Skip to main content
Erschienen in: Current Osteoporosis Reports 4/2012

01.12.2012 | Epidemiology and Pathophysiology (RA Adler, Section Editor)

Idiopathic Hypercalciuria and Bone Health

verfasst von: Laura E. Ryan, Steven W. Ing

Erschienen in: Current Osteoporosis Reports | Ausgabe 4/2012

Einloggen, um Zugang zu erhalten

Abstract

Calcium is an important participant in many physiologic processes including coagulation, cell membrane transfer, hormone release, neuromuscular activation, and myocardial contraction. The body cooperates in a sophisticated web of hormonally mediated interactions to maintain stable extracellular calcium levels. Calcium is vital for skeletal mineralization, and perturbations in extracellular calcium may be corrected at the expense of bone strength and integrity. The aim of this review is to delineate our current understanding of idiopathic hypercalciuria in the context of bone health, specifically its definition, etiology, epidemiology, laboratory evaluation, and potential therapeutic management.
Literatur
1.
Zurück zum Zitat Albright F, Henneman P, Benedict PH, Forbes AP. Idiopathic hypercalciuria: a preliminary report. Proc R Soc Med. 1953;46(12):1077–81.PubMed Albright F, Henneman P, Benedict PH, Forbes AP. Idiopathic hypercalciuria: a preliminary report. Proc R Soc Med. 1953;46(12):1077–81.PubMed
2.
Zurück zum Zitat Pak CY, Oata M, Lawrence EC, Snyder W. The hypercalciurias. Causes, parathyroid functions, and diagnostic criteria. J Clin Invest. 1974;54(2):387–400.PubMedCrossRef Pak CY, Oata M, Lawrence EC, Snyder W. The hypercalciurias. Causes, parathyroid functions, and diagnostic criteria. J Clin Invest. 1974;54(2):387–400.PubMedCrossRef
3.
Zurück zum Zitat Pacifici R, Filipponi P, Mannarelli C, Vespasiani G, et al. Classification of idiopathic hypercalciuric patients by isotopic calcium absorption: a comparison with oral calcium tolerance test. Calcif Tissue Int. 1985;37(5):467–73.PubMedCrossRef Pacifici R, Filipponi P, Mannarelli C, Vespasiani G, et al. Classification of idiopathic hypercalciuric patients by isotopic calcium absorption: a comparison with oral calcium tolerance test. Calcif Tissue Int. 1985;37(5):467–73.PubMedCrossRef
4.
Zurück zum Zitat Pak CY. Pathophysiology of calcium nephrolithiasis. In: Seldin DW, Giebiscg G, editors. The Kidney: Physiology and Pathophysiology. New York, NY: Raven Press; 1992. p. 2461–80. Pak CY. Pathophysiology of calcium nephrolithiasis. In: Seldin DW, Giebiscg G, editors. The Kidney: Physiology and Pathophysiology. New York, NY: Raven Press; 1992. p. 2461–80.
5.
Zurück zum Zitat Frick KK, Bushinsky DA. Molecular mechanisms of primary hypercalciuria. J Am Soc Nephrol. 2003;14:1082–95.PubMedCrossRef Frick KK, Bushinsky DA. Molecular mechanisms of primary hypercalciuria. J Am Soc Nephrol. 2003;14:1082–95.PubMedCrossRef
6.
Zurück zum Zitat Pacifici R, Rothstein M, Rifas L, et al. Increased monocyte interleukin-1 activity and decreased vertebral bone density in patients with fasting idiopathic hypercalciuria. J Clin Endocrinol Metab. 1990;71(1):138–45.PubMedCrossRef Pacifici R, Rothstein M, Rifas L, et al. Increased monocyte interleukin-1 activity and decreased vertebral bone density in patients with fasting idiopathic hypercalciuria. J Clin Endocrinol Metab. 1990;71(1):138–45.PubMedCrossRef
7.
Zurück zum Zitat Messa P, Mioni G, Montanaro D, et al. About a primitive osseous origin of the so-called ‘renal hypercalciuria’. Contrib Nephrol. 1987;58:106–10.PubMed Messa P, Mioni G, Montanaro D, et al. About a primitive osseous origin of the so-called ‘renal hypercalciuria’. Contrib Nephrol. 1987;58:106–10.PubMed
8.
Zurück zum Zitat •• Zerwekh JE. Bone disease and idiopathic hypercalciuria. Clinic Rev Bone Miner Metab. 2008;6:82–94. Review specifically highlights the relationship between IH and bone health.CrossRef •• Zerwekh JE. Bone disease and idiopathic hypercalciuria. Clinic Rev Bone Miner Metab. 2008;6:82–94. Review specifically highlights the relationship between IH and bone health.CrossRef
