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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 5/2016

13.09.2016 | Biomechanics (M Silva and K Jepsen, Section Editors)

Cortical Bone Porosity: What Is It, Why Is It Important, and How Can We Detect It?

verfasst von: D. M. L. Cooper, C. E. Kawalilak, K. Harrison, B. D. Johnston, J. D. Johnston

Erschienen in: Current Osteoporosis Reports | Ausgabe 5/2016

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Abstract

There is growing recognition of the role of micro-architecture in osteoporotic bone loss and fragility. This trend has been driven by advances in imaging technology, which have enabled a transition from measures of mass to micro-architecture. Imaging trabecular bone has been a key research focus, but advances in resolution have also enabled the detection of cortical bone micro-architecture, particularly the network of vascular canals, commonly referred to as ‘cortical porosity.’ This review aims to provide an overview of what this level of porosity is, why it is important, and how it can be characterized by imaging. Moving beyond a ‘trabeculocentric’ view of bone loss holds the potential to improve diagnosis and monitoring of interventions. Furthermore, cortical porosity is intimately linked to the remodeling process, which underpins bone loss, and thus a larger potential exists to improve our fundamental understanding of bone health through imaging of both humans and animal models.
Literatur
1.
2.
Bala Y, Zebaze R, Seeman E. Role of cortical bone in bone fragility. Curr Opin Rheumatol. 2015;27(4):406–13.PubMedCrossRef
3.
Schapira D, Schapira C. Osteoporosis: the evolution of a scientific term. Osteoporos Int. 1992;2(4):164–7.PubMedCrossRef
4.
Havers C. Osteologia nova, or, some new observations of the bones and the parts belonging to them, with the manner of their accretion, and nutrition, communicated to the Royal Society in several discourses. Ann Arbor: University Microfilms International; 1691.
5.
Leeuwenhoeck A. Microscopical observations of the structure of teeth and other bones: made and communicated, in a Letter by Mr. Anthony Leeuwenhoeck. Philos Trans R Soc Lond B Biol Sci. 1677–78;12:1002–3.
6.••
Zebaze R, Seeman E. Cortical bone: a challenging geography. J Bone Miner Res: Off J Am Soc Bone Miner Res. 2015;30(1):24–9. Review emphasizing the importance of cortical porosity in age-related bone loss and ultimately fracture. This study candidly discusses the problem of accurately imaging cortical porosity with modern imaging technology using practical examples and contemporary studies.
7.
Buenzli PR, Sims NA. Quantifying the osteocyte network in the human skeleton. Bone. 2015;75:144–50.PubMedCrossRef
8.••
Kawalilak CE, Johnston JD, Olszynski WP, Kontulainen SA. Characterizing micro-architectural changes at the distal radius and tibia in postmenopausal women using HR-pQCT. Osteoporos Int. 2014;25(8):2057–66. Report annual changes in trabecular and cortical bone micro-architecture at the distal radius and tibia in postmenopausal women. Lost trabeculae with corresponding increase in trabecular thickness at the radius and thinning tibial cortex indicated trabecularization of the cortex at both sites.
9.••
Currey JD, Shahar R. Cavities in the compact bone in tetrapods and fish and their effect on mechanical properties. J Struct Biol. 2013;183(2):107–22. Extensive comparative review of the organization of cortical bone porosity and its functional significance.PubMedCrossRef
10.
Tomes J, de Morgan C. Observations on the structure and development of bone. Philos Trans R Soc Lond B Biol Sci. 1853;143:109–39.CrossRef
11.
Johnson LC. Morphologic analysis of pathology. In: Frost HM, editor. Bone biodynamics. Boston: Little, Brown, and Company; 1964. p. 543–654.
12.
Hattner R, Epker BN, Frost HM. Suggested sequential mode of control of changes in cell behavior in adult bone remodeling. Nature. 1965;206:489–90.PubMedCrossRef
13.
