Skip to main content
Erschienen in: Current Treatment Options in Neurology 5/2010

01.09.2010 | Psychiatric Manifestations of Neurologic Disease

Cognitive Rehabilitation in Traumatic Brain Injury

verfasst von: Alison N. Cernich, PhD, Shira M. Kurtz, PhD, Kristen L. Mordecai, PhD, Patricia B. Ryan, PhD

Erschienen in: Current Treatment Options in Neurology | Ausgabe 5/2010

Einloggen, um Zugang zu erhalten

Opinion statement

Traumatic brain injury (TBI) is a major public health problem with neurobehavioral sequelae contributing to the long-term disability that is often associated with the moderate to severe levels of injury. Rehabilitation of cognitive skills is central to encouraging the full participation of the individual in home, vocational, and social roles. The review of available evidence points to four major recommendations for the rehabilitation of cognition following brain injury: 1) Access to subacute rehabilitation that is holistic in nature and involves a multidisciplinary or transdisciplinary team to work in an integrated fashion to support physical, cognitive, and social skill retraining is vital to support positive outcome following TBI. The collaborative effort of these individuals allows for continual reinforcement and evaluation of treatment goals and will often involve the family and/or important others in the individual’s life to prepare for community re-entry. 2) Trials of medication, especially methylphenidate, to assist individuals with significant attention and memory impairment appear well supported by the available evidence. Though some data suggest that the use of cholinesterase inhibitors may be of use for individuals with memory impairments, there is less support for this practice and there are indications that it may worsen the behavioral sequelae of the injury. 3) Randomized controlled trials demonstrate the utility of specific rehabilitation approaches to attention retraining and retraining of executive functioning skills. Future research is needed on rehabilitation techniques in other domains of cognition. 4) Training in the use of supportive devices (either a memory book or more technologically enhanced compensatory devices) to support the individual’s daily activities remains central to the independent function of the individual in the community. Though emerging treatments (eg, virtual reality environments) show relative degrees of promise for inclusion in the rehabilitation of the individual with TBI, these need further evaluation in systematic trials.
Literatur
2.
Zurück zum Zitat Faul M, Xu L, Wald MM, et al.: Traumatic brain injury in the United States: emergency department visits, hospitalizations, and deaths. Atlanta: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control; 2010. Faul M, Xu L, Wald MM, et al.: Traumatic brain injury in the United States: emergency department visits, hospitalizations, and deaths. Atlanta: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control; 2010.
3.
Zurück zum Zitat Finkelstein E, Corso P, Miller T, et al.: The Incidence and Economic Burden of Injuries in the United States. New York: Oxford University Press; 2006.CrossRef Finkelstein E, Corso P, Miller T, et al.: The Incidence and Economic Burden of Injuries in the United States. New York: Oxford University Press; 2006.CrossRef
4.
Zurück zum Zitat Masel B: Conceptualizing Brain Injury as a Chronic Disease. Vienna: Brain Injury Association of America; 2009. Masel B: Conceptualizing Brain Injury as a Chronic Disease. Vienna: Brain Injury Association of America; 2009.
5.
Zurück zum Zitat Katz DI, Ashley MJ, O’Shanick GJ, Connors SH: Cognitive Rehabilitation: The Evidence, Funding and Case for Advocacy for Brain Injury. McLean: Brain Injury Association of America; 2006. Katz DI, Ashley MJ, O’Shanick GJ, Connors SH: Cognitive Rehabilitation: The Evidence, Funding and Case for Advocacy for Brain Injury. McLean: Brain Injury Association of America; 2006.
6.
Zurück zum Zitat High WM, Sander AM, Struchen MA, et al.: Rehabilitation for Traumatic Brain Injury. New York: Oxford University Press; 2005. High WM, Sander AM, Struchen MA, et al.: Rehabilitation for Traumatic Brain Injury. New York: Oxford University Press; 2005.