9.
Zurück zum Zitat Coe FL. Treated and untreated recurrent calcium nephrolithiasis in patients with idiopathic hypercalciuria, hyperuricosuria, or no metabolic disorder. Ann Intern Med. 1977;87(4):404–10.PubMed Coe FL. Treated and untreated recurrent calcium nephrolithiasis in patients with idiopathic hypercalciuria, hyperuricosuria, or no metabolic disorder. Ann Intern Med. 1977;87(4):404–10.PubMed
10.
Zurück zum Zitat Lemann Jr J. Pathogenesis of idiopathic hypercalciuria and nephrolithiasis. In: Coe FL, Favus MJ, editors. Disorders of Bone and Mineral Metabolism. New York, NY: Raven Press; 1992. p. 685–706. Lemann Jr J. Pathogenesis of idiopathic hypercalciuria and nephrolithiasis. In: Coe FL, Favus MJ, editors. Disorders of Bone and Mineral Metabolism. New York, NY: Raven Press; 1992. p. 685–706.
11.
Zurück zum Zitat • Coe FL, Parks JH, Moore ES. Familial idiopathic hypercalciuria. N Engl J Med. 1979;300(7):337–40. Study of 9 families that clearly illustrates an autosomal dominant transmission of some types of hypercalciuria.PubMedCrossRef • Coe FL, Parks JH, Moore ES. Familial idiopathic hypercalciuria. N Engl J Med. 1979;300(7):337–40. Study of 9 families that clearly illustrates an autosomal dominant transmission of some types of hypercalciuria.PubMedCrossRef
12.
Zurück zum Zitat Giannini S, Nobile M, Dalle Carbonare L, et al. Hypercalciuria is a common and important finding in postmenopausal women with osteoporosis. Eur J Endocrinol. 2003;149(3):209–13.PubMedCrossRef Giannini S, Nobile M, Dalle Carbonare L, et al. Hypercalciuria is a common and important finding in postmenopausal women with osteoporosis. Eur J Endocrinol. 2003;149(3):209–13.PubMedCrossRef
13.
Zurück zum Zitat Tannenbaum C, Clark J, Schwartzman K, et al. Yield of laboratory testing to identify secondary contributors to osteoporosis in otherwise healthy women. J Clin Endocrinol Metab. 2002;87(10):4431–7.PubMedCrossRef Tannenbaum C, Clark J, Schwartzman K, et al. Yield of laboratory testing to identify secondary contributors to osteoporosis in otherwise healthy women. J Clin Endocrinol Metab. 2002;87(10):4431–7.PubMedCrossRef
14.
Zurück zum Zitat Cerda Gabaroi D, Peris P, Monegal A, et al. Search for hidden secondary causes in postmenopausal women with osteoporosis. Menopause. 2010;17(1):135–9.PubMedCrossRef Cerda Gabaroi D, Peris P, Monegal A, et al. Search for hidden secondary causes in postmenopausal women with osteoporosis. Menopause. 2010;17(1):135–9.PubMedCrossRef
15.
Zurück zum Zitat Hodgkinson A, Pyrah LN. The urinary excretion of calcium and inorganic phosphate in 344 patients with calcium stone of renal origin. Br J Surg. 1958;46(195):10–8.PubMedCrossRef Hodgkinson A, Pyrah LN. The urinary excretion of calcium and inorganic phosphate in 344 patients with calcium stone of renal origin. Br J Surg. 1958;46(195):10–8.PubMedCrossRef
16.
Zurück zum Zitat Ettinger B, Insogna KL. Nephrolithiasis. In: Felig P, Baxter JD, Frohman LA, editors. Endocrinology and Metabolism. McGraw-Hill, Inc; 1995. p. 1565–1615. Ettinger B, Insogna KL. Nephrolithiasis. In: Felig P, Baxter JD, Frohman LA, editors. Endocrinology and Metabolism. McGraw-Hill, Inc; 1995. p. 1565–1615.
17.
Zurück zum Zitat Walser M. Creatinine excretion as a measure of protein nutrition in adults of varying age. J Parenter Enteral Nutr. 1987;11 Suppl 5:73S–8S.CrossRef Walser M. Creatinine excretion as a measure of protein nutrition in adults of varying age. J Parenter Enteral Nutr. 1987;11 Suppl 5:73S–8S.CrossRef
18.
Zurück zum Zitat Heaney RP, Recker RR, Ryan RA. Urinary calcium in perimenopausal women: normative values. Osteoporos Int. 1999;9(1):13–8.PubMedCrossRef Heaney RP, Recker RR, Ryan RA. Urinary calcium in perimenopausal women: normative values. Osteoporos Int. 1999;9(1):13–8.PubMedCrossRef
19.
Zurück zum Zitat Bleich HL, Moore MJ, Lemann Jr J, et al. Urinary calcium excretion in human beings. N Engl J Med. 1979;301(10):535–41.PubMedCrossRef Bleich HL, Moore MJ, Lemann Jr J, et al. Urinary calcium excretion in human beings. N Engl J Med. 1979;301(10):535–41.PubMedCrossRef