Jee WS. The past, present, and future of bone morphometry: its contribution to an improved understanding of bone biology. J Bone Miner Metab. 2005;23(Suppl):1–10.PubMed
14.
Frost HM. Tetracycline-based histological analysis of bone remodeling. Calcif Tissue Res. 1969;3(3):211–37.PubMedCrossRef
15.
Cooper DML, Thomas CDL, Clement JG, Hallgrímsson B. Three-dimensional microcomputed tomography imaging of basic multicellular unit-related resorption spaces in human cortical bone. Anat Rec A: Discov Mol Cell Evol Biol. 2006;288A(7):806–16.CrossRef
16.
Britz HM, Thomas CD, Clement JG, Cooper DM. The relation of femoral osteon geometry to age, sex, height and weight. Bone. 2009;45(1):77–83.PubMedCrossRef
17.
Parfitt AM. Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem. 1994;55(3):273–86.PubMedCrossRef
18.
Jaworski ZF, Meunier P, Frost HM. Observations on two types of resorption cavities in human lamellar cortical bone. Clin Orthop Relat Res. 1972;83:279–85.PubMedCrossRef
19.
Richman EA, Ortner DJ, Schulter-Ellis FP. Differences in intracortical bone remodeling in three aboriginal American populations: possible dietary factors. Calcif Tissue Int. 1979;28(3):209–14.PubMedCrossRef
20.
Cooper DML, Thomas CDL, Clement JG, Turinsky AL, Sensen CW, Hallgrímsson B. Age-dependent change in the 3D structure of cortical porosity at the human femoral midshaft. Bone. 2007;40(4):957–65.PubMedCrossRef
21.
Bui M, Bjornerem A, Ghasem-Zadeh A, Dite GS, Hopper JL, Seeman E. Architecture of cortical bone determines in part its remodelling and structural decay. Bone. 2013;55(2):353–8.PubMedCrossRef
22.
Cardoso L, Fritton SP, Gailani G, Benalla M, Cowin SC. Advances in assessment of bone porosity, permeability and interstitial fluid flow. J Biomech. 2013;46(2):253–65.PubMedCrossRef
23.
MacNeil JA, Boyd SK. Load distribution and the predictive power of morphological indices in the distal radius and tibia by high resolution peripheral quantitative computed tomography. Bone. 2007;41(1):129–37.PubMedCrossRef
24.
Spadaro JA, Werner FW, Brenner RA, Fortino MD, Fay LA, Edwards WT. Cortical and trabecular bone contribute strength to the osteopenic distal radius. J Orthop Res. 1994;12(2):211–8.PubMedCrossRef
25.
Augat P, Claes LE. Prediction of fracture load at different skeletal sites by geometric properties of the cortical shell. J Bone Miner Res. 1996;11(9):1356–63.PubMedCrossRef
26.
Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S. Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia. J Bone Miner Res. 2010;25(5):983–93.PubMed
27.
Rockoff SD, Sweet E, Bleustein J. The relative contribution of trabecular and cortical bone to the strength of the human lumbar vertebrae. Calcif Tissue Res. 1969;3:163–75.PubMedCrossRef
28.
Holzer G, von Skrbensky G, Holzer LA, Pichl W. Hip fractures and the contribution of cortical versus trabecular bone to femoral neck strength. J Bone Miner Res. 2009;24(3):468–74.PubMedCrossRef
29.
Augat P, Schorlemmer S. The role of cortical bone and its microstructure in bone strength. Age Ageing. 2006;35 Suppl 2:ii27–31.PubMed
30.
McCalden RW, McGeough JA, Barker MB, Court-Brown CM. Age related changes in the tensile properties of cortical bone. J Bone Joint Surg. 1993;75A(8):1193–205.
31.
Currey JD. Changes in the impact energy absorption of bone with age. J Biomech. 1979;12:459–69.PubMedCrossRef
32.
Currey JD. The effect of porosity and mineral content on the Young’s modulus of elasticity of compact bone. J Biomech. 1988;21(2):131–9.PubMedCrossRef
33.
