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Erschienen in: Current Cardiology Reports 4/2019

01.04.2019 | Diabetes and Cardiovascular Disease (N Wong, Section Editor)

Epidemiology of Diabetes Mellitus and Cardiovascular Disease

verfasst von: Diana Glovaci, Wenjun Fan, Nathan D. Wong

Erschienen in: Current Cardiology Reports | Ausgabe 4/2019

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Abstract

Purpose of Review

Diabetes mellitus (DM) has become a rising epidemic in the last century, more pressing in the last few decades with the exponential rise of obesity, and has become one of the leading causes of death worldwide.

Recent Findings

Genetic variants have also been a new field of epidemiology research to determine the underlying genetic component of those risk factors and the association of DM with CVD.

Summary

In light of its significant prevalence, patients remain unaware of their disease progression that arises from genetic and metabolic risk factors. As compared to non-diabetics, those with type 2 DM carry a higher mortality risk from cardiovascular disease (CVD) across different ethnicity groups and sex. The most common cardiovascular manifestations in those with DM include heart failure, peripheral arterial disease, and coronary heart disease. Although DM does predispose patients to CVD, it in fact is not a risk equivalent, but carries significant heterogeneity in risk for CVD.
Literatur
3.
Zurück zum Zitat Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, et al. Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation. 2018;137(12):e67–e492. Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, et al. Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation. 2018;137(12):e67–e492.
4.
Zurück zum Zitat Beckman JA, Creager MA, Libby P. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA. 2002;287:2570–81.CrossRef Beckman JA, Creager MA, Libby P. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA. 2002;287:2570–81.CrossRef
5.
Zurück zum Zitat Redberg RF, Greenland P, Fuster V, Pyörälä K, Blair SN, Folsom AR, et al. Prevention Conference VI: Diabetes and cardiovascular disease: writing group III: risk assessment in persons with diabetes. Circulation. 2002;105(18):e144–52. Redberg RF, Greenland P, Fuster V, Pyörälä K, Blair SN, Folsom AR, et al. Prevention Conference VI: Diabetes and cardiovascular disease: writing group III: risk assessment in persons with diabetes. Circulation. 2002;105(18):e144–52.
6.
Zurück zum Zitat Mayer-Davis EJ, Lawrence JM, Dabelea D, Divers J, Isom S, Dolan L, et al. Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012. N Engl J Med. 2017;376:1419–29. Mayer-Davis EJ, Lawrence JM, Dabelea D, Divers J, Isom S, Dolan L, et al. Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012. N Engl J Med. 2017;376:1419–29.
7.
Zurück zum Zitat Centers for Disease Control and Prevention. National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011. Atlanta: US Department of health and human services, Centers for Disease Control and Prevention; 2011. Centers for Disease Control and Prevention. National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011. Atlanta: US Department of health and human services, Centers for Disease Control and Prevention; 2011.
8.
Zurück zum Zitat Dokken B. The pathophysiology of cardiovascular disease and diabetes: beyond blood pressure and lipids. Diabetes Spectr. 2008;21(3):160–5.CrossRef Dokken B. The pathophysiology of cardiovascular disease and diabetes: beyond blood pressure and lipids. Diabetes Spectr. 2008;21(3):160–5.CrossRef
9.
Zurück zum Zitat Bellamy L, Casas JP, Hingorani AD, Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet. 2009;373:1773–9.CrossRef Bellamy L, Casas JP, Hingorani AD, Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet. 2009;373:1773–9.CrossRef
10.
Zurück zum Zitat Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care. 2002;25:1862–8.CrossRef Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care. 2002;25:1862–8.CrossRef
11.
Zurück zum Zitat Lee AJ, Hiscock RJ, Wein P, Walker SP, Permezel M. Gestational diabetes mellitus: clinical predictors and long-term risk of developing type 2 diabetes: a retrospective cohort study using survival analysis. Diabetes Care. 2007;30:878–83.CrossRef Lee AJ, Hiscock RJ, Wein P, Walker SP, Permezel M. Gestational diabetes mellitus: clinical predictors and long-term risk of developing type 2 diabetes: a retrospective cohort study using survival analysis. Diabetes Care. 2007;30:878–83.CrossRef
13.
