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Journal of Clinical Immunology

Erschienen in:

01.05.2010

The Role of IgA and IgA Fc Receptors as Anti-Inflammatory Agents

verfasst von: Renato C. Monteiro

Erschienen in: Journal of Clinical Immunology | Sonderheft 1/2010

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Abstract

Materials and methods

Serum monomeric immunoglobulin A (IgA) has powerful immunomodulatory roles in its ability to suppress immune responses. Monomeric IgA acts through FcαRI, which plays a significant role in vivo in maintaining the integrity of immune responses by an inhibitory immunoreceptor tyrosine-based activation motif-mediated process and powerful inhibitory cellular effector mechanisms elicited by the IgA system.

Results

Triggering of FcαRI-mediated inhibitory function by Fab anti-FcαRI-mediated inhibitory function is able to inhibit several inflammatory and autoimmune diseases including asthma and glomerulonephritis.

Conclusion

The use of monomeric IgA as a therapeutic tool in human inflammatory diseases may offer much potential.

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Titel: The Role of IgA and IgA Fc Receptors as Anti-Inflammatory Agents
verfasst von: Renato C. Monteiro
Publikationsdatum: 01.05.2010
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe Sonderheft 1/2010
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-010-9397-2

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