20.
Zurück zum Zitat Breslau NA, Brinkley L, Hill KD, Pak CY. Relationship of animal protein-rich diet to kidney stone formation and calcium metabolism. J Clin Endocrinol Metab. 1988;66(1):140–6.PubMedCrossRef Breslau NA, Brinkley L, Hill KD, Pak CY. Relationship of animal protein-rich diet to kidney stone formation and calcium metabolism. J Clin Endocrinol Metab. 1988;66(1):140–6.PubMedCrossRef
21.
Zurück zum Zitat Li XQ, Tembe V, Horwitz GM, et al. Increased intestinal vitamin D receptor in genetic hypercalciuric rats. A cause of intestinal calcium hyperabsorption. J Clin Invest. 1993;91(2):661–7.PubMedCrossRef Li XQ, Tembe V, Horwitz GM, et al. Increased intestinal vitamin D receptor in genetic hypercalciuric rats. A cause of intestinal calcium hyperabsorption. J Clin Invest. 1993;91(2):661–7.PubMedCrossRef
22.
Zurück zum Zitat Yao J, Kathpalia P, Bushinsky DA, Favus MJ. Hyperresponsiveness of vitamin D receptor gene expression to 1,25-dihydroxyvitamin D3. A new characteristic of genetic hypercalciuric stone-forming rats. J Clin Invest. 1998;101(10):2223–32.PubMedCrossRef Yao J, Kathpalia P, Bushinsky DA, Favus MJ. Hyperresponsiveness of vitamin D receptor gene expression to 1,25-dihydroxyvitamin D3. A new characteristic of genetic hypercalciuric stone-forming rats. J Clin Invest. 1998;101(10):2223–32.PubMedCrossRef
23.
Zurück zum Zitat Pietschmann F, Breslau NA, Pak CY. Reduced vertebral bone density in hypercalciuric nephrolithiasis. J Bone Miner Res. 1992;7(12):1383–8.PubMedCrossRef Pietschmann F, Breslau NA, Pak CY. Reduced vertebral bone density in hypercalciuric nephrolithiasis. J Bone Miner Res. 1992;7(12):1383–8.PubMedCrossRef
24.
Zurück zum Zitat Jaeger P, Lippuner K, Casez JP, et al. Low bone mass in idiopathic renal stone formers: magnitude and significance. J Bone Miner Res. 1994;9(10):1525–32.PubMedCrossRef Jaeger P, Lippuner K, Casez JP, et al. Low bone mass in idiopathic renal stone formers: magnitude and significance. J Bone Miner Res. 1994;9(10):1525–32.PubMedCrossRef
25.
Zurück zum Zitat Vezzoli G, Soldati L, Arcidiacono T, et al. Urinary calcium is a determinant of bone mineral density in elderly men participating in the InCHIANTI study. Kidney Int. 2005;67:2006–14.PubMedCrossRef Vezzoli G, Soldati L, Arcidiacono T, et al. Urinary calcium is a determinant of bone mineral density in elderly men participating in the InCHIANTI study. Kidney Int. 2005;67:2006–14.PubMedCrossRef
26.
Zurück zum Zitat Lemann Jr J, Worcester EM, Gray RW. Hypercalciuria and stones. Am J Kidney Dis. 1991;17(4):386–91.PubMed Lemann Jr J, Worcester EM, Gray RW. Hypercalciuria and stones. Am J Kidney Dis. 1991;17(4):386–91.PubMed
27.
Zurück zum Zitat Gokce C, Gokce O, Baydinc C, et al. Use of random urine samples to estimate total urinary calcium and phosphate excretion. Arch Intern Med. 1991;151(8):1587–8.PubMedCrossRef Gokce C, Gokce O, Baydinc C, et al. Use of random urine samples to estimate total urinary calcium and phosphate excretion. Arch Intern Med. 1991;151(8):1587–8.PubMedCrossRef
28.
Zurück zum Zitat Jones AN, Shafer MM, Keuler NS, et al. Fasting and postprandial spot urine calcium-to-creatinine ratios do not detect hypercalciuria. Osteoporos Int. 2012;23(2):553–62.PubMedCrossRef Jones AN, Shafer MM, Keuler NS, et al. Fasting and postprandial spot urine calcium-to-creatinine ratios do not detect hypercalciuria. Osteoporos Int. 2012;23(2):553–62.PubMedCrossRef
29.
Zurück zum Zitat Frick KK, Bushinsky DA. Metabolic acidosis stimulates RANKL RNA expression in bone through a cyclo-oxygenase-dependent mechanism. J Bone Miner Res. 2003;18(7):1317–25.PubMedCrossRef Frick KK, Bushinsky DA. Metabolic acidosis stimulates RANKL RNA expression in bone through a cyclo-oxygenase-dependent mechanism. J Bone Miner Res. 2003;18(7):1317–25.PubMedCrossRef
30.