Zurück zum Zitat Centers for Disease Control and Prevention. National diabetes statistics report: estimates of diabetes and its burden in the United States, 2014. Atlanta: US Department of Health and Human Services; 2014. Centers for Disease Control and Prevention. National diabetes statistics report: estimates of diabetes and its burden in the United States, 2014. Atlanta: US Department of Health and Human Services; 2014.
15.
Zurück zum Zitat Hardy OT, Czech MP, Corvera S. What causes the insulin resistance underlying obesity? Curr Opin Endocrinol Diabetes Obes. 2012;19:81.CrossRef Hardy OT, Czech MP, Corvera S. What causes the insulin resistance underlying obesity? Curr Opin Endocrinol Diabetes Obes. 2012;19:81.CrossRef
16.
Zurück zum Zitat [No authors listed]. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. National Institutes of Health. Obes Res. 1998;6(Suppl 2):51S–209S. [No authors listed]. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. National Institutes of Health. Obes Res. 1998;6(Suppl 2):51S–209S.
17.
Zurück zum Zitat Lavie C, Milani R, Ventura H. Obesity and cardiovascular disease risk factor, paradox and impact of weight loss. JACC. 2009;53(21):1925–32.CrossRef Lavie C, Milani R, Ventura H. Obesity and cardiovascular disease risk factor, paradox and impact of weight loss. JACC. 2009;53(21):1925–32.CrossRef
18.
Zurück zum Zitat Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2003;289:76–9. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2003;289:76–9.
19.
Zurück zum Zitat Ko GT, Chan JC, Woo J, Lau E, Yeung VT, Chow CC, et al. Simple anthropometric indexes and cardiovascular risk factors in Chinese. Int J Obes Relat Metab Disord. 1997;21:995–1001. Ko GT, Chan JC, Woo J, Lau E, Yeung VT, Chow CC, et al. Simple anthropometric indexes and cardiovascular risk factors in Chinese. Int J Obes Relat Metab Disord. 1997;21:995–1001.
20.
Zurück zum Zitat Oh SW, Shin SA, Yun YH, Yoo T, Huh BY. Cut-off point of BMI and obesity related comorbidities and mortality in middle-aged Koreans. Obes Res. 2004;12:2031–40.CrossRef Oh SW, Shin SA, Yun YH, Yoo T, Huh BY. Cut-off point of BMI and obesity related comorbidities and mortality in middle-aged Koreans. Obes Res. 2004;12:2031–40.CrossRef
21.
Zurück zum Zitat Shin CS, Lee HK, Koh CS, Kim YI, Shin YS, Yoo KY, et al. Risk factors for the development of NIDDM in Yonchon County, Korea. Diabetes Care. 1997;20:1842–6. Shin CS, Lee HK, Koh CS, Kim YI, Shin YS, Yoo KY, et al. Risk factors for the development of NIDDM in Yonchon County, Korea. Diabetes Care. 1997;20:1842–6.
22.
Zurück zum Zitat Yoon KH, Lee JH, Kim JW, Cho JH, Choi YH, Ko SH, et al. Epidemic obesity and type 2 diabetes in Asia. Lancet. 2006;368:1681–8. Yoon KH, Lee JH, Kim JW, Cho JH, Choi YH, Ko SH, et al. Epidemic obesity and type 2 diabetes in Asia. Lancet. 2006;368:1681–8.
25.
Zurück zum Zitat Kaveeshwar SA, Cornwall J. The current state of diabetes mellitus in India. Austr Med J. 2014;7:45–8.CrossRef Kaveeshwar SA, Cornwall J. The current state of diabetes mellitus in India. Austr Med J. 2014;7:45–8.CrossRef
26.
