Skip to main content
Erschienen in: Familial Cancer 3/2013

01.09.2013 | Original Article

Unmet support needs and distress among women with a BRCA1/2 mutation

verfasst von: Ashley Farrelly, Victoria White, Bettina Meiser, Michael Jefford, Mary-Anne Young, Sandra Ieropoli, Ingrid Winship, Jessica Duffy

Erschienen in: Familial Cancer | Ausgabe 3/2013

Einloggen, um Zugang zu erhalten

Abstract

Distress levels among female BRCA1/2 mutation carriers can be similar to levels found among breast cancer patients. While psychological distress has been associated with unmet needs among cancer patients no study has examined this among BRCA1/2 mutation carriers. The objectives of this study were to: (1) describe the unmet support needs of women with a known BRCA1/2 mutation, (2) determine how unmet needs are related to psychological distress, and (3) identify variables that predict level of unmet need and distress. Female BRCA1/2 mutation carriers were identified through Familial Cancer Centers in 3 Australian states. Two-hundred and seventy-nine participants completed surveys assessing need for help on 16 information and support items. The Impact of Events Scale assessed genetic test related distress. Participants reported an average of 5.4 (SD = 4.9) moderate to very high unmet needs. Twenty-one percent had scores indicating moderate distress, and 13 % indicating severe distress. Younger age (t = −3.34; p < 0.01), not having someone to confide in about the gene mutation (t = 2.57; p = 0.01) and shorter time since notification of mutation status (t = −2.49; p = 0.01) were associated with higher unmet need scores in linear regression analyses. Greater number of unmet needs was associated with a greater likelihood of moderate to severe levels of distress (OR = 1.19; p < 0.01) in logistic regression analyses. Identifying appropriate interventions that target unmet needs among younger women and those with no confidante may help to reduce distress. Interventions that provide an opportunity for women to confide in someone, such as Peer support programs, may be one way of meeting the emotional needs of this population.
Literatur
1.
Zurück zum Zitat Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL, Loman N, Olsson H, Johannsson O, Borg A, Pasini B, Radice P, Manoukian S, Eccles DM, Tang N, Olah E, Anton-Culver H, Warner E, Lubinski J, Gronwald J, Gorski B, Tulinius H, Thorlacius S, Eerola H, Nevanlinna H, Syrjakoski K, Kallioniemi OP, Thompson D, Evans C, Peto J, Lalloo F, Evans DG, Easton DF (2003) Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 72(5):1117–1130. doi:10.1086/375033 PubMedCrossRef Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL, Loman N, Olsson H, Johannsson O, Borg A, Pasini B, Radice P, Manoukian S, Eccles DM, Tang N, Olah E, Anton-Culver H, Warner E, Lubinski J, Gronwald J, Gorski B, Tulinius H, Thorlacius S, Eerola H, Nevanlinna H, Syrjakoski K, Kallioniemi OP, Thompson D, Evans C, Peto J, Lalloo F, Evans DG, Easton DF (2003) Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 72(5):1117–1130. doi:10.​1086/​375033 PubMedCrossRef
2.
Zurück zum Zitat Rebbeck TR, Friebel T, Lynch HT, Neuhausen SL, van’t Veer L, Garber JE, Evans GR, Narod SA, Isaacs C, Matloff E, Daly MB, Olopade OO, Weber BL (2004) Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation barriers: the PROSE Study Group. J Clin Oncol 22(6):1055–1062PubMedCrossRef Rebbeck TR, Friebel T, Lynch HT, Neuhausen SL, van’t Veer L, Garber JE, Evans GR, Narod SA, Isaacs C, Matloff E, Daly MB, Olopade OO, Weber BL (2004) Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation barriers: the PROSE Study Group. J Clin Oncol 22(6):1055–1062PubMedCrossRef
3.
Zurück zum Zitat Rebbeck TR, Lynch HT, Neuhausen SL, Narod SA, van’t Veer L, Garber JE, Evans GR, Isaacs C, Daly MB, Matloff E, Olopade OO, Weber BL (2002) Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations. N Engl J Med 346(21):1616–1622PubMedCrossRef Rebbeck TR, Lynch HT, Neuhausen SL, Narod SA, van’t Veer L, Garber JE, Evans GR, Isaacs C, Daly MB, Matloff E, Olopade OO, Weber BL (2002) Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations. N Engl J Med 346(21):1616–1622PubMedCrossRef