Zurück zum Zitat • Borghi L, Schianchi T, Meschi T, et al. Comparison of 2 diets for the prevention of recurrent stones in idiopathic hypercalciuria. N Engl J Med. 2002;346(2):77–84. Study highlights the importance of dietary modification in reducing hypercalciuria, especially diets low in salt and low in animal-protein.PubMedCrossRef • Borghi L, Schianchi T, Meschi T, et al. Comparison of 2 diets for the prevention of recurrent stones in idiopathic hypercalciuria. N Engl J Med. 2002;346(2):77–84. Study highlights the importance of dietary modification in reducing hypercalciuria, especially diets low in salt and low in animal-protein.PubMedCrossRef
31.
Zurück zum Zitat • Ghazali A, Fuentes V, Desaint C, et al. Low bone mineral density and peripheral blood monocyte activation profile in calcium stone formers with idiopathic hypercalciuria. J Clin Endocrinol Metab. 1997;82(1):32–8. Reports on likely pathogenetic mechanism separating idiopathic hypercalciuria from other classifications.PubMedCrossRef • Ghazali A, Fuentes V, Desaint C, et al. Low bone mineral density and peripheral blood monocyte activation profile in calcium stone formers with idiopathic hypercalciuria. J Clin Endocrinol Metab. 1997;82(1):32–8. Reports on likely pathogenetic mechanism separating idiopathic hypercalciuria from other classifications.PubMedCrossRef
32.
Zurück zum Zitat Gomes SA, dos Reis LM, Noronha IL, et al. RANKL is a mediator of bone resorption in idiopathic hypercalciuria. Clin J Am Soc Nephrol. 2008;3(5):1446–52.PubMedCrossRef Gomes SA, dos Reis LM, Noronha IL, et al. RANKL is a mediator of bone resorption in idiopathic hypercalciuria. Clin J Am Soc Nephrol. 2008;3(5):1446–52.PubMedCrossRef
33.
Zurück zum Zitat Sakhaee K, Maalouf NM, Kumar R, et al. Nephrolithiasis-associated bone disease: pathogenesis and treatment options. Kidney Int. 2011;79:393–403.PubMedCrossRef Sakhaee K, Maalouf NM, Kumar R, et al. Nephrolithiasis-associated bone disease: pathogenesis and treatment options. Kidney Int. 2011;79:393–403.PubMedCrossRef
34.
Zurück zum Zitat Broadus AE, Insogna KL, Lang R, et al. Evidence for disordered control of 1,25-dihydroxyvitamin D production in absorptive hypercalciuria. N Engl J Med. 1984;311(2):73–8.PubMedCrossRef Broadus AE, Insogna KL, Lang R, et al. Evidence for disordered control of 1,25-dihydroxyvitamin D production in absorptive hypercalciuria. N Engl J Med. 1984;311(2):73–8.PubMedCrossRef
35.
Zurück zum Zitat Tasca A, Cacciola A, Ferrarese P, et al. Bone alterations in patients with idiopathic hypercalciuria and calcium nephrolithiasis. Urology. 2002;59(6):865–9.PubMedCrossRef Tasca A, Cacciola A, Ferrarese P, et al. Bone alterations in patients with idiopathic hypercalciuria and calcium nephrolithiasis. Urology. 2002;59(6):865–9.PubMedCrossRef
36.
Zurück zum Zitat Melton III LJ, Crowson CS, Khosla S, et al. Fracture risk among patients with urolithiasis: a population-based cohort study. Kidney Int. 1998;53:459–64.PubMedCrossRef Melton III LJ, Crowson CS, Khosla S, et al. Fracture risk among patients with urolithiasis: a population-based cohort study. Kidney Int. 1998;53:459–64.PubMedCrossRef
37.
Zurück zum Zitat Lauderdale DS, Thisted RA, Wen M, Favus MJ. Bone mineral density and fracture among prevalent kidney stone cases in the Third National Health and Nutrition Examination Survey. J Bone Miner Res. 2001;16(10):1893–8.PubMedCrossRef Lauderdale DS, Thisted RA, Wen M, Favus MJ. Bone mineral density and fracture among prevalent kidney stone cases in the Third National Health and Nutrition Examination Survey. J Bone Miner Res. 2001;16(10):1893–8.PubMedCrossRef
38.
Zurück zum Zitat Cauley JA, Fullman RL, Stone KL, et al. Factors associated with the lumbar spine and proximal femur bone mineral density in older men. Osteoporos Int. 2005;16(12):1525–37.PubMedCrossRef Cauley JA, Fullman RL, Stone KL, et al. Factors associated with the lumbar spine and proximal femur bone mineral density in older men. Osteoporos Int. 2005;16(12):1525–37.PubMedCrossRef
39.