Zurück zum Zitat Weinstein AR, Sesso HD, Lee IM, Cook NR, Manson JE, Buring JE, et al. Relationship of physical activity vs body mass index with type 2 diabetes in women. JAMA. 2004;292:1188–94. Weinstein AR, Sesso HD, Lee IM, Cook NR, Manson JE, Buring JE, et al. Relationship of physical activity vs body mass index with type 2 diabetes in women. JAMA. 2004;292:1188–94.
27.
Zurück zum Zitat Lee IM, Rexrode KM, Cook NR, Manson JE, Buring JE. Physical activity and coronary heart disease in women: is ‘no pain, no gain’ passe? JAMA. 2001;285:1447–54.CrossRef Lee IM, Rexrode KM, Cook NR, Manson JE, Buring JE. Physical activity and coronary heart disease in women: is ‘no pain, no gain’ passe? JAMA. 2001;285:1447–54.CrossRef
28.
Zurück zum Zitat Lynch J, Helmrich SP, Lakka TA, Kaplan GA, Cohen RD, Salonen R, et al. Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle aged men. Arch Intern Med. 1996;156:1307–14. Lynch J, Helmrich SP, Lakka TA, Kaplan GA, Cohen RD, Salonen R, et al. Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle aged men. Arch Intern Med. 1996;156:1307–14.
29.
Zurück zum Zitat Gregg EW, Gerzoff RB, Caspersen CJ, Williamson DF, Narayan KV. Relationship of walking to mortality among US adults with diabetes. Arch Intern Med. 2003;163:1440–7.CrossRef Gregg EW, Gerzoff RB, Caspersen CJ, Williamson DF, Narayan KV. Relationship of walking to mortality among US adults with diabetes. Arch Intern Med. 2003;163:1440–7.CrossRef
30.
Zurück zum Zitat Shurtleff D. The Framingham study: an epidemiologic investigation of cardiovascular disease, section 26. Washington, DC: US Government Printing Office; 1970. Shurtleff D. The Framingham study: an epidemiologic investigation of cardiovascular disease, section 26. Washington, DC: US Government Printing Office; 1970.
31.
Zurück zum Zitat SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA. 1991;265:3255–64.CrossRef SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA. 1991;265:3255–64.CrossRef
32.
33.
Zurück zum Zitat Johnson ML, Pietz K, Battleman DS, Beyth RJ. Prevalence of comorbid hypertension and dyslipidemia and associated cardiovascular disease. Am J Manag Care. 2004;10:926–32.PubMed Johnson ML, Pietz K, Battleman DS, Beyth RJ. Prevalence of comorbid hypertension and dyslipidemia and associated cardiovascular disease. Am J Manag Care. 2004;10:926–32.PubMed
34.
Zurück zum Zitat Gress TW, Nieto FJ, Shahar E, Wofford MR, Brancati FL. Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. N Engl J Med. 2000;342:905–12.CrossRef Gress TW, Nieto FJ, Shahar E, Wofford MR, Brancati FL. Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. N Engl J Med. 2000;342:905–12.CrossRef
35.
Zurück zum Zitat UKPDS Group. UK prospective diabetes study 38: tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes. BMJ. 1998;317:703–13.CrossRef UKPDS Group. UK prospective diabetes study 38: tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes. BMJ. 1998;317:703–13.CrossRef
36.
Zurück zum Zitat UKPDS Group. Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. BMJ. 1998;317:713–20.CrossRef UKPDS Group. Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. BMJ. 1998;317:713–20.CrossRef
37.
Zurück zum Zitat American Diabetes Association. Implications of the United Kingdom prospective diabetes study. Diabetes Care. 2000;23(Suppl 1):S28–32. American Diabetes Association. Implications of the United Kingdom prospective diabetes study. Diabetes Care. 2000;23(Suppl 1):S28–32.
38.
Zurück zum Zitat Fan W. Epidemiology in diabetes mellitus and cardiovascular disease. Cardiovasc Endocrinol. 2017;6(1):8–16.CrossRef Fan W. Epidemiology in diabetes mellitus and cardiovascular disease. Cardiovasc Endocrinol. 2017;6(1):8–16.CrossRef
39.
