nach oben

Obesity Surgery

Erschienen in:

05.09.2017 | Original Contributions

A Meta-Analysis of GLP-1 After Roux-En-Y Gastric Bypass: Impact of Surgical Technique and Measurement Strategy

verfasst von: Pichamol Jirapinyo, David X. Jin, Taha Qazi, Nitin Mishra, Christopher C. Thompson

Erschienen in: Obesity Surgery | Ausgabe 3/2018

Einloggen, um Zugang zu erhalten

Abstract

Background

Roux-en-Y gastric bypass (RYGB) is an effective treatment for diabetes. Glucagon-like peptide-1 (GLP-1) is a gut hormone that is important to glucose homeostasis.

Objective

This study aimed to assess GLP-1 level and its predictors after RYGB.

Methods

The study design was a meta-analysis. The data sources were MEDLINE, EMBASE, Web of Science, and the Cochrane Databases. The study selection composed of studies with pre- and post-RYGB levels. The main outcomes were as follows: Primary outcome was the change in postprandial GLP-1 levels after RYGB. Secondary outcomes included the changes in fasting glucose, fasting insulin, and fasting GLP-1 levels after RYGB. Meta-regression to determine predictors of changes in GLP-1 levels was performed. Outcomes were reported using Hedge’s g.

Results

Twenty-four studies with 368 patients were included. Postprandial GLP-1 levels increased after RYGB (Hedge’s g = 1.29, p < 0.0001), while fasting GLP-1 did not change (p = 0.23). Peak postprandial GLP-1 levels gave the most consistent results (I ² = 9.11). Fasting glucose and insulin levels decreased after RYGB (p < 0.0001).

Roux limb length was a significant predictor for amount of GLP-1 increase (β = − 0.01, p = 0.02). Diabetes status, amount of weight loss, length of biliopancreatic limb, and time of measurement were not significant predictors (p > 0.05).

Conclusion

Postprandial GLP-1 levels increase after RYGB, while fasting levels remain unchanged. Shorter Roux limb length is associated with greater increase in postprandial GLP-1, which may lead to better glycemic control in this population.

WHO | Obesity and overweight. WHO n.d. http://www.who.int/mediacentre/factsheets/fs311/en/ Accessed 16 Aug 2016.

Ogden CL, Carroll MD, Fryar CD, Flegal KM. Prevalence of obesity among adults and youth: United States, 2011-2014. NCHS Data Brief. 2015:1–8.

Cawley J, Meyerhoefer C. The medical care costs of obesity: an instrumental variables approach. J Health Econ. 2012;31:219–30. https://doi.org/10.1016/j.jhealeco.2011.10.003.CrossRefPubMed

Mason EE, Ito C. Gastric bypass in obesity. Surg Clin North Am. 1967;47:1345–51.CrossRefPubMed

Sjöström L, Narbro K, Sjöström CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357:741–52. https://doi.org/10.1056/NEJMoa066254.CrossRefPubMed

Schauer PR, Bhatt DL, Kirwan JP, et al. Bariatric surgery versus intensive medical therapy for diabetes—3-year outcomes. N Engl J Med. 2014;370:2002–13. https://doi.org/10.1056/NEJMoa1401329.CrossRefPubMedPubMedCentral

Mason EE. The mechanisms of surgical treatment of type 2 diabetes. Obes Surg. 2005;15:459–61. https://doi.org/10.1381/0960892053723330.CrossRefPubMed

Meek CL, Lewis HB, Reimann F, et al. The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones. Peptides. 2016;77:28–37. https://doi.org/10.1016/j.peptides.2015.08.013.CrossRefPubMed

Anderwald C-H, Tura A, Promintzer-Schifferl M, et al. Alterations in gastrointestinal, endocrine, and metabolic processes after bariatric Roux-en-Y gastric bypass surgery. Diabetes Care. 2012;35:2580–7. https://doi.org/10.2337/dc12-0197.CrossRefPubMedPubMedCentral

10.

