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Erschienen in: Digestive Diseases and Sciences 6/2021

20.07.2020 | Original Article

Identifying Patient Priorities for Preconception and Pregnancy Counseling in IBD

verfasst von: Aiya Aboubakr, Alexa Rae Riggs, Darwin Jimenez, Maria Teresa Mella, Marla C. Dubinsky

Erschienen in: Digestive Diseases and Sciences | Ausgabe 6/2021

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Abstract

Background

Inflammatory bowel disease (IBD) commonly affects women of reproductive age. Many patients lacking knowledge about IBD and reproduction make uninformed decisions, such as voluntary childlessness and medication cessation. Education should be individualized to the patient’s knowledge base and include topics of most importance to the patient. Our study aimed to describe the priority rankings of topics selected by patients seeking preconception and pregnancy counseling.

Methods

As part of an ongoing prospective study, patients with IBD were asked to rank, in order of importance, nine a priori preconception, pregnancy, and postpartum topics they would like addressed by our specialized care team, which includes an IBD physician and a high-risk obstetrician. χ2 and Fisher’s exact tests were used to assess associations between clinical and demographic characteristics and priority rankings, and a p value cutoff for significance was set as .05.

Results

One hundred and fifty-eight women with IBD (mean (IQR) age; 32 (28–37) years) were seen in consultation, and 116 (70 (60%) CD, 43 (37%) UC, and 3 (3%) IBD-U) completed intake forms were analyzed. There were 78 (68%) women seen in the preconception stage, median age 31 (IQR 28–34), and 38 women (32%) were pregnant, median age 32 (IQR 28–33). Safety of IBD medications during pregnancy was most commonly ranked as top priority (40%) for all patients regardless of pregnancy status, followed by control of IBD disease activity and impact on pregnancy (31%), impact of IBD and surgery on fertility (19%), pregnancy outcomes for the baby (18%), mode of delivery (6%), inheritance of IBD (4%), breastfeeding (2%), nutritional health (2%), and vaccines and newborn care (1%). The impact of IBD and surgery on fertility was ranked as the number one priority more often in the preconception group (p value < 0.01) and mode of delivery in the pregnancy group (p value 0.04). Conclusion: Safety of IBD medications remains a priority topic for patients seeking preconception and pregnancy counseling.
Literatur
1.
Zurück zum Zitat Heetun ZS, Byrnes C, Neary P, O’Morain C. Review article: reproduction in the patient with inflammatory bowel disease. Aliment Pharmacol Ther. 2007;26:513–533.CrossRef Heetun ZS, Byrnes C, Neary P, O’Morain C. Review article: reproduction in the patient with inflammatory bowel disease. Aliment Pharmacol Ther. 2007;26:513–533.CrossRef
2.
Zurück zum Zitat Baiocco PJ, Korelitz BI. The influence of inflammatory bowel disease and its treatment on pregnancy and fetal outcome. J Clin Gastroenterol. 1984;6:211–216.PubMed Baiocco PJ, Korelitz BI. The influence of inflammatory bowel disease and its treatment on pregnancy and fetal outcome. J Clin Gastroenterol. 1984;6:211–216.PubMed
3.
Zurück zum Zitat Selinger CP, Eaden J, Selby W, et al. Patients’ knowledge of pregnancy-related issues in inflammatory bowel disease and validation of a novel assessment tool (‘CCPKnow’). Aliment Pharmacol Ther. 2012;36:57–63.CrossRef Selinger CP, Eaden J, Selby W, et al. Patients’ knowledge of pregnancy-related issues in inflammatory bowel disease and validation of a novel assessment tool (‘CCPKnow’). Aliment Pharmacol Ther. 2012;36:57–63.CrossRef
4.
Zurück zum Zitat Carbery I, Ghorayeb J, Madill A, Selinger CP. Pregnancy and inflammatory bowel disease: do we provide enough patient education? A British study of 1324 women. World J Gastroenterol. 2016;22:8219–8225.CrossRef Carbery I, Ghorayeb J, Madill A, Selinger CP. Pregnancy and inflammatory bowel disease: do we provide enough patient education? A British study of 1324 women. World J Gastroenterol. 2016;22:8219–8225.CrossRef