5.
Zurück zum Zitat Youlden DR, Cramb SM, Dunn NAM, Muller JM, Pyke CM, Baade PD (2012) The descriptive epidemiology of female breast cancer: an international comparison of screening, incidence, survival and mortality. Cancer Epidemiol 36(3):237–248PubMedCrossRef Youlden DR, Cramb SM, Dunn NAM, Muller JM, Pyke CM, Baade PD (2012) The descriptive epidemiology of female breast cancer: an international comparison of screening, incidence, survival and mortality. Cancer Epidemiol 36(3):237–248PubMedCrossRef
6.
Zurück zum Zitat Kriege M, Brekelmans C, Boetes C, Besnard P, Zonderland H, Obdeijn I, Manoliu R, Kok T, Peterse H, Tilanus-Linthorst M, Muller SH, Meijer S, Oosterwijk JC, Beex L, Tollenaar R, de Koning H, Rutgers E, Klijn JGM (2004) Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med 351(5):427–437PubMedCrossRef Kriege M, Brekelmans C, Boetes C, Besnard P, Zonderland H, Obdeijn I, Manoliu R, Kok T, Peterse H, Tilanus-Linthorst M, Muller SH, Meijer S, Oosterwijk JC, Beex L, Tollenaar R, de Koning H, Rutgers E, Klijn JGM (2004) Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med 351(5):427–437PubMedCrossRef
7.
Zurück zum Zitat Meiser B, Butow P, Friedlander M, Barratt A, Schnieden V, Watson M, Brown J, Tucker K (2002) Psychological impact of genetic testing in women from high-risk breast cancer families. Eur J Cancer 38:2025–2033PubMedCrossRef Meiser B, Butow P, Friedlander M, Barratt A, Schnieden V, Watson M, Brown J, Tucker K (2002) Psychological impact of genetic testing in women from high-risk breast cancer families. Eur J Cancer 38:2025–2033PubMedCrossRef
8.
Zurück zum Zitat Croyle R, Smith K, Botkin J, Baty B, Nash J (1997) Psychological responses to BRCA1 mutation testing: preliminary findings. Health Psychol 16:63–72PubMedCrossRef Croyle R, Smith K, Botkin J, Baty B, Nash J (1997) Psychological responses to BRCA1 mutation testing: preliminary findings. Health Psychol 16:63–72PubMedCrossRef
9.
Zurück zum Zitat Braithwaite D, Emery J, Walter F, Prevost AT, Sutton S (2004) Psychological impact of genetic counseling for familial cancer: a systematic review and meta-analysis. J Natl Cancer Inst 96:122–123PubMedCrossRef Braithwaite D, Emery J, Walter F, Prevost AT, Sutton S (2004) Psychological impact of genetic counseling for familial cancer: a systematic review and meta-analysis. J Natl Cancer Inst 96:122–123PubMedCrossRef
11.
Zurück zum Zitat Tjemsland L, Soreide J, Malt U (1998) Posttraumatic distress symptoms in operable breast cancer III: status one year after surgery. Breast Cancer Res Treat 47:141–151PubMedCrossRef Tjemsland L, Soreide J, Malt U (1998) Posttraumatic distress symptoms in operable breast cancer III: status one year after surgery. Breast Cancer Res Treat 47:141–151PubMedCrossRef
12.
Zurück zum Zitat Lindberg NM, Wellisch DK (2004) Identification of traumatic stress reactions in women at increased risk for breast cancer. Psychosomatics 45:7–16PubMedCrossRef Lindberg NM, Wellisch DK (2004) Identification of traumatic stress reactions in women at increased risk for breast cancer. Psychosomatics 45:7–16PubMedCrossRef
13.
Zurück zum Zitat van Oostrom I, Meijers-Heijboer H, Lodder LN, Duivenvoorden HJ, van Gool AR, Seynaeve C, van der Meer CA, Klijn JGM, van Geel BN, Burger CW, Wladimiroff JW, Tibben A (2004) Long-term psychological impact of carrying a BRCA1/2 mutation and prophylactic surgery: a 5-year follow-up study. J Clin Oncol 21:3867–3874CrossRef van Oostrom I, Meijers-Heijboer H, Lodder LN, Duivenvoorden HJ, van Gool AR, Seynaeve C, van der Meer CA, Klijn JGM, van Geel BN, Burger CW, Wladimiroff JW, Tibben A (2004) Long-term psychological impact of carrying a BRCA1/2 mutation and prophylactic surgery: a 5-year follow-up study. J Clin Oncol 21:3867–3874CrossRef
14.
Zurück zum Zitat Hodgkinson K, Butow P, Hunt GE (2007) Breast cancer survivors’ supportive care needs 2–10 years after diagnosis. Support Care Cancer 15(5):515–523PubMedCrossRef Hodgkinson K, Butow P, Hunt GE (2007) Breast cancer survivors’ supportive care needs 2–10 years after diagnosis. Support Care Cancer 15(5):515–523PubMedCrossRef
