Skip to main content
Erschienen in: Current Neurology and Neuroscience Reports 5/2010

01.09.2010

Postural Control in Multiple Sclerosis: Implications for Fall Prevention

verfasst von: Michelle H. Cameron, Stephen Lord

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 5/2010

Einloggen, um Zugang zu erhalten

Abstract

People with multiple sclerosis (MS) often have poor postural control, which likely underlies their increased risk of falls. Based on several studies of balance and gait in MS, it appears that the primary mechanisms underlying the observed changes are slowed somatosensory conduction and impaired central integration. This review of the published research on balance, gait, and falls in people with MS demonstrates that people with MS have balance impairments characterized by increased sway in quiet stance, delayed responses to postural perturbations, and a reduced ability to move toward their limits of stability. These impairments are likely causes of falls in people with MS and are consistent with the reduced gait speed, as well as decreased stride length, cadence, and joint movement, observed in most studies of gait in MS. Based on these findings, we identify several factors that may be amenable to intervention to prevent falls in people with MS.
Literatur
1.
Zurück zum Zitat Jackson RT, Epstein CM, De l'Aune WR: Abnormalities in posturography and estimations of visual vertical and horizontal in multiple sclerosis. Am J Otol 1995, 16:88–93.PubMed Jackson RT, Epstein CM, De l'Aune WR: Abnormalities in posturography and estimations of visual vertical and horizontal in multiple sclerosis. Am J Otol 1995, 16:88–93.PubMed
2.
Zurück zum Zitat Soyuer F, Mirza M, Erkorkmaz U: Balance performance in three forms of multiple sclerosis. Neurol Res 2006, 28:555–562.CrossRefPubMed Soyuer F, Mirza M, Erkorkmaz U: Balance performance in three forms of multiple sclerosis. Neurol Res 2006, 28:555–562.CrossRefPubMed
3.
Zurück zum Zitat Nelson SR, Di Fabio RP, Anderson JH: Vestibular and sensory interaction deficits assessed by dynamic platform posturography in patients with multiple sclerosis. Ann Otol Rhinol Laryngol 1995, 104:62–68.PubMed Nelson SR, Di Fabio RP, Anderson JH: Vestibular and sensory interaction deficits assessed by dynamic platform posturography in patients with multiple sclerosis. Ann Otol Rhinol Laryngol 1995, 104:62–68.PubMed
4.
Zurück zum Zitat Corradini ML, Fioretti S, Leo T, Piperno R: Early recognition of postural disorders in multiple sclerosis through movement analysis: a modeling study. IEEE Trans Biomed Eng 1997, 44:1029–1038.CrossRefPubMed Corradini ML, Fioretti S, Leo T, Piperno R: Early recognition of postural disorders in multiple sclerosis through movement analysis: a modeling study. IEEE Trans Biomed Eng 1997, 44:1029–1038.CrossRefPubMed
5.
Zurück zum Zitat Karst GM, DM Venema, TG Roehrs, AE Tyler: Center of pressure measures during standing tasks in minimally impaired persons with multiple sclerosis. J Neurol Phys Ther 2005, 29:170–180.PubMed Karst GM, DM Venema, TG Roehrs, AE Tyler: Center of pressure measures during standing tasks in minimally impaired persons with multiple sclerosis. J Neurol Phys Ther 2005, 29:170–180.PubMed
6.
Zurück zum Zitat ML Daley, RL Swank: Quantitative posturography: use in multiple sclerosis. IEEE Trans Biomed Eng 1981, 28:668–671.CrossRefPubMed ML Daley, RL Swank: Quantitative posturography: use in multiple sclerosis. IEEE Trans Biomed Eng 1981, 28:668–671.CrossRefPubMed
7.
Zurück zum Zitat National Multiple Sclerosis Society: Multiple Sclerosis Information Sourcebook. New York: National MS Society; 2006. National Multiple Sclerosis Society: Multiple Sclerosis Information Sourcebook. New York: National MS Society; 2006.
8.
Zurück zum Zitat Pratt CA, Horak FB, Herndon RM: Differential effects of somatosensory and motor system deficits on postural dyscontrol in multiple sclerosis patients. In Posture and Gait: Control Mechanisms, vol 2. Edited by Woollacott M, Horak FB. Portland, OR: University of Oregon Books; 1992:118–121. Pratt CA, Horak FB, Herndon RM: Differential effects of somatosensory and motor system deficits on postural dyscontrol in multiple sclerosis patients. In Posture and Gait: Control Mechanisms, vol 2. Edited by Woollacott M, Horak FB. Portland, OR: University of Oregon Books; 1992:118–121.
