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Cancer and Metastasis Reviews

Erschienen in:

01.12.2013 | NON-THEMATIC REVIEW

Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review

verfasst von: Asfar S. Azmi, Bin Bao, Fazlul H. Sarkar

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 3-4/2013

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Abstract

Trafficking of biological material across membranes is an evolutionary conserved mechanism and is part of any normal cell homeostasis. Such transport is composed of active, passive, export through microparticles, and vesicular transport (exosomes) that collectively maintain proper compartmentalization of important micro- and macromolecules. In pathological states, such as cancer, aberrant activity of the export machinery results in expulsion of a number of key proteins and microRNAs resulting in their misexpression. Exosome-mediated expulsion of intracellular drugs could be another barrier in the proper action of most of the commonly used therapeutics, targeted agents, and their intracellular metabolites. Over the last decade, a number of studies have revealed that exosomes cross-talk and/or influence major tumor-related pathways, such as hypoxia-driven epithelial-to-mesenchymal transition, cancer stemness, angiogenesis, and metastasis involving many cell types within the tumor microenvironment. Emerging evidence suggests that exosome-secreted proteins can also propel fibroblast growth, resulting in desmoplastic reaction, a major barrier in effective cancer drug delivery. This comprehensive review highlights the advancements in the understanding of the biology of exosomes secretions and the consequence on cancer drug resistance. We propose that the successful combination of cancer treatments to tackle exosome-mediated drug resistance requires an interdisciplinary understanding of these cellular exclusion mechanisms, and how secreted biomolecules are involved in cellular cross-talk within the tumor microenvironment.

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Titel: Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review
verfasst von: Asfar S. Azmi
Bin Bao
Fazlul H. Sarkar
Publikationsdatum: 01.12.2013
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 3-4/2013
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-013-9441-9

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Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review

Abstract

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Dormancy in solid tumors: implications for prostate cancer

Tumor type-specific and skin region-selective metastasis of human cancers: another example of the “seed and soil” hypothesis

The pre-metastatic niche: finding common ground

Regulation of chromatin structure via histone post-translational modification and the link to carcinogenesis

Preface

Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos

Neu im Fachgebiet Onkologie

„Überwältigende“ Evidenz für Tripeltherapie beim metastasierten Prostata-Ca.

So sicher sind Tattoos: Neue Daten zur Risikobewertung

CAR-M-Zellen: Warten auf das große Fressen

Blutdrucksenkung könnte Uterusmyome verhindern

Update Onkologie