Borg C, le Roux C, Ghatei M, et al. Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Br J Surg. 2006;93:210–5. https://doi.org/10.1002/bjs.5227.CrossRefPubMed

11.

Bose M, Teixeira J, Olivan B, et al. Weight loss and incretin responsiveness improve glucose control independently after gastric bypass surgery. J Diabetes. 2010;2:47–55. https://doi.org/10.1111/j.1753-0407.2009.00064.x.CrossRefPubMed

12.

Breitman I, Saraf N, Kakade M, et al. The effects of an amino acid supplement on glucose homeostasis, inflammatory markers, and incretins after laparoscopic gastric bypass. J Am Coll Surg. 2011;212:617–25. https://doi.org/10.1016/j.jamcollsurg.2010.12.040.CrossRefPubMedPubMedCentral

13.

Bryant EJ, King NA, Falken Y, et al. Relationships among tonic and episodic aspects of motivation to eat, gut peptides, and weight before and after bariatric surgery. Surg Obes Relat Dis. 2013;9:802–8. https://doi.org/10.1016/j.soard.2012.09.011.CrossRefPubMed

14.

Campos GM, Rabl C, Peeva S, et al. Improvement in peripheral glucose uptake after gastric bypass surgery is observed only after substantial weight loss has occurred and correlates with the magnitude of weight lost. J Gastrointest Surg. 2010;14:15–22. https://doi.org/10.1007/s11605-009-1060-y.CrossRefPubMed

15.

Chronaiou A, Tsoli M, Kehagias I, et al. Lower ghrelin levels and exaggerated postprandial peptide-YY, glucagon-like peptide-1, and insulin responses, after gastric fundus resection, in patients undergoing Roux-en-Y gastric bypass: a randomized clinical trial. Obes Surg. 2012;22:1761–70. https://doi.org/10.1007/s11695-012-0738-5.CrossRefPubMed

16.

Evans S, Pamuklar Z, Rosko J, et al. Gastric bypass surgery restores meal stimulation of the anorexigenic gut hormones glucagon-like peptide-1 and peptide YY independently of caloric restriction. Surg Endosc Interv Tech. 2012;26:1086–94. https://doi.org/10.1007/s00464-011-2004-7.CrossRef

17.

Falken Y, Hellstrom PM, Holst JJ, et al. Changes in glucose homeostasis after Roux-en-Y gastric bypass surgery for obesity at day three, two months, and one year after surgery: role of gut peptides. J Clin Endocrinol Metab. 2011;96:2227–35. https://doi.org/10.1210/jc.2010-2876.CrossRefPubMed

18.

Fellici AC, Lambert G, Lima MMO, et al. Surgical treatment of type 2 diabetes in subjects with mild obesity: mechanisms underlying metabolic improvements. Obes Surg. 2015;25:36–44. https://doi.org/10.1007/s11695-014-1377-9.CrossRefPubMed

19.

Gandolfini M-P, Coupaye M, Bouaziz E, et al. Cardiovascular changes after gastric bypass surgery: involvement of increased secretions of glucagon-like peptide-1 and brain natriuretic peptide. Obes Surg. 2015;25:1933–9. https://doi.org/10.1007/s11695-015-1643-5.CrossRefPubMed

20.

Hansen EN, Tamboli RA, Isbell JM, et al. Role of the foregut in the early improvement in glucose tolerance and insulin sensitivity following Roux-en-Y gastric bypass surgery. Am J Physiol-Gastrointest LIVER Physiol. 2011;300:G795–802. https://doi.org/10.1152/ajpgi.00019.2011.CrossRefPubMedPubMedCentral

21.

Jorgensen NB, Jacobsen SH, Dirksen C, et al. Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with type 2 diabetes and normal glucose tolerance. Am J Physiol-Endocrinol Metab. 2012;303:E122–31. https://doi.org/10.1152/ajpendo.00073.2012.CrossRefPubMed

22.

Korner J, Inabnet W, Febres G, et al. Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass. Int J Obes. 2009;33:786–95. https://doi.org/10.1038/ijo.2009.79.CrossRef

23.

