nach oben

Erschienen in:

01.02.2013 | Original Article

Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population

verfasst von: Yong Tang, Xueyao Han, Xiuqin Sun, Chao Lv, Xiaomei Zhang, Wulan Guo, Qian Ren, Yingying Luo, Xiuying Zhang, Xianghai Zhou, Linong Ji

Erschienen in: Endocrine | Ausgabe 1/2013

Einloggen, um Zugang zu erhalten

Abstract

The insulin receptor substrate-1 (IRS1) plays an important role in insulin signaling. A recent genome-wide association study identified rs2943641C>T as a susceptibility locus for type 2 diabetes mellitus (T2DM) in Caucasian patients. Therefore, we determined whether this common variant near IRS1 is also associated with the risk of T2DM and T2DM-related phenotypes in a Chinese Han population. A total of 2,290 unrelated Chinese Han individuals residing in Beijing were recruited in this study, including 1177 T2DM patients and 1113 subjects with normal glucose tolerance (control group). The single nucleotide polymorphism (SNP) was genotyped using a MassARRAY iPLEX system. The frequency of risk allele C was 0.929 in the control group and 0.939 in patients with T2DM. We found no association between the C allele of rs2943641 and T2DM in a recessive model [OR 1.14, 95 % confidence interval (CI) 0.89–1.45, P = 0.298], or after adjusting for sex, age, and body mass index (BMI) (OR 1.10, 95 % CI 0.85–1.43, P = 0.301). Analysis of the clinical features of the control subjects with normal glucose tolerance revealed that the 30-min plasma glucose level during a 75-g oral glucose tolerance test was significantly different between the CC and CT+TT genotypes (P = 0.017). Linear regression analysis showed that the 30-min plasma glucose levels was significantly and positively associated with the CC genotype after adjusting for sex, age, and BMI (β = 0.065, 95 % CI 0.009–0.654, P = 0.044). In addition, a potential association between this SNP and increased waist circumference (β = 1.337, 95 % CI −0.179 to 2.853, P = 0.084) was observed with adjustment for the sex and age. Our study was not able to demonstrate the association between rs2943641 near IRS1 and T2DM in a Chinese Han population. However, this SNP may be associated with postprandial hyperglycemia.

W. Yang, J. Lu, J. Weng, W. Jia, L. Ji, J. Xiao, Z. Shan, J. Liu, H. Tian, Q. Ji, D. Zhu, J. Ge, L. Lin, L. Chen, X. Guo, Z. Zhao, Q. Li, Z. Zhou, G. Shan, China National Diabetes and Metabolic Disorders Study Group, Prevalence of diabetes among men and women in China. N. Eng. J. Med. 362, 1090–1101 (2010)CrossRef

M.E. Travers, M.I. McCarthy, Type 2 diabetes and obesity: genomics and the clinic. Hum. Genet. 130, 41–58 (2011)PubMedCrossRef

R.M. Watanabe, The genetics of insulin resistance: where’s Waldo? Curr. Diab. Rep. 10, 476–484 (2010)PubMedCrossRef

X.J. Sun, P. Rothenberg, C.R. Kahn, J.M. Backer, E. Araki, P.A. Wilden, D.A. Cahill, B.J. Goldstein, M.F. White, Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352, 73–77 (1991)PubMedCrossRef

K. Almind, C. Bjørbaek, H. Vestergaard, T. Hansen, S. Echwald, O. Pedersen, Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. Lancet 342, 828–832 (1993)PubMedCrossRef

A. Jellema, M.P. Zeegers, E.J. Feskens, P.C. Dagnelie, R.P. Mensink, Gly972Arg variant in the insulin receptor substrate-1 gene and association with type 2 diabetes: a meta-analysis of 27 studies. Diabetologia 46, 990–995 (2003)PubMedCrossRef

E. Morini, S. Prudente, E. Succurro, M. Chandalia, Y.Y. Zhang, S. Mammarella, F. Pellegrini, C. Powers, V. Proto, B. Dallapiccola, A. Cama, G. Sesti, N. Abate, A. Doria, V. Trischitta, IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of ‘low-frequency-low-risk’ variants. Diabetologia 52, 1852–1857 (2009)PubMedCrossRef