9.
Zurück zum Zitat Diener HC, Dichgans J, Hulser PJ, et al.: The significance of delayed long-loop responses to ankle displacement for the diagnosis of multiple sclerosis. Electroencephalogr Clin Neurophysiol 1984, 57:336–342.CrossRefPubMed Diener HC, Dichgans J, Hulser PJ, et al.: The significance of delayed long-loop responses to ankle displacement for the diagnosis of multiple sclerosis. Electroencephalogr Clin Neurophysiol 1984, 57:336–342.CrossRefPubMed
10.
Zurück zum Zitat • Cameron MH, Horak FB, Herndon RR, Bourdette D: Imbalance in multiple sclerosis: a result of slowed spinal somatosensory conduction. Somatosens Mot Res 2008, 25:113–122. This study indicates that slowed spinal somatosensory conduction correlates with impaired balance responses in MS. CrossRefPubMed • Cameron MH, Horak FB, Herndon RR, Bourdette D: Imbalance in multiple sclerosis: a result of slowed spinal somatosensory conduction. Somatosens Mot Res 2008, 25:113–122. This study indicates that slowed spinal somatosensory conduction correlates with impaired balance responses in MS. CrossRefPubMed
11.
Zurück zum Zitat Martin CL, Phillips BA, Kilpatrick TJ, et al.: Gait and balance impairment in early multiple sclerosis in the absence of clinical disability. Mult Scler 2006, 12:620–628.CrossRefPubMed Martin CL, Phillips BA, Kilpatrick TJ, et al.: Gait and balance impairment in early multiple sclerosis in the absence of clinical disability. Mult Scler 2006, 12:620–628.CrossRefPubMed
12.
Zurück zum Zitat Daley ML, Swank RL: Changes in postural control and vision induced by multiple sclerosis. Agressologie 1983, 24:327–329.PubMed Daley ML, Swank RL: Changes in postural control and vision induced by multiple sclerosis. Agressologie 1983, 24:327–329.PubMed
13.
Zurück zum Zitat Ramdharry GM, Marsden JF, Day BL, Thompson AJ: De-stabilizing and training effects of foot orthoses in multiple sclerosis. Mult Scler 2006, 12:219–226.CrossRefPubMed Ramdharry GM, Marsden JF, Day BL, Thompson AJ: De-stabilizing and training effects of foot orthoses in multiple sclerosis. Mult Scler 2006, 12:219–226.CrossRefPubMed
14.
Zurück zum Zitat Rougier P, Thoumie P, Cantalloube S, Lamotte D: What compensatory motor strategies do patients with multiple sclerosis develop for balance control? [in French]. Rev Neurol (Paris) 2007, 163:1054–1064. Rougier P, Thoumie P, Cantalloube S, Lamotte D: What compensatory motor strategies do patients with multiple sclerosis develop for balance control? [in French]. Rev Neurol (Paris) 2007, 163:1054–1064.
15.
Zurück zum Zitat Chung LH, Remelius JG, Van Emmerik RE, Kent-Braun JA: Leg power asymmetry and postural control in women with multiple sclerosis. Med Sci Sports Exerc 2008, 40:1717–1724.CrossRefPubMed Chung LH, Remelius JG, Van Emmerik RE, Kent-Braun JA: Leg power asymmetry and postural control in women with multiple sclerosis. Med Sci Sports Exerc 2008, 40:1717–1724.CrossRefPubMed
16.
Zurück zum Zitat Cattaneo D, Jonsdottir J: Sensory impairments in quiet standing in subjects with multiple sclerosis. Mult Scler 2009, 15:59–67.CrossRefPubMed Cattaneo D, Jonsdottir J: Sensory impairments in quiet standing in subjects with multiple sclerosis. Mult Scler 2009, 15:59–67.CrossRefPubMed
17.
Zurück zum Zitat Frzovic D, Morris ME, Vowels L: Clinical tests of standing balance: performance of persons with multiple sclerosis. Arch Phys Med Rehabil 2000, 81:215–221.PubMed Frzovic D, Morris ME, Vowels L: Clinical tests of standing balance: performance of persons with multiple sclerosis. Arch Phys Med Rehabil 2000, 81:215–221.PubMed
18.
Zurück zum Zitat Remelius JG, Hamill J, Kent-Braun J, Van Emmerik RE: Gait initiation in multiple sclerosis. Motor Control 2008, 12:93–108.PubMed Remelius JG, Hamill J, Kent-Braun J, Van Emmerik RE: Gait initiation in multiple sclerosis. Motor Control 2008, 12:93–108.PubMed
19.
Zurück zum Zitat Williams NP, Roland PS, Yellin W: Vestibular evaluation in patients with early multiple sclerosis. Am J Otol 1997, 18:93–100.PubMed Williams NP, Roland PS, Yellin W: Vestibular evaluation in patients with early multiple sclerosis. Am J Otol 1997, 18:93–100.PubMed
20.
Zurück zum Zitat Horak FB, Diener HC: Cerebellar control of postural scaling and central set in stance. J.Neurophysiol 1994, 72:479–493.PubMed Horak FB, Diener HC: Cerebellar control of postural scaling and central set in stance. J.Neurophysiol 1994, 72:479–493.PubMed
