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Current Psychiatry Reports

Erschienen in:

01.11.2017 | Genetic Disorders (F Goes, Section Editor)

Genomic Disorders in Psychiatry—What Does the Clinician Need to Know?

verfasst von: Chelsea Lowther, Gregory Costain, Danielle A. Baribeau, Anne S. Bassett

Erschienen in: Current Psychiatry Reports | Ausgabe 11/2017

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Abstract

Purpose of Review

The purpose of this review is to summarize the role of genomic disorders in various psychiatric conditions and to highlight important recent advances in the field that are of potential clinical relevance.

Recent Findings

Genomic disorders are caused by large rare recurrent deletions and duplications at certain chromosomal “hotspots” (e.g., 22q11.2, 16p11.2, 15q11-q13, 1q21.1, 15q13.3) across the genome. Most overlap multiple genes, affect development, and are associated with variable cognitive and other neuropsychiatric expression. Although individually rare, genomic disorders collectively account for a significant minority of intellectual disability, autism spectrum disorder, and schizophrenia.

Summary

Genome-wide chromosomal microarray analysis is capable of detecting all genomic disorders in a single test, offering the first opportunity for routine clinical genetic testing in psychiatric practice.

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Titel: Genomic Disorders in Psychiatry—What Does the Clinician Need to Know?
verfasst von: Chelsea Lowther
Gregory Costain
Danielle A. Baribeau
Anne S. Bassett
Publikationsdatum: 01.11.2017
Verlag: Springer US
Erschienen in: Current Psychiatry Reports / Ausgabe 11/2017
Print ISSN: 1523-3812
Elektronische ISSN: 1535-1645
DOI: https://doi.org/10.1007/s11920-017-0831-5

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Genomic Disorders in Psychiatry—What Does the Clinician Need to Know?

Abstract

Purpose of Review

Recent Findings

Summary

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