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Current Hypertension Reports

Erschienen in:

01.12.2011 | Special Situations in the Management of Hypertension (Theodore Kotchen, Section Editor)

Immune Mechanisms in Hypertension

verfasst von: Avshalom Leibowitz, Ernesto L. Schiffrin

Erschienen in: Current Hypertension Reports | Ausgabe 6/2011

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Abstract

Inflammation plays an important role in the pathogenesis of hypertension. Innate and adaptive immune response may contribute to this process. The mechanisms implicating immune response in hypertension are still elusive. To date, the evidence originates in three major areas of data: cytokine production, central nervous system (CNS) stimulation, and kidney damage. The cytokine microenvironment can become proinflammatory and propagate low-grade inflammation, which may contribute to vascular injury and end-organ damage in hypertension. In addition, stimulation of the CNS by some stimuli (e.g., angiotensin II) causes mild hypertension that may modulate peripheral immune responses leading to aggravation of blood pressure elevation. The immune response can induce kidney injury and also interfere with sodium excretion, further contributing to elevation of blood pressure. The purpose of this review is to discuss recent data regarding the contribution of the different immune cell subsets and their response and mechanism of action in promoting hypertension and target-organ damage.

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Titel: Immune Mechanisms in Hypertension
verfasst von: Avshalom Leibowitz
Ernesto L. Schiffrin
Publikationsdatum: 01.12.2011
Verlag: Current Science Inc.
Erschienen in: Current Hypertension Reports / Ausgabe 6/2011
Print ISSN: 1522-6417
Elektronische ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-011-0224-9

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