7.
Zurück zum Zitat Cappa SF, Benke T, Clarket S, et al.: EFNS guidelines on cognitive rehabilitation: report of an EFNS task force. Eur J Neurol 2005, 12:665–680.CrossRefPubMed Cappa SF, Benke T, Clarket S, et al.: EFNS guidelines on cognitive rehabilitation: report of an EFNS task force. Eur J Neurol 2005, 12:665–680.CrossRefPubMed
8.
Zurück zum Zitat Cicerone KD, Dahlberg C, Malec JF, et al.: Evidence-based cognitive rehabilitation: updated review of the literature from 1998 through 2002. Arch Phys Med Rehabil 2005, 86:1681–1692.CrossRefPubMed Cicerone KD, Dahlberg C, Malec JF, et al.: Evidence-based cognitive rehabilitation: updated review of the literature from 1998 through 2002. Arch Phys Med Rehabil 2005, 86:1681–1692.CrossRefPubMed
9.
Zurück zum Zitat Malec JF, Basford JS: Post-acute brain injury rehabilitation. Arch Phys Med Rehabil 1996, 77:198–207.CrossRefPubMed Malec JF, Basford JS: Post-acute brain injury rehabilitation. Arch Phys Med Rehabil 1996, 77:198–207.CrossRefPubMed
10.
Zurück zum Zitat Parry-Jones BL, Vaughan FL, Miles Cox W: Traumatic brain injury and substance misuse: a systematic review of prevalence and outcomes research (1994-2004). Neuropsychol Rehabil 2006, 16:537–560.CrossRefPubMed Parry-Jones BL, Vaughan FL, Miles Cox W: Traumatic brain injury and substance misuse: a systematic review of prevalence and outcomes research (1994-2004). Neuropsychol Rehabil 2006, 16:537–560.CrossRefPubMed
11.••
Zurück zum Zitat Writer BW, Schillerstrom JE: Psychopharmacological treatment for cognitive impairment in survivors of traumatic brain injury: a critical review. J Neuropsychiatry Clin Neurosci 2009, 21:362–370. This paper reviews the recent evidence supporting the use of various agents to treat the neurobehavioral sequelae of traumatic brain injury. The criteria are based on a large-scale review conducted by Warden and her colleagues in 2005 [18].PubMed Writer BW, Schillerstrom JE: Psychopharmacological treatment for cognitive impairment in survivors of traumatic brain injury: a critical review. J Neuropsychiatry Clin Neurosci 2009, 21:362–370. This paper reviews the recent evidence supporting the use of various agents to treat the neurobehavioral sequelae of traumatic brain injury. The criteria are based on a large-scale review conducted by Warden and her colleagues in 2005 [18].PubMed
12.
Zurück zum Zitat Stahl SM: Stahl’s Essential Psychopharmacology: The Prescriber’s Guide, edn 3rd. New York: Cambridge University Press; 2009. Stahl SM: Stahl’s Essential Psychopharmacology: The Prescriber’s Guide, edn 3rd. New York: Cambridge University Press; 2009.
13.
Zurück zum Zitat Wilmott C, Ponsford J: Efficacy of methylphenidate in the rehabilitation of attention following traumatic brain injury: a randomized, crossover, double blind, placebo controlled inpatient trial. J Neurol Neurosurg Psychiatry 2009, 80:552–557.CrossRef Wilmott C, Ponsford J: Efficacy of methylphenidate in the rehabilitation of attention following traumatic brain injury: a randomized, crossover, double blind, placebo controlled inpatient trial. J Neurol Neurosurg Psychiatry 2009, 80:552–557.CrossRef
14.•
Zurück zum Zitat Chew E, Zafonte RD: Pharmacological management of neurobehavioral disorders following traumatic brain injury—a state-of-the-art review. J Rehabil Res Dev 2009, 46:851–879. This thorough review of all relevant medication trials includes specific, trial-by-trial tables for various aspects of cognition and behavior.CrossRefPubMed Chew E, Zafonte RD: Pharmacological management of neurobehavioral disorders following traumatic brain injury—a state-of-the-art review. J Rehabil Res Dev 2009, 46:851–879. This thorough review of all relevant medication trials includes specific, trial-by-trial tables for various aspects of cognition and behavior.CrossRefPubMed
15.
