal adiposity.
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Metadaten
Titel
Epidemiology of basal-like breast cancer
verfasst von
Robert C. Millikan
Beth Newman
Chiu-Kit Tse
Patricia G. Moorman
Kathleen Conway
Lisa V. Smith
Miriam H. Labbok
Joseph Geradts
Jeannette T. Bensen
Susan Jackson
Sarah Nyante
Chad Livasy
Lisa Carey
H. Shelton Earp
Charles M. Perou
Publikationsdatum
01.05.2008
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 1/2008
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-007-9632-6

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