Zurück zum Zitat Malik S, Wong ND, Franklin S, Pio J, Fairchild C, Chen R. Cardiovascular disease in U.S. patients with metabolic syndrome, diabetes, and elevated C-reactive protein. Diabetes Care. 2005 Jul;28(7):1833–4. Malik S, Wong ND, Franklin S, Pio J, Fairchild C, Chen R. Cardiovascular disease in U.S. patients with metabolic syndrome, diabetes, and elevated C-reactive protein. Diabetes Care. 2005 Jul;28(7):1833–4.
40.
Zurück zum Zitat Vu JD, Vu JB, Pio JR, Malik S, Franklin SS, Chen RS, et al. Impact of C-reactive protein on the likelihood of peripheral arterial disease in United States adults with the metabolic syndrome, diabetes mellitus, and preexisting cardiovascular disease. Am J Cardiol. 2005;96(5):655–8. Vu JD, Vu JB, Pio JR, Malik S, Franklin SS, Chen RS, et al. Impact of C-reactive protein on the likelihood of peripheral arterial disease in United States adults with the metabolic syndrome, diabetes mellitus, and preexisting cardiovascular disease. Am J Cardiol. 2005;96(5):655–8.
41.
Zurück zum Zitat Malik S, Zhao Y, Budoff M, Nasir K, Blumenthal R, Bertoni A, et al. Coronary artery calcium score for long-term risk classification in individuals with type 2 diabetes and metabolic syndrome from the multi-ethnic study of atherosclerosis. JAMA Cardiol. 2017;2(12):1332–40. Malik S, Zhao Y, Budoff M, Nasir K, Blumenthal R, Bertoni A, et al. Coronary artery calcium score for long-term risk classification in individuals with type 2 diabetes and metabolic syndrome from the multi-ethnic study of atherosclerosis. JAMA Cardiol. 2017;2(12):1332–40.
42.
Zurück zum Zitat Morrish NJ, Wang SL, Stevens LK, Fuller JH, Keen H. WHO multinational study group. Mortality and causes of death in the WHO multinational study of vascular disease in diabetes. Diabetologia. 2001;44(Suppl 2):S14–21.CrossRef Morrish NJ, Wang SL, Stevens LK, Fuller JH, Keen H. WHO multinational study group. Mortality and causes of death in the WHO multinational study of vascular disease in diabetes. Diabetologia. 2001;44(Suppl 2):S14–21.CrossRef
43.
Zurück zum Zitat Gu K, Cowie CC, Harris MI. Diabetes and decline in heart disease mortality in US adults. JAMA. 1999;281:1291–7.CrossRef Gu K, Cowie CC, Harris MI. Diabetes and decline in heart disease mortality in US adults. JAMA. 1999;281:1291–7.CrossRef
44.
Zurück zum Zitat Kannel WB, McGee DL. Diabetes and cardiovascular disease: the Framingham study. Jama. 1979;241:2035–8.CrossRef Kannel WB, McGee DL. Diabetes and cardiovascular disease: the Framingham study. Jama. 1979;241:2035–8.CrossRef
45.
Zurück zum Zitat Manson JE, Colditz GA, Stampfer MJ, Willett WC, Krolewski AS, Rosner B, et al. A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women. Arch Intern Med. 1991;151:1141–7. Manson JE, Colditz GA, Stampfer MJ, Willett WC, Krolewski AS, Rosner B, et al. A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women. Arch Intern Med. 1991;151:1141–7.
46.
Zurück zum Zitat Wingard DL, Barrett-Connor E. Heart disease and diabetes. In: Harris MI, Cowie CC, Stern MP, Boyko EJ, Rieber GE, Bennett PH, editors. Diabetes in America. 2nd ed. Bethesda: National Institutes of Health; 1995. p. 429–48. Wingard DL, Barrett-Connor E. Heart disease and diabetes. In: Harris MI, Cowie CC, Stern MP, Boyko EJ, Rieber GE, Bennett PH, editors. Diabetes in America. 2nd ed. Bethesda: National Institutes of Health; 1995. p. 429–48.