Zurück zum Zitat Ballesteros J, Guemes I, Ibarra N, et al.: The effectiveness of donepezil for cognitive rehabilitation after traumatic brain injury: a systematic review. J Head Trauma Rehabil 2008, 23:171–180.CrossRefPubMed Ballesteros J, Guemes I, Ibarra N, et al.: The effectiveness of donepezil for cognitive rehabilitation after traumatic brain injury: a systematic review. J Head Trauma Rehabil 2008, 23:171–180.CrossRefPubMed
16.
Zurück zum Zitat Tenuovou O, Alin J, Helenius H: A randomized controlled trial of rivastigmine for chronic sequels of traumatic brain injury—what it showed and taught? Brain Inj 2009, 23:548–558.CrossRef Tenuovou O, Alin J, Helenius H: A randomized controlled trial of rivastigmine for chronic sequels of traumatic brain injury—what it showed and taught? Brain Inj 2009, 23:548–558.CrossRef
17.
Zurück zum Zitat Silver JM, Koumaras B, Meng X, et al.: Long-term effects of rivastigmine capsules in patients with traumatic brain injury. Brain Inj 2009, 23:123–132.CrossRefPubMed Silver JM, Koumaras B, Meng X, et al.: Long-term effects of rivastigmine capsules in patients with traumatic brain injury. Brain Inj 2009, 23:123–132.CrossRefPubMed
18.
Zurück zum Zitat Neurobehavioral Guidelines Working Group, Warden DL, Gordon B, et al.: Guidelines for the pharmacologic treatment of neurobehavioral sequelae of traumatic brain injury. J Neurotrauma 2006, 23:1468–1501.CrossRefPubMed Neurobehavioral Guidelines Working Group, Warden DL, Gordon B, et al.: Guidelines for the pharmacologic treatment of neurobehavioral sequelae of traumatic brain injury. J Neurotrauma 2006, 23:1468–1501.CrossRefPubMed
19.
Zurück zum Zitat Whyte J, Vaccaro M, Grieb-Neff P, et al.: The effects of bromocriptine on attention deficits after traumatic brain injury. Am J Phys Med Rehabil 2008, 87:85–99.CrossRefPubMed Whyte J, Vaccaro M, Grieb-Neff P, et al.: The effects of bromocriptine on attention deficits after traumatic brain injury. Am J Phys Med Rehabil 2008, 87:85–99.CrossRefPubMed
20.
Zurück zum Zitat Sawyer E, Mauro LS, Ohlinger MJ: Amantadine enhancement of arousal and cognition after traumatic brain injury. Ann Pharmacother 2008, 42:247–252.CrossRefPubMed Sawyer E, Mauro LS, Ohlinger MJ: Amantadine enhancement of arousal and cognition after traumatic brain injury. Ann Pharmacother 2008, 42:247–252.CrossRefPubMed
21.•
Zurück zum Zitat Tsaousides T, Gordon WA: Cognitive rehabilitation following traumatic brain injury: assessment to treatment. Mt Sinai J Med 2009, 76:173–181. This paper provides a brief review of the evidence supporting common interventions, as well as descriptions of techniques to help providers who are unfamiliar with them.CrossRefPubMed Tsaousides T, Gordon WA: Cognitive rehabilitation following traumatic brain injury: assessment to treatment. Mt Sinai J Med 2009, 76:173–181. This paper provides a brief review of the evidence supporting common interventions, as well as descriptions of techniques to help providers who are unfamiliar with them.CrossRefPubMed
22.
Zurück zum Zitat Galbiati S, Recla M, Pastore VA, et al.: Attention remediation following traumatic brain injury in childhood and adolescence. Neuropsychology 2009, 23:40–49.CrossRefPubMed Galbiati S, Recla M, Pastore VA, et al.: Attention remediation following traumatic brain injury in childhood and adolescence. Neuropsychology 2009, 23:40–49.CrossRefPubMed
23.••
Zurück zum Zitat Rohling ML, Faust ME, Beverly B, et al.: Effectiveness of cognitive rehabilitation following acquired brain injury: a meta-analytic re-examination of Cicerone et al’.s (2000, 2005) systematic reviews. Neuropsychology 2009, 23:20–39. This is a large meta-analytic paper of 115 studies of cognitive rehabilitation trials. Domain-specific effects of moderate size were found for attention intervention. Only weak support was found for memory and language treatment domains. No domain-specific evidence was found for visuospatial treatments. However, the authors noted that findings based on single group pretest/posttest designs (61% of studies considered) may overrepresent naturally occurring retest effects. Age, etiology of deficit, and recovery level were also noted to be significant confounders in rehabilitation studies.CrossRefPubMed Rohling ML, Faust