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Erschienen in: Neurocritical Care 1/2012

01.08.2012 | Review

Guidelines for the Evaluation and Management of Status Epilepticus

verfasst von: Gretchen M. Brophy, Rodney Bell, Jan Claassen, Brian Alldredge, Thomas P. Bleck, Tracy Glauser, Suzette M. LaRoche, James J. Riviello Jr., Lori Shutter, Michael R. Sperling, David M. Treiman, Paul M. Vespa, Neurocritical Care Society Status Epilepticus Guideline Writing Committee

Erschienen in: Neurocritical Care | Ausgabe 1/2012

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Abstract

Status epilepticus (SE) treatment strategies vary substantially from one institution to another due to the lack of data to support one treatment over another. To provide guidance for the acute treatment of SE in critically ill patients, the Neurocritical Care Society organized a writing committee to evaluate the literature and develop an evidence-based and expert consensus practice guideline. Literature searches were conducted using PubMed and studies meeting the criteria established by the writing committee were evaluated. Recommendations were developed based on the literature using standardized assessment methods from the American Heart Association and Grading of Recommendations Assessment, Development, and Evaluation systems, as well as expert opinion when sufficient data were lacking.
Literatur
1.
Zurück zum Zitat Beran RG. An alternative perspective on the management of status epilepticus. Epilepsy Behav. 2008;12(3):349–53.PubMedCrossRef Beran RG. An alternative perspective on the management of status epilepticus. Epilepsy Behav. 2008;12(3):349–53.PubMedCrossRef
2.
Zurück zum Zitat Seif-Eddeine H, Treiman DM. Problems and controversies in status epilepticus: a review and recommendations. Expert Rev Neurother. 2011;11(12):1747–58.PubMedCrossRef Seif-Eddeine H, Treiman DM. Problems and controversies in status epilepticus: a review and recommendations. Expert Rev Neurother. 2011;11(12):1747–58.PubMedCrossRef
3.
Zurück zum Zitat Rossetti AO, Lowenstein DH. Management of refractory status epilepticus in adults: still more questions than answers. Lancet Neurol. 2011;10(10):922–30.PubMedCrossRef Rossetti AO, Lowenstein DH. Management of refractory status epilepticus in adults: still more questions than answers. Lancet Neurol. 2011;10(10):922–30.PubMedCrossRef
4.
Zurück zum Zitat Gibbons RJ, Smith S, Antman E. American College of Cardiology/American Heart Association clinical practice guidelines: Part I: where do they come from? Circulation. 2003;107(23):2979–86.PubMedCrossRef Gibbons RJ, Smith S, Antman E. American College of Cardiology/American Heart Association clinical practice guidelines: Part I: where do they come from? Circulation. 2003;107(23):2979–86.PubMedCrossRef
5.
Zurück zum Zitat Jaeschke R, Guyatt GH, Dellinger P, Schunemann H, Levy MM, Kunz R, Norris S, Bion J. Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive. BMJ. 2008;337:a744.PubMedCrossRef Jaeschke R, Guyatt GH, Dellinger P, Schunemann H, Levy MM, Kunz R, Norris S, Bion J. Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive. BMJ. 2008;337:a744.PubMedCrossRef
6.
Zurück zum Zitat Abend NS, Dlugos DJ, Hahn CD, Hirsch LJ, Herman ST. Use of EEG monitoring and management of non-convulsive seizures in critically ill patients: a survey of neurologists. Neurocrit Care. 2010;12(3):382–9.PubMedCrossRef Abend NS, Dlugos DJ, Hahn CD, Hirsch LJ, Herman ST. Use of EEG monitoring and management of non-convulsive seizures in critically ill patients: a survey of neurologists. Neurocrit Care. 2010;12(3):382–9.PubMedCrossRef
7.
Zurück zum Zitat Jenssen S, Gracely EJ, Sperling MR. How long do most seizures last? A systematic comparison of seizures recorded in the epilepsy monitoring unit. Epilepsia. 2006;47(9):1499–503.PubMedCrossRef Jenssen S, Gracely EJ, Sperling MR. How long do most seizures last? A systematic comparison of seizures recorded in the epilepsy monitoring unit. Epilepsia. 2006;47(9):1499–503.PubMedCrossRef
8.
9.
Zurück zum Zitat Theodore WH, Porter RJ, Albert P, Kelley K, Bromfield E, Devinsky O, Sato S. The secondarily generalized tonic-clonic seizure: a videotape analysis. Neurology. 1994;44(8):1403–7.PubMedCrossRef Theodore WH, Porter RJ, Albert P, Kelley K, Bromfield E, Devinsky O, Sato S. The secondarily generalized tonic-clonic seizure: a videotape analysis. Neurology. 1994;44(8):1403–7.PubMedCrossRef
10.
11.
Zurück zum Zitat Meldrum BS, Horton RW. Physiology of status epilepticus in primates. Arch Neurol. 1973;28(1):1–9.PubMedCrossRef Meldrum BS, Horton RW. Physiology of status epilepticus in primates. Arch Neurol. 1973;28(1):1–9.PubMedCrossRef
12.
Zurück zum Zitat Chen JWY, Wasterlain CG. Status epilepticus: pathophysiology and management in adults. Lancet Neurol. 2006;5(3):246–56.PubMedCrossRef Chen JWY, Wasterlain CG. Status epilepticus: pathophysiology and management in adults. Lancet Neurol. 2006;5(3):246–56.PubMedCrossRef
13.
Zurück zum Zitat Kapur J. Rapid seizure-induced reduction of benzodiazepine and Zn2 sensitivity of hippocampal dentate granule cell GABAA receptors. J Neurosci. 1997;17(19):7532.PubMed Kapur J. Rapid seizure-induced reduction of benzodiazepine and Zn2 sensitivity of hippocampal dentate granule cell GABAA receptors. J Neurosci. 1997;17(19):7532.PubMed
14.
Zurück zum Zitat Mazarati AM. Time-dependent decrease in the effectiveness of antiepileptic drugs during the course of self-sustaining status epilepticus. Brain Res. 1998;814(1–2):179.PubMedCrossRef Mazarati AM. Time-dependent decrease in the effectiveness of antiepileptic drugs during the course of self-sustaining status epilepticus. Brain Res. 1998;814(1–2):179.PubMedCrossRef
15.
Zurück zum Zitat Hirsch LJ. Status epilepticus. CONTINUUM Lifelong Learn Neurol. 2007;13(4):121–51. Hirsch LJ. Status epilepticus. CONTINUUM Lifelong Learn Neurol. 2007;13(4):121–51.
16.
Zurück zum Zitat Lowenstein DH. Status epilepticus: an overview of the clinical problem. Epilepsia. 1999;40(Suppl 1):S3–8. discussion S21–22.PubMedCrossRef Lowenstein DH. Status epilepticus: an overview of the clinical problem. Epilepsia. 1999;40(Suppl 1):S3–8. discussion S21–22.PubMedCrossRef
17.
Zurück zum Zitat Meldrum BS. The revised operational definition of generalised tonic-clonic (TC) status epilepticus in adults. Epilepsia. 1999;40(1):123–4.PubMedCrossRef Meldrum BS. The revised operational definition of generalised tonic-clonic (TC) status epilepticus in adults. Epilepsia. 1999;40(1):123–4.PubMedCrossRef
18.
Zurück zum Zitat Knake S, Hamer HM, Rosenow F. Status epilepticus: a critical review. Epilepsy Behav. 2009;15(1):10–4.PubMedCrossRef Knake S, Hamer HM, Rosenow F. Status epilepticus: a critical review. Epilepsy Behav. 2009;15(1):10–4.PubMedCrossRef
19.
Zurück zum Zitat Alldredge BK. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med. 2001;345(9):631–7.PubMedCrossRef Alldredge BK. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med. 2001;345(9):631–7.PubMedCrossRef
20.
Zurück zum Zitat Meierkord H, Boon P, Engelsen B, Göcke K, Shorvon S, Tinuper P, Holtkamp M. EFNS guideline on the management of status epilepticus. Eur J Neurol. 2006;13(5):445–50.PubMedCrossRef Meierkord H, Boon P, Engelsen B, Göcke K, Shorvon S, Tinuper P, Holtkamp M. EFNS guideline on the management of status epilepticus. Eur J Neurol. 2006;13(5):445–50.PubMedCrossRef
21.
Zurück zum Zitat Walker M. Status epilepticus: an evidence based guide. Br Med J (Clin Res Ed). 2005;331(7518):673–7.CrossRef Walker M. Status epilepticus: an evidence based guide. Br Med J (Clin Res Ed). 2005;331(7518):673–7.CrossRef
22.
Zurück zum Zitat Shorvon S. The management of status epilepticus. J Neurol Neurosurg Psychiatry. 2001;70(Suppl 2):22–7. Shorvon S. The management of status epilepticus. J Neurol Neurosurg Psychiatry. 2001;70(Suppl 2):22–7.
23.
Zurück zum Zitat Kaplan PW. Nonconvulsive status epilepticus in the emergency room. Epilepsia. 1996;37(7):643–50.PubMedCrossRef Kaplan PW. Nonconvulsive status epilepticus in the emergency room. Epilepsia. 1996;37(7):643–50.PubMedCrossRef
24.
Zurück zum Zitat Shorvon S. What is nonconvulsive status epilepticus, and what are its subtypes? Epilepsia. 2007;48(Suppl 8):35–8.PubMedCrossRef Shorvon S. What is nonconvulsive status epilepticus, and what are its subtypes? Epilepsia. 2007;48(Suppl 8):35–8.PubMedCrossRef
25.
Zurück zum Zitat Towne AR, Waterhouse EJ, Boggs JG, Garnett LK, Brown AJ, Smith JR Jr, DeLorenzo RJ. Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology. 2000;54(2):340–5.PubMedCrossRef Towne AR, Waterhouse EJ, Boggs JG, Garnett LK, Brown AJ, Smith JR Jr, DeLorenzo RJ. Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology. 2000;54(2):340–5.PubMedCrossRef
26.
Zurück zum Zitat Rossetti AO, Reichhart MD, Schaller MD, Despland PA, Bogousslavsky J. Propofol treatment of refractory status epilepticus: a study of 31 episodes. Epilepsia. 2004;45(7):757–63.PubMedCrossRef Rossetti AO, Reichhart MD, Schaller MD, Despland PA, Bogousslavsky J. Propofol treatment of refractory status epilepticus: a study of 31 episodes. Epilepsia. 2004;45(7):757–63.PubMedCrossRef
27.
Zurück zum Zitat Krishnamurthy KB, Drislane FW. Depth of EEG suppression and outcome in barbiturate anesthetic treatment for refractory status epilepticus. Epilepsia. 1999;40(6):759–62.PubMedCrossRef Krishnamurthy KB, Drislane FW. Depth of EEG suppression and outcome in barbiturate anesthetic treatment for refractory status epilepticus. Epilepsia. 1999;40(6):759–62.PubMedCrossRef
28.
