nach oben

Inflammopharmacology

Erschienen in:

30.12.2017 | Review

Molecular signature of nitric oxide on major cancer hallmarks of colorectal carcinoma

verfasst von: Paramita Mandal

Erschienen in: Inflammopharmacology | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

Colorectal cancer (CRC) is the one of the most important diseases throughout the world. Several aetiological risk factors, viz. sedentary life style, smoking, alcohol intake, less physical activity, red meat, and microbiota, are associated with the development of CRC. Molecular pathophysiology of CRC implies inflammation, metastasis, apotosis and angiogenesis. Inflammation involves interaction between various immune cells, inflammatory cells, chemokines, cytokines, and pro-inflammatory mediators, such as cyclooxygenase (COX) and lipoxygenase (LOX) pathways, which may lead to signalling towards, tumour cell proliferation, growth, and invasion whereas nitric oxide (NO) has been associated with metastasis, apoptosis, and angiogenesis. Therefore, this review emphasises on the potential molecular mechanisms associated with NO with alteration of cancer biomarkers during development of colorectal carcinogenesis.

Baum B, Settleman J, Quinlan MP (2008) Transitions between epithelial and mesenchymal states in development and disease. Semin Cell Dev Biol 19(3):294–308CrossRefPubMed

Bing RJ, Miyataka M, Rich KA, Hanson N, Wang X, Slosser HD, Shi SR (2001) Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer. Clin Cancer Res 7(11):3385–3392PubMed

Brüne B (2003) Nitric oxide: NO apoptosis or turning it ON? Cell Death Differ 10(8):864–869CrossRefPubMed

Cannon RO III (1998) Role of nitric oxide in cardiovascular disease: focus on the endothelium. Clin Chem 44:1809PubMed

Choi BM, Pae HO, Jang SI, Kim YM, Chung HT (2002) Nitric oxide as a proapoptotic as well as anti-apoptotic modulator. J Biochem Mol Biol 35:116–126PubMed

Choudhari SK, Chaudhary M, Bagde S, Gadbail AR, Joshi V (2013) Nitric oxide and cancer: a review. World J Surg Oncol 11:118CrossRefPubMed

Colmean MP, Esteve J, Damiecki P et al (1993) Trends in cancer incidence and mortality, vol 21. IARC Scientific Publication, Lyon

Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A (2009) Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30(7):1073–1081CrossRefPubMed

Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420(6917):860–867CrossRefPubMedPubMedCentral

Cross RK, Wilson KT (2003) Nitric oxide in inflammatory bowel disease. Inflamm Bowel Dis 9:179–189CrossRefPubMed

Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE (2007) Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol 147(2):227–235PubMedPubMedCentral

Gal A, Wogan GN (1996) Mutagenesis associated with nitric oxide production in transgenic SJL mice. Proc Natl Acad Sci USA 93:15102–15107CrossRefPubMedPubMedCentral

Ghafourifar P, Cadenas E (2005) Mitochondrial nitric oxide synthase. Trends Pharmacol Sci 26:190–195CrossRefPubMed

Grasselli A, Nanni S, Colussi C et al (2008) Estrogen receptor-alpha and endothelial nitric oxide synthase nuclear complex regulates transcription of human telomerase. Circ Res 103:34CrossRefPubMed

Ha KS, Kim KM, Kwon YG, Bai SK, Nam WD, Yoo YM, Kim PK, Chung HT, Billiar TR, Kim YM (2003) Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/Akt activation. FASEB J 17(9):1036–1047CrossRefPubMed

Hanahan D, Weinberg RA (2011a) Hallmarks of cancer: the next generation. Cell 144(5):646–674CrossRefPubMed

Hanahan D, Weinberg RA (2011b) Hallmarks of cancer: the next generation. Cell 144(5):646–674CrossRefPubMed

Hofseth LJ, Wargovich MJ (2007) Inflammation, cancer, and targets of ginseng. J Nutr 137(1):183S–185SCrossRefPubMed