15.
Zurück zum Zitat Harrison JD, Young JM, Price MA, Butow PN, Solomon MJ (2009) What are the unmet supportive care needs of people with cancer? A systematic review. Support Care Cancer 17:1117–1128PubMedCrossRef Harrison JD, Young JM, Price MA, Butow PN, Solomon MJ (2009) What are the unmet supportive care needs of people with cancer? A systematic review. Support Care Cancer 17:1117–1128PubMedCrossRef
16.
Zurück zum Zitat Thewes B, Meiser B, Tucker M, Tucker K (2003) The unmet information and support needs of women with a family history of breast cancer: a descriptive survey. J Genet Couns 12(1):61–76CrossRef Thewes B, Meiser B, Tucker M, Tucker K (2003) The unmet information and support needs of women with a family history of breast cancer: a descriptive survey. J Genet Couns 12(1):61–76CrossRef
17.
Zurück zum Zitat Iredale R, Brain K, Edwards L, Gray J, France E (2003) The information and support needs of women at high risk of familial breast and ovarian cancer: how can cancer genetic services give patients what they want? Fam Cancer 2:119–121PubMedCrossRef Iredale R, Brain K, Edwards L, Gray J, France E (2003) The information and support needs of women at high risk of familial breast and ovarian cancer: how can cancer genetic services give patients what they want? Fam Cancer 2:119–121PubMedCrossRef
18.
Zurück zum Zitat Werner-Lin A (2008) Formal and informal support needs of young women with BRCA mutations. J Psychosoc Oncol 26(4):111–133PubMedCrossRef Werner-Lin A (2008) Formal and informal support needs of young women with BRCA mutations. J Psychosoc Oncol 26(4):111–133PubMedCrossRef
19.
Zurück zum Zitat Beckmann K, Tait C, McCormack J, Suthers G (2004) Information and support needs of people with genetic errors associated with increased cancer risk: summary report of study findings. SA Clinical Genetics Service and The Cancer Council South Australia, Adelaide, South Australia Beckmann K, Tait C, McCormack J, Suthers G (2004) Information and support needs of people with genetic errors associated with increased cancer risk: summary report of study findings. SA Clinical Genetics Service and The Cancer Council South Australia, Adelaide, South Australia
20.
Zurück zum Zitat Metcalfe KA, Liede A, Hoodfar E, Scott A, Foulkes WD, Narod SA (2000) An evaluation of needs of female BRCA1 and BRCA2 carriers undergoing genetic counselling. J Med Genet 37:866–874PubMedCrossRef Metcalfe KA, Liede A, Hoodfar E, Scott A, Foulkes WD, Narod SA (2000) An evaluation of needs of female BRCA1 and BRCA2 carriers undergoing genetic counselling. J Med Genet 37:866–874PubMedCrossRef
21.
Zurück zum Zitat Mor V, Allen SM, Siegel K, Houts P (1992) Determinants of needs and unmet need among cancer patients residing at home. Health Serv Res 27:337–360PubMed Mor V, Allen SM, Siegel K, Houts P (1992) Determinants of needs and unmet need among cancer patients residing at home. Health Serv Res 27:337–360PubMed
23.
Zurück zum Zitat Butow PN, Phillips F, Schweder J, White K, Underhill C, Goldstein D (2011) Psychosocial well-being and supportive care needs of cancer patients living in urban and rural/regional areas: a systematic review. Support Care Cancer 20(1):1–22PubMedCrossRef Butow PN, Phillips F, Schweder J, White K, Underhill C, Goldstein D (2011) Psychosocial well-being and supportive care needs of cancer patients living in urban and rural/regional areas: a systematic review. Support Care Cancer 20(1):1–22PubMedCrossRef
24.
Zurück zum Zitat Sanson-Fisher R, Girgis A, Boyes A, Bonevski B, Burton L, Cook P (2000) The unmet supportive care needs of patients with cancer. Cancer 88(1):226–237PubMedCrossRef Sanson-Fisher R, Girgis A, Boyes A, Bonevski B, Burton L, Cook P (2000) The unmet supportive care needs of patients with cancer. Cancer 88(1):226–237PubMedCrossRef
25.
