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The International Journal of Cardiovascular Imaging

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01.03.2009 | Original Paper

In vivo non-invasive serial monitoring of FDG-PET progression and regression in a rabbit model of atherosclerosis

verfasst von: Stephen G. Worthley, Zhuang Y. Zhang, Josef Machac, Gérard Helft, Cheuk Tang, Gary Y. H. Liew, Azfar G. Zaman, Matthew I. Worthley, Zahi A. Fayad, Monte S. Buchsbaum, Valentin Fuster, Juan J. Badimon

Erschienen in: The International Journal of Cardiovascular Imaging | Ausgabe 3/2009

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Abstract

We investigated the ability of fluorodeoxyglucose positron emission tomography (FDG PET) imaging to serially monitor macrophage content in a rabbit model of atherosclerosis. Atherosclerosis was induced in rabbits (n = 8) by a combination of atherogenic diet and balloon denudation of the aorta. At the end of nine months, the rabbits were randomized to a further six months of the same atherogenic diet (progression group) or normal diet (regression group). In vivo uptake of FDG by the thoracic aorta was measured using aortic uptake-to-blood radioactivity ratios at the start and end of the randomized period. A significant increase in FDG uptake of the progression group after continued cholesterol feeding (aortic uptake-to-blood radioactivity: 0.57 ± 0.02 to 0.68 ± 0.02, P = 0.001), and a corresponding fall in FDG uptake of the regression group after returning to a normal chow diet (aortic uptake-to-blood radioactivity ratios: 0.67 ± 0.02 to 0.53 ± 0.02, P < 0.0001). FDG PET can quantify in vivo macrophage content and serially monitor changes in FDG activity in this rabbit model.

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Titel: In vivo non-invasive serial monitoring of FDG-PET progression and regression in a rabbit model of atherosclerosis
verfasst von: Stephen G. Worthley
Zhuang Y. Zhang
Josef Machac
Gérard Helft
Cheuk Tang
Gary Y. H. Liew
Azfar G. Zaman
Matthew I. Worthley
Zahi A. Fayad
Monte S. Buchsbaum
Valentin Fuster
Juan J. Badimon
Publikationsdatum: 01.03.2009
Verlag: Springer Netherlands
Erschienen in: The International Journal of Cardiovascular Imaging / Ausgabe 3/2009
Print ISSN: 1569-5794
Elektronische ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-008-9377-2

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