Zurück zum Zitat Claassen J, Hirsch LJ, Emerson RG, Bates JE, Thompson TB, Mayer SA. Continuous EEG monitoring and midazolam infusion for refractory nonconvulsive status epilepticus. Neurology. 2001;57(6):1036–42.PubMedCrossRef Claassen J, Hirsch LJ, Emerson RG, Bates JE, Thompson TB, Mayer SA. Continuous EEG monitoring and midazolam infusion for refractory nonconvulsive status epilepticus. Neurology. 2001;57(6):1036–42.PubMedCrossRef
30.
Zurück zum Zitat Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ, Handforth A, Faught E, Calabrese VP, Uthman BM, et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans affairs status epilepticus cooperative study group. N Engl J Med. 1998;339(12):792–8.PubMedCrossRef Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ, Handforth A, Faught E, Calabrese VP, Uthman BM, et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans affairs status epilepticus cooperative study group. N Engl J Med. 1998;339(12):792–8.PubMedCrossRef
31.
Zurück zum Zitat Jirsch J, Hirsch LJ. Nonconvulsive seizures: developing a rational approach to the diagnosis and management in the critically ill population. Clin Neurophysiol. 2007;118(8):1660–70.PubMedCrossRef Jirsch J, Hirsch LJ. Nonconvulsive seizures: developing a rational approach to the diagnosis and management in the critically ill population. Clin Neurophysiol. 2007;118(8):1660–70.PubMedCrossRef
32.
33.
Zurück zum Zitat Shinnar S, Pellock JM, Moshe SL, Maytal J, O’Dell C, Driscoll SM, Alemany M, Newstein D, DeLorenzo RJ. In whom does status epilepticus occur: age-related differences in children. Epilepsia. 1997;38(8):907–14.PubMedCrossRef Shinnar S, Pellock JM, Moshe SL, Maytal J, O’Dell C, Driscoll SM, Alemany M, Newstein D, DeLorenzo RJ. In whom does status epilepticus occur: age-related differences in children. Epilepsia. 1997;38(8):907–14.PubMedCrossRef
34.
Zurück zum Zitat Chin RF, Neville BG, Peckham C, Bedford H, Wade A, Scott RC. Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study. Lancet. 2006;368(9531):222–9.PubMedCrossRef Chin RF, Neville BG, Peckham C, Bedford H, Wade A, Scott RC. Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study. Lancet. 2006;368(9531):222–9.PubMedCrossRef
35.
Zurück zum Zitat Riviello JJ, Ashwal S, Hirtz D, Glauser T, Ballaban-Gil K, Kelley K, Morton LD, Phillips S, Sloan E, Shinnar S. Practice parameter: diagnostic assessment of the child with status epilepticus (an evidence-based review). Neurology. 2006;67(9):1542–50.PubMedCrossRef Riviello JJ, Ashwal S, Hirtz D, Glauser T, Ballaban-Gil K, Kelley K, Morton LD, Phillips S, Sloan E, Shinnar S. Practice parameter: diagnostic assessment of the child with status epilepticus (an evidence-based review). Neurology. 2006;67(9):1542–50.PubMedCrossRef
36.
Zurück zum Zitat Claassen J, Lokin JK, Fitzsimmons BF, Mendelsohn FA, Mayer SA. Predictors of functional disability and mortality after status epilepticus. Neurology. 2002;58(1):139–42.PubMedCrossRef Claassen J, Lokin JK, Fitzsimmons BF, Mendelsohn FA, Mayer SA. Predictors of functional disability and mortality after status epilepticus. Neurology. 2002;58(1):139–42.PubMedCrossRef
37.
Zurück zum Zitat Rossetti AO, Hurwitz S, Logroscino G, Bromfield EB. Prognosis of status epilepticus: role of aetiology, age, and consciousness impairment at presentation. J Neurol Neurosurg Psychiatry. 2006;77(5):611–5.PubMedCrossRef Rossetti AO, Hurwitz S, Logroscino G, Bromfield EB. Prognosis of status epilepticus: role of aetiology, age, and consciousness impairment at presentation. J Neurol Neurosurg Psychiatry. 2006;77(5):611–5.PubMedCrossRef
38.
Zurück zum Zitat Novy J, Rossetti AO. Oral pregabalin as an add-on treatment for status epilepticus. Epilepsia. 2010;51(10):2207–10.PubMedCrossRef Novy J, Rossetti AO. Oral pregabalin as an add-on treatment for status epilepticus. Epilepsia. 2010;51(10):2207–10.PubMedCrossRef
39.
Zurück zum Zitat Logroscino G, Hesdorffer DC, Cascino G, Annegers JF, Hauser WA. Short-term mortality after a first episode of status epilepticus. Epilepsia. 1997;38(12):1344–9.PubMedCrossRef Logroscino G, Hesdorffer DC, Cascino G, Annegers JF, Hauser WA. Short-term mortality after a first episode of status epilepticus. Epilepsia. 1997;38(12):1344–9.PubMedCrossRef
40.
Zurück zum Zitat Legriel S, Mourvillier B, Bele N, Amaro J, Fouet P, Manet P, Hilpert F. Outcomes in 140 critically ill patients with status epilepticus. Intensive Care Med. 2008;34(3):476–80.PubMedCrossRef Legriel S, Mourvillier B, Bele N, Amaro J, Fouet P, Manet P, Hilpert F. Outcomes in 140 critically ill patients with status epilepticus. Intensive Care Med. 2008;34(3):476–80.PubMedCrossRef
41.
Zurück zum Zitat Legriel S. Functional outcome after convulsive status epilepticus. Crit Care Med. 2010;38(12):2295–303.PubMedCrossRef Legriel S. Functional outcome after convulsive status epilepticus. Crit Care Med. 2010;38(12):2295–303.PubMedCrossRef
42.
Zurück zum Zitat Logroscino G, Hesdorffer DC, Cascino GD, Annegers JF, Bagiella E, Hauser WA. Long-term mortality after a first episode of status epilepticus. Neurology. 2002;58(4):537–41.PubMedCrossRef Logroscino G, Hesdorffer DC, Cascino GD, Annegers JF, Bagiella E, Hauser WA. Long-term mortality after a first episode of status epilepticus. Neurology. 2002;58(4):537–41.PubMedCrossRef
43.
Zurück zum Zitat Riviello JJ, Holmes GL. The treatment of status epilepticus. Semin Pediatr Neurol. 2004;11(2):129–38.PubMedCrossRef Riviello JJ, Holmes GL. The treatment of status epilepticus. Semin Pediatr Neurol. 2004;11(2):129–38.PubMedCrossRef
44.
Zurück zum Zitat Oxbury JM. Causes and consequences of status epilepticus in adults. A study of 86 cases. Brain. 1971;94(4):733–44.PubMedCrossRef Oxbury JM. Causes and consequences of status epilepticus in adults. A study of 86 cases. Brain. 1971;94(4):733–44.PubMedCrossRef
45.
Zurück zum Zitat Aminoff MJ, Simon RP. Status epilepticus: causes, clinical features and consequences in 98 patients. Am J Med. 1980;69(5):657–66.PubMedCrossRef Aminoff MJ, Simon RP. Status epilepticus: causes, clinical features and consequences in 98 patients. Am J Med. 1980;69(5):657–66.PubMedCrossRef
46.
Zurück zum Zitat Lowenstein DH, Alldredge BK. Status epilepticus at an urban public hospital in the 1980s. Neurology. 1993;43(3 Pt 1):483–8.PubMedCrossRef Lowenstein DH, Alldredge BK. Status epilepticus at an urban public hospital in the 1980s. Neurology. 1993;43(3 Pt 1):483–8.PubMedCrossRef
47.
Zurück zum Zitat Scholtes FB, Renier WO, Meinardi H. Generalized convulsive status epilepticus: causes, therapy, and outcome in 346 patients. Epilepsia. 1994;35(5):1104–12.PubMedCrossRef Scholtes FB, Renier WO, Meinardi H. Generalized convulsive status epilepticus: causes, therapy, and outcome in 346 patients. Epilepsia. 1994;35(5):1104–12.PubMedCrossRef
48.
Zurück zum Zitat Logroscino G, Hesdorffer DC, Cascino G, Annegers JF, Hauser WA. Time trends in incidence, mortality, and case-fatality after first episode of status epilepticus. Epilepsia. 2001;42(8):1031–5.PubMedCrossRef Logroscino G, Hesdorffer DC, Cascino G, Annegers JF, Hauser WA. Time trends in incidence, mortality, and case-fatality after first episode of status epilepticus. Epilepsia. 2001;42(8):1031–5.PubMedCrossRef
49.
Zurück zum Zitat Delanty N, French JA, Labar DR, Pedley TA, Rowan AJ. Status epilepticus arising de novo in hospitalized patients: an analysis of 41 patients. Seizure. 2001;10(2):116–9.PubMed Delanty N, French JA, Labar DR, Pedley TA, Rowan AJ. Status epilepticus arising de novo in hospitalized patients: an analysis of 41 patients. Seizure. 2001;10(2):116–9.PubMed
50.
Zurück zum Zitat Aranda A, Foucart G, Ducassé JL, Grolleau S, McGonigal A, Valton L. Generalized convulsive status epilepticus management in adults: a cohort study with evaluation of professional practice. Epilepsia. 2010;51(10):2159–67.PubMedCrossRef Aranda A, Foucart G, Ducassé JL, Grolleau S, McGonigal A, Valton L. Generalized convulsive status epilepticus management in adults: a cohort study with evaluation of professional practice. Epilepsia. 2010;51(10):2159–67.PubMedCrossRef
51.
Zurück zum Zitat Young B, Jordan K, Doig G. An assessment of nonconvulsive seizures in the intensive care unit using continuous EEG monitoring: an investigation of variables associated with mortality. Neurology. 1996;47:83–9.PubMedCrossRef Young B, Jordan K, Doig G. An assessment of nonconvulsive seizures in the intensive care unit using continuous EEG monitoring: an investigation of variables associated with mortality. Neurology. 1996;47:83–9.PubMedCrossRef
52.
Zurück zum Zitat Litt B, Wityk RJ, Hertz SH, Mullen PD, Weiss H, Ryan DD, Henry TR. Nonconvulsive status epilepticus in the critically ill elderly. Epilepsia. 1998;39(11):1194–202.PubMedCrossRef Litt B, Wityk RJ, Hertz SH, Mullen PD, Weiss H, Ryan DD, Henry TR. Nonconvulsive status epilepticus in the critically ill elderly. Epilepsia. 1998;39(11):1194–202.PubMedCrossRef
53.
Zurück zum Zitat Shneker BF, Fountain NB. Assessment of acute morbidity and mortality in nonconvulsive status epilepticus. Neurology. 2003;61(8):1066–73.PubMedCrossRef Shneker BF, Fountain NB. Assessment of acute morbidity and mortality in nonconvulsive status epilepticus. Neurology. 2003;61(8):1066–73.PubMedCrossRef
54.
Zurück zum Zitat DeLorenzo RJ, Waterhouse EJ, Towne AR, Boggs JG, Ko D, DeLorenzo GA, Brown A, Garnett L. Persistent nonconvulsive status epilepticus after the control of convulsive status epilepticus. Epilepsia. 1998;39(8):833–40.PubMedCrossRef DeLorenzo RJ, Waterhouse EJ, Towne AR, Boggs JG, Ko D, DeLorenzo GA, Brown A, Garnett L. Persistent nonconvulsive status epilepticus after the control of convulsive status epilepticus. Epilepsia. 1998;39(8):833–40.PubMedCrossRef
55.