Lips MA, de Groot GH, van Klinken JB, et al. Calorie restriction is a major determinant of the short-term metabolic effects of gastric bypass surgery in obese type 2 diabetic patients. Clin Endocrinol. 2014;80:834–42. https://doi.org/10.1111/cen.12254.CrossRef

24.

Morinigo R, Lacy AM, Casamitjana R, et al. GLP-1 and changes in glucose tolerance following gastric bypass surgery in morbidly obese subjects. Obes Surg. 2006;16:1594–601. https://doi.org/10.1381/096089206779319338.CrossRefPubMed

25.

Nosso G, Griffo E, Cotugno M, et al. Comparative effects of Roux-en-Y gastric bypass and sleeve gastrectomy on glucose homeostasis and incretin hormones in obese type 2 diabetic patients: a one-year prospective study. Horm Metab Res. 2016;48:312–7. https://doi.org/10.1055/s-0041-111505.CrossRefPubMed

26.

O’Brien CS, Wang G, McGinty J, et al. Effects of gastrogastric fistula repair on weight loss and gut hormone levels. Obes Surg. 2013;23:1294–301. https://doi.org/10.1007/s11695-013-0917-z.CrossRefPubMedPubMedCentral

27.

Peterli R, Steinert RE, Woelnerhanssen B, et al. Metabolic and hormonal changes after laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy: a randomized, prospective trial. Obes Surg. 2012;22:740–8. https://doi.org/10.1007/s11695-012-0622-3.CrossRefPubMedPubMedCentral

28.

Promintzer-Schifferl M, Prager G, Anderwald C, et al. Effects of gastric bypass surgery on insulin resistance and insulin secretion in nondiabetic obese patients. Obesity. 2011;19:1420–6. https://doi.org/10.1038/oby.2011.92.CrossRefPubMed

29.

Rubino F, Gagner M, Gentileschi P, et al. The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism. Ann Surg. 2004;240:236–42. https://doi.org/10.1097/01.sla.0000133117.12646.48.CrossRefPubMedPubMedCentral

30.

Salinari S, Bertuzzi A, Guidone C, et al. Insulin sensitivity and secretion changes after gastric bypass in normotolerant and diabetic obese subjects. Ann Surg. 2013;257:462–8. https://doi.org/10.1097/SLA.0b013e318269cf5c.CrossRefPubMed

31.

Samat A, Malin SK, Huang H, et al. Ghrelin suppression is associated with weight loss and insulin action following gastric bypass surgery at 12 months in obese adults with type 2 diabetes. Diabetes Obes Metab. 2013;15:963–6. https://doi.org/10.1111/dom.12118.CrossRefPubMedPubMedCentral

32.

Steven S, Hollingsworth KG, Small PK, et al. Weight loss decreases excess pancreatic triacylglycerol specifically in type 2 diabetes. Diabetes Care. 2016;39:158–65. https://doi.org/10.2337/dc15-0750.CrossRefPubMed

33.

Umeda LM, Silva EA, Carneiro G, et al. Early improvement in glycemic control after bariatric surgery and its relationships with insulin, GLP-1, and glucagon secretion in type 2 diabetic patients. Obes Surg. 2011;21:896–901. https://doi.org/10.1007/s11695-011-0412-3.CrossRefPubMed

34.

Yan W, Polidori D, Yieh L, et al. Effects of meal size on the release of GLP-1 and PYY after Roux-en-Y gastric bypass surgery in obese subjects with or without type 2 diabetes. Obes Surg. 2014;24:1969–74. https://doi.org/10.1007/s11695-014-1316-9.CrossRefPubMed

35.

Yip S, Signal M, Smith G, et al. Lower glycemic fluctuations early after bariatric surgery partially explained by caloric restriction. Obes Surg. 2014;24:62–70. https://doi.org/10.1007/s11695-013-1043-7.CrossRefPubMed

36.