Currey J. Incompatible mechanical properties in compact bone. J Theor Biol. 2004;231(4):569–80.PubMedCrossRef
34.
Schaffler MB, Burr DB. Stiffness of compact bone: effects of porosity and density. J Biomech. 1988;21(1):13–6.PubMedCrossRef
35.
Schaffler MB, Burr DB. Stiffness of compact bone: effects of porosity and density. J Biomech. 1988;21(1):13–6.PubMedCrossRef
36.
Martin RB. Porosity and specific surface of bone. Crit Rev BIomed Eng. 1984;10:179–222.PubMed
37.
Troy KL, Grabiner MD. Off-axis loads cause failure of the distal radius at lower magnitudes than axial loads: a finite element analysis. J Biomech. 2007;40(8):1670–5.PubMedPubMedCentralCrossRef
38.
Lotz JC, Cheal EJ, Hayes WC. Stress distributions within the proximal femur during gait and falls: implications for osteoporotic fracture. Osteoporos Int. 1995;5:252–61.PubMedCrossRef
39.
de Bakker PM, Manske SL, Ebacher V, Oxland TR, Cripton PA, Guy P. During sideways falls proximal femur fractures initiate in the superolateral cortex: evidence from high-speed video of simulated fractures. J Biomech. 2009;42(12):1917–25.PubMedCrossRef
40.
Edwards WB, Troy KL. Simulating distal radius fracture strength using biomechanical tests: a modeling study examining the influence of boundary conditions. J Biomech Eng. 2011;133(11):114501.PubMedCrossRef
41.
Adam MJ, Amini M, Johnston G, Kontulainen S, Johnston JD. Distal radius strain distribution during off-axis loading. Banff: Alberta Biomedical Engineering Conference; 2014.
42.
Reilly DT, Burstein AH. The elastic and ultimate properties of compact bone tissue. J Biomech. 1975;8(6):393–405.PubMedCrossRef
43.
Zebaze RMD, Ghasem-Zadeh A, Bohte A, Iuliano-Burns S, Mirams M, Price RI, et al. Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study. Lancet. 2010;375:1729–36.PubMedCrossRef
44.••
Turnbull TL, Baumann AP, Roeder RK. Fatigue microcracks that initiate fracture are located near elevated intracortical porosity but not elevated mineralization. J Biomech. 2014;47(12):3135–42. Investigated spatial correlation between cortical porosity, mineralization, and micro-damage via sequential micro-CT imaging combined with fatigue loading and tensile overload to fracture. Results indicated human cortical bone to be tolerant of most micro-cracks, but a single micro-crack of sufficient size located in spatial proximity to cortical porosity compromised fracture resistance.
45.•
Patsch JM, Burghardt AJ, Yap SP, Baum T, Schwartz AV, Joseph GB, et al. Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures. J Bone Miner Res. 2013;28(2):313–24. Investigated trabecular and cortical bone micro-architecture and strength at the distal radius and tibia in postmenopausal women with type 2 diabetes with and without fragility fractures. Deficits in stiffness, failure load, and cortical load fraction were linked to cortical porosity. Results indicated that severe deficits in cortical bone were responsible for fragility fractures in postmenopausal diabetic women.
46.
Bell KL, Loveridge N, Jordan GR, Power CR. A novel mechanism for induction of increased cortical porosity in cases of intracapsular hip fracture. Bone. 2000;26:305–13.PubMedCrossRef
47.•
Bala Y, Zebaze R, Ghasem-Zadeh A, Atkinson EJ, Iuliano S, Peterson JM, et al. Cortical porosity identifies women with osteopenia at increased risk for forearm fractures. J Bone Miner Res. 2014;29(6):1356–62. Investigated cortical porosity at the distal radius in postmenopausal women with and without forearm fractures. In women with osteoporosis, measuring cortical porosity did not improve diagnostic sensitivity more so than aBMD. However, in women with osteopenia, cortical porosity was associated with forearm fractures.
48.
