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30.09.2017 | ORIGINAL ARTICLE

MicroRNA-155 Inhibits Polarization of Macrophages to M2-Type and Suppresses Choroidal Neovascularization

verfasst von: Pengfei Zhang, Hong Wang, Xueting Luo, Haiyun Liu, Bing Lu, Tong Li, Shiqi Yang, Qing Gu, Bin Li, Fenghua Wang, Xiaodong Sun

Erschienen in: Inflammation | Ausgabe 1/2018

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Abstract

Arg-1⁺Ym-1⁺ M2-type macrophages play essential roles in the development of choroidal neovascularization (CNV). Thus, inhibition of M2-type macrophages may be effective in suppressing CNV. However, the potential mechanisms of macrophage polarization during development of CNV remain unclear. In this study, we report that microRNA-155 (miR-155) inhibited M2 polarization by targeting C/EBPβ in CNV model mice and in bone marrow-derived primary macrophages. Moreover, our data show that intravitreous injection of miR-155 mimics suppressed subretinal leakage and neovascularization. Therefore, we conclude that C/EBPβ plays a significant role in M2 macrophage polarization in CNV model, while miR-155 mimics could suppress CNV by inhibiting C/EBPβ activity and M2 macrophage polarization.

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Titel: MicroRNA-155 Inhibits Polarization of Macrophages to M2-Type and Suppresses Choroidal Neovascularization
verfasst von: Pengfei Zhang
Hong Wang
Xueting Luo
Haiyun Liu
Bing Lu
Tong Li
Shiqi Yang
Qing Gu
Bin Li
Fenghua Wang
Xiaodong Sun
Publikationsdatum: 30.09.2017
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 1/2018
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-017-0672-8

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