21.
Zurück zum Zitat Lanzetta D, Cattaneo D, Pellegatta D, Cardini R: Trunk control in unstable sitting posture during functional activities in healthy subjects and patients with multiple sclerosis. Arch Phys Med Rehabil 2004, 85:279–283.CrossRefPubMed Lanzetta D, Cattaneo D, Pellegatta D, Cardini R: Trunk control in unstable sitting posture during functional activities in healthy subjects and patients with multiple sclerosis. Arch Phys Med Rehabil 2004, 85:279–283.CrossRefPubMed
22.
Zurück zum Zitat Gehlsen G, Beekman K, Assmann N, et al.: Gait characteristics in multiple sclerosis: progressive changes and effects of exercise on parameters. Arch Phys Med Rehabil 1986, 67:536–539.PubMed Gehlsen G, Beekman K, Assmann N, et al.: Gait characteristics in multiple sclerosis: progressive changes and effects of exercise on parameters. Arch Phys Med Rehabil 1986, 67:536–539.PubMed
23.
Zurück zum Zitat Morris ME, Cantwell C, Vowels L, Dodd K: Changes in gait and fatigue from morning to afternoon in people with multiple sclerosis. J Neurol Neurosurg Psychiatry 2002, 72:361–365.CrossRefPubMed Morris ME, Cantwell C, Vowels L, Dodd K: Changes in gait and fatigue from morning to afternoon in people with multiple sclerosis. J Neurol Neurosurg Psychiatry 2002, 72:361–365.CrossRefPubMed
24.
Zurück zum Zitat Mevellec E, Lamotte D, Cantalloube S, et al.: Relationship between gait speed and strength parameters in multiple sclerosis [in French]. Ann Readapt Med Phys 2003, 46:85–90.PubMed Mevellec E, Lamotte D, Cantalloube S, et al.: Relationship between gait speed and strength parameters in multiple sclerosis [in French]. Ann Readapt Med Phys 2003, 46:85–90.PubMed
25.
Zurück zum Zitat Benedetti MG, Piperno R, Simoncini L, et al.: Gait abnormalities in minimally impaired multiple sclerosis patients. Mult Scler 1999, 5:363–368.PubMed Benedetti MG, Piperno R, Simoncini L, et al.: Gait abnormalities in minimally impaired multiple sclerosis patients. Mult Scler 1999, 5:363–368.PubMed
26.
Zurück zum Zitat Thoumie P, Lamotte D, Cantalloube S, et al.: Motor determinants of gait in 100 ambulatory patients with multiple sclerosis. Mult Scler 2005, 11:485–491.CrossRefPubMed Thoumie P, Lamotte D, Cantalloube S, et al.: Motor determinants of gait in 100 ambulatory patients with multiple sclerosis. Mult Scler 2005, 11:485–491.CrossRefPubMed
27.
Zurück zum Zitat Crenshaw SJ, Royer TD, Richards JG, Hudson DJ: Gait variability in people with multiple sclerosis. Mult Scler 2006, 12:613–619.CrossRefPubMed Crenshaw SJ, Royer TD, Richards JG, Hudson DJ: Gait variability in people with multiple sclerosis. Mult Scler 2006, 12:613–619.CrossRefPubMed
28.
Zurück zum Zitat Givon U, Zeilig G, Achiron A: Gait analysis in multiple sclerosis: characterization of temporal-spatial parameters using GAITRite functional ambulation system. Gait Posture 2009, 29:138–142.CrossRefPubMed Givon U, Zeilig G, Achiron A: Gait analysis in multiple sclerosis: characterization of temporal-spatial parameters using GAITRite functional ambulation system. Gait Posture 2009, 29:138–142.CrossRefPubMed
29.
Zurück zum Zitat • Hamilton F, Rochester L, Paul L, et al.: Walking and talking: an investigation of cognitive-motor dual tasking in multiple sclerosis. Mult Scler 2009, 15:1215–1227. This study found greater slowing of gait in people with MS than in healthy controls when concurrently performing a cognitive task, indicating the contribution of impaired central processing to postural control dysfunction in MS. CrossRefPubMed • Hamilton F, Rochester L, Paul L, et al.: Walking and talking: an investigation of cognitive-motor dual tasking in multiple sclerosis. Mult Scler 2009, 15:1215–1227. This study found greater slowing of gait in people with MS than in healthy controls when concurrently performing a cognitive task, indicating the contribution of impaired central processing to postural control dysfunction in MS. CrossRefPubMed
30.
Zurück zum Zitat Motl RW, Snook EM, Agiovlasitis S, Suh Y: Calibration of accelerometer output for ambulatory adults with multiple sclerosis. Arch Phys Med Rehabil 2009, 90:1778–1784.CrossRefPubMed Motl RW, Snook EM, Agiovlasitis S, Suh Y: Calibration of accelerometer output for ambulatory adults with multiple sclerosis. Arch Phys Med Rehabil 2009, 90:1778–1784.CrossRefPubMed