Bell KL, Loveridge N, Power J, Garrahan N, Meggitt BF, Reeve J. Regional differences in cortical porosity in the fractured femoral neck. Bone. 1999;24(1):57–64.PubMedCrossRef
49.
Martin RB, Burr DB, Sharkey NA. Skeletal tissue mechanics. New York: Springer; 1998.CrossRef
50.
Anderson TL. Fracture mechanics: fundamentals and applications. 3rd ed. Boca Raton: Taylor and Francis Group; 2005.
51.
WHO scientific group on the assessment of osteoporosis at primary health care level. WHO Scientific Group on the Assessment of Osteoporosis at the Primary Health Care Level; 7-MAY-2004; Brussels, WHO Press; 2004.
52.
Beck T. Measuring the structural strength of bones with dual-energy X-ray absorptiometry: principles, technical limitations, and future possibilities. Osteoporos Int. 2003;14 Suppl 5:S81–8.PubMedCrossRef
53.
Sanders KM, Nicholson GC, Watts JJ, Pasco JA, Henry MJ, Kotowicz MA, et al. Half the burden of fragility fractures in the community occur in women without osteoporosis. When is fracture prevention cost-effective? Bone. 2006;38(5):694–700.PubMedCrossRef
54.
Stone KL, Seeley DG, Lui L-Y, Cauley JA, Ensrud K, Browner W, et al. BMD at multiple sites and risk of fracture of multiple types: long-term results from the study of osteoporotic fractures. J Bone Miner Res. 2003;18(11):1947–54.PubMedCrossRef
55.
Sornay-Rendu E, Munoz F, Garnero P, Duboeuf F, Delmas PD. Identification of osteopenic women at high risk of fracture: the OFELY study. J Bone Miner Res. 2005;20(10):1813–9.PubMedCrossRef
56.
Cranney A, Jamal SA, Tsang JF, Josse RG, Leslie WD. Low bone mineral density and fracture burden in postmenopausal women. Can Med Assoc J (CMAJ). 2007;177(6):575–80.CrossRef
57.
Burghardt AJ, Buie HR, Laib A, Majumdar S, Boyd SK. Reproducibility of direct quantitative measures of cortical bone micro-architecture of the distal radius and tibia by HR-pQCT. Bone. 2010;47(3):519–28.PubMedPubMedCentralCrossRef
58.
Dalzell N, Kaptoge S, Morris N, Berthier A, Koller B, Braak L, et al. Bone micro-architecture and determinants of strength in the radius and tibia: age-related changes in a population-based study of normal adults measured with high-resolution pQCT. Osteoporos Int. 2009;20(10):1683–94.PubMedCrossRef
59.
Macdonald HM, Nishiyama KK, Kang J, Hanley DA, Boyd SK. Age-related patterns of trabecular and cortical bone loss differ between sexes and skeletal sites: a population-based HR-pQCT study. J Bone Miner Res. 2011;26(1):50–62.PubMedCrossRef
60.
Nishiyama KK, Macdonald HM, Buie HR, Hanley DA, Boyd SK. Postmenopausal women with osteopenia have higher cortical porosity and thinner cortices at the distal radius and tibia than women with normal aBMD: an in vivo HR-pQCT study. J Bone Miner Res. 2010;25(4):882–90.PubMed
61.
Nishiyama KK, Macdonald HM, Hanley DA, Boyd SK. Women with previous fragility fractures can be classified based on bone micro-architecture and finite element analysis measured with HR-pQCT. Osteoporos Int. 2012;24(5):1733–40.PubMedCrossRef
62.
Kontulainen S, Hughes JM, Macdonald HM, Johnston JD. The biomechanical basis of bone strength development during growth. In: Daly RM, Petit MA, editors. Optimizing bone mass and strength: the role of physical activity and nutrition during growth. 51. Basel: Medicine and Sport Science; 2007. p. 13–32.CrossRef
63.
Sornay-Rendu E, Boutroy S, Munoz F, Delmas PD. Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study. J Bone Miner Res. 2007;22(3):425–33.PubMedCrossRef
64.
