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Breast Cancer Research and Treatment
Erschienen in: Breast Cancer Research and Treatment 1/2012

01.08.2012 | Clinical Trial

Intraoperative ultrasound guidance for excision of non-palpable invasive breast cancer: a hospital-based series and an overview of the literature

verfasst von: M. W. Barentsz, T. van Dalen, P. D. Gobardhan, V. Bongers, C. I. Perre, R. M. Pijnappel, M. A. A. J. van den Bosch, H. M. Verkooijen

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 1/2012

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Abstract

Intraoperative ultrasound (IOUS) can be used in the operation theatre for localization of non-palpable breast cancers. In this prospective cohort study, we compared the yield of IOUS to guidewire localization (GWL). A total of 258 consecutive patients with non-palpable invasive breast cancer underwent breast conserving surgery between 1999 and 2010. GWL was performed in 138 (54 %) and IOUS in 120 (46 %) patients. Tumor dimensions, resection volume, margin status and re-excision rates were compared by means of multivariate regression analysis. The groups were similar in terms of age, histological subtype and presence of DCIS. Lesions in the IOUS group were larger (1.24 vs. 0.98 cm, P < 0.001), while microcalcifications were more common in the GWL group (19 vs. 3 %, P < 0.001). Even after stratification for tumor diameter, presence of DCIS and findings on mammography, resection volumes were similar in both groups. Tumor-free resection margins were obtained in >93 % of patients (93.5 % with GWL vs. 93.3 % with IOUS, P = 0.958) and re-excision was performed in 11 % of patients undergoing GWL and 12.5 % of patients undergoing IOUS (P = 0.684). For localization of non-palpable breast cancer, IOUS is a reliable alternative to GWL, as it achieves similar results in terms of complete tumor removal, re-excision rate and excised volume.
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Metadaten
Titel
Intraoperative ultrasound guidance for excision of non-palpable invasive breast cancer: a hospital-based series and an overview of the literature
verfasst von
M. W. Barentsz
T. van Dalen
P. D. Gobardhan
V. Bongers
C. I. Perre
R. M. Pijnappel
M. A. A. J. van den Bosch
H. M. Verkooijen
Publikationsdatum
01.08.2012
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 1/2012
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-012-2165-7

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