31.
Zurück zum Zitat Remelius JG, Jones SL, House JD, Van Emmerik RE: The influence of walking speed on the spatiotemporal parameters of gait in people with multiple sclerosis. Proc Intl Soc Posture Gait Res 2009. Remelius JG, Jones SL, House JD, Van Emmerik RE: The influence of walking speed on the spatiotemporal parameters of gait in people with multiple sclerosis. Proc Intl Soc Posture Gait Res 2009.
32.
Zurück zum Zitat Cattaneo D, De Nuzzo C, Fascia T, et al.: Risk of falls in subjects with multiple sclerosis. Arch Phys Med Rehabil 2002, 83:864–867.CrossRefPubMed Cattaneo D, De Nuzzo C, Fascia T, et al.: Risk of falls in subjects with multiple sclerosis. Arch Phys Med Rehabil 2002, 83:864–867.CrossRefPubMed
33.
Zurück zum Zitat Finlayson ML, Peterson EW, Cho CC: Risk factors for falling among people aged 45 to 90 years with multiple sclerosis. Arch Phys Med Rehabil 2006, 87:1274–1279.CrossRefPubMed Finlayson ML, Peterson EW, Cho CC: Risk factors for falling among people aged 45 to 90 years with multiple sclerosis. Arch Phys Med Rehabil 2006, 87:1274–1279.CrossRefPubMed
34.
Zurück zum Zitat Peterson EW, Cho CC, Finlayson ML: Fear of falling and associated activity curtailment among middle aged and older adults with multiple sclerosis. Mult Scler 2007, 13:1168–1175.CrossRefPubMed Peterson EW, Cho CC, Finlayson ML: Fear of falling and associated activity curtailment among middle aged and older adults with multiple sclerosis. Mult Scler 2007, 13:1168–1175.CrossRefPubMed
35.
Zurück zum Zitat Peterson EW, Cho CC, von Koch L, Finlayson ML: Injurious falls among middle aged and older adults with multiple sclerosis. Arch Phys Med Rehabil 2008, 89:1031–1037.CrossRefPubMed Peterson EW, Cho CC, von Koch L, Finlayson ML: Injurious falls among middle aged and older adults with multiple sclerosis. Arch Phys Med Rehabil 2008, 89:1031–1037.CrossRefPubMed
36.
Zurück zum Zitat • Nilsagard Y, Lundholm C, Denison E, Gunnarsson LG: Predicting accidental falls in people with multiple sclerosis—a longitudinal study. Clin Rehabil 2009, 23:259–269. This is the only prospective study of fall frequency in people with MS; 48 of 76 subjects registered a total of 270 falls over 3 months. CrossRefPubMed • Nilsagard Y, Lundholm C, Denison E, Gunnarsson LG: Predicting accidental falls in people with multiple sclerosis—a longitudinal study. Clin Rehabil 2009, 23:259–269. This is the only prospective study of fall frequency in people with MS; 48 of 76 subjects registered a total of 270 falls over 3 months. CrossRefPubMed
37.
Zurück zum Zitat Bronnum-Hansen H, Hansen T, Koch-Henriksen N, Stenager E: Fatal accidents among Danes with multiple sclerosis. Mult Scler 2006, 12:329–332.CrossRefPubMed Bronnum-Hansen H, Hansen T, Koch-Henriksen N, Stenager E: Fatal accidents among Danes with multiple sclerosis. Mult Scler 2006, 12:329–332.CrossRefPubMed
38.
Zurück zum Zitat Hauer K, Lamb SE, Jorstad EC, et al.: Systematic review of definitions and methods of measuring falls in randomised controlled fall prevention trials. Age Ageing 2006, 35:5–10.CrossRefPubMed Hauer K, Lamb SE, Jorstad EC, et al.: Systematic review of definitions and methods of measuring falls in randomised controlled fall prevention trials. Age Ageing 2006, 35:5–10.CrossRefPubMed
39.
Zurück zum Zitat Nilsagard Y, Denison E, Gunnarsson LG, Bostrom K: Factors perceived as being related to accidental falls by persons with multiple sclerosis. Disabil Rehabil 2009, 31:1301–1310.CrossRefPubMed Nilsagard Y, Denison E, Gunnarsson LG, Bostrom K: Factors perceived as being related to accidental falls by persons with multiple sclerosis. Disabil Rehabil 2009, 31:1301–1310.CrossRefPubMed
40.
Zurück zum Zitat Gillespie LD, Robertson MC, Gillespie WJ, et al.: Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev 2009, CD007146. Gillespie LD, Robertson MC, Gillespie WJ, et al.: Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev 2009, CD007146.
41.
Zurück zum Zitat Freeman J, Allison R: Group exercise classes in people with multiple sclerosis: a pilot study. Physiother Res Int 2004, 9:104–107.CrossRefPubMed Freeman J, Allison R: Group exercise classes in people with multiple sclerosis: a pilot study. Physiother Res Int 2004, 9:104–107.CrossRefPubMed
42.