J. Rung, S. Cauchi, A. Albrechtsen, L. Shen, G. Rocheleau, C. Cavalcanti-Proença, F. Bacot, B. Balkau, A. Belisle, K. Borch-Johnsen, G. Charpentier, C. Dina, E. Durand, P. Elliott, S. Hadjadj, M.R. Järvelin, J. Laitinen, T. Lauritzen, M. Marre, A. Mazur, D. Meyre, A. Montpetit, C. Pisinger, B. Posner, P. Poulsen, A. Pouta, M. Prentki, R. Ribel-Madsen, A. Ruokonen, A. Sandbaek, D. Serre, J. Tichet, M. Vaxillaire, J.F. Wojtaszewski, A. Vaag, T. Hansen, C. Polychronakos, O. Pedersen, P. Froguel, R. Sladek, Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat. Genet. 41, 1110–1115 (2009)PubMedCrossRef

Y. Liu, Z. Liu, Y. Song, D. Zhou, D. Zhang, T. Zhao, Z. Chen, L. Yu, Y. Yang, G. Feng, J. Li, J. Zhang, S. Liu, Z. Zhang, L. He, H. Xu, Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. Obesity (Silver Spring) 18, 1619–1624 (2010)CrossRef

10.

Y. Luo, H. Wang, X. Han, Q. Ren, F. Wang, X. Zhang, X. Sun, X. Zhou, L. Ji, Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population. Diab. Res. Clin. Pract. 85, 139–146 (2009)CrossRef

11.

W.L. Guo, Y. Tang, X.Y. Han, L.N. Ji, Meta-analysis of Pro12Ala polymorphism of PPARγ gene with type 2 diabetes in Chinese Han population. Chin. J. Diab. 19, 483–488 (2011)

12.

W. Huang, Y. Sun, J. Sun, Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populations. Endocrine 39, 69–74 (2011)PubMedCrossRef

13.

Y.Y. Zheng, X. Xie, Y.T. Ma, Y.N. Yang, Z.Y. Fu, X.M. Li, X. Ma, B.D. Chen, F. Liu, Relationship between type 2 diabetes mellitus and a novel polymorphism C698T in C5L2 in the Chinese Han population. Endocrine 41, 296–301 (2012)PubMedCrossRef

14.

X. Zhou, L. Ji, Y. Luo, X. Han, X. Zhang, X. Sun, Q. Ren, Q. Qiao, Risk factors associated with the presence of diabetes in Chinese communities in Beijing. Diab. Res. Clin. Pract. 86, 233–238 (2009)CrossRef

15.

X.H. Zhou, L.N. Ji, Y.Y. Luo, X.Y. Zhang, X.Y. Han, Q. Qiao, Performance of HbA(1c) for detecting newly diagnosed diabetes and pre-diabetes in Chinese communities living in Beijing. Diabet. Med. 26, 1262–1268 (2009)PubMedCrossRef

16.

D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, R.C. Turner, Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412–419 (1985)PubMedCrossRef

17.

Y. Kaburagi, T. Yamauchi, R. Yamamoto-Honda, K. Ueki, K. Tobe, Y. Akanuma, Y. Yazaki, T. Kadowaki, The mechanism of insulin-induced signal transduction mediated by the insulin receptor substrate family. Endocr. J. 46(Suppl), s25–s34 (1999)PubMedCrossRef

18.

R.N. Kulkarni, J.C. Brüning, J.N. Winnay, C. Postic, M.A. Magnuson, C.R. Kahn, Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96, 329–339 (1999)PubMedCrossRef

19.

J.C. Brüning, M.D. Michael, J.N. Winnay, T. Hayashi, D. Hörsch, D. Accili, L.J. Goodyear, C.R. Kahn, A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol. Cell 2, 559–569 (1998)PubMedCrossRef

20.

D. Lauro, Y. Kido, A.L. Castle, M.J. Zarnowski, H. Hayashi, Y. Ebina, D. Accili, Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue. Nat. Genet. 20, 294–298 (1998)PubMedCrossRef

21.

H. Tamemoto, T. Kadowaki, K. Tobe, T. Yagi, H. Sakura, T. Hayakawa, Y. Terauchi, K. Ueki, Y. Kaburagi, S. Satoh et al., Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372, 182–186 (1994)PubMedCrossRef

22.

D.J. Withers, J.S. Gutierrez, H. Towery, D.J. Burks, J.M. Ren, S. Previs, Y. Zhang, D. Bernal, S. Pons, G.I. Shulman, S. Bonner-Weir, M.F. White, Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391, 900–904 (1998)PubMedCrossRef

23.

N. Yiannakouris, J.A. Cooper, S. Shah, F. Drenos, H.A. Ireland, J.W. Stephens, K.W. Li, R. Elkeles, I.F. Godsland, M. Kivimaki, A.D. Hingorani, M. Kumari, P.J. Talmud, S.E. Humphries, IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk. Nutr. Metab. Cardiovasc. Dis. (2011). doi:10.1016/j.numecd.2011.05.009

24.