Yousseif A, Emmanuel J, Karra E, et al. Differential effects of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on appetite, circulating acyl-ghrelin, peptide YY3-36 and active GLP-1 levels in non-diabetic humans. Obes Surg. 2014;24:241–52. https://doi.org/10.1007/s11695-013-1066-0.CrossRefPubMed

37.

Zhang X, Cheng Z, Xiao Z, et al. Comparison of short- and mid-term efficacy and the mechanisms of gastric bypass surgeries on managing obese and nonobese type 2 diabetes mellitus: a prospective study. Arch Med Res. 2015;46:303–9. https://doi.org/10.1016/j.arcmed.2015.06.003.CrossRefPubMed

38.

Laferrere B. Effect of gastric bypass surgery on the incretins. Diabetes Metab. 2009;35:513–7.CrossRefPubMedPubMedCentral

39.

Nausheen S, Shah IH, Pezeshki A, et al. Effects of sleeve gastrectomy and ileal transposition, alone and in combination, on food intake, body weight, gut hormones, and glucose metabolism in rats. Am J Physiol Endocrinol Metab. 2013;305:E507–18. https://doi.org/10.1152/ajpendo.00130.2013.CrossRefPubMed

40.

Rubino F, Forgione A, Cummings DE, et al. The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes. Ann Surg. 2006;244:741–9. https://doi.org/10.1097/01.sla.0000224726.61448.1b.CrossRefPubMedPubMedCentral

41.

Penney NC, Kinross J, Newton RC, et al. The role of bile acids in reducing the metabolic complications of obesity after bariatric surgery: a systematic review. Int J Obes. 2015;39:1565–74. https://doi.org/10.1038/ijo.2015.115.CrossRef

42.

Kohli R, Bradley D, Setchell KD, et al. Weight loss induced by Roux-en-Y gastric bypass but not laparoscopic adjustable gastric banding increases circulating bile acids. J Clin Endocrinol Metab. 2013;98:E708–12. https://doi.org/10.1210/jc.2012-3736.CrossRefPubMedPubMedCentral

43.

Ahmad NN, Pfalzer A, Kaplan LM. Roux-en-Y gastric bypass normalizes the blunted postprandial bile acid excursion associated with obesity. Int J Obes. 2013;37:1553–9. https://doi.org/10.1038/ijo.2013.38.CrossRef

44.

Gerhard GS, Styer AM, Wood GC, et al. A role for fibroblast growth factor 19 and bile acids in diabetes remission after Roux-en-Y gastric bypass. Diabetes Care. 2013;36:1859–64. https://doi.org/10.2337/dc12-2255.CrossRefPubMedPubMedCentral

45.

Gleysteen JJ. Five-year outcome with gastric bypass: Roux limb length makes a difference. Surg Obes Relat Dis Off J Am Soc Bariatr Surg. 2009;5:242–247; discussion 247-249. https://doi.org/10.1016/j.soard.2008.08.005.CrossRef

46.

Stefanidis D, Kuwada TS, Gersin KS. The importance of the length of the limbs for gastric bypass patients—an evidence-based review. Obes Surg. 2011;21:119–24. https://doi.org/10.1007/s11695-010-0239-3.CrossRefPubMed

47.

Orci L, Chilcott M, Huber O. Short versus long Roux-limb length in Roux-en-Y gastric bypass surgery for the treatment of morbid and super obesity: a systematic review of the literature. Obes Surg. 2011;21:797–804. https://doi.org/10.1007/s11695-011-0409-y.CrossRefPubMed

48.

Dogan K, Homan J, Aarts EO, et al. A short or a long Roux limb in gastric bypass surgery: does it matter? Surg Endosc. 2016; https://doi.org/10.1007/s00464-016-5188-z.

49.

Kaska L, Kobiela J, Proczko M, et al. Does the length of the biliary limb influence medium-term laboratory remission of type 2 diabetes mellitus after Roux-en-Y gastric bypass in morbidly obese patients? Wideochirurgia Inne Tech Małoinwazyjne Videosurgery Miniinvasive Tech Kwart Pod Patronatem Sekc Wideochirurgii TChP Oraz Sekc Chir Bariatrycznej TChP. 2014;9:31–9. https://doi.org/10.5114/wiitm.2014.40383.