Zurück zum Zitat Cattaneo D, Marazzini F, Crippa A, Cardini R: Do static or dynamic AFOs improve balance? Clin Rehabil 2002, 16:894–899.CrossRefPubMed Cattaneo D, Marazzini F, Crippa A, Cardini R: Do static or dynamic AFOs improve balance? Clin Rehabil 2002, 16:894–899.CrossRefPubMed
43.
Zurück zum Zitat Smedal T, Lygren H, Myhr KM, et al.: Balance and gait improved in patients with MS after physiotherapy based on the Bobath concept. Physiother Res Int 2006, 11:104–116.CrossRefPubMed Smedal T, Lygren H, Myhr KM, et al.: Balance and gait improved in patients with MS after physiotherapy based on the Bobath concept. Physiother Res Int 2006, 11:104–116.CrossRefPubMed
44.
Zurück zum Zitat •• Cattaneo D, Jonsdottir J, Zocchi M, Regola A: Effects of balance exercises on people with multiple sclerosis: a pilot study. Clin Rehabil 2007, 21:771–781.This study demonstrates that balance rehabilitation to improve sensory as well as motor strategies improves balance and reduces fall frequency more effectively than balance rehabilitation aimed only at improving motor strategies or than nonspecific rehabilitation treatments. CrossRefPubMed •• Cattaneo D, Jonsdottir J, Zocchi M, Regola A: Effects of balance exercises on people with multiple sclerosis: a pilot study. Clin Rehabil 2007, 21:771–781.This study demonstrates that balance rehabilitation to improve sensory as well as motor strategies improves balance and reduces fall frequency more effectively than balance rehabilitation aimed only at improving motor strategies or than nonspecific rehabilitation treatments. CrossRefPubMed
45.
Zurück zum Zitat Jeka JJ, Lackner JR: Fingertip contact influences human postural control. Exp Brain Res 1994, 100:495–502.CrossRefPubMed Jeka JJ, Lackner JR: Fingertip contact influences human postural control. Exp Brain Res 1994, 100:495–502.CrossRefPubMed
46.
Zurück zum Zitat Rogers MW, Wardman DL, Lord SR, Fitzpatrick RC: Passive tactile sensory input improves stability during standing. Exp Brain Res 2001, 136:514–522.CrossRefPubMed Rogers MW, Wardman DL, Lord SR, Fitzpatrick RC: Passive tactile sensory input improves stability during standing. Exp Brain Res 2001, 136:514–522.CrossRefPubMed
47.
Zurück zum Zitat Menz HB, Lord SR, Fitzpatrick RC: A tactile stimulus applied to the leg improves postural stability in young, old and neuropathic subjects. Neurosci Lett 2006, 406:23–26.CrossRefPubMed Menz HB, Lord SR, Fitzpatrick RC: A tactile stimulus applied to the leg improves postural stability in young, old and neuropathic subjects. Neurosci Lett 2006, 406:23–26.CrossRefPubMed
48.
Zurück zum Zitat Lord SR, Bashford GM, Howland A, Munroe BJ: Effects of shoe collar height and sole hardness on balance in older women. J Am Geriatr Soc 1999, 47:681–684.PubMed Lord SR, Bashford GM, Howland A, Munroe BJ: Effects of shoe collar height and sole hardness on balance in older women. J Am Geriatr Soc 1999, 47:681–684.PubMed
49.
Zurück zum Zitat Maki BE, Perry SD, Norrie RG, McIlroy WE: Effect of facilitation of sensation from plantar foot-surface boundaries on postural stabilization in young and older adults. J Gerontol Biol Sci Med Sci 1999, 54:M281–M287. Maki BE, Perry SD, Norrie RG, McIlroy WE: Effect of facilitation of sensation from plantar foot-surface boundaries on postural stabilization in young and older adults. J Gerontol Biol Sci Med Sci 1999, 54:M281–M287.
50.
Zurück zum Zitat Ashton-Miller JA, Yeh MW, Richardson JK, Galloway T: A cane reduces loss of balance in patients with peripheral neuropathy: results from a challenging unipedal balance test. Arch Phys Med Rehabil 1996, 77:446–452.CrossRefPubMed Ashton-Miller JA, Yeh MW, Richardson JK, Galloway T: A cane reduces loss of balance in patients with peripheral neuropathy: results from a challenging unipedal balance test. Arch Phys Med Rehabil 1996, 77:446–452.CrossRefPubMed
51.
Zurück zum Zitat Magee DJ: Orthopedic Physical Assessment. edn 5. St. Louis: Elsevier; 2007. Magee DJ: Orthopedic Physical Assessment. edn 5. St. Louis: Elsevier; 2007.
Metadaten
Titel
Postural Control in Multiple Sclerosis: Implications for Fall Prevention
verfasst von
Michelle H. Cameron
Stephen Lord
Publikationsdatum
01.09.2010
Verlag
Current Science Inc.
Erschienen in
Current Neurology and Neuroscience Reports / Ausgabe 5/2010
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-010-0128-0