Zurück zum Zitat Young GB, Blume WT, Bolton CF, Warren KG. Anesthetic barbiturates in refractory status epilepticus. Can J Neurol Sci. 1980;7(4):291–2.PubMed Young GB, Blume WT, Bolton CF, Warren KG. Anesthetic barbiturates in refractory status epilepticus. Can J Neurol Sci. 1980;7(4):291–2.PubMed
56.
Zurück zum Zitat Rashkin MC, Youngs C, Penovich P. Pentobarbital treatment of refractory status epilepticus. Neurology. 1987;37(3):500.PubMedCrossRef Rashkin MC, Youngs C, Penovich P. Pentobarbital treatment of refractory status epilepticus. Neurology. 1987;37(3):500.PubMedCrossRef
57.
Zurück zum Zitat Osorio I, Reed RC. Treatment of refractory generalized tonic-clonic status epilepticus with pentobarbital anesthesia after high-dose phenytoin. Epilepsia. 1989;30(4):464–71.PubMedCrossRef Osorio I, Reed RC. Treatment of refractory generalized tonic-clonic status epilepticus with pentobarbital anesthesia after high-dose phenytoin. Epilepsia. 1989;30(4):464–71.PubMedCrossRef
58.
Zurück zum Zitat Van Ness PC. Pentobarbital and EEG burst suppression in treatment of status epilepticus refractory to benzodiazepines and phenytoin. Epilepsia. 1990;31(1):61–7.PubMedCrossRef Van Ness PC. Pentobarbital and EEG burst suppression in treatment of status epilepticus refractory to benzodiazepines and phenytoin. Epilepsia. 1990;31(1):61–7.PubMedCrossRef
59.
Zurück zum Zitat Yaffe K, Lowenstein DH. Prognostic factors of pentobarbital therapy for refractory generalized status epilepticus. Neurology. 1993;43(5):895.PubMedCrossRef Yaffe K, Lowenstein DH. Prognostic factors of pentobarbital therapy for refractory generalized status epilepticus. Neurology. 1993;43(5):895.PubMedCrossRef
60.
Zurück zum Zitat Sagduyu A, Tarlaci S, Sirin H. Generalized tonic-clonic status epilepticus: causes, treatment, complications and predictors of case fatality. J Neurol. 1998;245(10):640–6.PubMedCrossRef Sagduyu A, Tarlaci S, Sirin H. Generalized tonic-clonic status epilepticus: causes, treatment, complications and predictors of case fatality. J Neurol. 1998;245(10):640–6.PubMedCrossRef
61.
Zurück zum Zitat Brown L. Role of propofol in refractory status epilepticus. Ann Pharmacother. 1998;32(10):1053–9.PubMedCrossRef Brown L. Role of propofol in refractory status epilepticus. Ann Pharmacother. 1998;32(10):1053–9.PubMedCrossRef
62.
Zurück zum Zitat Stecker MM, Kramer TH, Raps EC, O’Meeghan R, Dulaney E, Skaar DJ. Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. Epilepsia. 1998;39(1):18–26.PubMedCrossRef Stecker MM, Kramer TH, Raps EC, O’Meeghan R, Dulaney E, Skaar DJ. Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. Epilepsia. 1998;39(1):18–26.PubMedCrossRef
63.
Zurück zum Zitat Claassen J, Hirsch LJ, Emerson RG, Mayer SA. Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic review. Epilepsia. 2002;43(2):146–53.PubMedCrossRef Claassen J, Hirsch LJ, Emerson RG, Mayer SA. Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic review. Epilepsia. 2002;43(2):146–53.PubMedCrossRef
64.
Zurück zum Zitat Drislane FW, Blum AS, Lopez MR, Gautam S, Schomer DL. Duration of refractory status epilepticus and outcome: loss of prognostic utility after several hours. Epilepsia. 2009;50(6):1566–71.PubMedCrossRef Drislane FW, Blum AS, Lopez MR, Gautam S, Schomer DL. Duration of refractory status epilepticus and outcome: loss of prognostic utility after several hours. Epilepsia. 2009;50(6):1566–71.PubMedCrossRef
65.
Zurück zum Zitat Holtkamp M, Othman J, Buchheim K, Meierkord H. Predictors and prognosis of refractory status epilepticus treated in a neurological intensive care unit. J Neurol Neurosurg Psychiatry. 2005;76(4):534–9.PubMedCrossRef Holtkamp M, Othman J, Buchheim K, Meierkord H. Predictors and prognosis of refractory status epilepticus treated in a neurological intensive care unit. J Neurol Neurosurg Psychiatry. 2005;76(4):534–9.PubMedCrossRef
66.
Zurück zum Zitat Rossetti AO, Logroscino G, Bromfield EB. Refractory status epilepticus: effect of treatment aggressiveness on prognosis. Arch Neurol. 2005;62(11):1698–702.PubMedCrossRef Rossetti AO, Logroscino G, Bromfield EB. Refractory status epilepticus: effect of treatment aggressiveness on prognosis. Arch Neurol. 2005;62(11):1698–702.PubMedCrossRef
67.
Zurück zum Zitat Drislane FW, Lopez MR, Blum AS, Schomer DL. Detection and treatment of refractory status epilepticus in the intensive care unit. J Clin Neurophysiol. 2008;25(4):181–6.PubMedCrossRef Drislane FW, Lopez MR, Blum AS, Schomer DL. Detection and treatment of refractory status epilepticus in the intensive care unit. J Clin Neurophysiol. 2008;25(4):181–6.PubMedCrossRef
68.
Zurück zum Zitat Rossetti AO, Milligan TA, Vulliemoz S, Michaelides C, Bertschi M, Lee JW. A randomized trial for the treatment of refractory status epilepticus. Neurocrit Care. 2011;14(1):4–10.PubMedCrossRef Rossetti AO, Milligan TA, Vulliemoz S, Michaelides C, Bertschi M, Lee JW. A randomized trial for the treatment of refractory status epilepticus. Neurocrit Care. 2011;14(1):4–10.PubMedCrossRef
69.
Zurück zum Zitat Saz EU, Karapinar B, Ozcetin M, Polat M, Tosun A, Serdaroglu G, Gokben S, Tekgul H. Convulsive status epilepticus in children: etiology, treatment protocol and outcome. Seizure. 2011;20(2):115–8.PubMedCrossRef Saz EU, Karapinar B, Ozcetin M, Polat M, Tosun A, Serdaroglu G, Gokben S, Tekgul H. Convulsive status epilepticus in children: etiology, treatment protocol and outcome. Seizure. 2011;20(2):115–8.PubMedCrossRef
70.
Zurück zum Zitat Sahin M, Menache CC, Holmes GL, Riviello JJ. Outcome of severe refractory status epilepticus in children. Epilepsia. 2001;42(11):1461–7.PubMedCrossRef Sahin M, Menache CC, Holmes GL, Riviello JJ. Outcome of severe refractory status epilepticus in children. Epilepsia. 2001;42(11):1461–7.PubMedCrossRef
71.
Zurück zum Zitat Sahin M, Menache CC, Holmes GL, Riviello JJ. Prolonged treatment for acute symptomatic refractory status epilepticus. Neurology. 2003;61(3):398–401.PubMedCrossRef Sahin M, Menache CC, Holmes GL, Riviello JJ. Prolonged treatment for acute symptomatic refractory status epilepticus. Neurology. 2003;61(3):398–401.PubMedCrossRef
72.
Zurück zum Zitat Gilbert DL, Gartside PS, Glauser TA. Efficacy and mortality in treatment of refractory generalized convulsive status epilepticus in children: a meta-analysis. J Child Neurol. 1999;14(9):602–9.PubMedCrossRef Gilbert DL, Gartside PS, Glauser TA. Efficacy and mortality in treatment of refractory generalized convulsive status epilepticus in children: a meta-analysis. J Child Neurol. 1999;14(9):602–9.PubMedCrossRef
73.
Zurück zum Zitat Mayer SA, Claassen J, Lokin J, Mendelsohn F, Dennis LJ, Fitzsimmons B-F. Refractory status epilepticus: frequency, risk factors, and impact on outcome. Arch Neurol. 2002;59(2):205–10.PubMedCrossRef Mayer SA, Claassen J, Lokin J, Mendelsohn F, Dennis LJ, Fitzsimmons B-F. Refractory status epilepticus: frequency, risk factors, and impact on outcome. Arch Neurol. 2002;59(2):205–10.PubMedCrossRef
74.
Zurück zum Zitat Maytal J, Shinnar S, Moshé SL, Alvarez LA. Low morbidity and mortality of status epilepticus in children. Pediatrics. 1989;83(3):323–31.PubMed Maytal J, Shinnar S, Moshé SL, Alvarez LA. Low morbidity and mortality of status epilepticus in children. Pediatrics. 1989;83(3):323–31.PubMed
75.
Zurück zum Zitat Towne AR, Pellock JM, Ko D, DeLorenzo RJ. Determinants of mortality in status epilepticus. Epilepsia. 1994;35(1):27–34.PubMedCrossRef Towne AR, Pellock JM, Ko D, DeLorenzo RJ. Determinants of mortality in status epilepticus. Epilepsia. 1994;35(1):27–34.PubMedCrossRef
76.
Zurück zum Zitat Lewena S, Pennington V, Acworth J, Thornton S, Ngo P, McIntyre S, Krieser D, Neutze J, Speldewinde D. Emergency management of pediatric convulsive status epilepticus: a multicenter study of 542 patients. Pediatr Emerg Care. 2009;25(2):83–7.PubMedCrossRef Lewena S, Pennington V, Acworth J, Thornton S, Ngo P, McIntyre S, Krieser D, Neutze J, Speldewinde D. Emergency management of pediatric convulsive status epilepticus: a multicenter study of 542 patients. Pediatr Emerg Care. 2009;25(2):83–7.PubMedCrossRef
77.
Zurück zum Zitat Roppolo LP, Walters K. Airway management in neurological emergencies. Neurocrit Care. 2004;1(4):405–14.PubMedCrossRef Roppolo LP, Walters K. Airway management in neurological emergencies. Neurocrit Care. 2004;1(4):405–14.PubMedCrossRef
78.
Zurück zum Zitat van Rijckevorsel K, Boon P, Hauman H, Legros B, Ossemanns M, Sadzot B, Schmedding E, van Zandijcke M. Standards of care for adults with convulsive status epilepticus: Belgian consensus recommendations. Acta Neurol Belg. 2005;105(3):111–8.PubMed van Rijckevorsel K, Boon P, Hauman H, Legros B, Ossemanns M, Sadzot B, Schmedding E, van Zandijcke M. Standards of care for adults with convulsive status epilepticus: Belgian consensus recommendations. Acta Neurol Belg. 2005;105(3):111–8.PubMed
79.
80.
