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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 5/2015

01.10.2015 | Therapeutics and Medical Management (E Shane and R Adler, Section Editors)

Skeletal Effects of Smoking

verfasst von: Natalie E. Cusano

Erschienen in: Current Osteoporosis Reports | Ausgabe 5/2015

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Abstract

Smoking is a leading cause of preventable death and disability. Smoking has long been identified as a risk factor for osteoporosis, with data showing that older smokers have decreased bone mineral density and increased fracture risk compared to nonsmokers, particularly at the hip. The increase in fracture risk in smokers is out of proportion to the effects on bone density, indicating deficits in bone quality. Advanced imaging techniques have demonstrated microarchitectural deterioration in smokers, particularly in the trabecular compartment. The mechanisms by which smoking affects skeletal health remain unclear, although multiple pathways have been proposed. Smoking cessation may at least partially reverse the adverse effects of smoking on the skeleton.
Literatur
1.
Jamal A, Agaku IT, O’Connor E, King BA, Kenemer JB, Neff L. Current cigarette smoking among adults—United States, 2005–2013. MMWR. 2014;63(47):1108–12.PubMed
2.
Ng M, Freeman MK, Fleming TD, Robinson M, Dwyer-Lindgren L, Thomson B, et al. Smoking prevalence and cigarette consumption in 187 countries, 1980–2012. JAMA. 2014;311(2):183–92.PubMedCrossRef
3.
4.
Daniell HW. Osteoporosis of the slender smoker. Vertebral compression fractures and loss of metacarpal cortex in relation to postmenopausal cigarette smoking and lack of obesity. Arch Intern Med. 1976;136(3):298–304.PubMedCrossRef
5.
Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J Bone Miner Res Off J Am Soc Bone Miner Res. 2007;22(3):465–75.CrossRef
6.
Kanis JA, Johnell O, Oden A, Johansson H, De Laet C, Eisman JA, et al. Smoking and fracture risk: a meta-analysis. Osteoporosis Int J Established Result Cooperation Between Eur Found Osteoporosis Natl Osteoporosis Found USA. 2005;16(2):155–62.CrossRef
7.
Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002;359(9321):1929–36.PubMedCrossRef
8.
Law MR, Hackshaw AK. A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect. BMJ. 1997;315(7112):841–6.PubMedCentralPubMedCrossRef
9.
Ward KD, Klesges RC. A meta-analysis of the effects of cigarette smoking on bone mineral density. Calcif Tissue Int. 2001;68(5):259–70.PubMedCrossRef
10.
Kiel DP, Zhang Y, Hannan MT, Anderson JJ, Baron JA, Felson DT. The effect of smoking at different life stages on bone mineral density in elderly men and women. Osteoporosis Int J Established Result Cooperation Between Eur Found Osteoporosis Natl Osteoporosis Found USA. 1996;6(3):240–8.CrossRef
11.
Vestergaard P, Mosekilde L. Fracture risk associated with smoking: a meta-analysis. J Intern Med. 2003;254(6):572–83.PubMedCrossRef
12.
Osteoporosis prevention, diagnosis, and therapy. NIH consensus statement. 2000;29;17(1):1-36.
13.
Leslie WD, Rubin MR, Schwartz AV, Kanis JA. Type 2 diabetes and bone. J Bone Miner Res Off J Am Soc Bone Miner Res. 2012;27(11):2231–7.CrossRef
14.
Stein EM, Silva BC, Boutroy S, Zhou B, Wang J, Udesky J, et al. Primary hyperparathyroidism is associated with abnormal cortical and trabecular microstructure and reduced bone stiffness in postmenopausal women. J Bone Miner Res Off J Am Soc Bone Miner Res. 2013;28(5):1029–40.CrossRef