ME, Beverly B, et al.: Effectiveness of cognitive rehabilitation following acquired brain injury: a meta-analytic re-examination of Cicerone et al’.s (2000, 2005) systematic reviews. Neuropsychology 2009, 23:20–39. This is a large meta-analytic paper of 115 studies of cognitive rehabilitation trials. Domain-specific effects of moderate size were found for attention intervention. Only weak support was found for memory and language treatment domains. No domain-specific evidence was found for visuospatial treatments. However, the authors noted that findings based on single group pretest/posttest designs (61% of studies considered) may overrepresent naturally occurring retest effects. Age, etiology of deficit, and recovery level were also noted to be significant confounders in rehabilitation studies.CrossRefPubMed
24.
Zurück zum Zitat Vallat-Azouvi C, Pradat-Diehl P, Azouvi P: Rehabilitation of the central executive of working memory after severe traumatic brain injury: two single-case studies. Brain Inj 2009, 23:585–594.CrossRefPubMed Vallat-Azouvi C, Pradat-Diehl P, Azouvi P: Rehabilitation of the central executive of working memory after severe traumatic brain injury: two single-case studies. Brain Inj 2009, 23:585–594.CrossRefPubMed
25.
Zurück zum Zitat Raskin SA, Sohlberg MM: Prospective memory intervention: a review and evaluation of a pilot restorative intervention. Brain Impair 2009, 10:76–86.CrossRef Raskin SA, Sohlberg MM: Prospective memory intervention: a review and evaluation of a pilot restorative intervention. Brain Impair 2009, 10:76–86.CrossRef
26.
Zurück zum Zitat O’Neill Pirozzi T, Strangman G, Goldstein R, et al.: A controlled treatment study of internal memory strategies (I-MEMS) following traumatic brain injury. J Head Trauma Rehabil 2010, 25(1):43–51.CrossRef O’Neill Pirozzi T, Strangman G, Goldstein R, et al.: A controlled treatment study of internal memory strategies (I-MEMS) following traumatic brain injury. J Head Trauma Rehabil 2010, 25(1):43–51.CrossRef
27.
Zurück zum Zitat Constantinidou F, Thomas RD, Robinson L: Benefits of categorization training in patients with traumatic brain injury during post-acute rehabilitation: additional evidence from a randomized controlled trial. J Head Trauma Rehabil 2008, 23:312–328.CrossRefPubMed Constantinidou F, Thomas RD, Robinson L: Benefits of categorization training in patients with traumatic brain injury during post-acute rehabilitation: additional evidence from a randomized controlled trial. J Head Trauma Rehabil 2008, 23:312–328.CrossRefPubMed
28.
Zurück zum Zitat Satish U, Streufert S, Eslinger PJ: Simulation-based executive cognitive assessment and rehabilitation after traumatic frontal lobe injury: a case report. Disabil Rehabil 2008, 30:468–478.CrossRefPubMed Satish U, Streufert S, Eslinger PJ: Simulation-based executive cognitive assessment and rehabilitation after traumatic frontal lobe injury: a case report. Disabil Rehabil 2008, 30:468–478.CrossRefPubMed
29.••
Zurück zum Zitat Kennedy MRT, Coelho C, Turkstra L, et al.: Intervention for executive functions after traumatic brain injury: a systematic review, meta-analysis and clinical recommendations. Neuropsychol Rehabil 2008, 18:257–299. The authors evaluated the evidence for specific therapies designed to improve everyday problem-solving, planning, and multi-tasking. Fifteen studies met inclusion criteria, five with Class I evidence. Support was found for treatments emphasizing self-monitoring of cognition. Metacognitive strategy instruction was recommended as a practice standard for young to middle-aged adults.CrossRefPubMed Kennedy MRT, Coelho C, Turkstra L, et al.: Intervention for executive functions after traumatic brain injury: a systematic review, meta-analysis and clinical recommendations. Neuropsychol Rehabil 2008, 18:257–299. The authors evaluated the evidence for specific therapies designed to improve everyday problem-solving, planning, and multi-tasking. Fifteen studies met inclusion criteria, five with Class I evidence. Support was found for treatments emphasizing self-monitoring of cognition. Metacognitive strategy instruction was recommended as a practice standard for young to middle-aged adults.CrossRefPubMed