Beck TJ. Hip structural analysis (HSA) program: BMD and structural geometry methodology. John Hopkins University: 2002.
65.
Beck TJ, Ruff CB, Warden KE, Scott Jr WW, Rao GU. Predicting femoral neck strength from bone mineral data: a structural approach. Invest Radiol. 1990;25(1):6–18.PubMedCrossRef
66.
Krug R, Burghardt AJ, Majumdar S, Link TM. High-resolution imaging techniques for the assessment of osteoporosis. Radiol Clin N Am. 2010;48(3):601–21.PubMedPubMedCentralCrossRef
67.
Li B, Aspden RM. Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarthritis. J Bone Miner Res: Off J Am Soc Bone Min Res. 1997;12(4):641–51.CrossRef
68.
Bousson V, Bergot C, Meunier A, Barbot F, Parlier-Cuau C, Laval-Jeantet AM, et al. CT of the middiaphyseal femur: cortical bone mineral density and relation to porosity. Radiology. 2000;217:179–87.PubMedCrossRef
69.
Rantalainen T, Nikander R, Heinonen A, Daly RM, Sievanen H. An open source approach for regional cortical bone mineral density analysis. J Musculoskelet Neuronal Interact. 2011;11(3):243–8.PubMed
70.•
Kawalilak CE, Johnston JD, Cooper DM, Olszynski WP, Kontulainen SA. Role of endocortical contouring methods on precision of HR-pQCT-derived cortical micro-architecture in postmenopausal women and young adults. Osteoporos Int. 2016;27(2):789–96. Compared precision of cortical bone metrics between automatically generated cortical contour and manual cortical contour using HR-pQCT in vivo in postmenopausal women. Study illustrated that in vivo measures of cortical porosity are possible and repeatable (with <10 % error) in postmenopausal women.
71.
Tjong W, Kazakia GJ, Burghardt AJ, Majumdar S. The effect of voxel size on high-resolution peripheral computed tomography measurements of trabecular and cortical bone microstructure. Med Phys. 2012;39(4):1893–903.PubMedPubMedCentralCrossRef
72.••
Ostertag A, Peyrin F, Fernandez S, Laredo JD, de Vernejoul MC, Chappard C. Cortical measurements of the tibia from high resolution peripheral quantitative computed tomography images: a comparison with synchrotron radiation micro-computed tomography. Bone. 2014;63C:7–14. Validated cortical porosity measures using HR-pQCT in cadaveric tibia to (gold standard) synchrotron using standard analysis methods. This research concluded that HR-pQCT can be used to accurately measure large resorption pores ex vivo at the distal tibia in humans. This also indicated that HR-pQCT underestimates cortical pore metrics relative to synchrotron.
73.•
Jorgenson BL, Buie HR, McErlain DD, Sandino C, Boyd SK. A comparison of methods for in vivo assessment of cortical porosity in the human appendicular skeleton. Bone. 2015;73:167–75. Research goal was to validate cortical porosity measures for HR-pQCT to (gold standard) synchrotron comparing two different analysis methods. This research concluded that HR-pQCT can be used to accurately measure large resorption pores ex vivo in human tibial shaft. This also indicated that HR-pQCT underestimates cortical pore metrics relative to synchrotron.
74.••
Chappard C, Bensalah S, Olivier C, Gouttenoire PJ, Marchadier A, Benhamou C, et al. 3D characterization of pores in the cortical bone of human femur in the elderly at different locations as determined by synchrotron micro-computed tomography images. Osteoporos Int. 2013;24(3):1023–33. The goal of this study was to characterize the 3D morphology and connectivity of the cortical pore network at different locations in the human femur that are subjected to different loading conditions using micro-CT and synchrotron. The study concluded that there are large variations in cortical pore structure and suggest cause being different remodeling mechanisms. This also provided an estimate for cortical porosity and a size range for cortical pore diameter.
75.
