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01.12.2008

Effect of Unfiltered Coffee on Carbon Tetrachloride-Induced Liver Injury in Rats

verfasst von: Orhan Kursat Poyrazoglu, Ibrahim Halil Bahcecioglu, Huseyin Ataseven, Kerem Metin, Adile Ferda Dagli, Mehmet Yalniz, Bilal Ustundag

Erschienen in: Inflammation | Ausgabe 6/2008

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Abstract

To assess the role of unfiltered coffee upon carbon tetrachloride (CCl₄) induced hepatotoxicity in rats. All rats were randomly divided into control group, CCl₄-treated, unfiltered coffee-treated and CCl₄/unfiltered coffee-treated. Hepatic damage was induced by repeated intraperitoneal injections of CCl₄ every other day. Unfiltered coffee was given as drinking fluid for 8 days starting the day before CCl₄ administration. Liver enzymes, plasma and liver tissue malondialdehyde were analyzed. Histopathological evaluation of liver sections was performed. Serum aminotransferase level significantly increased in CCl₄/unfiltered coffee-treated group compared to CCl₄-treated group, as well as, lipid peroxidation products in the plasma and liver tissue. In addition, histopathological findings including inflammation and necrosis were significantly confirmed these findings. Unfiltered coffee potentiates acute liver injury in rats with CCl₄-induced hepatotoxicity.

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Titel: Effect of Unfiltered Coffee on Carbon Tetrachloride-Induced Liver Injury in Rats
verfasst von: Orhan Kursat Poyrazoglu
Ibrahim Halil Bahcecioglu
Huseyin Ataseven
Kerem Metin
Adile Ferda Dagli
Mehmet Yalniz
Bilal Ustundag
Publikationsdatum: 01.12.2008
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 6/2008
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-008-9092-0

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