30.
Zurück zum Zitat Spikman JM, Boelen DH, Lamberts KF, et al.: Effects of a multifaceted treatment program for executive dysfunction after acquired brain injury on indications of executive functioning in daily life. J Int Neuropsychol Soc 2010, 16:118–129.CrossRefPubMed Spikman JM, Boelen DH, Lamberts KF, et al.: Effects of a multifaceted treatment program for executive dysfunction after acquired brain injury on indications of executive functioning in daily life. J Int Neuropsychol Soc 2010, 16:118–129.CrossRefPubMed
31.
Zurück zum Zitat Fong KN, Howie DR: Effects of an explicit problem-solving skills training program using a metacomponential approach for outpatients with acquired brain injury. Am J Occup Ther 2009, 63:525–534.PubMed Fong KN, Howie DR: Effects of an explicit problem-solving skills training program using a metacomponential approach for outpatients with acquired brain injury. Am J Occup Ther 2009, 63:525–534.PubMed
32.
Zurück zum Zitat Polatajko HJ, Mandich AD, Miller LT, Macnab JJ: Cognitive orientation to daily occupational performance (CO-OP): part II—the evidence. Phys Occup Ther Pediatr 2001, 20:83–106.PubMed Polatajko HJ, Mandich AD, Miller LT, Macnab JJ: Cognitive orientation to daily occupational performance (CO-OP): part II—the evidence. Phys Occup Ther Pediatr 2001, 20:83–106.PubMed
33.
Zurück zum Zitat Dawson DR, Gaya A, Hunt A, et al.: Using the cognitive orientation to occupational performance (CO-OP) with adults with executive dysfunction following traumatic brain injury. Can J Occup Ther 2009, 76:115–127.PubMed Dawson DR, Gaya A, Hunt A, et al.: Using the cognitive orientation to occupational performance (CO-OP) with adults with executive dysfunction following traumatic brain injury. Can J Occup Ther 2009, 76:115–127.PubMed
34.
Zurück zum Zitat Bergquist T, Geh C, Mandrekar J, et al.: The effect of internet-based cognitive rehabilitation in persons with memory impairments after severe traumatic brain injury. Brain Inj 2009, 23:790–799.CrossRefPubMed Bergquist T, Geh C, Mandrekar J, et al.: The effect of internet-based cognitive rehabilitation in persons with memory impairments after severe traumatic brain injury. Brain Inj 2009, 23:790–799.CrossRefPubMed
35.
Zurück zum Zitat Shoenberg MR, Ruwe WD, Dawson K, et al.: Comparison of functional outcomes and treatment cost between a computer-based cognitive rehabilitation teletherapy program and a face-to-face rehabilitation program. Prof Psychol Res Pr 2008, 39:169–175.CrossRef Shoenberg MR, Ruwe WD, Dawson K, et al.: Comparison of functional outcomes and treatment cost between a computer-based cognitive rehabilitation teletherapy program and a face-to-face rehabilitation program. Prof Psychol Res Pr 2008, 39:169–175.CrossRef
36.
Zurück zum Zitat Topolovec-Vranic J, Cullen N, Michalak D, et al.: Evaluation of an online cognitive behavioral therapy program by patients with traumatic brain injury and depression. Brain Inj 2010, 24:762–772.CrossRefPubMed Topolovec-Vranic J, Cullen N, Michalak D, et al.: Evaluation of an online cognitive behavioral therapy program by patients with traumatic brain injury and depression. Brain Inj 2010, 24:762–772.CrossRefPubMed
37.
Zurück zum Zitat Minardi J, Crocco TJ: Management of traumatic brain injury: first link in chain of survival. Mt Sinai J Med 2009, 76:138–144.CrossRefPubMed Minardi J, Crocco TJ: Management of traumatic brain injury: first link in chain of survival. Mt Sinai J Med 2009, 76:138–144.CrossRefPubMed
38.
Zurück zum Zitat Gentry T, Wallace J, Kvarfordt C, et al.: Personal digital assistants as cognitive aids for individuals with severe traumatic brain injury: a community-based trial. Brain Inj 2008, 22:19–24.CrossRefPubMed Gentry T, Wallace J, Kvarfordt C, et al.: Personal digital assistants as cognitive aids for individuals with severe traumatic brain injury: a community-based trial. Brain Inj 2008, 22:19–24.CrossRefPubMed
39.