T. Ohshige, M. Iwata, S. Omori, Y. Tanaka, H. Hirose, K. Kaku, H. Maegawa, H. Watada, A. Kashiwagi, R. Kawamori, K. Tobe, T. Kadowaki, Y. Nakamura, S. Maeda, Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. PLoS ONE (2011). doi:10.1371/journal.pone.0026911 PubMed

25.

K.H. Yoon, J.H. Lee, J.W. Kim, J.H. Cho, Y.H. Choi, S.H. Ko, P. Zimmet, H.Y. Son, Epidemic obesity and type 2 diabetes in Asia. Lancet 368, 1681–1688 (2006)PubMedCrossRef

26.

J.I. Torréns, J. Skurnick, A.L. Davidow, S.G. Korenman, N. Santoro, M. Soto-Greene, N. Lasser, Study of Women’s Health Across the Nation (SWAN), Ethnic differences in insulin sensitivity and beta-cell function in premenopausal or early perimenopausal women without diabetes: the Study of Women’s Health Across the Nation (SWAN). Diabetes Care 27, 354–361 (2004)PubMedCrossRef

27.

T.O. Kilpeläinen, M.C. Zillikens, A. Stančákova, F.M. Finucane, J.S. Ried, C. Langenberg, W. Zhang, J.S. Beckmann, J. Luan, L. Vandenput, U. Styrkarsdottir, Y. Zhou, A.V. Smith, J.H. Zhao, N. Amin, S. Vedantam, S.Y. Shin, T. Haritunians, M. Fu, M.F. Feitosa, M. Kumari, B.V. Halldorsson, E. Tikkanen, M. Mangino, C. Hayward, C. Song, A.M. Arnold, Y.S. Aulchenko, B.A. Oostra, H. Campbell, L.A. Cupples, K.E. Davis, A. Döring, G. Eiriksdottir, K. Estrada, J.M. Fernández-Real, M. Garcia, C. Gieger, N.L. Glazer, C. Guiducci, A. Hofman, S.E. Humphries, B. Isomaa, L.C. Jacobs, A. Jula, D. Karasik, M.K. Karlsson, K.T. Khaw, L.J. Kim, M. Kivimäki, N. Klopp, B. Kühnel, J. Kuusisto, Y. Liu, O. Ljunggren, M. Lorentzon, R.N. Luben, B. McKnight, D. Mellström, B.D. Mitchell, V. Mooser, J.M. Moreno, S. Männistö, J.R. O’Connell, L. Pascoe, L. Peltonen, B. Peral, M. Perola, B.M. Psaty, V. Salomaa, D.B. Savage, R.K. Semple, T. Skaric-Juric, G. Sigurdsson, K.S. Song, T.D. Spector, A.C. Syvänen, P.J. Talmud, G. Thorleifsson, U. Thorsteinsdottir, A.G. Uitterlinden, C.M. van Duijn, A. Vidal-Puig, S.H. Wild, A.F. Wright, D.J. Clegg, E. Schadt, J.F. Wilson, I. Rudan, S. Ripatti, I.B. Borecki, A.R. Shuldiner, E. Ingelsson, J.O. Jansson, R.C. Kaplan, V. Gudnason, T.B. Harris, L. Groop, D.P. Kiel, F. Rivadeneira, M. Walker, I. Barroso, P. Vollenweider, G. Waeber, J.C. Chambers, J.S. Kooner, N. Soranzo, J.N. Hirschhorn, K. Stefansson, H.E. Wichmann, C. Ohlsson, S. O’Rahilly, N.J. Wareham, E.K. Speliotes, C.S. Fox, M. Laakso, R.J. Loos, Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat. Genet. 43, 753–760 (2011)PubMedCrossRef

28.

C.S. Fox, N. Heard-Costa, L.A. Cupples, J. Dupuis, R.S. Vasan, L.D. Atwood, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100 K project. BMC Med. Genet. 8(Suppl 1), S18 (2007)PubMedCrossRef

29.

J.C. Chambers, P. Elliott, D. Zabaneh, W. Zhang, Y. Li, P. Froguel, D. Balding, J. Scott, J.S. Kooner, Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat. Genet. 40, 716–718 (2008)PubMedCrossRef

30.