Zurück zum Zitat Sowers MR, Jannausch M, Wood C, et al. Prevalence of renal stones in a population-based study with dietary calcium, oxalate and medication exposures. Am J Epidemiol. 1998;147(10):914–20.PubMedCrossRef Sowers MR, Jannausch M, Wood C, et al. Prevalence of renal stones in a population-based study with dietary calcium, oxalate and medication exposures. Am J Epidemiol. 1998;147(10):914–20.PubMedCrossRef
40.
Zurück zum Zitat Asplin JR, Bauer KA, Kinder J, et al. Bone mineral density and urine calcium excretion among subjects with and without nephrolithiasis. Kidney Int. 2003;63(2):662–9.PubMedCrossRef Asplin JR, Bauer KA, Kinder J, et al. Bone mineral density and urine calcium excretion among subjects with and without nephrolithiasis. Kidney Int. 2003;63(2):662–9.PubMedCrossRef
41.
Zurück zum Zitat Letavernier E, Traxer O, Daudon M, et al. Determinants of osteopenia in male renal-stone-disease patients with idiopathic hypercalciuria. Clin J Am Soc Nephrol. 2011;6(5):1149–54.PubMedCrossRef Letavernier E, Traxer O, Daudon M, et al. Determinants of osteopenia in male renal-stone-disease patients with idiopathic hypercalciuria. Clin J Am Soc Nephrol. 2011;6(5):1149–54.PubMedCrossRef
42.
Zurück zum Zitat Bataille P, Achard JM, Fournier A, et al. Diet, vitamin D and vertebral mineral density in hypercalciuric calcium stone formers. Kidney Int. 1991;39(6):1193–205.PubMedCrossRef Bataille P, Achard JM, Fournier A, et al. Diet, vitamin D and vertebral mineral density in hypercalciuric calcium stone formers. Kidney Int. 1991;39(6):1193–205.PubMedCrossRef
43.
Zurück zum Zitat Asplin JR, Donahue S, Kinder J, Coe FL. Urine calcium excretion predicts bone loss in idiopathic hypercalciuria. Kidney Int. 2006;70(8):1463–7.PubMedCrossRef Asplin JR, Donahue S, Kinder J, Coe FL. Urine calcium excretion predicts bone loss in idiopathic hypercalciuria. Kidney Int. 2006;70(8):1463–7.PubMedCrossRef
44.
Zurück zum Zitat Hunter D, De Lange M, Snieder H, et al. Genetic contribution to bone metabolism, calcium excretion, and vitamin D and parathyroid hormone regulation. J Bone Miner Res. 2001;16(2):371–8.PubMedCrossRef Hunter D, De Lange M, Snieder H, et al. Genetic contribution to bone metabolism, calcium excretion, and vitamin D and parathyroid hormone regulation. J Bone Miner Res. 2001;16(2):371–8.PubMedCrossRef
45.
Zurück zum Zitat Reed BY, Heller HJ, Gitomer WL, Pak CY. Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24. J Clin Endocrinol Metab. 1999;84(11):3907–13.PubMedCrossRef Reed BY, Heller HJ, Gitomer WL, Pak CY. Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24. J Clin Endocrinol Metab. 1999;84(11):3907–13.PubMedCrossRef
46.
Zurück zum Zitat Reed BY, Gitomer WL, Heller HJ, et al. Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density. J Clin Endocrinol Metab. 2002;87(4):1476–85.PubMedCrossRef Reed BY, Gitomer WL, Heller HJ, et al. Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density. J Clin Endocrinol Metab. 2002;87(4):1476–85.PubMedCrossRef
47.
Zurück zum Zitat Geng W, Wang Z, Zhang J, et al. Cloning and characterization of the human soluble adenylyl cyclase. Am J Physiol Cell Physiol. 2005;288(6):C1305–16.PubMedCrossRef Geng W, Wang Z, Zhang J, et al. Cloning and characterization of the human soluble adenylyl cyclase. Am J Physiol Cell Physiol. 2005;288(6):C1305–16.PubMedCrossRef
48.
Zurück zum Zitat Geng W, Hill K, Zerwekh JE, et al. Inhibition of osteoclast formation and function by bicarbonate: role of soluble adenylyl cyclase. J Cell Physiol. 2009;220(2):332–40.PubMedCrossRef Geng W, Hill K, Zerwekh JE, et al. Inhibition of osteoclast formation and function by bicarbonate: role of soluble adenylyl cyclase. J Cell Physiol. 2009;220(2):332–40.PubMedCrossRef
49.
Zurück zum Zitat Vezzoli G, Soldati L, Gambaro G. Update on primary hypercalciuria from a genetic perspective. J Urol. 2008;179(5):1676–82.PubMedCrossRef Vezzoli G, Soldati L, Gambaro G. Update on primary hypercalciuria from a genetic perspective. J Urol. 2008;179(5):1676–82.PubMedCrossRef
