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Targeted Oncology
Erschienen in: Targeted Oncology 3/2017

24.05.2017 | Current Opinion

Immune Checkpoint Inhibitor-Induced Colitis: Diagnosis and Management

verfasst von: Caroline Prieux-Klotz, Marie Dior, Diane Damotte, Johann Dreanic, Bertrand Brieau, Catherine Brezault, Vered Abitbol, Stanislas Chaussade, Romain Coriat

Erschienen in: Targeted Oncology | Ausgabe 3/2017

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Abstract

Immune checkpoint inhibitors are monoclonal antibodies indicated for an increasing number of malignant diseases. These agents can cause specific side effects, which need to be anticipated while clear patterns of management need to be established. Immune checkpoint inhibitor-mediated gastrointestinal side effects, including diarrhea and colitis, occur in up to 30% of patients. Severe colitis can lead to severe dehydration or intestinal perforation. Endoscopic lesions and histopathological features of immune checkpoint inhibitor-induced colitis are similar to an inflammatory bowel disease (IBD) flare. Patients with immune checkpoint inhibitor-induced diarrhea and colitis are treated with corticosteroids. Infliximab can be used in cases of corticosteroid failure. Rectosigmoïdoscopy or colonoscopy should be performed when severe immune checkpoint inhibitor-induced colitis is suspected, but endoscopic investigations should not delay treatment. Specific patient education as well as co-operation between oncologists and gastroenterologists is essential.
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Metadaten
Titel
Immune Checkpoint Inhibitor-Induced Colitis: Diagnosis and Management
verfasst von
Caroline Prieux-Klotz
Marie Dior
Diane Damotte
Johann Dreanic
Bertrand Brieau
Catherine Brezault
Vered Abitbol
Stanislas Chaussade
Romain Coriat
Publikationsdatum
24.05.2017
Verlag
Springer International Publishing
Erschienen in
Targeted Oncology / Ausgabe 3/2017
Print ISSN: 1776-2596
Elektronische ISSN: 1776-260X
DOI
https://doi.org/10.1007/s11523-017-0495-4

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