Hofseth LJ, Ying L (2006) Identifying and defusing weapons of mass inflammation in carcinogenesis. Biochim Biophys Acta 1765:74–84PubMed

Huerta S, Goulet EJ, Livingston EH (2006) Colon cancer and apoptosis. Am J Surg 191(4):517–526CrossRefPubMed

Igarashi J, Michel T (2008) S1P and eNOS regulation. Biochim Biophys Acta 1781:489CrossRefPubMed

Ihara A et al (2007) Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer. J Pharmacol Sci 103:24–32CrossRefPubMed

Israels LG, Israels ED (1999) Apoptosis. Oncologist 4:332–339PubMed

Jaiswal M, LaRusso NF, Gores GJ (2001) Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis. Am J Physiol - Gastrointest Liver Physiol 281 (3):G626–G34

Janakiram NB, Rao CV (2014) The role of inflammation in colon cancer. In: Aggarwal B (ed) Inflammation and cancer, advances in experimental medicine and biology, vol 816. Springer, New York. https://doi.org/10.1007/978-3-0348-0837-8_2

Jones R, Scobey M, Cheng J (2014) The risk of colon cancer in inflammatory bowel disease. J Gastrointest Dig Syst 4:1

Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Investig 119(6):1420–1428CrossRefPubMedPubMedCentral

Koehne CH, Dubois RN (2004) COX-2 inhibition and colorectal cancer. Semin Oncol 31:12–21CrossRefPubMed

Lagares-Garcia JA, Moore RA, Collier B, Heggere M, Diaz F, Qian F (2001) Nitric oxide synthase as a marker in colorectal carcinoma. Am Surg 67:709–713PubMed

Landskron G, Fuente MDL, Thuwajit P, Thuwajit C, Hermoso MA (2014) Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res. https://doi.org/10.1155/2014/149185 PubMedPubMedCentral

Li M, Wu X, Xu XC (2001) Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway. Clin Cancer Res 7(4):1010–1016PubMed

Lind DS (2004) Arginine and cancer. J Nutr 134:2837S–2841SCrossRefPubMed

Martinou JC, Desagher S, Antonsson B (2000) Cytochrome c release from mitochondria: all or nothing. Nat Cell Biol 2:E41–E43CrossRefPubMed

Mori M (2007) Regulation of nitric oxide synthesis and apoptosis by arginase and arginine recycling. J Nutr 137(6):1616S–1620SCrossRefPubMed

Mutoh M et al (2006) Roles of prostanoids in colon carcinogenesis and their potential targeting for cancer chemoprevention. Curr Pharm Des 12:2375–2382CrossRefPubMed

Oliveira CJ, Schindler F, Ventura AM et al (2003) Nitric oxide and cGMP activate the Ras–MAP kinase pathway-stimulating protein tyrosine phosphorylation in rabbit aortic endothelial cells. Free Rad Biol Med 35:381CrossRefPubMed

Oshima M, Dinchuk JE, Kargman SL, Oshima H, Hancock B, Kwong E, Trzaskos JM, Evans JF, Taketo MM (1996) Suppression of intestinal polyposis in Apc 716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87:803–809CrossRefPubMed

Piechota-Polanczyk A, Fichna J (2014) Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases. Naunyn-Schmiedeberg’s Arch Pharmacol 387:605–620CrossRef

Prescott SM et al (1996) Self-promotion? Intimate connections between APC and prostaglandin H synthase-2. Cell 87:783–786CrossRefPubMed

Scicinski J, Oronsky B, Ning S, Knox S, Peehl D, Kim MM, Langecker P, Fanger G (2015) NO to cancer: the complex and multifaceted role of nitric oxide and the epigenetic nitric oxide donor, RRx-001$. Redox Biol 6:1–8CrossRefPubMedPubMedCentral

Snyder CM, Shroff EH, Liu J, Chandel NS (2009) Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members. PLoS ONE 4(9):e7059CrossRefPubMedPubMedCentral