15.••
Szulc P, Debiesse E, Boutroy S, Vilauphiou N, Chapurlat R. Poor trabecular microarchitecture in male current smokers: the cross-sectional STRAMBO study. Calcif Tissue Int. 2011;89(4):303–11. This paper provides important data on skeletal microarchitectural changes in adult male smokers.PubMedCrossRef
16.
Lorentzon M, Mellstrom D, Haug E, Ohlsson C. Smoking is associated with lower bone mineral density and reduced cortical thickness in young men. J Clin Endocrinol Metab. 2007;92(2):497–503.PubMedCrossRef
17.••
Rudang R, Darelid A, Nilsson M, Nilsson S, Mellstrom D, Ohlsson C, et al. Smoking is associated with impaired bone mass development in young adult men: a 5-year longitudinal study. J Bone Miner Res Off J Am Soc Bone Miner Res. 2012;27(10):2189–97. Paper presents evidence that smoking impairs bone quality in young men.CrossRef
18.
Taes Y, Lapauw B, Vanbillemont G, Bogaert V, De Bacquer D, Goemaere S, et al. Early smoking is associated with peak bone mass and prevalent fractures in young, healthy men. J Bone Miner Res Off J Am Soc Bone Miner Res. 2010;25(2):379–87.CrossRef
19.
Nelson HD, Nevitt MC, Scott JC, Stone KL, Cummings SR. Smoking, alcohol, and neuromuscular and physical function of older women. Study of Osteoporotic Fractures Research Group. JAMA. 1994;272(23):1825–31.PubMedCrossRef
20.
Szulc P, Duboeuf F, Marchand F, Delmas PD. Hormonal and lifestyle determinants of appendicular skeletal muscle mass in men: the MINOS study. Am J Clin Nutr. 2004;80(2):496–503.PubMed
21.
Fletcher PC, Hirdes JP. Risk factor for accidental injuries within senior citizens’ homes: analysis of the Canadian survey on ageing and independence. J Gerontol Nurs. 2005;31(2):49–57.PubMedCrossRef
22.
Faulkner KA, Cauley JA, Studenski SA, Landsittel DP, Cummings SR, Ensrud KE, et al. Lifestyle predicts falls independent of physical risk factors. Osteoporosis Int J Established Result Cooperation Between Eur Found Osteoporosis Natl Osteoporosis Found USA. 2009;20(12):2025–34.CrossRef
23.
Lord SR, Ward JA, Williams P, Anstey KJ. An epidemiological study of falls in older community-dwelling women: the Randwick falls and fractures study. Aust J Public Health. 1993;17(3):240–5.PubMedCrossRef
24.
Grundstrom AC, Guse CE, Layde PM. Risk factors for falls and fall-related injuries in adults 85 years of age and older. Arch Gerontol Geriatr. 2012;54(3):421–8.PubMedCentralPubMedCrossRef
25.•
Cairoli E, Eller-Vainicher C, Ulivieri FM, Zhukouskaya VV, Palmieri S, Morelli V, et al. Factors associated with bisphosphonate treatment failure in postmenopausal women with primary osteoporosis. Osteoporosis Int J Established Result Cooperation Between Eur Found Osteoporosis Natl Osteoporosis Found USA. 2014;25(4):1401–10. Paper provides data that smoking may cause bisphosphonate treatment failure.CrossRef
26.•
Scolaro JA, Schenker ML, Yannascoli S, Baldwin K, Mehta S, Ahn J. Cigarette smoking increases complications following fracture: a systematic review. J Bone Joint Surg Am. 2014;96(8):674–81. Excellent review of the post-fracture complications of smoking.PubMedCrossRef
27.
28.
Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, Gundisch D, et al. Nicotine decreases food intake through activation of POMC neurons. Science. 2011;332(6035):1330–2.PubMedCentralPubMedCrossRef