47.
Zurück zum Zitat Shah AD, Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP, et al. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1.9 million people. Lancet Diabetes Endocrinol. 2015;3:105–13. Shah AD, Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP, et al. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1.9 million people. Lancet Diabetes Endocrinol. 2015;3:105–13.
48.
Zurück zum Zitat Wei M, Gaskill SP, Haffner SM, Stern MP. Effects of diabetes and level of glycemia on all-cause and cardiovascular mortality: the San Antonio heart study. Diabetes Care. 1998;21:1167–72.CrossRef Wei M, Gaskill SP, Haffner SM, Stern MP. Effects of diabetes and level of glycemia on all-cause and cardiovascular mortality: the San Antonio heart study. Diabetes Care. 1998;21:1167–72.CrossRef
49.
Zurück zum Zitat Go AS, Mozaffarian D, Roger VL. Heart disease and stroke statistics—2014 update: a report from the American Heart Association. Circulation. 2014;129:e28–e292.CrossRef Go AS, Mozaffarian D, Roger VL. Heart disease and stroke statistics—2014 update: a report from the American Heart Association. Circulation. 2014;129:e28–e292.CrossRef
50.
Zurück zum Zitat Ohira T, Shahar E, Chambless LE, Rosamond WD, Mosley TH, Folsom AR. Risk factors for ischemic stroke subtypes the atherosclerosis risk in communities study. Stroke. 2006;37:2493–8.CrossRef Ohira T, Shahar E, Chambless LE, Rosamond WD, Mosley TH, Folsom AR. Risk factors for ischemic stroke subtypes the atherosclerosis risk in communities study. Stroke. 2006;37:2493–8.CrossRef
51.
Zurück zum Zitat Emerging Risk Factors Collaboration. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative metaanalysis of 102 prospective studies. Lancet. 2010;375:2215–22.CrossRef Emerging Risk Factors Collaboration. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative metaanalysis of 102 prospective studies. Lancet. 2010;375:2215–22.CrossRef
52.
Zurück zum Zitat Barbash GI, White HD, Modan M, Van de Werf F. Significance of diabetes mellitus in patients with acute myocardial infarction receiving thrombolytic therapy. J Am Coll Cardiol. 1993;22:707–13.CrossRef Barbash GI, White HD, Modan M, Van de Werf F. Significance of diabetes mellitus in patients with acute myocardial infarction receiving thrombolytic therapy. J Am Coll Cardiol. 1993;22:707–13.CrossRef
53.
Zurück zum Zitat Zuanetti G, Latini R, Maggioni AP, Santoro L, Franzosi MG. GISSI-2 investigators. Influence of diabetes on mortality in acute myocardial infarction: data from the GISSI-2 study. J Am Coll Cardiol. 1993;22:1788–94.CrossRef Zuanetti G, Latini R, Maggioni AP, Santoro L, Franzosi MG. GISSI-2 investigators. Influence of diabetes on mortality in acute myocardial infarction: data from the GISSI-2 study. J Am Coll Cardiol. 1993;22:1788–94.CrossRef
54.
Zurück zum Zitat Granger CB, Califf RM, Young S, Candela R, Samara J, Worley S, et al. Outcome of patients with diabetes mellitus and acute myocardial infarction treated with thrombolytic agents. J Am Coll Cardiol. 1993;21:920–5. Granger CB, Califf RM, Young S, Candela R, Samara J, Worley S, et al. Outcome of patients with diabetes mellitus and acute myocardial infarction treated with thrombolytic agents. J Am Coll Cardiol. 1993;21:920–5.
55.
Zurück zum Zitat Abbud ZA, Shindler DM, Wilson AC, Kostis JB. Myocardial infarction data acquisition system study group. Effect of diabetes mellitus on short-and long-term mortality rates of patients with acute myocardial infarction: a statewide study. Am Heart J. 1995;130:51–8.CrossRef Abbud ZA, Shindler DM, Wilson AC, Kostis JB. Myocardial infarction data acquisition system study group. Effect of diabetes mellitus on short-and long-term mortality rates of patients with acute myocardial infarction: a statewide study. Am Heart J. 1995;130:51–8.CrossRef
56.
