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Digestive Diseases and Sciences

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01.12.2007 | Original Paper

The Effect of Acetaldehyde on Human Plasma Factor XIII Function

verfasst von: Elizabeth A. Suchocki, Arthur S. Brecher

Erschienen in: Digestive Diseases and Sciences | Ausgabe 12/2007

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Abstract

The effect of acetaldehyde on the transglutaminase activity in pooled normal human plasma has been investigated. In this study, 0.05, 0.2, and 0.7 ml of pooled human plasma were preincubated for 30 min. at room temperature with buffer or acetaldehyde at final concentrations of 40.6, 22.4, and 11.2 mM before being utilized for Factor XIIIa assay with fibrinogen and thrombin which had been preheated at 40°C to destroy endogenous Factor XIII/XIIIa activity. At all concentrations of acetaldehyde and all concentrations of plasma-containing Factor XIII which were employed, prolongation of both clotting time and stabilization time was observed. The 11.2 mM acetaldehyde is within the range of daily acetaldehyde production to be predicted in severe alcoholics as a consequence of imbibing alcohol. The stabilization times measured for Factor XIIIa activity appear to be the most sensitive to acetaldehyde compared to acetaldehyde effects on thrombin, Factor Xa, and fibrinogen studied earlier in this laboratory, as well as Factors II, VII, and X.

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Titel: The Effect of Acetaldehyde on Human Plasma Factor XIII Function
verfasst von: Elizabeth A. Suchocki
Arthur S. Brecher
Publikationsdatum: 01.12.2007
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 12/2007
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-007-9754-z

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