50.

Gupta RVN, Chamany T, Makam R. Does length of common limb influence remission of diabetes? Short-term results. J Minimal Access Surg. 2016;12:54–7. https://doi.org/10.4103/0972-9941.152104.CrossRef

51.

Dutra RA, Araújo WM, de Andrade JI. The effects of Roux-en-Y limb length on gastric emptying and enterogastric reflux in rats. Acta Cirúrgica Bras Soc Bras Para Desenvolv Pesqui Em Cir. 2008;23:179–83.

52.

Le Blanc-Louvry I, Ducrotté P, Lemeland JF, et al. Motility in the Roux-Y limb after distal gastrectomy: relation to the length of the limb and the afferent duodenojejunal segment—an experimental study. Neurogastroenterol Motil Off J Eur Gastrointest Motil Soc. 1999;11:365–74.CrossRef

Titel: A Meta-Analysis of GLP-1 After Roux-En-Y Gastric Bypass: Impact of Surgical Technique and Measurement Strategy
verfasst von: Pichamol Jirapinyo
David X. Jin
Taha Qazi
Nitin Mishra
Christopher C. Thompson
Publikationsdatum: 05.09.2017
Verlag: Springer US
Erschienen in: Obesity Surgery / Ausgabe 3/2018
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-017-2913-1

Neu im Fachgebiet Chirurgie

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Was nützt die Kraniektomie bei schwerer tiefer Hirnblutung?

17.05.2024 Hirnblutung Nachrichten

Eine Studie zum Nutzen der druckentlastenden Kraniektomie nach schwerer tiefer supratentorieller Hirnblutung deutet einen Nutzen der Operation an. Für überlebende Patienten ist das dennoch nur eine bedingt gute Nachricht.

Klinikreform soll zehntausende Menschenleben retten

15.05.2024 Klinik aktuell Nachrichten

Gesundheitsminister Lauterbach hat die vom Bundeskabinett beschlossene Klinikreform verteidigt. Kritik an den Plänen kommt vom Marburger Bund. Und in den Ländern wird über den Gang zum Vermittlungsausschuss spekuliert.

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Aktuelle BDC Leitlinien-Webinare

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare

CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare

CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske

Dr. med. Benjamin Meyknecht

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare

CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

A Meta-Analysis of GLP-1 After Roux-En-Y Gastric Bypass: Impact of Surgical Technique and Measurement Strategy

Abstract

Background

Objective

Methods

Results

Conclusion

Neu im Fachgebiet Chirurgie

Mehr Frauen im OP – weniger postoperative Komplikationen

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

Was nützt die Kraniektomie bei schwerer tiefer Hirnblutung?

Klinikreform soll zehntausende Menschenleben retten

Update Chirurgie

Aktuelle BDC Leitlinien-Webinare

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

S2e-Leitlinie „Distale Radiusfraktur“

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Background

Objective

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2018

High Incidence of Secondary Hyperparathyroidism in Bariatric Patients: Comparing Different Procedures

Effect of Health Literacy on Help-seeking Behavior in Morbidly Obese Patients Agreeing to Bariatric Surgery

Effects of Bariatric Surgery on Change of Brown Adipocyte Tissue and Energy Metabolism in Obese Mice

Differences in Body Composition in Patients with Obesity 1 Year After Roux-En-Y Gastric Bypass: Successful Vs. Unsuccessful Weight Loss

A Prospective Single-Arm Trial of Modified Long Biliopancreatic and Short Alimentary Limbs Roux-En-Y Gastric Bypass in Type 2 Diabetes Patients with Mild Obesity

Proximal Leakage After Laparoscopic Sleeve Gastrectomy: an Analysis of Preoperative and Operative Predictors on 1738 Consecutive Procedures

Update Chirurgie