Erschienen in:
01.01.2010 | Natural Resource Letter
Antiviral activities of diarylheptanoids against influenza virus in vitro
verfasst von:
Rie Sawamura, Yi Sun, Ken Yasukawa, Tomomi Shimizu, Wataru Watanabe, Masahiko Kurokawa
Erschienen in:
Journal of Natural Medicines
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Ausgabe 1/2010
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Abstract
The anti-influenza A/PR/8/34 (H1N1) virus activities of ten diarylheptanoids isolated from Alpinia officinarum were examined using the MTT method. The 50% inhibitory concentration of each diarylheptanoid examined was clearly lower than its 50% cytotoxic concentration determined by the MTT assay and/or maximum non-cytotoxic concentration (MNCC) determined by the morphological change of cells. In particular, the influenza virus was more susceptible to 7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl-4E-hepten-3-one (3) and (5S)-5-hydroxy-7-(4″-hydroxyphenyl)-1-phenyl-3-heptanone (8) than the other diarylheptanoids. Thus, all diarylheptanoids exhibited potential antiviral activity against influenza virus in vitro.