Zurück zum Zitat Kanaya AM, Wassel CL, Mathur D, Stewart A, Herrington D, Budoff MJ, et al. Prevalence and correlates of diabetes in South Asian Indians in the 14 Cardiovascular Endocrinology 2017, Vol 6 No 1 United States: findings from the metabolic syndrome and atherosclerosis in South Asians living in America study and the multi-ethnic study of atherosclerosis. Metab Syndr Relat Disord. 2010;8:157–64.CrossRef Kanaya AM, Wassel CL, Mathur D, Stewart A, Herrington D, Budoff MJ, et al. Prevalence and correlates of diabetes in South Asian Indians in the 14 Cardiovascular Endocrinology 2017, Vol 6 No 1 United States: findings from the metabolic syndrome and atherosclerosis in South Asians living in America study and the multi-ethnic study of atherosclerosis. Metab Syndr Relat Disord. 2010;8:157–64.CrossRef
57.
Zurück zum Zitat Misra R, Patel T, Kotha P, Raji A, Ganda O, Banerji M, et al. Prevalence of diabetes, metabolic syndrome, and cardiovascular risk factors in US Asian Indians: results from a national study. J Diabetes Complicat. 2010;24:145–53. Misra R, Patel T, Kotha P, Raji A, Ganda O, Banerji M, et al. Prevalence of diabetes, metabolic syndrome, and cardiovascular risk factors in US Asian Indians: results from a national study. J Diabetes Complicat. 2010;24:145–53.
58.
Zurück zum Zitat Roth GA, Forouzanfar MH, Moran AE, Barber R, Nguyen G, Feigin VL, et al. Demographic and epidemiologic drivers of global cardiovascular mortality. N Engl J Med. 2015;372:1333–41. Roth GA, Forouzanfar MH, Moran AE, Barber R, Nguyen G, Feigin VL, et al. Demographic and epidemiologic drivers of global cardiovascular mortality. N Engl J Med. 2015;372:1333–41.
59.
Zurück zum Zitat Barrett-Connor E, Wingard DL. Sex differential in ischemic heart disease mortality in diabetics: a prospective population-based study. Am J Epidemiol. 1983;118:489–96.CrossRef Barrett-Connor E, Wingard DL. Sex differential in ischemic heart disease mortality in diabetics: a prospective population-based study. Am J Epidemiol. 1983;118:489–96.CrossRef
60.
Zurück zum Zitat Wenger NK. You’ve come a long way, baby cardiovascular health and disease in women: problems and prospects. Circulation. 2004;109:558–60.CrossRef Wenger NK. You’ve come a long way, baby cardiovascular health and disease in women: problems and prospects. Circulation. 2004;109:558–60.CrossRef
61.
Zurück zum Zitat Manson JE, Colditz GA, Stampfer MJ, Willett WC, Krolewski AS, Rosner B, et al. A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women. Arch Intern Med. 1991;151:1141–7. Manson JE, Colditz GA, Stampfer MJ, Willett WC, Krolewski AS, Rosner B, et al. A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women. Arch Intern Med. 1991;151:1141–7.
62.
Zurück zum Zitat Hu G, Jousilahti P, Qiao Q, Katoh S, Tuomilehto J. Sex differences in cardiovascular and total mortality among diabetic and non-diabetic individuals with or without history of myocardial infarction. Diabetologia. 2005;48:856–61.CrossRef Hu G, Jousilahti P, Qiao Q, Katoh S, Tuomilehto J. Sex differences in cardiovascular and total mortality among diabetic and non-diabetic individuals with or without history of myocardial infarction. Diabetologia. 2005;48:856–61.CrossRef
63.