N.L. Heard-Costa, M.C. Zillikens, K.L. Monda, A. Johansson, T.B. Harris, M. Fu, T. Haritunians, M.F. Feitosa, T. Aspelund, G. Eiriksdottir, M. Garcia, L.J. Launer, A.V. Smith, B.D. Mitchell, P.F. McArdle, A.R. Shuldiner, S.J. Bielinski, E. Boerwinkle, F. Brancati, E.W. Demerath, J.S. Pankow, A.M. Arnold, Y.D. Chen, N.L. Glazer, B. McKnight, B.M. Psaty, J.I. Rotter, N. Amin, H. Campbell, U. Gyllensten, C. Pattaro, P.P. Pramstaller, I. Rudan, M. Struchalin, V. Vitart, X. Gao, A. Kraja, M.A. Province, Q. Zhang, L.D. Atwood, J. Dupuis, J.N. Hirschhorn, C.E. Jaquish, C.J. O’Donnell, R.S. Vasan, C.C. White, Y.S. Aulchenko, K. Estrada, A. Hofman, F. Rivadeneira, A.G. Uitterlinden, J.C. Witteman, B.A. Oostra, R.C. Kaplan, V. Gudnason, J.R. O’Connell, I.B. Borecki, C.M. van Duijn, L.A. Cupples, C.S. Fox, K.E. North, NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet. (2009). doi:10.1371/journal.pgen.1000539 PubMed

31.

D.C. Croteau-Chonka, A.F. Marvelle, E.M. Lange, N.R. Lee, L.S. Adair, L.A. Lange, K.L. Mohlke, Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. Obesity (Silver Spring) 19, 1019–1027 (2011)CrossRef

32.

A.T. Kraja, D. Vaidya, J.S. Pankow, M.O. Goodarzi, T.L. Assimes, I.J. Kullo, U. Sovio, R.A. Mathias, Y.V. Sun, N. Franceschini, D. Absher, G. Li, Q. Zhang, M.F. Feitosa, N.L. Glazer, T. Haritunians, A.L. Hartikainen, J.W. Knowles, K.E. North, C. Iribarren, B. Kral, L. Yanek, P.F. O’Reilly, M.I. McCarthy, C. Jaquish, D.J. Couper, A. Chakravarti, B.M. Psaty, L.C. Becker, M.A. Province, E. Boerwinkle, T. Quertermous, L. Palotie, M.R. Jarvelin, D.M. Becker, S.L. Kardia, J.I. Rotter, Y.D. Chen, I.B. Borecki, A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes 60, 1329–1339 (2011)PubMedCrossRef

33.

K. Almind, G. Inoue, O. Pedersen, C.R. Kahn, A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies. J. Clin. Investig. 97, 2569–2575 (1996)PubMedCrossRef

34.