50.
Zurück zum Zitat Reid IR, Ames RW, Orr-Walker BJ, et al. Hydrochlorothiazide reduces loss of cortical bone in normal postmenopausal women: a randomized controlled trial. Am J Med. 2000;109(5):362–70.PubMedCrossRef Reid IR, Ames RW, Orr-Walker BJ, et al. Hydrochlorothiazide reduces loss of cortical bone in normal postmenopausal women: a randomized controlled trial. Am J Med. 2000;109(5):362–70.PubMedCrossRef
51.
Zurück zum Zitat Bolland MJ, Ames RW, Horne AM, et al. The effect of treatment with a thiazide diuretic for 4 years on bone density in normal postmenopausal women. Osteoporos Int. 2007;18(4):479–86.PubMedCrossRef Bolland MJ, Ames RW, Horne AM, et al. The effect of treatment with a thiazide diuretic for 4 years on bone density in normal postmenopausal women. Osteoporos Int. 2007;18(4):479–86.PubMedCrossRef
52.
Zurück zum Zitat LaCroix AZ, Ott SM, Ichikawa L, et al. Low-dose hydrochlorothiazide and preservation of bone mineral density in older adults. Ann Intern Med. 2000;133:516–26.PubMed LaCroix AZ, Ott SM, Ichikawa L, et al. Low-dose hydrochlorothiazide and preservation of bone mineral density in older adults. Ann Intern Med. 2000;133:516–26.PubMed
53.
Zurück zum Zitat Wasnich RD, Davis JW, He Y-F, et al. A randomized, double-masked, placebo-controlled trial of chlorthalidone and bone loss in elderly women. Osteoporos Int. 1995;5:247–51.PubMedCrossRef Wasnich RD, Davis JW, He Y-F, et al. A randomized, double-masked, placebo-controlled trial of chlorthalidone and bone loss in elderly women. Osteoporos Int. 1995;5:247–51.PubMedCrossRef
54.
Zurück zum Zitat Adams JS, Song CF, Kantorovich V. Rapid recovery of bone mass in hypercalciuric, osteoporotic men treated with hydrochlorothiazide. Ann Intern Med. 1999;130:658–60.PubMed Adams JS, Song CF, Kantorovich V. Rapid recovery of bone mass in hypercalciuric, osteoporotic men treated with hydrochlorothiazide. Ann Intern Med. 1999;130:658–60.PubMed
55.
Zurück zum Zitat Feskanich D, Willett WC, Stampfer MJ, Colditz GA. A prospective study of thiazide use and fractures in women. Osteoporos Int. 1997;7(1):79–84.PubMedCrossRef Feskanich D, Willett WC, Stampfer MJ, Colditz GA. A prospective study of thiazide use and fractures in women. Osteoporos Int. 1997;7(1):79–84.PubMedCrossRef
56.
Zurück zum Zitat Lamberg BA, Kuhlback B. Effect of chlorothiazide and hydrochlorothiazide on the excretion of calcium in the urine. Scand J Clin Lab Invest. 1959;11:351–7.PubMedCrossRef Lamberg BA, Kuhlback B. Effect of chlorothiazide and hydrochlorothiazide on the excretion of calcium in the urine. Scand J Clin Lab Invest. 1959;11:351–7.PubMedCrossRef
57.
Zurück zum Zitat Lajeunesse D, Delalandre A, Guggino SE. Thiazide diuretics affect osteocalcin production in human osteoblasts at the transcription level without affecting vitamin D3 receptors. J Bone Miner Res. 2000;15(5):894–901.PubMedCrossRef Lajeunesse D, Delalandre A, Guggino SE. Thiazide diuretics affect osteocalcin production in human osteoblasts at the transcription level without affecting vitamin D3 receptors. J Bone Miner Res. 2000;15(5):894–901.PubMedCrossRef
58.
Zurück zum Zitat • Garcia-Nieto V, Monge-Zamorano M, Gonzalez-Garcia M, et al. Effect of thiazides on bone mineral density in children with idiopathic hypercalciuria. Pediatr Nephrol. 2012;27:261–8. A provocative paper challenging commonly held beliefs about the impact of thiazides on bone.PubMedCrossRef • Garcia-Nieto V, Monge-Zamorano M, Gonzalez-Garcia M, et al. Effect of thiazides on bone mineral density in children with idiopathic hypercalciuria. Pediatr Nephrol. 2012;27:261–8. A provocative paper challenging commonly held beliefs about the impact of thiazides on bone.PubMedCrossRef
59.
Zurück zum Zitat Bushinsky DA, Favus MJ. Mechanism of hypercalciuria in genetic hypercalciuric rats. Inherited defect in intestinal calcium transport. J Clin Invest. 1988;82(5):1585–91.PubMedCrossRef Bushinsky DA, Favus MJ. Mechanism of hypercalciuria in genetic hypercalciuric rats. Inherited defect in intestinal calcium transport. J Clin Invest. 1988;82(5):1585–91.PubMedCrossRef
