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Current Urology Reports
Erschienen in: Current Urology Reports 1/2011

01.02.2011

Impact of Genetics on the Diagnosis and Treatment of Renal Cancer

verfasst von: Eric A. Singer, Gennady Bratslavsky, Lindsay Middelton, Ramaprasad Srinivasan, W. Marston Linehan

Erschienen in: Current Urology Reports | Ausgabe 1/2011

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Abstract

Kidney cancer is a heterogeneous disease comprised of a number of histologic subtypes, each associated with unique genetic mutations, clinical features, and sensitivity to treatment. By examining families affected with the hereditary kidney cancer syndromes von Hippel-Lindau, hereditary papillary renal cell carcinoma, hereditary leiomyomatosis and renal cell carcinoma, and Birt-Hogg-Dubé, researchers have been able to identify the genes responsible for these syndromes. This work has revealed that kidney cancer is fundamentally a metabolic disorder, and as such, novel targeted therapies specific to their molecular biology have been developed and employed in both the hereditary and sporadic forms of renal cell carcinoma.
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Metadaten
Titel
Impact of Genetics on the Diagnosis and Treatment of Renal Cancer
verfasst von
Eric A. Singer
Gennady Bratslavsky
Lindsay Middelton
Ramaprasad Srinivasan
W. Marston Linehan
Publikationsdatum
01.02.2011
Verlag
Current Science Inc.
Erschienen in
Current Urology Reports / Ausgabe 1/2011
Print ISSN: 1527-2737
Elektronische ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-010-0156-y

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