Zurück zum Zitat Huxley R, Barzi F, Woodward M. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ. 2006;332:73–8.CrossRef Huxley R, Barzi F, Woodward M. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ. 2006;332:73–8.CrossRef
64.
Zurück zum Zitat Peters SA, Huxley RR, Woodward M. Diabetes as a risk factor for stroke in women compared with men: a systematic review and meta-analysis of 64 cohorts, including 775 385 individuals and 12 539 strokes. Lancet. 2014;383:1973–80.CrossRef Peters SA, Huxley RR, Woodward M. Diabetes as a risk factor for stroke in women compared with men: a systematic review and meta-analysis of 64 cohorts, including 775 385 individuals and 12 539 strokes. Lancet. 2014;383:1973–80.CrossRef
66.
Zurück zum Zitat Malmberg K, Yusuf S, Gerstein HC, Brown J, Zhao F, Hunt D, et al. OASIS registry investigators. Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction results of the OASIS (organization to assess strategies for ischemic syndromes) registry. Circulation. 2000;102:1014–9. Malmberg K, Yusuf S, Gerstein HC, Brown J, Zhao F, Hunt D, et al. OASIS registry investigators. Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction results of the OASIS (organization to assess strategies for ischemic syndromes) registry. Circulation. 2000;102:1014–9.
67.
Zurück zum Zitat Mukamal KJ, Nesto RW, Cohen MC, Muller JE, Maclure M, Sherwood JB, et al. Impact of diabetes on long-term survival after acute myocardial infarction comparability of risk with prior myocardial infarction. Diabetes Care. 2001;24:1422–7. Mukamal KJ, Nesto RW, Cohen MC, Muller JE, Maclure M, Sherwood JB, et al. Impact of diabetes on long-term survival after acute myocardial infarction comparability of risk with prior myocardial infarction. Diabetes Care. 2001;24:1422–7.
68.
Zurück zum Zitat Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Type 2 diabetes as a ‘coronary heart disease equivalent’: an 18-year prospective population-based study in Finnish subjects. Diabetes Care. 2005;28:2901–7.CrossRef Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Type 2 diabetes as a ‘coronary heart disease equivalent’: an 18-year prospective population-based study in Finnish subjects. Diabetes Care. 2005;28:2901–7.CrossRef
69.
Zurück zum Zitat Hu FB, Stampfer MJ, Solomon CG, Liu S, Willett WC, Speizer FE, et al. The impact of diabetes mellitus on mortality from all causes and coronary heart disease in women: 20 years of follow-up. Arch Intern Med. 2001;161:1717–23. Hu FB, Stampfer MJ, Solomon CG, Liu S, Willett WC, Speizer FE, et al. The impact of diabetes mellitus on mortality from all causes and coronary heart disease in women: 20 years of follow-up. Arch Intern Med. 2001;161:1717–23.
70.
Zurück zum Zitat Bulugahapitiya U, Siyambalapitiya S, Sithole J, Idris I. Is diabetes a coronary risk equivalent? Systematic review and meta-analysis. Diabet Med. 2009;26:142–8.CrossRef Bulugahapitiya U, Siyambalapitiya S, Sithole J, Idris I. Is diabetes a coronary risk equivalent? Systematic review and meta-analysis. Diabet Med. 2009;26:142–8.CrossRef
71.
Zurück zum Zitat Wong ND, Glovaci D, Wong K, Malik S, Franklin SS, Wygant G, et al. Global cardiovascular disease risk assessment in United States adults with diabetes. Diab Vasc Dis Res. 2012;9:146–52. Wong ND, Glovaci D, Wong K, Malik S, Franklin SS, Wygant G, et al. Global cardiovascular disease risk assessment in United States adults with diabetes. Diab Vasc Dis Res. 2012;9:146–52.
72.
Zurück zum Zitat Ford ES. Trends in the risk for coronary heart disease among adults with diagnosed diabetes in the US findings from the national health and nutrition examination survey, 1999–2008. Diabetes Care. 2011;34:1337–43.CrossRef Ford ES. Trends in the risk for coronary heart disease among adults with diagnosed diabetes in the US findings from the national health and nutrition examination survey, 1999–2008. Diabetes Care. 2011;34:1337–43.CrossRef
73.
