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Cancer and Metastasis Reviews

Erschienen in:

01.03.2008

Inflammation, inflammatory cells and angiogenesis: decisions and indecisions

verfasst von: Douglas M. Noonan, Andrea De Lerma Barbaro, Nicola Vannini, Lorenzo Mortara, Adriana Albini

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 1/2008

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Abstract

Endothelial-immune cell cross-talk goes well beyond leukocyte and lymphocyte trafficking, since immune cells are able to intimately regulate vessel formation and function. Here we review the evidence that most immune cells are capable of polarization towards a dichotomous activity either inducing or inhibiting angiogenesis. In addition to the well-known roles of tumor associated macrophages, we find that neutrophils, myeloid-derived suppressor and dendritic cells clearly have the potential for influencing tumor angiogenesis. Further, the physiological functions of NK cells suggest that these cells may also show a potentially important role in pro- or anti-angiogenesis regulation within the tumor microenvironment. At the same time many angiogenic factors influence the activity and function of immune cells that generally favor tumor survival and tolerance. Thus the immune system itself represents a major pharmaceutical target and links angiogenesis inhibition to immunotherapy.

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Titel: Inflammation, inflammatory cells and angiogenesis: decisions and indecisions
verfasst von: Douglas M. Noonan
Andrea De Lerma Barbaro
Nicola Vannini
Lorenzo Mortara
Adriana Albini
Publikationsdatum: 01.03.2008
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 1/2008
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-007-9108-5

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