Geusens P, Chapurlat R, Schett G, Ghasem-Zadeh A, Seeman E, de Jong J, et al. High-resolution in vivo imaging of bone and joints: a window to micro-architecture. Nat Rev Rheumatol. 2014;10(5):304–13.PubMedCrossRef
76.
Muller R. Hierarchical microimaging of bone structure and function. Nat Rev Rheumatol. 2009;5(7):373–81.PubMedCrossRef
77.•
Zebaze R, Ghasem-Zadeh A, Mbala A, Seeman E. A new method of segmentation of compact-appearing, transitional and trabecular compartments and quantification of cortical porosity from high resolution peripheral quantitative computed tomographic images. Bone. 2013;54(1):8–20. The goal of this study was to create an accurate and repeatable segmentation method to define the transition region between the cortical and trabecular bones furthering the examination of cortical trabecularization at the endocortical/endosteal region. Importance of this is to be able to better identify those at risk of fracture.
78.
Goldenstein J, Kazakia G, Majumdar S. In vivo evaluation of the presence of bone marrow in cortical porosity in postmenopausal osteopenic women. Ann Biomed Eng. 2010;38(2):235–46.PubMedCrossRef
79.••
Bae WC, Patil S, Biswas R, Li S, Chang EY, Statum S, et al. Magnetic resonance imaging assessed cortical porosity is highly correlated with muCT porosity. Bone. 2014;66:56–61. Imaged bone water using fast spin echo sequences with MR imaging and correlated it with measures of micro-CT cortical porosity so as to validate MRI’s ability to quantify cortical porosity and obtain in vivo clinical assessment of cortical porosity.
80.
Chen J, Grogan SP, Shao H, D’Lima D, Bydder GM, Wu Z, et al. Evaluation of bound and pore water in cortical bone using ultrashort-TE MRI. NMR Biomed. 2015;28(12):1754–62.PubMedCrossRef
81.
Akbari A, Abbasi-Rad S, Rad HS. T correlates age: a short-TE MR relaxometry study in vivo on human cortical bone free water at 1.5T. Bone. 2016;83:17–22.PubMedCrossRef
82.
Chang EY, Bae WC, Shao H, Biswas R, Li S, Chen J, et al. Ultrashort echo time magnetization transfer (UTE-MT) imaging of cortical bone. NMR Biomed. 2015;28(7):873–80.PubMedPubMedCentralCrossRef
83.
Granke M, Does MD, Nyman JS. The role of water compartments in the material properties of cortical bone. Calcif Tissue Int. 2015;97(3):292–307.PubMedPubMedCentralCrossRef
84.
Manhard MK, Horch RA, Harkins KD, Gochberg DF, Nyman JS, Does MD. Validation of quantitative bound- and pore-water imaging in cortical bone. Magn Reson Med. 2014;71(6):2166–71.PubMedCrossRef
85.
Rajapakse CS, Bashoor-Zadeh M, Li C, Sun W, Wright A, Wehrli FW. Volumetric cortical bone porosity assessment with MR imaging: validation and clinical feasibility. Radiology. 2015;276(2):526–35.PubMedPubMedCentralCrossRef
86.
Seifert AC, Wehrli SL, Wehrli FW. Bi-component T2* analysis of bound and pore bone water fractions fails at high field strengths. NMR Biomed. 2015;28(7):861–72.PubMedPubMedCentralCrossRef
87.
Du J, Hermida JC, Diaz E, Corbeil J, Znamirowski R, D’Lima DD, et al. Assessment of cortical bone with clinical and ultrashort echo time sequences. Magn Reson Med. 2013;70(3):697–704.PubMedCrossRef
88.
Wang X, Qingwen N. Determination of cortical bone porosity and pore size distribution using a low field pulsed NMR approach. J Orthop Res. 2003;21:312–9.PubMedCrossRef
89.
Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, et al. In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging. J Bone Miner Res. 2008;23(4):463–74.PubMedCrossRef
90.