60.
Zurück zum Zitat Grynpas M, Waldman S, Holmyard D, Bushinsky DA. Genetic hypercalciuric stone-forming rats have a primary decrease in BMD and strength. J Bone Miner Res. 2009;24(8):1420–6.PubMedCrossRef Grynpas M, Waldman S, Holmyard D, Bushinsky DA. Genetic hypercalciuric stone-forming rats have a primary decrease in BMD and strength. J Bone Miner Res. 2009;24(8):1420–6.PubMedCrossRef
61.
Zurück zum Zitat •• Bushinsky DA, Willett T, Asplin JR, et al. Chlorthalidone improves vertebral bone quality in genetic hypercalciuric stone-forming rats. J Bone Miner Res. 2011;26(8):1904–12. Uses genetic hypercalciuric rats to study thiazide impact on bone mineralization and architecture in a population known to have idiopathic hypercalciuria.PubMedCrossRef •• Bushinsky DA, Willett T, Asplin JR, et al. Chlorthalidone improves vertebral bone quality in genetic hypercalciuric stone-forming rats. J Bone Miner Res. 2011;26(8):1904–12. Uses genetic hypercalciuric rats to study thiazide impact on bone mineralization and architecture in a population known to have idiopathic hypercalciuria.PubMedCrossRef
62.
Zurück zum Zitat Pak CY, Heller HJ, Pearle MS, et al. Prevention of stone formation and bone loss in absorptive hypercalciuria by combined dietary and pharmacological interventions. J Urol. 2003;169(2):465–9.PubMedCrossRef Pak CY, Heller HJ, Pearle MS, et al. Prevention of stone formation and bone loss in absorptive hypercalciuria by combined dietary and pharmacological interventions. J Urol. 2003;169(2):465–9.PubMedCrossRef
63.
Zurück zum Zitat Vescini F, Buffa A, LaManna G, et al. Long-term potassium citrate therapy and bone mineral density in idiopathic calcium stone formers. J Endocrinol Invest. 2005;28(3):218–22.PubMed Vescini F, Buffa A, LaManna G, et al. Long-term potassium citrate therapy and bone mineral density in idiopathic calcium stone formers. J Endocrinol Invest. 2005;28(3):218–22.PubMed
64.
Zurück zum Zitat Ruml LA, Dubois SK, Roberts ML, et al. Prevention of hypercalciuria and stone-forming propensity during prolonged bedrest by alendronate. J Bone Miner Res. 1995;10(4):655–62.PubMedCrossRef Ruml LA, Dubois SK, Roberts ML, et al. Prevention of hypercalciuria and stone-forming propensity during prolonged bedrest by alendronate. J Bone Miner Res. 1995;10(4):655–62.PubMedCrossRef
65.
Zurück zum Zitat Alonzo E, Bellorin-Font E, Carlini R, et al. Role of the bone in the pathogenesis of idiopathic hypercalciuria: effect of aminobisphosphonate alendronate. Medicina. 1997;57 Suppl 1:45–8.PubMed Alonzo E, Bellorin-Font E, Carlini R, et al. Role of the bone in the pathogenesis of idiopathic hypercalciuria: effect of aminobisphosphonate alendronate. Medicina. 1997;57 Suppl 1:45–8.PubMed
66.
Zurück zum Zitat Heilberg IP, Martini LA, Teixeira SH, et al. Effect of etidronate treatment on bone mass of male nephrolithiasis patients with idiopathic hypercalciuria and osteopenia. Nephron. 1998;79(4):430–7.PubMedCrossRef Heilberg IP, Martini LA, Teixeira SH, et al. Effect of etidronate treatment on bone mass of male nephrolithiasis patients with idiopathic hypercalciuria and osteopenia. Nephron. 1998;79(4):430–7.PubMedCrossRef
67.
Zurück zum Zitat Bushinsky DA, Neumann KJ, Asplin J, Krieger NS. Alendronate decreases urine calcium and supersaturation in genetic hypercalciuric rats. Kidney Int. 1999;55(1):234–43.PubMedCrossRef Bushinsky DA, Neumann KJ, Asplin J, Krieger NS. Alendronate decreases urine calcium and supersaturation in genetic hypercalciuric rats. Kidney Int. 1999;55(1):234–43.PubMedCrossRef
68.
Zurück zum Zitat Riccardi D, Park J, Lee WS, et al. Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor. Proc Natl Acad Sci USA. 1995;92(1):131–5.PubMedCrossRef Riccardi D, Park J, Lee WS, et al. Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor. Proc Natl Acad Sci USA. 1995;92(1):131–5.PubMedCrossRef
69.
