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11.11.2019 | Bone Marrow and Adipose Tissue (G Duque and B Lecka-Czernik, Section Editors)

Bone Marrow Adipose Tissue Quantification by Imaging

verfasst von: Ebrahim Bani Hassan, Ali Ghasem-Zadeh, Mahdi Imani, Numan Kutaiba, David K. Wright, Tara Sepehrizadeh, Gustavo Duque

Erschienen in: Current Osteoporosis Reports | Ausgabe 6/2019

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Abstract

Purpose of Review

The significance and roles of marrow adipose tissue (MAT) are increasingly known, and it is no more considered a passive fat storage but a tissue with significant paracrine and endocrine activities that can cause lipotoxicity and inflammation.

Recent Findings

Changes in the MAT volume and fatty acid composition appear to drive bone and hematopoietic marrow deterioration, and studying it may open new horizons to predict bone fragility and anemia development. MAT has the potential to negatively impact bone volume and strength through several mechanisms that are partially described by inflammaging and lipotoxicity terminology.

Summary

Evidence indicates paramount importance of MAT in age-associated decline of bone and red marrow structure and function. Currently, MAT measurement is being tested and validated by several techniques. However, purpose-specific adaptation of existing imaging technologies and, more importantly, development of new modalities to quantitatively measure MAT are yet to be done.

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•• Duque G, Li W, Adams M, Xu S, Phipps R. Effects of risedronate on bone marrow adipocytes in postmenopausal women. Osteoporos Int. 2011;22(5):1547–53. https://doi.org/10.1007/s00198-010-1353-8Bisphosphonate therapy decreases MAT volume about 10 times more than it increases bone volume; which is the very much ignored aspect of how MAT impacts bone health. Interestingly, increased bone volumes only explain a small fraction of fracture risk decline that may be predicted by MAT decline—if reliable and affordable measurement tools are developed. CrossRefPubMed

Titel: Bone Marrow Adipose Tissue Quantification by Imaging
verfasst von: Ebrahim Bani Hassan
Ali Ghasem-Zadeh
Mahdi Imani
Numan Kutaiba
David K. Wright
Tara Sepehrizadeh
Gustavo Duque
Publikationsdatum: 11.11.2019
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 6/2019
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-019-00539-5

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Bone Marrow Adipose Tissue Quantification by Imaging

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