Zurück zum Zitat Privitera M, Hoffman M, Moore JL, Jester D. EEG detection of nontonic-clonic status epilepticus in patients with altered consciousness. Epilepsy Res. 1994;18(2):155–66.PubMedCrossRef Privitera M, Hoffman M, Moore JL, Jester D. EEG detection of nontonic-clonic status epilepticus in patients with altered consciousness. Epilepsy Res. 1994;18(2):155–66.PubMedCrossRef
81.
Zurück zum Zitat Drislane FW. Presentation, evaluation, and treatment of nonconvulsive status epilepticus. Epilepsy Behav. 2000;1(5):301–14.PubMedCrossRef Drislane FW. Presentation, evaluation, and treatment of nonconvulsive status epilepticus. Epilepsy Behav. 2000;1(5):301–14.PubMedCrossRef
82.
Zurück zum Zitat Oddo M, Carrera E, Claassen J, Mayer SA, Hirsch LJ. Continuous electroencephalography in the medical intensive care unit. Crit Care Med. 2009;37(6):2051–6.PubMedCrossRef Oddo M, Carrera E, Claassen J, Mayer SA, Hirsch LJ. Continuous electroencephalography in the medical intensive care unit. Crit Care Med. 2009;37(6):2051–6.PubMedCrossRef
83.
Zurück zum Zitat Leppik IE, Derivan AT, Homan RW, Walker J, Ramsay RE, Patrick B. Double-blind study of lorazepam and diazepam in status epilepticus. JAMA. 1983;249(11):1452–4.PubMedCrossRef Leppik IE, Derivan AT, Homan RW, Walker J, Ramsay RE, Patrick B. Double-blind study of lorazepam and diazepam in status epilepticus. JAMA. 1983;249(11):1452–4.PubMedCrossRef
84.
Zurück zum Zitat Silbergleit R, Durkalski V, Lowenstein D, Conwit R, Pancioli A, Palesch Y, Barsan W. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 2012;366(7):591–600.PubMedCrossRef Silbergleit R, Durkalski V, Lowenstein D, Conwit R, Pancioli A, Palesch Y, Barsan W. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 2012;366(7):591–600.PubMedCrossRef
85.
Zurück zum Zitat Alvarez N, Besag F, Iivanainen M. Use of antiepileptic drugs in the treatment of epilepsy in people with intellectual disability. J Intellect Disabil Res. 1998;42(Suppl 1):1–15.PubMed Alvarez N, Besag F, Iivanainen M. Use of antiepileptic drugs in the treatment of epilepsy in people with intellectual disability. J Intellect Disabil Res. 1998;42(Suppl 1):1–15.PubMed
86.
Zurück zum Zitat Troester MM, Hastriter EV, Ng YT. Dissolving oral clonazepam wafers in the acute treatment of prolonged seizures. J Child Neurol. 2010;25(12):1468–72.PubMedCrossRef Troester MM, Hastriter EV, Ng YT. Dissolving oral clonazepam wafers in the acute treatment of prolonged seizures. J Child Neurol. 2010;25(12):1468–72.PubMedCrossRef
87.
Zurück zum Zitat Treiman DM, Walker MC. Treatment of seizure emergencies: convulsive and non-convulsive status epilepticus. Epilepsy Res. 2006;68(Suppl 1):S77–82.PubMedCrossRef Treiman DM, Walker MC. Treatment of seizure emergencies: convulsive and non-convulsive status epilepticus. Epilepsy Res. 2006;68(Suppl 1):S77–82.PubMedCrossRef
88.
Zurück zum Zitat Appleton R, Sweeney A, Choonara I, Robson J, Molyneux E. Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. Dev Med Child Neurol. 1995;37(8):682–8.PubMedCrossRef Appleton R, Sweeney A, Choonara I, Robson J, Molyneux E. Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. Dev Med Child Neurol. 1995;37(8):682–8.PubMedCrossRef
89.
Zurück zum Zitat Walker JE, Homan RW, Vasko MR, Crawford IL, Bell RD, Tasker WG. Lorazepam in status epilepticus. Ann Neurol. 1979;6(3):207–13.PubMedCrossRef Walker JE, Homan RW, Vasko MR, Crawford IL, Bell RD, Tasker WG. Lorazepam in status epilepticus. Ann Neurol. 1979;6(3):207–13.PubMedCrossRef
90.
Zurück zum Zitat Cock HR, Schapira AH. A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus. QJM. 2002;95(4):225–31.PubMedCrossRef Cock HR, Schapira AH. A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus. QJM. 2002;95(4):225–31.PubMedCrossRef
91.
Zurück zum Zitat Crawford TO, Mitchell WG, Snodgrass SR. Lorazepam in childhood status epilepticus and serial seizures: effectiveness and tachyphylaxis. Neurology. 1987;37(2):190–5.PubMedCrossRef Crawford TO, Mitchell WG, Snodgrass SR. Lorazepam in childhood status epilepticus and serial seizures: effectiveness and tachyphylaxis. Neurology. 1987;37(2):190–5.PubMedCrossRef
92.
Zurück zum Zitat Kapur J. Prehospital treatment of status epilepticus with benzodiazepines is effective and safe. Epilepsy Curr. 2002;2(4):121–4.PubMedCrossRef Kapur J. Prehospital treatment of status epilepticus with benzodiazepines is effective and safe. Epilepsy Curr. 2002;2(4):121–4.PubMedCrossRef
93.
94.
Zurück zum Zitat Prasad K, Krishnan PR, Al-Roomi K, Sequeira R. Anticonvulsant therapy for status epilepticus. Br J Clin Pharmacol. 2007;63(6):640–7.PubMedCrossRef Prasad K, Krishnan PR, Al-Roomi K, Sequeira R. Anticonvulsant therapy for status epilepticus. Br J Clin Pharmacol. 2007;63(6):640–7.PubMedCrossRef
95.
Zurück zum Zitat Giang DW, McBride MC. Lorazepam versus diazepam for the treatment of status epilepticus. Pediatr Neurol. 1988;4(6):358–61.PubMedCrossRef Giang DW, McBride MC. Lorazepam versus diazepam for the treatment of status epilepticus. Pediatr Neurol. 1988;4(6):358–61.PubMedCrossRef
96.
Zurück zum Zitat Labar DR, Ali A, Root J. High-dose intravenous lorazepam for the treatment of refractory status epilepticus. Neurology. 1994;44(8):1400–3.PubMedCrossRef Labar DR, Ali A, Root J. High-dose intravenous lorazepam for the treatment of refractory status epilepticus. Neurology. 1994;44(8):1400–3.PubMedCrossRef
97.
Zurück zum Zitat Sreenath TG, Gupta P, Sharma KK, Krishnamurthy S. Lorazepam versus diazepam-phenytoin combination in the treatment of convulsive status epilepticus in children: a randomized controlled trial. Eur J Paediatr Neurol. 2010;14(2):162–8.PubMedCrossRef Sreenath TG, Gupta P, Sharma KK, Krishnamurthy S. Lorazepam versus diazepam-phenytoin combination in the treatment of convulsive status epilepticus in children: a randomized controlled trial. Eur J Paediatr Neurol. 2010;14(2):162–8.PubMedCrossRef
98.
Zurück zum Zitat Qureshi A, Wassmer E, Davies P, Berry K, Whitehouse WP. Comparative audit of intravenous lorazepam and diazepam in the emergency treatment of convulsive status epilepticus in children. Seizure. 2002;11(3):141–4.PubMedCrossRef Qureshi A, Wassmer E, Davies P, Berry K, Whitehouse WP. Comparative audit of intravenous lorazepam and diazepam in the emergency treatment of convulsive status epilepticus in children. Seizure. 2002;11(3):141–4.PubMedCrossRef
99.
Zurück zum Zitat McMullan J, Sasson C, Pancioli A, Silbergleit R. Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta-analysis. Acad Emerg Med. 2010;17(6):575–82.PubMedCrossRef McMullan J, Sasson C, Pancioli A, Silbergleit R. Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta-analysis. Acad Emerg Med. 2010;17(6):575–82.PubMedCrossRef
100.
Zurück zum Zitat Nakken KO, Lossius MI. Buccal midazolam or rectal diazepam for treatment of residential adult patients with serial seizures or status epilepticus. Acta Neurol Scand. 2011;124(2):99–103.PubMedCrossRef Nakken KO, Lossius MI. Buccal midazolam or rectal diazepam for treatment of residential adult patients with serial seizures or status epilepticus. Acta Neurol Scand. 2011;124(2):99–103.PubMedCrossRef
101.
Zurück zum Zitat Baysun S, Aydin OF, Atmaca E, Gurer YK. A comparison of buccal midazolam and rectal diazepam for the acute treatment of seizures. Clin Pediatr (Phila). 2005;44(9):771–6.CrossRef Baysun S, Aydin OF, Atmaca E, Gurer YK. A comparison of buccal midazolam and rectal diazepam for the acute treatment of seizures. Clin Pediatr (Phila). 2005;44(9):771–6.CrossRef
102.
Zurück zum Zitat Lahat E, Goldman M, Barr J, Bistritzer T, Berkovitch M. Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study. BMJ. 2000;321(7253):83–6.PubMedCrossRef Lahat E, Goldman M, Barr J, Bistritzer T, Berkovitch M. Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study. BMJ. 2000;321(7253):83–6.PubMedCrossRef
103.
Zurück zum Zitat McIntyre J, Robertson S, Norris E, Appleton R, Whitehouse WP, Phillips B, Martland T, Berry K, Collier J, Smith S, et al. Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial. Lancet. 2005;366(9481):205–10.PubMedCrossRef McIntyre J, Robertson S, Norris E, Appleton R, Whitehouse WP, Phillips B, Martland T, Berry K, Collier J, Smith S, et al. Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial. Lancet. 2005;366(9481):205–10.PubMedCrossRef
104.
Zurück zum Zitat Scott RC, Besag FM, Neville BG. Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. Lancet. 1999;353(9153):623–6.PubMedCrossRef Scott RC, Besag FM, Neville BG. Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. Lancet. 1999;353(9153):623–6.PubMedCrossRef
105.
Zurück zum Zitat Mahmoudian T, Zadeh MM. Comparison of intranasal midazolam with intravenous diazepam for treating acute seizures in children. Epilepsy Behav. 2004;5(2):253–5.PubMedCrossRef Mahmoudian T, Zadeh MM. Comparison of intranasal midazolam with intravenous diazepam for treating acute seizures in children. Epilepsy Behav. 2004;5(2):253–5.PubMedCrossRef
106.
Zurück zum Zitat Yoshikawa H, Yamazaki S, Abe T, Oda Y. Midazolam as a first-line agent for status epilepticus in children. Brain Dev. 2000;22(4):239–42.PubMedCrossRef Yoshikawa H, Yamazaki S, Abe T, Oda Y. Midazolam as a first-line agent for status epilepticus in children. Brain Dev. 2000;22(4):239–42.PubMedCrossRef
107.
Zurück zum Zitat Brevoord JC, Joosten KF, Arts WF, van Rooij RW, de Hoog M. Status epilepticus: clinical analysis of a treatment protocol based on midazolam and phenytoin. J Child Neurol. 2005;20(6):476–81.PubMed Brevoord JC, Joosten KF, Arts WF, van Rooij RW, de Hoog M. Status epilepticus: clinical analysis of a treatment protocol based on midazolam and phenytoin. J Child Neurol. 2005;20(6):476–81.PubMed
108.
