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Current Rheumatology Reports

Erschienen in:

01.07.2014 | VASCULITIS (LR ESPINOZA, SECTION EDITOR)

Genetics of ANCA-associated Vasculitides

verfasst von: Manuel F. Ugarte-Gil, Luis R. Espinoza

Erschienen in: Current Rheumatology Reports | Ausgabe 7/2014

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Abstract

The distribution of the anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) is not uniform across geographical regions and ethnic and racial groups, suggesting that genetic and environmental factors affect the pathogenesis of these diseases. In addition, genetic factors affect not only the clinical syndrome phenotypes and their prognosis, but also ANCA specificity; these data suggest that AAV may need reclassification. Several genes have been evaluated, including ANCA targets and those of the immune system, for example co-stimulatory molecules, signaling regulators, cytokines, Fc and other receptors, and other proteins. This article provides a review of genetic factors affecting the pathogenesis and prognosis of AAV. Further studies to determine the effect of genetic factors on the clinical syndrome phenotypes and ANCA specificity need to be performed across different ethnic groups.

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Titel: Genetics of ANCA-associated Vasculitides
verfasst von: Manuel F. Ugarte-Gil
Luis R. Espinoza
Publikationsdatum: 01.07.2014
Verlag: Springer US
Erschienen in: Current Rheumatology Reports / Ausgabe 7/2014
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI: https://doi.org/10.1007/s11926-014-0428-5

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