Zurück zum Zitat T.M. Teslovich, K. Musunuru, A.V. Smith, A.C. Edmondson, I.M.Stylianou, M. Koseki, J.P. Pirruccello, S. Ripatti, D.I. Chasman, C.J. Willer, C.T. Johansen, S.W. Fouchier, A. Isaacs, G.M. Peloso, M. Barbalic, S.L. Ricketts, J.C. Bis, Y.S. Aulchenko, G. Thorleifsson, M.F. Feitosa, J. Chambers, M. Orho-Melander, O. Melander, T. Johnson, X. Li, X. Guo, M. Li, Y. Shin Cho, M. Jin Go, Y. Jin Kim, J.Y. Lee, T. Park, K. Kim, X. Sim, R. Twee-Hee Ong, D.C. Croteau-Chonka, L.A. Lange, J.D. Smith, K. Song, J. Hua Zhao, X. Yuan, J. Luan, C. Lamina, A. Ziegler, W. Zhang, R.Y. Zee, A.F. Wright, J.C. Witteman, J.F. Wilson, G. Willemsen, H.E. Wichmann, J.B. Whitfield, D.M. Waterworth, N.J. Wareham, G. Waeber, P. Vollenweider, B.F. Voight, V. Vitart, A.G. Uitterlinden, M. Uda, J. Tuomilehto, J.R. Thompson, T. Tanaka, I. Surakka, H.M. Stringham, T.D. Spector, N. Soranzo, J.H. Smit, J. Sinisalo, K. Silander, E.J. Sijbrands, A. Scuteri, J. Scott, D. Schlessinger, S. Sanna, V. Salomaa, J. Saharinen, C. Sabatti, A. Ruokonen, I. Rudan, L.M. Rose, R. Roberts, M. Rieder, B.M. Psaty, P.P. Pramstaller, I. Pichler, M. Perola, B.W. Penninx, N.L. Pedersen, C. Pattaro, A.N. Parker, G. Pare, B.A. Oostra, C.J. O’Donnell, M.S. Nieminen, D.A. Nickerson, G.W. Montgomery, T. Meitinger, R. McPherson, M.I. McCarthy, W. McArdle, D. Masson, N.G. Martin, F. Marroni, M. Mangino, P.K. Magnusson, G. Lucas, R. Luben, R.J. Loos, M.L. Lokki, G. Lettre, C. Langenberg, L.J. Launer, E.G. Lakatta, R. Laaksonen, K.O. Kyvik, F. Kronenberg, I.R. König, K.T. Khaw, J. Kaprio, L.M. Kaplan, A. Johansson, M.R. Jarvelin, A.C. Janssens, E. Ingelsson, W. Igl, G. Kees Hovingh, J.J. Hottenga, A. Hofman, A.A. Hicks, C Hengstenberg, I.M. Heid, C. Hayward, A.S. Havulinna, N.D. Hastie, T.B. Harris, T. Haritunians, A.S. Hall, U. Gyllensten, C. Guiducci, L.C. Groop, E. Gonzalez, C. Gieger, N.B. Freimer, L. Ferrucci, J. Erdmann, P. Elliott, K.G. Ejebe, A . Döring, A.F. Dominiczak, S. Demissie, P. Deloukas, E.J. de Geus, U. de Faire, G. Crawford, F.S. Collins, Y.D. Chen, M.J. Caulfield, H. Campbell, N.P. Burtt, L.L. Bonnycastle, D.I. Boomsma, S.M. Boekholdt, R.N. Bergman, I. Barroso, S. Bandinelli, C.M. Ballantyne, T.L. Assimes, T. Quertermous, D. Altshuler, M. Seielstad, T.Y. Wong, E.S. Tai, A.B. Feranil, C.W. Kuzawa, L.S. Adair, H.A. Taylor Jr, I.B. Borecki, S.B. Gabriel, J.G. Wilson, H. Holm, U. Thorsteinsdottir, V. Gudnason, R.M. Krauss, K.L. Mohlke, J.M. Ordovas, P.B. Munroe, J.S. Kooner, A.R. Tall, R.A. Hegele, J.J. Kastelein, E.E. Schadt, J.I. Rotter, E. Boerwinkle, D.P. Strachan, V. Mooser, K. Stefansson, M.P. Reilly, N.J. Samani, H. Schunkert, L.A. Cupples, M.S. Sandhu, P.M. Ridker, D.J. Rader, C.M. van Duijn, L. Peltonen, G.R. Abecasis, M. Boehnke, S. Kathiresan, Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466 707–713 (2010) T.M. Teslovich, K. Musunuru, A.V. Smith, A.C. Edmondson, I.M.Stylianou, M. Koseki, J.P. Pirruccello, S. Ripatti, D.I. Chasman, C.J. Willer, C.T. Johansen, S.W. Fouchier, A. Isaacs, G.M. Peloso, M. Barbalic, S.L. Ricketts, J.C. Bis, Y.S. Aulchenko, G. Thorleifsson, M.F. Feitosa, J. Chambers, M. Orho-Melander, O. Melander, T. Johnson, X. Li, X. Guo, M. Li, Y. Shin Cho, M. Jin Go, Y. Jin Kim, J.Y. Lee, T. Park, K. Kim, X. Sim, R. Twee-Hee Ong, D.C. Croteau-Chonka, L.A. Lange, J.D. Smith, K. Song, J. Hua Zhao, X. Yuan, J. Luan, C. Lamina, A. Ziegler, W. Zhang, R.Y. Zee, A.F. Wright, J.C. Witteman, J.F. Wilson, G. Willemsen, H.E. Wichmann, J.B. Whitfield, D.M. Waterworth, N.J. Wareham, G. Waeber, P. Vollenweider, B.F. Voight, V. Vitart, A.G. Uitterlinden, M. Uda, J. Tuomilehto, J.R. Thompson, T. Tanaka, I. Surakka, H.M. Stringham, T.D. Spector, N. Soranzo, J.H. Smit, J. Sinisalo, K. Silander, E.J. Sijbrands, A. Scuteri, J. Scott, D. Schlessinger, S. Sanna, V. Salomaa, J. Saharinen, C. Sabatti, A. Ruokonen, I. Rudan, L.M. Rose, R. Roberts, M. Rieder, B.M. Psaty, P.P. Pramstaller, I. Pichler, M. Perola, B.W. Penninx, N.L. Pedersen, C. Pattaro, A.N. Parker, G. Pare, B.A. Oostra, C.J. O’Donnell, M.S. Nieminen, D.A. Nickerson, G.W. Montgomery, T. Meitinger, R. McPherson, M.I. McCarthy, W. McArdle, D. Masson, N.G. Martin, F. Marroni, M. Mangino, P.K. Magnusson, G. Lucas, R. Luben, R.J. Loos, M.L. Lokki, G. Lettre, C. Langenberg, L.J. Launer, E.G. Lakatta, R. Laaksonen, K.O. Kyvik, F. Kronenberg, I.R. König, K.T. Khaw, J. Kaprio, L.M. Kaplan, A. Johansson, M.R. Jarvelin, A.C. Janssens, E. Ingelsson, W. Igl, G. Kees Hovingh, J.J. Hottenga, A. Hofman, A.A. Hicks, C Hengstenberg, I.M. Heid, C. Hayward, A.S. Havulinna, N.D. Hastie, T.B. Harris, T. Haritunians, A.S. Hall, U. Gyllensten, C. Guiducci, L.C. Groop, E. Gonzalez, C. Gieger, N.B. Freimer, L. Ferrucci, J. Erdmann, P. Elliott, K.G. Ejebe, A . Döring, A.F. Dominiczak, S. Demissie, P. Deloukas, E.J. de Geus, U. de Faire, G. Crawford, F.S. Collins, Y.D. Chen, M.J. Caulfield, H. Campbell, N.P. Burtt, L.L. Bonnycastle, D.I. Boomsma, S.M. Boekholdt, R.N. Bergman, I. Barroso, S. Bandinelli, C.M. Ballantyne, T.L. Assimes, T. Quertermous, D. Altshuler, M. Seielstad, T.Y. Wong, E.S. Tai, A.B. Feranil, C.W. Kuzawa, L.S. Adair, H.A. Taylor Jr, I.B. Borecki, S.B. Gabriel, J.G. Wilson, H. Holm, U. Thorsteinsdottir, V. Gudnason, R.M. Krauss, K.L. Mohlke, J.M. Ordovas, P.B. Munroe, J.S. Kooner, A.R. Tall, R.A. Hegele, J.J. Kastelein, E.E. Schadt, J.I. Rotter, E. Boerwinkle, D.P. Strachan, V. Mooser, K. Stefansson, M.P. Reilly, N.J. Samani, H. Schunkert, L.A. Cupples, M.S. Sandhu, P.M. Ridker, D.J. Rader, C.M. van Duijn, L. Peltonen, G.R. Abecasis, M. Boehnke, S. Kathiresan, Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466 707–713 (2010)