29.
Krall EA, Dawson-Hughes B. Smoking and bone loss among postmenopausal women. J Bone Miner Res Off J Am Soc Bone Miner Res. 1991;6(4):331–8.CrossRef
30.
Krall EA, Dawson-Hughes B. Smoking increases bone loss and decreases intestinal calcium absorption. J Bone Miner Res Off J Am Soc Bone Miner Res. 1999;14(2):215–20.CrossRef
31.
Landin-Wilhelmsen K, Wilhelmsen L, Lappas G, Rosen T, Lindstedt G, Lundberg PA, et al. Serum intact parathyroid hormone in a random population sample of men and women: relationship to anthropometry, life-style factors, blood pressure, and vitamin D. Calcif Tissue Int. 1995;56(2):104–8.PubMedCrossRef
32.
Brot C, Jorgensen NR, Sorensen OH. The influence of smoking on vitamin D status and calcium metabolism. Eur J Clin Nutr. 1999;53(12):920–6.PubMedCrossRef
33.
Szulc P, Garnero P, Claustrat B, Marchand F, Duboeuf F, Delmas PD. Increased bone resorption in moderate smokers with low body weight: the Minos study. J Clin Endocrinol Metab. 2002;87(2):666–74.PubMedCrossRef
34.
Wong PK, Christie JJ, Wark JD. The effects of smoking on bone health. Clin Sci (Lond). 2007;113(5):233–41.CrossRef
35.
Winternitz WW, Quillen D. Acute hormonal response to cigarette smoking. J Clin Pharmacol. 1977;17(7):389–97.PubMedCrossRef
36.
Wilkins JN, Carlson HE, Van Vunakis H, Hill MA, Gritz E, Jarvik ME. Nicotine from cigarette smoking increases circulating levels of cortisol, growth hormone, and prolactin in male chronic smokers. Psychopharmacology (Berlin). 1982;78(4):305–8.CrossRef
37.
Seyler Jr LE, Fertig J, Pomerleau O, Hunt D, Parker K. The effects of smoking on ACTH and cortisol secretion. Life Sci. 1984;34(1):57–65.PubMedCrossRef
38.
Baron JA, Comi RJ, Cryns V, Brinck-Johnsen T, Mercer NG. The effect of cigarette smoking on adrenal cortical hormones. J Pharmacol Exp Ther. 1995;272(1):151–5.PubMed
39.
Field AE, Colditz GA, Willett WC, Longcope C, McKinlay JB. The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men. J Clin Endocrinol Metab. 1994;79(5):1310–6.PubMed
40.
Yeh J, Barbieri RL. Twenty-four-hour urinary-free cortisol in premenopausal cigarette smokers and nonsmokers. Fertil Steril. 1989;52(6):1067–9.PubMed
41.
McKinlay SM, Bifano NL, McKinlay JB. Smoking and age at menopause in women. Ann Intern Med. 1985;103(3):350–6.PubMedCrossRef
42.
Midgette AS, Baron JA. Cigarette smoking and the risk of natural menopause. Epidemiology. 1990;1(6):474–80.PubMedCrossRef
43.
Bjarnason NH, Christiansen C. The influence of thinness and smoking on bone loss and response to hormone replacement therapy in early postmenopausal women. J Clin Endocrinol Metab. 2000;85(2):590–6.PubMedCrossRef
44.
Michnovicz JJ, Hershcopf RJ, Naganuma H, Bradlow HL, Fishman J. Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking. N Engl J Med. 1986;315(21):1305–9.PubMedCrossRef
45.
Briggs MH. Cigarette smoking and infertility in men. Med J Aust. 1973;1(12):616–7.PubMed
46.
Shaarawy M, Mahmoud KZ. Endocrine profile and semen characteristics in male smokers. Fertil Steril. 1982;38(2):255–7.PubMed
47.
English KM, Pugh PJ, Parry H, Scutt NE, Channer KS, Jones TH. Effect of cigarette smoking on levels of bioavailable testosterone in healthy men. Clin Sci (Lond). 2001;100(6):661–5.CrossRef
48.
Wang W, Yang X, Liang J, Liao M, Zhang H, Qin X, et al. Cigarette smoking has a positive and independent effect on testosterone levels. Hormones (Athens). 2013;12(4):567–77.CrossRef