Zurück zum Zitat Fatouros M, Baltoyiannis G, Roukos DH (2007) The predominant role of surgery in the prevention and new trends in the surgical treatment of women with BRCA1/2 mutations. Ann Surg Oncol 15(1):21–33PubMedCrossRef Fatouros M, Baltoyiannis G, Roukos DH (2007) The predominant role of surgery in the prevention and new trends in the surgical treatment of women with BRCA1/2 mutations. Ann Surg Oncol 15(1):21–33PubMedCrossRef
26.
Zurück zum Zitat Bonevski B, Sanson-Fisher R, Girgis A, Burton L, Cook P, Boyes A, Supportive Care Review Group (2000) Evaluation of an instrument to assess the needs of patients with cancer. Cancer 88(1):217–225PubMedCrossRef Bonevski B, Sanson-Fisher R, Girgis A, Burton L, Cook P, Boyes A, Supportive Care Review Group (2000) Evaluation of an instrument to assess the needs of patients with cancer. Cancer 88(1):217–225PubMedCrossRef
27.
Zurück zum Zitat Foot G, Sanson-Fisher R (1995) Measuring the unmet needs of people living with cancer. Cancer Forum 19(2):131–135 Foot G, Sanson-Fisher R (1995) Measuring the unmet needs of people living with cancer. Cancer Forum 19(2):131–135
28.
Zurück zum Zitat Horowitz M, Wilner N, Alvarez W (1979) Impact of event scale: a measure of subjective stress. Psychosom Med 41:209–218PubMed Horowitz M, Wilner N, Alvarez W (1979) Impact of event scale: a measure of subjective stress. Psychosom Med 41:209–218PubMed
30.
Zurück zum Zitat Finch A, Metcalfe KA, Chiang J, Elit L, McLaughlin J, Springate C, Esplen MJ, Demsky R, Murphy J, Rosen B, Narod SA (2011) The impact of prophylactic salpingo-oophorectomy on quality of life and psychological distress in women with a BRCA mutation. Psychooncology. doi:10.1002/pon.2041 PubMed Finch A, Metcalfe KA, Chiang J, Elit L, McLaughlin J, Springate C, Esplen MJ, Demsky R, Murphy J, Rosen B, Narod SA (2011) The impact of prophylactic salpingo-oophorectomy on quality of life and psychological distress in women with a BRCA mutation. Psychooncology. doi:10.​1002/​pon.​2041 PubMed
31.
Zurück zum Zitat Thewes B, Meiser B, Hickie IB (2001) Psychometric properties of the Impact of Event Scale amongst women at increased risk for hereditary breast cancer. Psychooncology 10(6):459–468PubMedCrossRef Thewes B, Meiser B, Hickie IB (2001) Psychometric properties of the Impact of Event Scale amongst women at increased risk for hereditary breast cancer. Psychooncology 10(6):459–468PubMedCrossRef
32.
Zurück zum Zitat Froot KA (1989) Consistent covariance matrix estimation with cross-sectional dependence and heteroskedasticity in financial data. J Fin Quant Anal 24:333–355CrossRef Froot KA (1989) Consistent covariance matrix estimation with cross-sectional dependence and heteroskedasticity in financial data. J Fin Quant Anal 24:333–355CrossRef
33.
Zurück zum Zitat Thewes B, Butow P, Girgis A, Pendlebury S (2004) The psychosocial needs of breast cancer survivors: a qualitative study of the shared and unique needs of younger versus older survivors. Psychooncology 13:177–189PubMedCrossRef Thewes B, Butow P, Girgis A, Pendlebury S (2004) The psychosocial needs of breast cancer survivors: a qualitative study of the shared and unique needs of younger versus older survivors. Psychooncology 13:177–189PubMedCrossRef
34.
Zurück zum Zitat Thewes B, Meiser B, Taylor A, Phillips KA, Capp PA, Dalley D, Goldstein D, Baber R, Friedlander ML (2005) Fertility and menopause related information needs of younger women with a diagnosis of early breast cancer. J Clin Oncol 23(22):5155–5165PubMedCrossRef Thewes B, Meiser B, Taylor A, Phillips KA, Capp PA, Dalley D, Goldstein D, Baber R, Friedlander ML (2005) Fertility and menopause related information needs of younger women with a diagnosis of early breast cancer. J Clin Oncol 23(22):5155–5165PubMedCrossRef
35.
Zurück zum Zitat Hoey LM, Ieropoli SC, White VM, Jefford M (2008) Systematic review of peer-support programs for people with cancer. Patient Educ Couns 70(3):315–337PubMedCrossRef Hoey LM, Ieropoli SC, White VM, Jefford M (2008) Systematic review of peer-support programs for people with cancer. Patient Educ Couns 70(3):315–337PubMedCrossRef
36.