Zurück zum Zitat Wilson BA, Emslie H, Quirk K, et al.: A randomized control trial to evaluate a paging system for people with traumatic brain injury. Brain Inj 2005, 19:891–894.CrossRefPubMed Wilson BA, Emslie H, Quirk K, et al.: A randomized control trial to evaluate a paging system for people with traumatic brain injury. Brain Inj 2005, 19:891–894.CrossRefPubMed
40.
Zurück zum Zitat Blake H, Batson M: Exercise intervention in brain injury: a pilot randomized study of Tai Chi Qigong. Clin Rehabil 2009, 23:589–598.CrossRefPubMed Blake H, Batson M: Exercise intervention in brain injury: a pilot randomized study of Tai Chi Qigong. Clin Rehabil 2009, 23:589–598.CrossRefPubMed
41.
Zurück zum Zitat Leddy JJ, Kozlowski K, Donnelly JP, et al.: A preliminary study of subsymptom threshold exercise training for refractory post-concussion syndrome. Clin J Sport Med 2010, 20:21–27.CrossRefPubMed Leddy JJ, Kozlowski K, Donnelly JP, et al.: A preliminary study of subsymptom threshold exercise training for refractory post-concussion syndrome. Clin J Sport Med 2010, 20:21–27.CrossRefPubMed
42.
Zurück zum Zitat Yip BCB, Man DWK: Virtual reality (VR)–based community living skills training for people with acquired brain injury: a pilot study. Brain Inj 2009, 23:1017–1026.CrossRefPubMed Yip BCB, Man DWK: Virtual reality (VR)–based community living skills training for people with acquired brain injury: a pilot study. Brain Inj 2009, 23:1017–1026.CrossRefPubMed
43.
Zurück zum Zitat Golden Z, Colden CJ, Neubauer RA: Improving neuropsychological function after chronic brain injury with hyperbaric oxygen. Disabil Rehabil 2006, 28:1379–1386.CrossRefPubMed Golden Z, Colden CJ, Neubauer RA: Improving neuropsychological function after chronic brain injury with hyperbaric oxygen. Disabil Rehabil 2006, 28:1379–1386.CrossRefPubMed
44.
Zurück zum Zitat Wright JK, Zant E, Groom K, et al.: Case report: treatment of mild traumatic brain injury with hyperbaric oxygen. Undersea Hyperb Med 2009, 36:391–399.PubMed Wright JK, Zant E, Groom K, et al.: Case report: treatment of mild traumatic brain injury with hyperbaric oxygen. Undersea Hyperb Med 2009, 36:391–399.PubMed
45.
Zurück zum Zitat Thornton KE, Carmody DP: Traumatic brain injury rehabilitation: QEEG biofeedback treatment protocols. Appl Psychophysiol Biofeedback 2009, 34:59–68.CrossRefPubMed Thornton KE, Carmody DP: Traumatic brain injury rehabilitation: QEEG biofeedback treatment protocols. Appl Psychophysiol Biofeedback 2009, 34:59–68.CrossRefPubMed
46.••
Zurück zum Zitat Laatsch L, Harrington D, Hotz G, et al.: An evidenced-based review of cognitive and behavioral rehabilitation treatment studies in children with acquired brain injury. J Head Trauma Rehabil 2010, 25:43–51. Two treatment recommendations and one treatment option were developed as a result of this evidence-based review of cognitive and behavioral treatments for children with a history of acquired brain injury.CrossRef Laatsch L, Harrington D, Hotz G, et al.: An evidenced-based review of cognitive and behavioral rehabilitation treatment studies in children with acquired brain injury. J Head Trauma Rehabil 2010, 25:43–51. Two treatment recommendations and one treatment option were developed as a result of this evidence-based review of cognitive and behavioral treatments for children with a history of acquired brain injury.CrossRef
47.
Zurück zum Zitat Glang A, Ylvisaker M, Stein M, et al.: Validated instructional practices: application to students with traumatic brain injury. J Head Trauma Rehabil 2008, 23:243–251.CrossRefPubMed Glang A, Ylvisaker M, Stein M, et al.: Validated instructional practices: application to students with traumatic brain injury. J Head Trauma Rehabil 2008, 23:243–251.CrossRefPubMed
Metadaten
Titel
Cognitive Rehabilitation in Traumatic Brain Injury
verfasst von
Alison N. Cernich, PhD
Shira M. Kurtz, PhD
Kristen L. Mordecai, PhD
Patricia B. Ryan, PhD
Publikationsdatum
01.09.2010
Verlag
Current Science Inc.
Erschienen in
Current Treatment Options in Neurology / Ausgabe 5/2010
Print ISSN: 1092-8480
Elektronische ISSN: 1534-3138
DOI
https://doi.org/10.1007/s11940-010-0085-6