Zurück zum Zitat Peacock M, Bolognese MA, Borofsky M, et al. Cinacalcet treatment of primary hyperparathyroidism: biochemical and bone densitometric outcomes in a 5-year study. J Clin Endocrinol Metab. 2009;94(12):4860–7.PubMedCrossRef Peacock M, Bolognese MA, Borofsky M, et al. Cinacalcet treatment of primary hyperparathyroidism: biochemical and bone densitometric outcomes in a 5-year study. J Clin Endocrinol Metab. 2009;94(12):4860–7.PubMedCrossRef
70.
Zurück zum Zitat Bushinsky DA, LaPlante K, Asplin JR. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006;69:1586–92.PubMedCrossRef Bushinsky DA, LaPlante K, Asplin JR. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006;69:1586–92.PubMedCrossRef
71.
Zurück zum Zitat Filipponi P, Mannarelli C, Pacifici R, et al. Evidence for a prostaglandin-mediated bone resorptive mechanism in subjects with fasting hypercalciuria. Calcif Tissue Int. 1988;43:61–6.PubMedCrossRef Filipponi P, Mannarelli C, Pacifici R, et al. Evidence for a prostaglandin-mediated bone resorptive mechanism in subjects with fasting hypercalciuria. Calcif Tissue Int. 1988;43:61–6.PubMedCrossRef
72.
Zurück zum Zitat Gomaa AA, Hassan HA, Ghaneimah SA. Effect of aspirin and indomethacin on the serum and urinary calcium, magnesium and phosphate. Pharmacol Res. 1990;22(1):59–70.PubMedCrossRef Gomaa AA, Hassan HA, Ghaneimah SA. Effect of aspirin and indomethacin on the serum and urinary calcium, magnesium and phosphate. Pharmacol Res. 1990;22(1):59–70.PubMedCrossRef
73.
Zurück zum Zitat Buck AC, Davies RL, Harrison T. The protective role of eicosapentaenoic acid (EPA) in the pathogenesis of nephrolithiasis. J Urol. 1991;146(1):188–94.PubMed Buck AC, Davies RL, Harrison T. The protective role of eicosapentaenoic acid (EPA) in the pathogenesis of nephrolithiasis. J Urol. 1991;146(1):188–94.PubMed
74.
Zurück zum Zitat Ortiz-Alvarado O, Miyaoka R, Kriedberg C, et al. Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid in the management of hypercalciuric stone formers. Urology. 2012;79(2):282–6.PubMedCrossRef Ortiz-Alvarado O, Miyaoka R, Kriedberg C, et al. Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid in the management of hypercalciuric stone formers. Urology. 2012;79(2):282–6.PubMedCrossRef
75.
Zurück zum Zitat Orchard TS, Pan X, Cheek F, Ing SW, Jackson RD. A systematic review of omega-3 fatty acids and osteoporosis. Br J Nutr. 2012;107 Suppl 2:S253–60.PubMedCrossRef Orchard TS, Pan X, Cheek F, Ing SW, Jackson RD. A systematic review of omega-3 fatty acids and osteoporosis. Br J Nutr. 2012;107 Suppl 2:S253–60.PubMedCrossRef
Metadaten
Titel
Idiopathic Hypercalciuria and Bone Health
verfasst von
Laura E. Ryan
Steven W. Ing
Publikationsdatum
01.12.2012
Verlag
Current Science Inc.
Erschienen in
Current Osteoporosis Reports / Ausgabe 4/2012
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-012-0120-5

Weitere Artikel der Ausgabe 4/2012

Current Osteoporosis Reports 4/2012 Zur Ausgabe

Epidemiology and Pathophysiology (RA Adler, Section Editor)

HIV Infection and Osteoporosis: Pathophysiology, Diagnosis, and Treatment Options

Management of Osteoporotic Fractures (EG Meinberg, Section Editor)

Co-managed Care: The Gold Standard for Geriatric Fracture Care

Management of Osteoporotic Fractures (EG Meinberg, Section Editor)

Primary Arthroplasty for Management of Osteoporotic Fractures about the Knee

Management of Osteoporotic Fractures (EG Meinberg, Section Editor)

Augmentation of Implant Fixation in Osteoporotic Bone

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Häusliche Gewalt in der orthopädischen Notaufnahme oft nicht erkannt

28.05.2024 Traumatologische Notfälle Nachrichten

In der Notaufnahme wird die Chance, Opfer von häuslicher Gewalt zu identifizieren, von Orthopäden und Orthopädinnen offenbar zu wenig genutzt. Darauf deuten die Ergebnisse einer Fragebogenstudie an der Sahlgrenska-Universität in Schweden hin.

Fehlerkultur in der Medizin – Offenheit zählt!

Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.