Zurück zum Zitat Ganz PA (2008) Psychological and social aspects of breast cancer. Oncology 22(6):642–646PubMed Ganz PA (2008) Psychological and social aspects of breast cancer. Oncology 22(6):642–646PubMed
37.
Zurück zum Zitat Schwartz MD, Peshkin BN, Hughes C, Main D, Isaacs C, Lerman C (2002) Impact of BRCA1/BRCA2 mutation testing on psychologic distress in a clinic-based sample. J Clin Oncol 20(2):514–520PubMedCrossRef Schwartz MD, Peshkin BN, Hughes C, Main D, Isaacs C, Lerman C (2002) Impact of BRCA1/BRCA2 mutation testing on psychologic distress in a clinic-based sample. J Clin Oncol 20(2):514–520PubMedCrossRef
38.
Zurück zum Zitat Smith K, West J, Croyle R, Botkin JR (1999) Familial context of genetic testing for cancer susceptibility: moderating effect of siblings’ test results on psychological distress one to two weeks after BRCA1 mutation testing. Cancer Epidemiol Biomarkers Prev 8:385–392PubMed Smith K, West J, Croyle R, Botkin JR (1999) Familial context of genetic testing for cancer susceptibility: moderating effect of siblings’ test results on psychological distress one to two weeks after BRCA1 mutation testing. Cancer Epidemiol Biomarkers Prev 8:385–392PubMed
39.
Zurück zum Zitat den Heijer M, Seynaeve C, Vanheusden K, Duivenvoorden HJ, Bartels CCM, Menke-Pluymers MBE, Tibben A (2011) Psychological distress in women at risk for hereditary breast cancer: the role of family communication and perceived social support. Psychooncology 2:1317–1323CrossRef den Heijer M, Seynaeve C, Vanheusden K, Duivenvoorden HJ, Bartels CCM, Menke-Pluymers MBE, Tibben A (2011) Psychological distress in women at risk for hereditary breast cancer: the role of family communication and perceived social support. Psychooncology 2:1317–1323CrossRef
40.
Zurück zum Zitat Hamilton R, Hurley KE (2010) Conditions and consequences of a BRCA mutation in young, single women of childbearing age. Oncol Nurs Forum 37(5):627–634PubMedCrossRef Hamilton R, Hurley KE (2010) Conditions and consequences of a BRCA mutation in young, single women of childbearing age. Oncol Nurs Forum 37(5):627–634PubMedCrossRef
41.
Zurück zum Zitat Madalinska JB, Hollenstein J, Bleiker E, van Beurden M, Valdimarsdottir HB, Massuger LF, Katja N, Gaarenstroom KN, Mourits MJE, Verheijen RHM, van Dorst EBL, van der Putten H, van der Velden K, Boonstra H, Aaronson NK (2005) Quality of life effects of prophylactic salpingo-oophorectomy versus gynecologic screening among women at increased risk of hereditary ovarian cancer. J Clin Oncol 23(28):6890–6898PubMedCrossRef Madalinska JB, Hollenstein J, Bleiker E, van Beurden M, Valdimarsdottir HB, Massuger LF, Katja N, Gaarenstroom KN, Mourits MJE, Verheijen RHM, van Dorst EBL, van der Putten H, van der Velden K, Boonstra H, Aaronson NK (2005) Quality of life effects of prophylactic salpingo-oophorectomy versus gynecologic screening among women at increased risk of hereditary ovarian cancer. J Clin Oncol 23(28):6890–6898PubMedCrossRef
42.
Zurück zum Zitat Bresser PJC, Seynaeve C, Van Gool AR, Niermeijer MF, Duivenvoorden HJ, van Dooren S, van Geel AN, Menke-Pluijmers M, Klijn JGM, Tibben A (2007) The course of distress in women at increased risk of breast and ovarian cancer due to an (identified) genetic susceptibility who opt for prophylactic mastectomy and/or salpingo oophorectomy. Eur J Cancer 43:95–103PubMedCrossRef Bresser PJC, Seynaeve C, Van Gool AR, Niermeijer MF, Duivenvoorden HJ, van Dooren S, van Geel AN, Menke-Pluijmers M, Klijn JGM, Tibben A (2007) The course of distress in women at increased risk of breast and ovarian cancer due to an (identified) genetic susceptibility who opt for prophylactic mastectomy and/or salpingo oophorectomy. Eur J Cancer 43:95–103PubMedCrossRef
Metadaten
Titel
Unmet support needs and distress among women with a BRCA1/2 mutation
verfasst von
Ashley Farrelly
Victoria White
Bettina Meiser
Michael Jefford
Mary-Anne Young
Sandra Ieropoli
Ingrid Winship
Jessica Duffy
Publikationsdatum
01.09.2013
Verlag
Springer Netherlands
Erschienen in
Familial Cancer / Ausgabe 3/2013
Print ISSN: 1389-9600
Elektronische ISSN: 1573-7292
DOI
https://doi.org/10.1007/s10689-012-9596-5