49.
Duthie GG, Arthur JR, James WP. Effects of smoking and vitamin E on blood antioxidant status. Am J Clin Nutr. 1991;53(4 Suppl):1061S–3.PubMed
50.
Valavanidis A, Vlachogianni T, Fiotakis K. Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles. Int J Environ Res Public Health. 2009;6(2):445–62.PubMedCentralPubMedCrossRef
51.
Callaway DA, Jiang JX. Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases. J Bone Miner Metab. 2015.
52.
Melhus H, Michaelsson K, Holmberg L, Wolk A, Ljunghall S. Smoking, antioxidant vitamins, and the risk of hip fracture. J Bone Miner Res Off J Am Soc Bone Miner Res. 1999;14(1):129–35.CrossRef
53.•
Yan C, Avadhani NG, Iqbal J. The effects of smoke carcinogens on bone. Curr Osteoporos Rep. 2011;9(4):202–9. Excellent review on the effects of nicotine and other cigarette toxins on bone tissue.PubMedCrossRef
54.
Walker LM, Preston MR, Magnay JL, Thomas PB, El Haj AJ. Nicotinic regulation of c-fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ culture. Bone. 2001;28(6):603–8.PubMedCrossRef
55.
Wejheden C, Brunnberg S, Larsson S, Lind PM, Andersson G, Hanberg A. Transgenic mice with a constitutively active aryl hydrocarbon receptor display a gender-specific bone phenotype. Toxicol Sci. 2010;114(1):48–58.PubMedCrossRef
56.
Singh SU, Casper RF, Fritz PC, Sukhu B, Ganss B, Girard Jr B, et al. Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol. J Endocrinol. 2000;167(1):183–95.PubMedCrossRef
57.•
Ko CH, Chan RL, Siu WS, Shum WT, Leung PC, Zhang L, et al. Deteriorating effect on bone metabolism and microstructure by passive cigarette smoking through dual actions on osteoblast and osteoclast. Calcif Tissue Int. 2015;96(5):389–400. This paper provides evidence that passive smoking exposure may have direct effects on osteoblasts and osteoclasts.PubMedCrossRef
58.
Nguyen TV, Kelly PJ, Sambrook PN, Gilbert C, Pocock NA, Eisman JA. Lifestyle factors and bone density in the elderly: implications for osteoporosis prevention. J Bone Miner Res Off J Am Soc Bone Miner Res. 1994;9(9):1339–46.CrossRef
59.
Hollenbach KA, Barrett-Connor E, Edelstein SL, Holbrook T. Cigarette smoking and bone mineral density in older men and women. Am J Public Health. 1993;83(9):1265–70.PubMedCentralPubMedCrossRef
60.
Cornuz J, Feskanich D, Willett WC, Colditz GA. Smoking, smoking cessation, and risk of hip fracture in women. Am J Med. 1999;106(3):311–4.PubMedCrossRef
61.
Olofsson H, Byberg L, Mohsen R, Melhus H, Lithell H, Michaelsson K. Smoking and the risk of fracture in older men. J Bone Miner Res Off J Am Soc Bone Miner Res. 2005;20(7):1208–15.CrossRef
62.
Anthonisen NR, Skeans MA, Wise RA, Manfreda J, Kanner RE, Connett JE, et al. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann Intern Med. 2005;142(4):233–9.PubMedCrossRef
63.
64.
Cao Y, Kenfield S, Song Y, Rosner B, Qiu W, Sesso HD, et al. Cigarette smoking cessation and total and cause-specific mortality: a 22-year follow-up study among US male physicians. Arch Intern Med. 2011;171(21):1956–9.PubMedCentralPubMedCrossRef
Metadaten
Titel
Skeletal Effects of Smoking
verfasst von
Natalie E. Cusano
Publikationsdatum
01.10.2015
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 5/2015
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-015-0278-8

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