Flannery BP, Deckman HW, Roberge WG, D’Amico KL. Three-dimensional X-ray microtomography. Science. 1987;237:1439.PubMedCrossRef
91.
Feldkamp LA, Goldstein SA, Parfitt MA, Jesion G, Kleerekoper M. The direct examination of three-dimensional bone architecture in vitro by computed tomography. J Bone Miner Res. 1989;4(1):3–11.PubMedCrossRef
92.
Borah B, Gross GJ, Dufresne TE, Smith TS, Cockman MD, Chmielewski PA, et al. Three-dimensional microimaging (MRmicroI and microCT), finite element modeling, and rapid prototyping provide unique insights into bone architecture in osteoporosis. Anat Rec. 2001;265(2):101–10.PubMedCrossRef
93.
Jiang Y, Zhao J, White DL, Genant HK. Micro CT and micro MR imaging of 3D architecture of animal skeleton. J Musculoskelet Neuronal Interact. 2000;1(1):45–51.PubMed
94.
Dalstra M, Karaj E, Beckmann F, Andersen T, Cattaneo PM. Osteonal mineralization patterns in cortical bone studied by synchrotron-radiation-based computed microtomography and scanning acoustic microscopy. 2004 In: SPIE Proceedings Vol 5535 Developments in X-ray Tomography IV.
95.
Bousson V, Peyrin F, Bergot C, Hausard M, Sautet A, Laredo JD. Cortical bone in the human femoral neck: three-dimensional appearance and porosity using synchrotron radiation. J Bone Min Res: Off J Am Soc Bone Miner Res. 2004;19(5):794–801.CrossRef
96.
Peyrin F, Cloetens P, editors. Synchrotron radiation μCT of biological tissue. IEEE International Symposium on Biomedical Imaging; 2002.
97.
Martin-Badosa E, Amblard D, Nuzzo S, Elmoutaouakkil A, Vico L, Peyrin F. Excised bone structures in mice: imaging at three-dimensional synchrotron radiation micro CT. Radiology. 2003;229(3):921–8.PubMedCrossRef
98.
Cooper DML, Turinsky AL, Sensen CW, Hallgrímsson B. Quantitative 3D analysis of the canal network in cortical bone by micro-computed tomography. Anat Rec Part B: New Anat. 2003;274B(1):169–79.CrossRef
99.
Perilli E, Bala Y, Zebaze R, Reynolds KJ, Seeman E. Regional heterogeneity in the configuration of the intracortical canals of the femoral shaft. Calcif Tissue Int. 2015;97(4):327–35.PubMedCrossRef
100.
Ford NL, Thornton MM, Holdsworth DW. Fundamental image quality limits for microcomputed tomography in small animals. Med Phys. 2003;30(11):2869–77.PubMedCrossRef
101.
Sietsema WK. Animal models of cortical porosity. Bone. 1995;17(4 Suppl):297S–305S.PubMed
102.
Turner AS. Animal models of osteoporosis—necessity and limitations. Eur Cells Mater. 2001;1:66–81.
103.
Jee WS, Yao W. Overview: animal models of osteopenia and osteoporosis. J Musculoskelet Neuronal Interact. 2001;1(3):193–207.PubMed
104.
Pearce AI, Richards RG, Milz S, Schneider E, Pearce SG. Animal models for implant biomaterial research in bone: a review. Eur Cells Mater. 2007;13:1–10.
105.
Reinwald S, Burr D. Review of nonprimate, large animal models for osteoporosis research. J Bone Miner Res: Off J Am Soc Bone Miner Res. 2008;23(9):1353–68.CrossRef
106.
Jilka RL. The relevance of mouse models for investigating age-related bone loss in humans. J Gerontol Ser A Biol Med Sci. 2013;68(10):1209–17.CrossRef
107.
Pazzaglia UE, Bonaspetti G, Rodella LF, Ranchetti F, Azzola F. Design, morphometry and development of the secondary osteonal system in the femoral shaft of the rabbit. J Anat. 2007;211(3):303–12.PubMedPubMedCentralCrossRef
108.
