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Journal of Mammary Gland Biology and Neoplasia
Erschienen in: Journal of Mammary Gland Biology and Neoplasia 2/2010

01.06.2010

microRNAs and EMT in Mammary Cells and Breast Cancer

verfasst von: Josephine A. Wright, Jennifer K. Richer, Gregory J. Goodall

Erschienen in: Journal of Mammary Gland Biology and Neoplasia | Ausgabe 2/2010

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Abstract

MicroRNAs are master regulators of gene expression in many biological and pathological processes, including mammary gland development and breast cancer. The differentiation program termed the epithelial to mesenchymal transition (EMT) involves changes in a number of microRNAs. Some of these microRNAs have been shown to control cellular plasticity through the suppression of EMT-inducers or to influence cellular phenotype through the suppression of genes involved in defining the epithelial and mesenchymal cell states. This has led to the suggestion that microRNAs maybe a novel therapeutic target for the treatment of breast cancer. In this review, we will discuss microRNAs that are involved in EMT in mammary cells and breast cancer.
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Metadaten
Titel
microRNAs and EMT in Mammary Cells and Breast Cancer
verfasst von
Josephine A. Wright
Jennifer K. Richer
Gregory J. Goodall
Publikationsdatum
01.06.2010
Verlag
Springer US
Erschienen in
Journal of Mammary Gland Biology and Neoplasia / Ausgabe 2/2010
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI
https://doi.org/10.1007/s10911-010-9183-z

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