5.
Zurück zum Zitat Marri SR, Ahn C, Buchman AL. Voluntary childlessness is increased in women with inflammatory bowel disease. Inflamm Bowel Dis. 2007;13:591–599.CrossRef Marri SR, Ahn C, Buchman AL. Voluntary childlessness is increased in women with inflammatory bowel disease. Inflamm Bowel Dis. 2007;13:591–599.CrossRef
6.
Zurück zum Zitat Mountifield R, Bampton P, Prosser R, Muller K, Andrews JM. Fear and fertility in inflammatory bowel disease: a mismatch of perception and reality affects family planning decisions. Inflamm Bowel Dis. 2009;15:720–725.CrossRef Mountifield R, Bampton P, Prosser R, Muller K, Andrews JM. Fear and fertility in inflammatory bowel disease: a mismatch of perception and reality affects family planning decisions. Inflamm Bowel Dis. 2009;15:720–725.CrossRef
7.
Zurück zum Zitat Baird DD, Narendranathan M, Sandler RS. Increased risk of preterm birth for women with inflammatory bowel disease. Gastroenterology. 1990;99:987–994.CrossRef Baird DD, Narendranathan M, Sandler RS. Increased risk of preterm birth for women with inflammatory bowel disease. Gastroenterology. 1990;99:987–994.CrossRef
8.
Zurück zum Zitat Selinger CP, Ghorayeb J, Madill A. What factors might drive voluntary childlessness (VC) in women with IBD? Does IBD-specific pregnancy-related knowledge matter? J Crohns Colitis. 2016;10:1151–1158.CrossRef Selinger CP, Ghorayeb J, Madill A. What factors might drive voluntary childlessness (VC) in women with IBD? Does IBD-specific pregnancy-related knowledge matter? J Crohns Colitis. 2016;10:1151–1158.CrossRef
9.
Zurück zum Zitat de Lima A, Zelinkova Z, Mulders AG, van der Woude CJ. Preconception care reduces relapse of inflammatory bowel disease during pregnancy. Clin Gastroenterol Hepatol. 2016;14:1285–1292.e1281.CrossRef de Lima A, Zelinkova Z, Mulders AG, van der Woude CJ. Preconception care reduces relapse of inflammatory bowel disease during pregnancy. Clin Gastroenterol Hepatol. 2016;14:1285–1292.e1281.CrossRef
10.
Zurück zum Zitat Mountifield R, Andrews JM, Bampton P. It IS worth the effort: patient knowledge of reproductive aspects of inflammatory bowel disease improves dramatically after a single group education session. J Crohns Colitis. 2014;8:796–801.CrossRef Mountifield R, Andrews JM, Bampton P. It IS worth the effort: patient knowledge of reproductive aspects of inflammatory bowel disease improves dramatically after a single group education session. J Crohns Colitis. 2014;8:796–801.CrossRef
12.
Zurück zum Zitat Mahadevan U, Robinson C, Bernasko N, et al. Inflammatory bowel disease in pregnancy clinical care pathway: a report from the american gastroenterological association ibd parenthood project working group. Gastroenterology. 2019;156:1508–1524.CrossRef Mahadevan U, Robinson C, Bernasko N, et al. Inflammatory bowel disease in pregnancy clinical care pathway: a report from the american gastroenterological association ibd parenthood project working group. Gastroenterology. 2019;156:1508–1524.CrossRef
14.
Zurück zum Zitat Robinson A. Review article: inflammatory bowel disease–empowering the patient and improving outcome. Aliment Pharmacol Ther. 2004;20:84–87.CrossRef Robinson A. Review article: inflammatory bowel disease–empowering the patient and improving outcome. Aliment Pharmacol Ther. 2004;20:84–87.CrossRef
15.
Zurück zum Zitat Sandborn WJ, Feagan BG, Hanauer SB, et al. A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn’s disease. Gastroenterology. 2002;122:512–530.CrossRef Sandborn WJ, Feagan BG, Hanauer SB, et al. A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn’s disease. Gastroenterology. 2002;122:512–530.CrossRef
16.
Zurück zum Zitat Lewis JD, Chuai S, Nessel L, Lichtenstein GR, Aberra FN, Ellenberg JH. Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis. Inflamm Bowel Dis. 2008;14:1660–1666.CrossRef Lewis JD, Chuai S, Nessel L, Lichtenstein GR, Aberra FN, Ellenberg JH. Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis. Inflamm Bowel Dis. 2008;14:1660–1666.CrossRef
17.