Weitere Artikel der Ausgabe 5/2010

Current Neurology and Neuroscience Reports 5/2010 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Demenzkranke durch Antipsychotika vielfach gefährdet

Demenz Nachrichten

Der Einsatz von Antipsychotika gegen psychische und Verhaltenssymptome in Zusammenhang mit Demenzerkrankungen erfordert eine sorgfältige Nutzen-Risiken-Abwägung. Neuen Erkenntnissen zufolge sind auf der Risikoseite weitere schwerwiegende Ereignisse zu berücksichtigen.

Nicht Creutzfeldt Jakob, sondern Abführtee-Vergiftung

29.05.2024 Hyponatriämie Nachrichten

Eine ältere Frau trinkt regelmäßig Sennesblättertee gegen ihre Verstopfung. Der scheint plötzlich gut zu wirken. Auf Durchfall und Erbrechen folgt allerdings eine Hyponatriämie. Nach deren Korrektur kommt es plötzlich zu progredienten Kognitions- und Verhaltensstörungen.

Schutz der Synapsen bei Alzheimer

29.05.2024 Morbus Alzheimer Nachrichten

Mit einem Neurotrophin-Rezeptor-Modulator lässt sich möglicherweise eine bestehende Alzheimerdemenz etwas abschwächen: Erste Phase-2-Daten deuten auf einen verbesserten Synapsenschutz.

Sozialer Aufstieg verringert Demenzgefahr

24.05.2024 Demenz Nachrichten

Ein hohes soziales Niveau ist mit die beste Versicherung gegen eine Demenz. Noch geringer ist das Demenzrisiko für Menschen, die sozial aufsteigen: Sie gewinnen fast zwei demenzfreie Lebensjahre. Umgekehrt steigt die Demenzgefahr beim sozialen Abstieg.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.