Weitere Artikel der Ausgabe 5/2010

Current Treatment Options in Neurology 5/2010 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Demenzkranke durch Antipsychotika vielfach gefährdet

Demenz Nachrichten

Der Einsatz von Antipsychotika gegen psychische und Verhaltenssymptome in Zusammenhang mit Demenzerkrankungen erfordert eine sorgfältige Nutzen-Risiken-Abwägung. Neuen Erkenntnissen zufolge sind auf der Risikoseite weitere schwerwiegende Ereignisse zu berücksichtigen.

Nicht Creutzfeldt Jakob, sondern Abführtee-Vergiftung

29.05.2024 Hyponatriämie Nachrichten

Eine ältere Frau trinkt regelmäßig Sennesblättertee gegen ihre Verstopfung. Der scheint plötzlich gut zu wirken. Auf Durchfall und Erbrechen folgt allerdings eine Hyponatriämie. Nach deren Korrektur kommt es plötzlich zu progredienten Kognitions- und Verhaltensstörungen.

Schutz der Synapsen bei Alzheimer

29.05.2024 Morbus Alzheimer Nachrichten

Mit einem Neurotrophin-Rezeptor-Modulator lässt sich möglicherweise eine bestehende Alzheimerdemenz etwas abschwächen: Erste Phase-2-Daten deuten auf einen verbesserten Synapsenschutz.

Sozialer Aufstieg verringert Demenzgefahr

24.05.2024 Demenz Nachrichten

Ein hohes soziales Niveau ist mit die beste Versicherung gegen eine Demenz. Noch geringer ist das Demenzrisiko für Menschen, die sozial aufsteigen: Sie gewinnen fast zwei demenzfreie Lebensjahre. Umgekehrt steigt die Demenzgefahr beim sozialen Abstieg.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.