35.

R. Sharma, S. Prudente, F. Andreozzi, C. Powers, G. Mannino, S. Bacci, E.V. Gervino, T.H. Hauser, E. Succurro, L. Mercuri, E.H. Goheen, H. Shah, V. Trischitta, G. Sesti, A. Doria, The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects. Atherosclerosis 216, 157–160 (2011)PubMedCrossRef

Titel: Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population
verfasst von: Yong Tang
Xueyao Han
Xiuqin Sun
Chao Lv
Xiaomei Zhang
Wulan Guo
Qian Ren
Yingying Luo
Xiuying Zhang
Xianghai Zhou
Linong Ji
Publikationsdatum: 01.02.2013
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 1/2013
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-012-9693-0

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Bei seelischem Stress sind Checkpoint-Hemmer weniger wirksam

Antikörper mobilisiert Neutrophile gegen Krebs

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

Update Innere Medizin

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2013

TLR-10 polymorphism and papillary thyroid cancer: one more SNP to consider?

Gastric estrogen increases pituitary estrogen receptor α and prolactin mRNAs during the different pathological conditions of the liver

Diagnostic performance of positron emission tomography using 11C-methionine in patients with suspected parathyroid adenoma: a meta-analysis

Ghrelin concentrations in maternal and cord blood of Type 1 diabetic and non-diabetic pregnancies at term

Adrenal venous catecholamine concentrations in patients with adrenal masses other than pheochromocytoma

A novel formulation of l-thyroxine (l-T4) reduces the problem of l-T4 malabsorption by coffee observed with traditional tablet formulations

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Bei seelischem Stress sind Checkpoint-Hemmer weniger wirksam

Antikörper mobilisiert Neutrophile gegen Krebs

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

Update Innere Medizin