Zurück zum Zitat Mountifield RE, Prosser R, Bampton P, Muller K, Andrews JM. Pregnancy and IBD treatment: this challenging interplay from a patients’ perspective. J Crohns Colitis. 2010;4:176–182.CrossRef Mountifield RE, Prosser R, Bampton P, Muller K, Andrews JM. Pregnancy and IBD treatment: this challenging interplay from a patients’ perspective. J Crohns Colitis. 2010;4:176–182.CrossRef
18.
Zurück zum Zitat Gallinger ZR, Rumman A, Nguyen GC. Perceptions and attitudes towards medication adherence during pregnancy in inflammatory bowel disease. J Crohns Colitis. 2016;10:892–897.CrossRef Gallinger ZR, Rumman A, Nguyen GC. Perceptions and attitudes towards medication adherence during pregnancy in inflammatory bowel disease. J Crohns Colitis. 2016;10:892–897.CrossRef
19.
Zurück zum Zitat Ellul P, Zammita SC, Katsanos KH, et al. Perception of reproductive health in women with inflammatory bowel disease. J Crohns Colitis. 2016;10:886–891.CrossRef Ellul P, Zammita SC, Katsanos KH, et al. Perception of reproductive health in women with inflammatory bowel disease. J Crohns Colitis. 2016;10:886–891.CrossRef
20.
Zurück zum Zitat Nordeng H, Koren G, Einarson A. Pregnant women’s beliefs about medications–a study among 866 Norwegian women. Ann Pharmacother. 2010;44:1478–1484.CrossRef Nordeng H, Koren G, Einarson A. Pregnant women’s beliefs about medications–a study among 866 Norwegian women. Ann Pharmacother. 2010;44:1478–1484.CrossRef
21.
Zurück zum Zitat Keller MS, Mosadeghi S, Cohen ER, Kwan J, Spiegel BMR. Reproductive health and medication concerns for patients with inflammatory bowel disease: thematic and quantitative analysis using social listening. J Med Internet Res. 2018;20:e206.CrossRef Keller MS, Mosadeghi S, Cohen ER, Kwan J, Spiegel BMR. Reproductive health and medication concerns for patients with inflammatory bowel disease: thematic and quantitative analysis using social listening. J Med Internet Res. 2018;20:e206.CrossRef
22.
Zurück zum Zitat Selinger CP, Eaden J, Selby W, et al. Inflammatory bowel disease and pregnancy: lack of knowledge is associated with negative views. J Crohns Colitis. 2013;7:e206–213.CrossRef Selinger CP, Eaden J, Selby W, et al. Inflammatory bowel disease and pregnancy: lack of knowledge is associated with negative views. J Crohns Colitis. 2013;7:e206–213.CrossRef
23.
Zurück zum Zitat Abhyankar A, Ham M, Moss AC. Meta-analysis: the impact of disease activity at conception on disease activity during pregnancy in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:460–466.CrossRef Abhyankar A, Ham M, Moss AC. Meta-analysis: the impact of disease activity at conception on disease activity during pregnancy in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:460–466.CrossRef
24.
Zurück zum Zitat Tavernier N, Fumery M, Peyrin-Biroulet L, Colombel JF, Gower-Rousseau C. Systematic review: fertility in non-surgically treated inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:847–853.CrossRef Tavernier N, Fumery M, Peyrin-Biroulet L, Colombel JF, Gower-Rousseau C. Systematic review: fertility in non-surgically treated inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:847–853.CrossRef
25.
Zurück zum Zitat Betteridge JD, Armbruster SP, Maydonovitch C, Veerappan GR. Inflammatory bowel disease prevalence by age, gender, race, and geographic location in the U.S. military health care population. Inflamm Bowel Dis. 2013;19:1421–1427.CrossRef Betteridge JD, Armbruster SP, Maydonovitch C, Veerappan GR. Inflammatory bowel disease prevalence by age, gender, race, and geographic location in the U.S. military health care population. Inflamm Bowel Dis. 2013;19:1421–1427.CrossRef
Metadaten
Titel
Identifying Patient Priorities for Preconception and Pregnancy Counseling in IBD
verfasst von
Aiya Aboubakr
Alexa Rae Riggs
Darwin Jimenez
Maria Teresa Mella
Marla C. Dubinsky
Publikationsdatum
20.07.2020
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 6/2021
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-020-06480-3

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