Zurück zum Zitat Koul RL, Raj Aithala G, Chacko A, Joshi R, Elbualy M. Continuous midazolam infusion as treatment of status epilepticus. Arch Dis Child. 1997;76(5):445–8.PubMedCrossRef Koul RL, Raj Aithala G, Chacko A, Joshi R, Elbualy M. Continuous midazolam infusion as treatment of status epilepticus. Arch Dis Child. 1997;76(5):445–8.PubMedCrossRef
109.
Zurück zum Zitat Nicol CF, Tutton JC, Smith BH. Parenteral diazepam in status epilepticus. Neurology. 1969;19(4):332–43.PubMedCrossRef Nicol CF, Tutton JC, Smith BH. Parenteral diazepam in status epilepticus. Neurology. 1969;19(4):332–43.PubMedCrossRef
110.
Zurück zum Zitat Parsonage MJ, Norris JW. Use of diazepam in treatment of severe convulsive status epilepticus. Br Med J. 1967;3(5557):85–8.PubMedCrossRef Parsonage MJ, Norris JW. Use of diazepam in treatment of severe convulsive status epilepticus. Br Med J. 1967;3(5557):85–8.PubMedCrossRef
111.
Zurück zum Zitat Dieckmann RA. Rectal diazepam for prehospital pediatric status epilepticus. Ann Emerg Med. 1994;23(2):216–24.PubMedCrossRef Dieckmann RA. Rectal diazepam for prehospital pediatric status epilepticus. Ann Emerg Med. 1994;23(2):216–24.PubMedCrossRef
112.
Zurück zum Zitat McMorris S, McWilliam PK. Status epilepticus in infants and young children treated with parenteral diazepam. Arch Dis Child. 1969;44(237):604–11.PubMedCrossRef McMorris S, McWilliam PK. Status epilepticus in infants and young children treated with parenteral diazepam. Arch Dis Child. 1969;44(237):604–11.PubMedCrossRef
113.
114.
Zurück zum Zitat Shaner DM, McCurdy SA, Herring MO, Gabor AJ. Treatment of status epilepticus: a prospective comparison of diazepam and phenytoin versus phenobarbital and optional phenytoin. Neurology. 1988;38(2):202–7.PubMedCrossRef Shaner DM, McCurdy SA, Herring MO, Gabor AJ. Treatment of status epilepticus: a prospective comparison of diazepam and phenytoin versus phenobarbital and optional phenytoin. Neurology. 1988;38(2):202–7.PubMedCrossRef
115.
Zurück zum Zitat Sugai K. Treatment of convulsive status epilepticus in infants and young children in Japan. Acta Neurol Scand Suppl. 2007;186:62–70.PubMedCrossRef Sugai K. Treatment of convulsive status epilepticus in infants and young children in Japan. Acta Neurol Scand Suppl. 2007;186:62–70.PubMedCrossRef
116.
Zurück zum Zitat Gilad R, Izkovitz N, Dabby R, Rapoport A, Sadeh M, Weller B, Lampl Y. Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin. Acta Neurol Scand. 2008;118(5):296–300.PubMedCrossRef Gilad R, Izkovitz N, Dabby R, Rapoport A, Sadeh M, Weller B, Lampl Y. Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin. Acta Neurol Scand. 2008;118(5):296–300.PubMedCrossRef
117.
Zurück zum Zitat Misra UK, Kalita J, Patel R. Sodium valproate vs phenytoin in status epilepticus: a pilot study. Neurology. 2006;67(2):340–2.PubMedCrossRef Misra UK, Kalita J, Patel R. Sodium valproate vs phenytoin in status epilepticus: a pilot study. Neurology. 2006;67(2):340–2.PubMedCrossRef
118.
Zurück zum Zitat Prasad K, Al-Roomi K, Krishnan PR, Sequeira R: Anticonvulsant therapy for status epilepticus. Cochrane Database Syst Rev 2005(4):CD003723. Prasad K, Al-Roomi K, Krishnan PR, Sequeira R: Anticonvulsant therapy for status epilepticus. Cochrane Database Syst Rev 2005(4):CD003723.
119.
Zurück zum Zitat Swisher CB, Doreswamy M, Gingrich KJ, Vredenburgh JJ, Kolls BJ. Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. Neurocrit Care. 2011;16(1):109–13.CrossRef Swisher CB, Doreswamy M, Gingrich KJ, Vredenburgh JJ, Kolls BJ. Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. Neurocrit Care. 2011;16(1):109–13.CrossRef
120.
Zurück zum Zitat Limdi NA, Shimpi AV, Faught E, Gomez CR, Burneo JG. Efficacy of rapid IV administration of valproic acid for status epilepticus. Neurology. 2005;64(2):353–5.PubMedCrossRef Limdi NA, Shimpi AV, Faught E, Gomez CR, Burneo JG. Efficacy of rapid IV administration of valproic acid for status epilepticus. Neurology. 2005;64(2):353–5.PubMedCrossRef
121.
Zurück zum Zitat Giroud M. Use of injectable valproic acid in status epilepticus: a pilot study. Clinical Drug Investig. 1993;5:154. Giroud M. Use of injectable valproic acid in status epilepticus: a pilot study. Clinical Drug Investig. 1993;5:154.
122.
Zurück zum Zitat Peters CN, Pohlmann-Eden B. Intravenous valproate as an innovative therapy in seizure emergency situations including status epilepticus: experience in 102 adult patients. Seizure. 2005;14(3):164–9.PubMedCrossRef Peters CN, Pohlmann-Eden B. Intravenous valproate as an innovative therapy in seizure emergency situations including status epilepticus: experience in 102 adult patients. Seizure. 2005;14(3):164–9.PubMedCrossRef
123.
Zurück zum Zitat Berning S, Boesebeck F, van Baalen A, Kellinghaus C. Intravenous levetiracetam as treatment for status epilepticus. J Neurol. 2009;256(10):1634–42.PubMedCrossRef Berning S, Boesebeck F, van Baalen A, Kellinghaus C. Intravenous levetiracetam as treatment for status epilepticus. J Neurol. 2009;256(10):1634–42.PubMedCrossRef
124.
Zurück zum Zitat Eue S, Grumbt M, Muller M, Schulze A. Two years of experience in the treatment of status epilepticus with intravenous levetiracetam. Epilepsy Behav. 2009;15(4):467–9.PubMedCrossRef Eue S, Grumbt M, Muller M, Schulze A. Two years of experience in the treatment of status epilepticus with intravenous levetiracetam. Epilepsy Behav. 2009;15(4):467–9.PubMedCrossRef
125.
Zurück zum Zitat Beyenburg S, Reuber M, Maraite N. Intravenous levetiracetam for epileptic seizure emergencies in older people. Gerontology. 2009;55(1):27–31.PubMedCrossRef Beyenburg S, Reuber M, Maraite N. Intravenous levetiracetam for epileptic seizure emergencies in older people. Gerontology. 2009;55(1):27–31.PubMedCrossRef
126.
Zurück zum Zitat Ruegg S, Naegelin Y, Hardmeier M, Winkler DT, Marsch S, Fuhr P. Intravenous levetiracetam: treatment experience with the first 50 critically ill patients. Epilepsy Behav. 2008;12(3):477–80.PubMedCrossRef Ruegg S, Naegelin Y, Hardmeier M, Winkler DT, Marsch S, Fuhr P. Intravenous levetiracetam: treatment experience with the first 50 critically ill patients. Epilepsy Behav. 2008;12(3):477–80.PubMedCrossRef
127.
Zurück zum Zitat Rupprecht S, Franke K, Fitzek S, Witte OW, Hagemann G. Levetiracetam as a treatment option in non-convulsive status epilepticus. Epilepsy Res. 2007;73(3):238–44.PubMedCrossRef Rupprecht S, Franke K, Fitzek S, Witte OW, Hagemann G. Levetiracetam as a treatment option in non-convulsive status epilepticus. Epilepsy Res. 2007;73(3):238–44.PubMedCrossRef
128.
Zurück zum Zitat Fattouch J, Di Bonaventura C, Casciato S, Bonini F, Petrucci S, Lapenta L, Manfredi M, Prencipe M, Giallonardo AT. Intravenous levetiracetam as first-line treatment of status epilepticus in the elderly. Acta Neurol Scand. 2010;121(6):418–21.PubMedCrossRef Fattouch J, Di Bonaventura C, Casciato S, Bonini F, Petrucci S, Lapenta L, Manfredi M, Prencipe M, Giallonardo AT. Intravenous levetiracetam as first-line treatment of status epilepticus in the elderly. Acta Neurol Scand. 2010;121(6):418–21.PubMedCrossRef
129.
Zurück zum Zitat Abend NS, Monk HM, Licht DJ, Dlugos DJ. Intravenous levetiracetam in critically ill children with status epilepticus or acute repetitive seizures. Pediatr Crit Care Med. 2009;10(4):505–10.PubMedCrossRef Abend NS, Monk HM, Licht DJ, Dlugos DJ. Intravenous levetiracetam in critically ill children with status epilepticus or acute repetitive seizures. Pediatr Crit Care Med. 2009;10(4):505–10.PubMedCrossRef
130.
Zurück zum Zitat Uges JW, van Huizen MD, Engelsman J, Wilms EB, Touw DJ, Peeters E, Vecht CJ. Safety and pharmacokinetics of intravenous levetiracetam infusion as add-on in status epilepticus. Epilepsia. 2009;50(3):415–21.PubMedCrossRef Uges JW, van Huizen MD, Engelsman J, Wilms EB, Touw DJ, Peeters E, Vecht CJ. Safety and pharmacokinetics of intravenous levetiracetam infusion as add-on in status epilepticus. Epilepsia. 2009;50(3):415–21.PubMedCrossRef
131.
Zurück zum Zitat Yu KT, Mills S, Thompson N, Cunanan C. Safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures. Epilepsia. 2003;44(5):724–6.PubMedCrossRef Yu KT, Mills S, Thompson N, Cunanan C. Safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures. Epilepsia. 2003;44(5):724–6.PubMedCrossRef
132.
Zurück zum Zitat Agarwal P, Kumar N, Chandra R, Gupta G, Antony AR, Garg N. Randomized study of intravenous valproate and phenytoin in status epilepticus. Seizure. 2007;16(6):527–32.PubMedCrossRef Agarwal P, Kumar N, Chandra R, Gupta G, Antony AR, Garg N. Randomized study of intravenous valproate and phenytoin in status epilepticus. Seizure. 2007;16(6):527–32.PubMedCrossRef
133.
Zurück zum Zitat Alvarez V, Januel JM, Burnand B, Rossetti AO. Second-line status epilepticus treatment: comparison of phenytoin, valproate, and levetiracetam. Epilepsia. 2011;52(7):1292–6.PubMedCrossRef Alvarez V, Januel JM, Burnand B, Rossetti AO. Second-line status epilepticus treatment: comparison of phenytoin, valproate, and levetiracetam. Epilepsia. 2011;52(7):1292–6.PubMedCrossRef
134.