Weitere Artikel der Ausgabe 3/2013

Familial Cancer 3/2013 Zur Ausgabe

Mehr Brustkrebs, aber weniger andere gynäkologische Tumoren mit Levonorgestrel-IUS

04.06.2024 Levonorgestrel Nachrichten

Unter Frauen, die ein Levonorgestrel-freisetzendes intrauterines System (IUS) verwenden, ist die Brustkrebsrate um 13% erhöht. Dafür kommt es deutlich seltener zu Endometrium-, Zervix- und Ovarialkarzinomen.

Bei seelischem Stress sind Checkpoint-Hemmer weniger wirksam

03.06.2024 NSCLC Nachrichten

Wie stark Menschen mit fortgeschrittenem NSCLC von einer Therapie mit Immun-Checkpoint-Hemmern profitieren, hängt offenbar auch davon ab, wie sehr die Diagnose ihre psychische Verfassung erschüttert

Antikörper mobilisiert Neutrophile gegen Krebs

03.06.2024 Onkologische Immuntherapie Nachrichten

Ein bispezifischer Antikörper formiert gezielt eine Armee neutrophiler Granulozyten gegen Krebszellen. An den Antikörper gekoppeltes TNF-alpha soll die Zellen zudem tief in solide Tumoren hineinführen.

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

29.05.2024 Larynxkarzinom Nachrichten

Fast ein Viertel der Personen mit mäßig dysplastischen Stimmlippenläsionen entwickelt einen Kehlkopftumor. Solche Personen benötigen daher eine besonders enge ärztliche Überwachung.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.