Soumaoro LT et al (2006) Expression of 5-lipoxygenase in human colorectal cancer. World J Gastroenterol 12:6355–6360CrossRefPubMedPubMedCentral

Sun Y (1990) Free radicals, antioxidant enzymes and carcinogenesis. Free Radical Biol Med 8:583–599CrossRef

Tavolari S, Bonafè M, Marini M, Ferreri C, Bartolini G, Brighenti E, Manara S, Tomasi V, Laufer S, Guarnieri T (2008) Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis 29(2):371–380CrossRefPubMed

Vahora H, Khan MA, Alalami U, Hussain A (2016a) The potential role of nitric oxide in halting cancer progression through chemoprevention. J Cancer Prev 21:1–12CrossRefPubMedPubMedCentral

Vahora H, Khan MA, Alalami U, Hussain A (2016b) The potential role of nitric oxide in halting cancer progression through chemoprevention. J Cancer Prev 21:1–12CrossRefPubMedPubMedCentral

Weiss JM, Ridnour LA, Back T, Hussain SP, He P, Maciag AE et al (2010) Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy. J Exp Med 207:2455–2467CrossRefPubMedPubMedCentral

Wink DA, Vodovotz Y, Laval J, Laval F, Dewhirst MW, Mitchell JB (1998) The multifaceted roles of nitric oxide in cancer. Carcinogenesis 19(5):711–721CrossRefPubMed

Xu W, Liu LZ, Loizidou M, Ahmed M, Charles IG (2002a) The role of nitric oxide in cancer. Cell Res 12(5–6):311–320CrossRefPubMed

Xu W, Liu LZ, Loizidou M, Ahmed M, Charles IG (2002b) The role of nitric oxide in cancer. Cell Res 12(5–6):311–320CrossRefPubMed

Xu J, Lamouille S, Derynck R (2009) TGF-Β-induced epithelial to mesenchymal transition. Cell Res 19(2):156–172CrossRefPubMedPubMedCentral

Yang HT, Yan Z, Abraham JA, Terjung RL (2001) VEGF(121)- and bFGF-induced increase in collateral blood flow requires normal nitric oxide production. Am J Physiol 280:H1097CrossRef

Ye YN et al (2005) Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. Carcinogenesis 26:827–834CrossRefPubMed

Ying L, Hofseth LJ (2007) An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer. Cancer Res 67(4):1407–1410CrossRefPubMed

Zhang L, Yu J (2013) Role of apoptosis in colon cancer biology, therapy, and prevention. Curr Colorectal Cancer Rep 9(4):331–340CrossRef

Ziche M, Morbidelli L (2009) Molecular regulation of tumour angiogenesis by nitric oxide. Eur Cytokine Netw 20(4):164–170PubMed

Titel: Molecular signature of nitric oxide on major cancer hallmarks of colorectal carcinoma
verfasst von: Paramita Mandal
Publikationsdatum: 30.12.2017
Verlag: Springer International Publishing
Erschienen in: Inflammopharmacology / Ausgabe 2/2018
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-017-0435-z

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Molecular signature of nitric oxide on major cancer hallmarks of colorectal carcinoma

Abstract

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2018

CCR2 contributes to the recruitment of monocytes and leads to kidney inflammation and fibrosis development

Modafinil attenuates inflammation via inhibiting Akt/NF-κB pathway in apoE-deficient mouse model of atherosclerosis

PPARα/γ antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats

Terminalia arjuna prevents Interleukin-18-induced atherosclerosis via modulation of NF-κB/PPAR-γ-mediated pathway in Apo E−/− mice

Constituents of leaves from Bauhinia curvula Benth. exert gastroprotective activity in rodents: role of quercitrin and kaempferol

Caffeic acid phenethyl ester is protective in experimental ulcerative colitis via reduction in levels of pro-inflammatory mediators and enhancement of epithelial barrier function