Zurück zum Zitat Chen L, Feng P, Wang J, Liu L, Zhou D. Intravenous sodium valproate in mainland China for the treatment of diazepam refractory convulsive status epilepticus. J Clin Neurosci. 2009;16(4):524–6.PubMedCrossRef Chen L, Feng P, Wang J, Liu L, Zhou D. Intravenous sodium valproate in mainland China for the treatment of diazepam refractory convulsive status epilepticus. J Clin Neurosci. 2009;16(4):524–6.PubMedCrossRef
135.
Zurück zum Zitat Olsen KB, Tauboll E, Gjerstad L. Valproate is an effective, well-tolerated drug for treatment of status epilepticus/serial attacks in adults. Acta Neurol Scand Suppl. 2007;187:51–4.PubMedCrossRef Olsen KB, Tauboll E, Gjerstad L. Valproate is an effective, well-tolerated drug for treatment of status epilepticus/serial attacks in adults. Acta Neurol Scand Suppl. 2007;187:51–4.PubMedCrossRef
136.
Zurück zum Zitat Sinha S, Naritoku DK. Intravenous valproate is well tolerated in unstable patients with status epilepticus. Neurology. 2000;55(5):722–4.PubMedCrossRef Sinha S, Naritoku DK. Intravenous valproate is well tolerated in unstable patients with status epilepticus. Neurology. 2000;55(5):722–4.PubMedCrossRef
137.
Zurück zum Zitat Chin RF, Neville BG, Peckham C, Wade A, Bedford H, Scott RC. Treatment of community-onset, childhood convulsive status epilepticus: a prospective, population-based study. Lancet Neurol. 2008;7(8):696–703.PubMedCrossRef Chin RF, Neville BG, Peckham C, Wade A, Bedford H, Scott RC. Treatment of community-onset, childhood convulsive status epilepticus: a prospective, population-based study. Lancet Neurol. 2008;7(8):696–703.PubMedCrossRef
138.
Zurück zum Zitat Crawford TO, Mitchell WG, Fishman LS, Snodgrass SR. Very-high-dose phenobarbital for refractory status epilepticus in children. Neurology. 1988;38(7):1035–40.PubMedCrossRef Crawford TO, Mitchell WG, Fishman LS, Snodgrass SR. Very-high-dose phenobarbital for refractory status epilepticus in children. Neurology. 1988;38(7):1035–40.PubMedCrossRef
139.
Zurück zum Zitat Lowenstein DH, Aminoff MJ, Simon RP. Barbiturate anesthesia in the treatment of status epilepticus: clinical experience with 14 patients. Neurology. 1988;38(3):395–400.PubMedCrossRef Lowenstein DH, Aminoff MJ, Simon RP. Barbiturate anesthesia in the treatment of status epilepticus: clinical experience with 14 patients. Neurology. 1988;38(3):395–400.PubMedCrossRef
140.
Zurück zum Zitat Moddel G, Bunten S, Dobis C, Kovac S, Dogan M, Fischera M, Dziewas R, Schabitz WR, Evers S, Happe S. Intravenous levetiracetam: a new treatment alternative for refractory status epilepticus. J Neurol Neurosurg Psychiatry. 2009;80(6):689–92.PubMedCrossRef Moddel G, Bunten S, Dobis C, Kovac S, Dogan M, Fischera M, Dziewas R, Schabitz WR, Evers S, Happe S. Intravenous levetiracetam: a new treatment alternative for refractory status epilepticus. J Neurol Neurosurg Psychiatry. 2009;80(6):689–92.PubMedCrossRef
141.
Zurück zum Zitat Gamez-Leyva G, Aristin JL, Fernandez E, Pascual J. Experience with intravenous levetiracetam in status epilepticus: a retrospective case series. CNS Drugs. 2009;23(11):983–7.PubMedCrossRef Gamez-Leyva G, Aristin JL, Fernandez E, Pascual J. Experience with intravenous levetiracetam in status epilepticus: a retrospective case series. CNS Drugs. 2009;23(11):983–7.PubMedCrossRef
142.
Zurück zum Zitat Singhi S, Murthy A, Singhi P, Jayashree M. Continuous midazolam versus diazepam infusion for refractory convulsive status epilepticus. J Child Neurol. 2002;17(2):106–10.PubMedCrossRef Singhi S, Murthy A, Singhi P, Jayashree M. Continuous midazolam versus diazepam infusion for refractory convulsive status epilepticus. J Child Neurol. 2002;17(2):106–10.PubMedCrossRef
143.
Zurück zum Zitat Ozdemir D, Gulez P, Uran N, Yendur G, Kavakli T, Aydin A. Efficacy of continuous midazolam infusion and mortality in childhood refractory generalized convulsive status epilepticus. Seizure. 2005;14(2):129–32.PubMedCrossRef Ozdemir D, Gulez P, Uran N, Yendur G, Kavakli T, Aydin A. Efficacy of continuous midazolam infusion and mortality in childhood refractory generalized convulsive status epilepticus. Seizure. 2005;14(2):129–32.PubMedCrossRef
144.
Zurück zum Zitat Prasad A, Worrall BB, Bertram EH, Bleck TP. Propofol and midazolam in the treatment of refractory status epilepticus. Epilepsia. 2001;42(3):380–6.PubMedCrossRef Prasad A, Worrall BB, Bertram EH, Bleck TP. Propofol and midazolam in the treatment of refractory status epilepticus. Epilepsia. 2001;42(3):380–6.PubMedCrossRef
145.
Zurück zum Zitat Ulvi H, Yoldas T, Mungen B, Yigiter R. Continuous infusion of midazolam in the treatment of refractory generalized convulsive status epilepticus. Neurol Sci. 2002;23(4):177–82.PubMedCrossRef Ulvi H, Yoldas T, Mungen B, Yigiter R. Continuous infusion of midazolam in the treatment of refractory generalized convulsive status epilepticus. Neurol Sci. 2002;23(4):177–82.PubMedCrossRef
146.
Zurück zum Zitat Rivera R, Segnini M, Baltodano A, Perez V. Midazolam in the treatment of status epilepticus in children. Crit Care Med. 1993;21(7):991–4.PubMedCrossRef Rivera R, Segnini M, Baltodano A, Perez V. Midazolam in the treatment of status epilepticus in children. Crit Care Med. 1993;21(7):991–4.PubMedCrossRef
147.
Zurück zum Zitat Kumar A, Bleck TP. Intravenous midazolam for the treatment of refractory status epilepticus. Crit Care Med. 1992;20(4):483–8.PubMedCrossRef Kumar A, Bleck TP. Intravenous midazolam for the treatment of refractory status epilepticus. Crit Care Med. 1992;20(4):483–8.PubMedCrossRef
148.
Zurück zum Zitat Koul R, Chacko A, Javed H, Al Riyami K. Eight-year study of childhood status epilepticus: midazolam infusion in management and outcome. J Child Neurol. 2002;17(12):908–10.PubMedCrossRef Koul R, Chacko A, Javed H, Al Riyami K. Eight-year study of childhood status epilepticus: midazolam infusion in management and outcome. J Child Neurol. 2002;17(12):908–10.PubMedCrossRef
149.
Zurück zum Zitat Igartua J, Silver P, Maytal J, Sagy M. Midazolam coma for refractory status epilepticus in children. Crit Care Med. 1999;27(9):1982–5.PubMedCrossRef Igartua J, Silver P, Maytal J, Sagy M. Midazolam coma for refractory status epilepticus in children. Crit Care Med. 1999;27(9):1982–5.PubMedCrossRef
150.
Zurück zum Zitat Morrison G, Gibbons E, Whitehouse WP. High-dose midazolam therapy for refractory status epilepticus in children. Intensive Care Med. 2006;32(12):2070–6.PubMedCrossRef Morrison G, Gibbons E, Whitehouse WP. High-dose midazolam therapy for refractory status epilepticus in children. Intensive Care Med. 2006;32(12):2070–6.PubMedCrossRef
151.
Zurück zum Zitat Cornfield DN, Tegtmeyer K, Nelson MD, Milla CE, Sweeney M. Continuous propofol infusion in 142 critically ill children. Pediatrics. 2002;110(6):1177–81.PubMedCrossRef Cornfield DN, Tegtmeyer K, Nelson MD, Milla CE, Sweeney M. Continuous propofol infusion in 142 critically ill children. Pediatrics. 2002;110(6):1177–81.PubMedCrossRef
152.
Zurück zum Zitat Fong JJ, Sylvia L, Ruthazer R, Schumaker G, Kcomt M, Devlin JW. Predictors of mortality in patients with suspected propofol infusion syndrome. Crit Care Med. 2008;36(8):2281–7.PubMedCrossRef Fong JJ, Sylvia L, Ruthazer R, Schumaker G, Kcomt M, Devlin JW. Predictors of mortality in patients with suspected propofol infusion syndrome. Crit Care Med. 2008;36(8):2281–7.PubMedCrossRef
153.
Zurück zum Zitat Parviainen I, Uusaro A, Kalviainen R, Mervaala E, Ruokonen E. Propofol in the treatment of refractory status epilepticus. Intensive Care Med. 2006;32(7):1075–9.PubMedCrossRef Parviainen I, Uusaro A, Kalviainen R, Mervaala E, Ruokonen E. Propofol in the treatment of refractory status epilepticus. Intensive Care Med. 2006;32(7):1075–9.PubMedCrossRef
154.
Zurück zum Zitat van Gestel JP, Blusse van Oud-Alblas HJ, Malingre M, Ververs FF, Braun KP, van Nieuwenhuizen O. Propofol and thiopental for refractory status epilepticus in children. Neurology. 2005;65(4):591–2.PubMedCrossRef van Gestel JP, Blusse van Oud-Alblas HJ, Malingre M, Ververs FF, Braun KP, van Nieuwenhuizen O. Propofol and thiopental for refractory status epilepticus in children. Neurology. 2005;65(4):591–2.PubMedCrossRef
155.
Zurück zum Zitat Iyer VN, Hoel R, Rabinstein AA. Propofol infusion syndrome in patients with refractory status epilepticus: an 11-year clinical experience. Crit Care Med. 2009;37(12):3024–30.PubMedCrossRef Iyer VN, Hoel R, Rabinstein AA. Propofol infusion syndrome in patients with refractory status epilepticus: an 11-year clinical experience. Crit Care Med. 2009;37(12):3024–30.PubMedCrossRef
156.
Zurück zum Zitat Krishnamurthy KB, Drislane FW. Relapse and survival after barbiturate anesthetic treatment of refractory status epilepticus. Epilepsia. 1996;37(9):863–7.PubMedCrossRef Krishnamurthy KB, Drislane FW. Relapse and survival after barbiturate anesthetic treatment of refractory status epilepticus. Epilepsia. 1996;37(9):863–7.PubMedCrossRef
157.
Zurück zum Zitat ter Maaten JC, Strack van Schijndel RJ, Heimans JJ, Schreuder WO. Ten patients with refractory status epilepticus in an intensive care department. Neth J Med. 1998;53(6):260–5.PubMedCrossRef ter Maaten JC, Strack van Schijndel RJ, Heimans JJ, Schreuder WO. Ten patients with refractory status epilepticus in an intensive care department. Neth J Med. 1998;53(6):260–5.PubMedCrossRef
158.