Zurück zum Zitat Rana JS, Liu JY, Moffet HH, Jaffe M, Karter AJ. Diabetes and prior coronary heart disease are not necessarily risk equivalent for future coronary heart disease events. J Gen Intern Med. 2016;31:387–93.CrossRef Rana JS, Liu JY, Moffet HH, Jaffe M, Karter AJ. Diabetes and prior coronary heart disease are not necessarily risk equivalent for future coronary heart disease events. J Gen Intern Med. 2016;31:387–93.CrossRef
74.
Zurück zum Zitat Malik S, Budoff MJ, Katz R, Blumenthal RS, Bertoni AG, Nasir K, et al. Impact of subclinical atherosclerosis on cardiovascular disease events in individuals with metabolic syndrome and diabetes: the multi-ethnic study of atherosclerosis. Diabetes Care. 2011;34(10):2285–90. https://doi.org/10.2337/dc11-0816. Malik S, Budoff MJ, Katz R, Blumenthal RS, Bertoni AG, Nasir K, et al. Impact of subclinical atherosclerosis on cardiovascular disease events in individuals with metabolic syndrome and diabetes: the multi-ethnic study of atherosclerosis. Diabetes Care. 2011;34(10):2285–90. https://​doi.​org/​10.​2337/​dc11-0816.
75.
Zurück zum Zitat Ross S, Hertzel G, Eikelboom J, Anand S, Yusufl S, Pare G. Mendelian randomization analysis supports the causal role of dysglycaemia and diabetes in the risk of coronary artery disease. Eur Heart J. 2015;36:1454–62.CrossRef Ross S, Hertzel G, Eikelboom J, Anand S, Yusufl S, Pare G. Mendelian randomization analysis supports the causal role of dysglycaemia and diabetes in the risk of coronary artery disease. Eur Heart J. 2015;36:1454–62.CrossRef
78.
Zurück zum Zitat •• Gottsäter M, Hindy G, Orho-Melander M, Nilsson PM, Melander O. A genetic risk score for fasting plasma glucose is independently associated with arterial stiffness: a Mendelian randomization study. J Hypertens. 2018;36(4):809–14. https://doi.org/10.1097/HJH.0000000000001646 This study demonstrated that the component of genetically elevated fasting glucose, not necessarily genetically elevated risk of type 2 diabetes was associated with arterial stiffness. CrossRefPubMed •• Gottsäter M, Hindy G, Orho-Melander M, Nilsson PM, Melander O. A genetic risk score for fasting plasma glucose is independently associated with arterial stiffness: a Mendelian randomization study. J Hypertens. 2018;36(4):809–14. https://​doi.​org/​10.​1097/​HJH.​0000000000001646​ This study demonstrated that the component of genetically elevated fasting glucose, not necessarily genetically elevated risk of type 2 diabetes was associated with arterial stiffness. CrossRefPubMed
79.
Zurück zum Zitat •• Ross S, Hertzel G, Pare G. The genetic link between diabetes and atherosclerosis. Can J Cardiol. 2018;34(5):565–74 This article illustrates the potential of genetic studies to understand the relationships among atherosclerotic disease, elevated fasting glucose, and diabetes. CrossRef •• Ross S, Hertzel G, Pare G. The genetic link between diabetes and atherosclerosis. Can J Cardiol. 2018;34(5):565–74 This article illustrates the potential of genetic studies to understand the relationships among atherosclerotic disease, elevated fasting glucose, and diabetes. CrossRef
Metadaten
Titel
Epidemiology of Diabetes Mellitus and Cardiovascular Disease
verfasst von
Diana Glovaci
Wenjun Fan
Nathan D. Wong
Publikationsdatum
01.04.2019
Verlag
Springer US
Erschienen in
Current Cardiology Reports / Ausgabe 4/2019
Print ISSN: 1523-3782
Elektronische ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-019-1107-y

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