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Current Urology Reports
Erschienen in: Current Urology Reports 1/2015

01.01.2015 | Kidney Diseases (G Ciancio, Section Editor)

Chronic Kidney Disease and Premature Ageing of the Adaptive Immune Response

verfasst von: Michiel GH Betjes, Nicolle HR Litjens

Erschienen in: Current Urology Reports | Ausgabe 1/2015

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Abstract

Los of renal function is associated with uremia-associated immune deficiency, which contributes significantly to the mortality and morbidity of end-stage renal disease (ESRD) patients. In this review, the effect of ESRD on the adaptive cellular immune system is discussed. Progressive loss of renal function causes a preferential loss of number and function of lymphoid cells. More in depth analysis of these changes reveals a loss of thymic function, attrition of telomeres, and expanded memory T cell population, which is compatible with the concept of premature immunological ageing. Latency for cytomegalovirus is associated with more profound changes and the expansion of a unique pro-inflammatory, cytotoxic subset of CD4-positive CD28null T cells. Epigenetically, modifications in hematopoietic stem cells may underlie uremia-associated immunological ageing, which is not reversed by kidney transplantation. Possible therapeutic options to reverse or halt uremia-associated immunological ageing are discussed.
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Metadaten
Titel
Chronic Kidney Disease and Premature Ageing of the Adaptive Immune Response
verfasst von
Michiel GH Betjes
Nicolle HR Litjens
Publikationsdatum
01.01.2015
Verlag
Springer US
Erschienen in
Current Urology Reports / Ausgabe 1/2015
Print ISSN: 1527-2737
Elektronische ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-014-0471-9

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