Zurück zum Zitat Partinen M, Kovanen J, Nilsson E. Status epilepticus treated by barbiturate anaesthesia with continuous monitoring of cerebral function. Br Med J (Clin Res Ed). 1981;282(6263):520–1.CrossRef Partinen M, Kovanen J, Nilsson E. Status epilepticus treated by barbiturate anaesthesia with continuous monitoring of cerebral function. Br Med J (Clin Res Ed). 1981;282(6263):520–1.CrossRef
159.
Zurück zum Zitat Tripathi M, Vibha D, Choudhary N, Prasad K, Srivastava MV, Bhatia R, Chandra SP. Management of refractory status epilepticus at a tertiary care centre in a developing country. Seizure. 2010;19(2):109–11.PubMedCrossRef Tripathi M, Vibha D, Choudhary N, Prasad K, Srivastava MV, Bhatia R, Chandra SP. Management of refractory status epilepticus at a tertiary care centre in a developing country. Seizure. 2010;19(2):109–11.PubMedCrossRef
160.
Zurück zum Zitat Mehta V, Singhi P, Singhi S. Intravenous sodium valproate versus diazepam infusion for the control of refractory status epilepticus in children: a randomized controlled trial. J Child Neurol. 2007;22(10):1191–7.PubMedCrossRef Mehta V, Singhi P, Singhi S. Intravenous sodium valproate versus diazepam infusion for the control of refractory status epilepticus in children: a randomized controlled trial. J Child Neurol. 2007;22(10):1191–7.PubMedCrossRef
161.
Zurück zum Zitat Uberall MA, Trollmann R, Wunsiedler U, Wenzel D. Intravenous valproate in pediatric epilepsy patients with refractory status epilepticus. Neurology. 2000;54(11):2188–9.PubMedCrossRef Uberall MA, Trollmann R, Wunsiedler U, Wenzel D. Intravenous valproate in pediatric epilepsy patients with refractory status epilepticus. Neurology. 2000;54(11):2188–9.PubMedCrossRef
162.
Zurück zum Zitat Knake S, Gruener J, Hattemer K, Klein KM, Bauer S, Oertel WH, Hamer HM, Rosenow F. Intravenous levetiracetam in the treatment of benzodiazepine refractory status epilepticus. J Neurol Neurosurg Psychiatry. 2008;79(5):588–9.PubMedCrossRef Knake S, Gruener J, Hattemer K, Klein KM, Bauer S, Oertel WH, Hamer HM, Rosenow F. Intravenous levetiracetam in the treatment of benzodiazepine refractory status epilepticus. J Neurol Neurosurg Psychiatry. 2008;79(5):588–9.PubMedCrossRef
163.
Zurück zum Zitat Patel NC, Landan IR, Levin J, Szaflarski J, Wilner AN. The use of levetiracetam in refractory status epilepticus. Seizure. 2006;15(3):137–41.PubMedCrossRef Patel NC, Landan IR, Levin J, Szaflarski J, Wilner AN. The use of levetiracetam in refractory status epilepticus. Seizure. 2006;15(3):137–41.PubMedCrossRef
164.
Zurück zum Zitat Gallentine WB, Hunnicutt AS, Husain AM. Levetiracetam in children with refractory status epilepticus. Epilepsy Behav. 2009;14(1):215–8.PubMedCrossRef Gallentine WB, Hunnicutt AS, Husain AM. Levetiracetam in children with refractory status epilepticus. Epilepsy Behav. 2009;14(1):215–8.PubMedCrossRef
165.
Zurück zum Zitat Miyahara A, Saito Y, Sugai K, Nakagawa E, Sakuma H, Komaki H, Sasaki M. Reassessment of phenytoin for treatment of late stage progressive myoclonus epilepsy complicated with status epilepticus. Epilepsy Res. 2009;84(2–3):201–9.PubMedCrossRef Miyahara A, Saito Y, Sugai K, Nakagawa E, Sakuma H, Komaki H, Sasaki M. Reassessment of phenytoin for treatment of late stage progressive myoclonus epilepsy complicated with status epilepticus. Epilepsy Res. 2009;84(2–3):201–9.PubMedCrossRef
166.
Zurück zum Zitat Albers JM, Moddel G, Dittrich R, Steidl C, Suntrup S, Ringelstein EB, Dziewas R. Intravenous lacosamide: an effective add-on treatment of refractory status epilepticus. Seizure. 2011;20(5):428–30.PubMedCrossRef Albers JM, Moddel G, Dittrich R, Steidl C, Suntrup S, Ringelstein EB, Dziewas R. Intravenous lacosamide: an effective add-on treatment of refractory status epilepticus. Seizure. 2011;20(5):428–30.PubMedCrossRef
167.
Zurück zum Zitat Goodwin H, Hinson HE, Shermock KM, Karanjia N, Lewin JJ 3rd. The use of lacosamide in refractory status epilepticus. Neurocrit Care. 2011;14(3):348–53.PubMedCrossRef Goodwin H, Hinson HE, Shermock KM, Karanjia N, Lewin JJ 3rd. The use of lacosamide in refractory status epilepticus. Neurocrit Care. 2011;14(3):348–53.PubMedCrossRef
168.
Zurück zum Zitat Kellinghaus C, Berning S, Immisch I, Larch J, Rosenow F, Rossetti AO, Tilz C, Trinka E. Intravenous lacosamide for treatment of status epilepticus. Acta Neurol Scand. 2011;123(2):137–41.PubMedCrossRef Kellinghaus C, Berning S, Immisch I, Larch J, Rosenow F, Rossetti AO, Tilz C, Trinka E. Intravenous lacosamide for treatment of status epilepticus. Acta Neurol Scand. 2011;123(2):137–41.PubMedCrossRef
169.
Zurück zum Zitat Towne AR, Garnett LK, Waterhouse EJ, Morton LD, DeLorenzo RJ. The use of topiramate in refractory status epilepticus. Neurology. 2003;60(2):332–4.PubMedCrossRef Towne AR, Garnett LK, Waterhouse EJ, Morton LD, DeLorenzo RJ. The use of topiramate in refractory status epilepticus. Neurology. 2003;60(2):332–4.PubMedCrossRef
170.
Zurück zum Zitat Shearer P, Riviello J. Generalized convulsive status epilepticus in adults and children: treatment guidelines and protocols. Emerg Med Clin North Am. 2011;29(1):51–64.PubMedCrossRef Shearer P, Riviello J. Generalized convulsive status epilepticus in adults and children: treatment guidelines and protocols. Emerg Med Clin North Am. 2011;29(1):51–64.PubMedCrossRef
171.
Zurück zum Zitat Rossetti AO. Which anesthetic should be used in the treatment of refractory status epilepticus? Epilepsia. 2007;48(Suppl 8):52–5.PubMedCrossRef Rossetti AO. Which anesthetic should be used in the treatment of refractory status epilepticus? Epilepsia. 2007;48(Suppl 8):52–5.PubMedCrossRef
172.
Zurück zum Zitat Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain. 2011;134(Pt 10):2802–18.PubMedCrossRef Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain. 2011;134(Pt 10):2802–18.PubMedCrossRef
173.
Zurück zum Zitat Cooper AD, Britton JW, Rabinstein AA. Functional and cognitive outcome in prolonged refractory status epilepticus. Arch Neurol. 2009;66(12):1505–9.PubMedCrossRef Cooper AD, Britton JW, Rabinstein AA. Functional and cognitive outcome in prolonged refractory status epilepticus. Arch Neurol. 2009;66(12):1505–9.PubMedCrossRef
174.
Zurück zum Zitat Lee WK, Liu KT, Young BW. Very-high-dose phenobarbital for childhood refractory status epilepticus. Pediatr Neurol. 2006;34(1):63–5.PubMedCrossRef Lee WK, Liu KT, Young BW. Very-high-dose phenobarbital for childhood refractory status epilepticus. Pediatr Neurol. 2006;34(1):63–5.PubMedCrossRef
175.
Zurück zum Zitat Mirski MA, Williams MA, Hanley DF. Prolonged pentobarbital and phenobarbital coma for refractory generalized status epilepticus. Crit Care Med. 1995;23(2):400–4.PubMedCrossRef Mirski MA, Williams MA, Hanley DF. Prolonged pentobarbital and phenobarbital coma for refractory generalized status epilepticus. Crit Care Med. 1995;23(2):400–4.PubMedCrossRef
176.
Zurück zum Zitat Bramstedt KA, Morris HH, Tanner A. Now we lay them down to sleep: ethical issues with the use of pharmacologic coma for adult status epilepticus. Epilepsy Behav. 2004;5(5):752–5.PubMedCrossRef Bramstedt KA, Morris HH, Tanner A. Now we lay them down to sleep: ethical issues with the use of pharmacologic coma for adult status epilepticus. Epilepsy Behav. 2004;5(5):752–5.PubMedCrossRef
177.
Zurück zum Zitat Dara SI, Tungpalan LA, Manno EM, Lee VH, Moder KG, Keegan MT, Fulgham JR, Brown DR, Berge KH, Whalen FX, et al. Prolonged coma from refractory status epilepticus. Neurocrit Care. 2006;4(2):140–2.PubMedCrossRef Dara SI, Tungpalan LA, Manno EM, Lee VH, Moder KG, Keegan MT, Fulgham JR, Brown DR, Berge KH, Whalen FX, et al. Prolonged coma from refractory status epilepticus. Neurocrit Care. 2006;4(2):140–2.PubMedCrossRef
178.
Zurück zum Zitat Kramer U, Shorer Z, Ben-Zeev B, Lerman-Sagie T, Goldberg-Stern H, Lahat E. Severe refractory status epilepticus owing to presumed encephalitis. J Child Neurol. 2005;20(3):184–7.PubMed Kramer U, Shorer Z, Ben-Zeev B, Lerman-Sagie T, Goldberg-Stern H, Lahat E. Severe refractory status epilepticus owing to presumed encephalitis. J Child Neurol. 2005;20(3):184–7.PubMed
179.
Zurück zum Zitat Mewasingh LD, Sekhara T, Aeby A, Christiaens FJ, Dan B. Oral ketamine in paediatric non-convulsive status epilepticus. Seizure. 2003;12(7):483–9.PubMedCrossRef Mewasingh LD, Sekhara T, Aeby A, Christiaens FJ, Dan B. Oral ketamine in paediatric non-convulsive status epilepticus. Seizure. 2003;12(7):483–9.PubMedCrossRef
180.
Zurück zum Zitat Haberlandt E, Weger C, Sigl SB, Rauchenzauner M, Scholl-Burgi S, Rostasy K, Karall D. Adrenocorticotropic hormone versus pulsatile dexamethasone in the treatment of infantile epilepsy syndromes. Pediatr Neurol. 2010;42(1):21–7.PubMedCrossRef Haberlandt E, Weger C, Sigl SB, Rauchenzauner M, Scholl-Burgi S, Rostasy K, Karall D. Adrenocorticotropic hormone versus pulsatile dexamethasone in the treatment of infantile epilepsy syndromes. Pediatr Neurol. 2010;42(1):21–7.PubMedCrossRef
181.