Pazzaglia UE, Congiu T, Raspanti M, Ranchetti F, Quacci D. Anatomy of the intracortical canal system: scanning electron microscopy study in rabbit femur. Clin Orthop Relat Res. 2009;467(9):2446–56.PubMedPubMedCentralCrossRef
109.
Pazzaglia UE, Zarattini G, Giacomini D, Rodella L, Menti AM, Feltrin G. Morphometric analysis of the canal system of cortical bone: an experimental study in the rabbit femur carried out with standard histology and micro-CT. Anat Histol Embryol. 2010;39(1):17–26.PubMedCrossRef
110.
Castaneda S, Calvo E, Largo R, Gonzalez-Gonzalez R, de la Piedra C, Diaz-Curiel M, et al. Characterization of a new experimental model of osteoporosis in rabbits. J Bone Miner Metab. 2008;26(1):53–9.PubMedCrossRef
111.
Baofeng L, Zhi Y, Bei C, Guolin M, Qingshui Y, Jian L. Characterization of a rabbit osteoporosis model induced by ovariectomy and glucocorticoid. Acta Orthop. 2010;81(3):396–401.PubMedPubMedCentralCrossRef
112.
Thompson DD, Simmons HA, Pirie CM, Ke HZ. FDA guidelines and animal models for osteoporosis. Bone. 1995;17(4 Suppl):125S–33S.PubMed
113.
Mosekilde L, Weisbrode SE, Safron JA, Stills HF, Jankowsky ML, Ebert DC, et al. Evaluation of the skeletal effects of combined mild dietary calcium restriction and ovariectomy in Sinclair S-1 minipigs: a pilot study. J Bone Miner Res: Off J Am Soc Bone Miner Res. 1993;8(11):1311–21.CrossRef
114.
115.••
Altman AR, Tseng W, de Bakker CMJ, Chandra A, Lan S, Huh BK, et al. Quantification of skeletal growth, modeling, and remodeling by in vivo micro computed tomography. Bone. 2015;81:370–9. Established in vivo micro-CT as a viable tool for detecting induced porosity via hormones in areas of growth in live rats. Such studies help in identifying the strengths and weaknesses of in vivo micro-CT for detecting both trabecular and cortical porosities in living tissues.
116.
Li Z, Kuhn G, von Salis-Soglio M, Cooke SJ, Schirmer M, Müller R, et al. In vivo monitoring of bone architecture and remodeling after implant insertion: the different responses of cortical and trabecular bone. Bone. 2015;81:468–77.PubMedCrossRef
117.
Zhou S-A, Brahme A. Development of phase-contrast X-ray imaging techniques and potential medical applications. Phys Med. 2008;24(3):129–48.PubMedCrossRef
118.••
Pratt IV, Belev G, Zhu N, Chapman LD, Cooper DML. In vivo imaging of rat cortical bone porosity by synchrotron phase contrast micro computed tomography. Phys Med Biol. 2015;60(1):211. Demonstrated proof-of-princple for phase contrast micro-CT imaging of cortical bone porosity in the rat. This was achieved at a radiation dose approaching that utilized in conventional laboratory in vivo micro-CT imaging.PubMedCrossRef
119.•
Harrison KD, Cooper DM. Modalities for visualization of cortical bone remodeling: the past, present, and future. Front Endocrinol. 2015;6:122. Concise overview of both current and emerging techniques for visualizing cortical bone porosity including basic multicellular units in living animals to better understand cortical remodeling.CrossRef
120.
Martin RB. Targeted bone remodeling involves BMU steering as well as activation. Bone. 2007;40(6):1574–80.PubMedCrossRef
Metadaten
Titel
Cortical Bone Porosity: What Is It, Why Is It Important, and How Can We Detect It?
verfasst von
D. M. L. Cooper
C. E. Kawalilak
K. Harrison
B. D. Johnston
J. D. Johnston
Publikationsdatum
13.09.2016
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 5/2016
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-016-0319-y

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