Zurück zum Zitat Granata T, Fusco L, Gobbi G, Freri E, Ragona F, Broggi G, Mantegazza R, Giordano L, Villani F, Capovilla G, et al. Experience with immunomodulatory treatments in Rasmussen’s encephalitis. Neurology. 2003;61(12):1807–10.PubMedCrossRef Granata T, Fusco L, Gobbi G, Freri E, Ragona F, Broggi G, Mantegazza R, Giordano L, Villani F, Capovilla G, et al. Experience with immunomodulatory treatments in Rasmussen’s encephalitis. Neurology. 2003;61(12):1807–10.PubMedCrossRef
182.
Zurück zum Zitat Mirsattari SM, Sharpe MD, Young GB. Treatment of refractory status epilepticus with inhalational anesthetic agents isoflurane and desflurane. Arch Neurol. 2004;61(8):1254–9.PubMedCrossRef Mirsattari SM, Sharpe MD, Young GB. Treatment of refractory status epilepticus with inhalational anesthetic agents isoflurane and desflurane. Arch Neurol. 2004;61(8):1254–9.PubMedCrossRef
183.
Zurück zum Zitat Kofke WA, Young RS, Davis P, Woelfel SK, Gray L, Johnson D, Gelb A, Meeke R, Warner DS, Pearson KS, et al. Isoflurane for refractory status epilepticus: a clinical series. Anesthesiology. 1989;71(5):653–9.PubMedCrossRef Kofke WA, Young RS, Davis P, Woelfel SK, Gray L, Johnson D, Gelb A, Meeke R, Warner DS, Pearson KS, et al. Isoflurane for refractory status epilepticus: a clinical series. Anesthesiology. 1989;71(5):653–9.PubMedCrossRef
184.
Zurück zum Zitat Zamponi N, Rychlicki F, Corpaci L, Cesaroni E, Trignani R. Vagus nerve stimulation (VNS) is effective in treating catastrophic 1 epilepsy in very young children. Neurosurg Rev. 2008;31(3):291–7.PubMedCrossRef Zamponi N, Rychlicki F, Corpaci L, Cesaroni E, Trignani R. Vagus nerve stimulation (VNS) is effective in treating catastrophic 1 epilepsy in very young children. Neurosurg Rev. 2008;31(3):291–7.PubMedCrossRef
185.
Zurück zum Zitat Shahwan A, Bailey C, Maxiner W, Harvey AS. Vagus nerve stimulation for refractory epilepsy in children: more to VNS than seizure frequency reduction. Epilepsia. 2009;50(5):1220–8.PubMedCrossRef Shahwan A, Bailey C, Maxiner W, Harvey AS. Vagus nerve stimulation for refractory epilepsy in children: more to VNS than seizure frequency reduction. Epilepsia. 2009;50(5):1220–8.PubMedCrossRef
186.
Zurück zum Zitat Abend NS, Dlugos DJ. Treatment of refractory status epilepticus: literature review and a proposed protocol. Pediatr Neurol. 2008;38(6):377–90.PubMedCrossRef Abend NS, Dlugos DJ. Treatment of refractory status epilepticus: literature review and a proposed protocol. Pediatr Neurol. 2008;38(6):377–90.PubMedCrossRef
187.
Zurück zum Zitat Nabbout R. Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES). Epilepsia (Copenhagen). 2010;51(10):2033.CrossRef Nabbout R. Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES). Epilepsia (Copenhagen). 2010;51(10):2033.CrossRef
188.
Zurück zum Zitat Nam SH, Lee BL, Lee CG, Yu HJ, Joo EY, Lee J, Lee M. The role of ketogenic diet in the treatment of refractory status epilepticus. Epilepsia. 2011;52(11):e181–4.PubMedCrossRef Nam SH, Lee BL, Lee CG, Yu HJ, Joo EY, Lee J, Lee M. The role of ketogenic diet in the treatment of refractory status epilepticus. Epilepsia. 2011;52(11):e181–4.PubMedCrossRef
189.
Zurück zum Zitat Corry JJ, Dhar R, Murphy T, Diringer MN. Hypothermia for refractory status epilepticus. Neurocrit Care. 2008;9(2):189–97.PubMedCrossRef Corry JJ, Dhar R, Murphy T, Diringer MN. Hypothermia for refractory status epilepticus. Neurocrit Care. 2008;9(2):189–97.PubMedCrossRef
190.
Zurück zum Zitat Orlowski JP, Erenberg G, Lueders H, Cruse RP. Hypothermia and barbiturate coma for refractory status epilepticus. Crit Care Med. 1984;12(4):367–72.PubMedCrossRef Orlowski JP, Erenberg G, Lueders H, Cruse RP. Hypothermia and barbiturate coma for refractory status epilepticus. Crit Care Med. 1984;12(4):367–72.PubMedCrossRef
191.
Zurück zum Zitat Kamel H, Cornes SB, Hegde M, Hall SE, Josephson SA. Electroconvulsive therapy for refractory status epilepticus: a case series. Neurocrit Care. 2010;12(2):204–10.PubMedCrossRef Kamel H, Cornes SB, Hegde M, Hall SE, Josephson SA. Electroconvulsive therapy for refractory status epilepticus: a case series. Neurocrit Care. 2010;12(2):204–10.PubMedCrossRef
192.
Zurück zum Zitat Rotenberg A, Muller P, Birnbaum D, Harrington M, Riviello JJ, Pascual-Leone A, Jensen FE. Seizure suppression by EEG-guided repetitive transcranial magnetic stimulation in the rat. Clin Neurophysiol. 2008;119(12):2697–702.PubMedCrossRef Rotenberg A, Muller P, Birnbaum D, Harrington M, Riviello JJ, Pascual-Leone A, Jensen FE. Seizure suppression by EEG-guided repetitive transcranial magnetic stimulation in the rat. Clin Neurophysiol. 2008;119(12):2697–702.PubMedCrossRef
193.
Zurück zum Zitat Loddenkemper T, Cosmo G, Kotagal P, Haut J, Klaas P, Gupta A, Lachhwani DK, Bingaman W, Wyllie E. Epilepsy surgery in children with electrical status epilepticus in sleep. Neurosurgery. 2009;64(2):328–37. discussion 337.PubMedCrossRef Loddenkemper T, Cosmo G, Kotagal P, Haut J, Klaas P, Gupta A, Lachhwani DK, Bingaman W, Wyllie E. Epilepsy surgery in children with electrical status epilepticus in sleep. Neurosurgery. 2009;64(2):328–37. discussion 337.PubMedCrossRef
194.
Zurück zum Zitat Alexopoulos A, Lachhwani DK, Gupta A, Kotagal P, Harrison AM, Bingaman W, Wyllie E. Resective surgery to treat refractory status epilepticus in children with focal epileptogenesis. Neurology. 2005;64(3):567–70.PubMedCrossRef Alexopoulos A, Lachhwani DK, Gupta A, Kotagal P, Harrison AM, Bingaman W, Wyllie E. Resective surgery to treat refractory status epilepticus in children with focal epileptogenesis. Neurology. 2005;64(3):567–70.PubMedCrossRef
195.
Zurück zum Zitat Ng YT, Kerrigan JF, Rekate HL. Neurosurgical treatment of status epilepticus. J Neurosurg. 2006;105(Suppl 5):378–81.PubMed Ng YT, Kerrigan JF, Rekate HL. Neurosurgical treatment of status epilepticus. J Neurosurg. 2006;105(Suppl 5):378–81.PubMed
196.
Zurück zum Zitat Ma X, Liporace J, O’Connor MJ, Sperling MR. Neurosurgical treatment of medically intractable status epilepticus. Epilepsy Res. 2001;46(1):33–8.PubMedCrossRef Ma X, Liporace J, O’Connor MJ, Sperling MR. Neurosurgical treatment of medically intractable status epilepticus. Epilepsy Res. 2001;46(1):33–8.PubMedCrossRef
197.
Zurück zum Zitat Rossetti AO, Oddo M, Liaudet L, Kaplan PW. Predictors of awakening from postanoxic status epilepticus after therapeutic hypothermia. Neurology. 2009;72(8):744–9.PubMedCrossRef Rossetti AO, Oddo M, Liaudet L, Kaplan PW. Predictors of awakening from postanoxic status epilepticus after therapeutic hypothermia. Neurology. 2009;72(8):744–9.PubMedCrossRef
198.
Zurück zum Zitat Rundgren M, Westhall E, Cronberg T, Rosen I, Friberg H. Continuous amplitude-integrated electroencephalogram predicts outcome in hypothermia-treated cardiac arrest patients. Crit Care Med. 2010;38(9):1838–44.PubMedCrossRef Rundgren M, Westhall E, Cronberg T, Rosen I, Friberg H. Continuous amplitude-integrated electroencephalogram predicts outcome in hypothermia-treated cardiac arrest patients. Crit Care Med. 2010;38(9):1838–44.PubMedCrossRef
199.
Zurück zum Zitat Rossetti AO. What is the value of hypothermia in acute neurologic diseases and status epilepticus? Epilepsia. 2011;52(Suppl 8):64–6.PubMedCrossRef Rossetti AO. What is the value of hypothermia in acute neurologic diseases and status epilepticus? Epilepsia. 2011;52(Suppl 8):64–6.PubMedCrossRef
200.
Zurück zum Zitat de Pont AC, de Jager CP, van den Bergh WM, Schultz MJ. Recovery from near drowning and postanoxic status epilepticus with controlled hypothermia. Neth J Med. 2011;69(4):196–7.PubMed de Pont AC, de Jager CP, van den Bergh WM, Schultz MJ. Recovery from near drowning and postanoxic status epilepticus with controlled hypothermia. Neth J Med. 2011;69(4):196–7.PubMed
201.
Zurück zum Zitat Shorvon S. Super-refractory status epilepticus: an approach to therapy in this difficult clinical situation. Epilepsia. 2011;52(Suppl 8):53–6.PubMedCrossRef Shorvon S. Super-refractory status epilepticus: an approach to therapy in this difficult clinical situation. Epilepsia. 2011;52(Suppl 8):53–6.PubMedCrossRef
202.
Zurück zum Zitat Harden CL, Hopp J, Ting TY, Pennell PB, French JA, Hauser WA, Wiebe S, Gronseth GS, Thurman D, Meador KJ, et al. Practice parameter update: management issues for women with epilepsy—focus on pregnancy (an evidence-based review): obstetrical complications and change in seizure frequency. Neurology. 2009;73(2):126–32.PubMedCrossRef Harden CL, Hopp J, Ting TY, Pennell PB, French JA, Hauser WA, Wiebe S, Gronseth GS, Thurman D, Meador KJ, et al. Practice parameter update: management issues for women with epilepsy—focus on pregnancy (an evidence-based review): obstetrical complications and change in seizure frequency. Neurology. 2009;73(2):126–32.PubMedCrossRef
203.
Zurück zum Zitat Jagoda A, Riggio S. Emergency department approach to managing seizures in pregnancy. Ann Emerg Med. 1991;20(1):80–5.PubMedCrossRef Jagoda A, Riggio S. Emergency department approach to managing seizures in pregnancy. Ann Emerg Med. 1991;20(1):80–5.PubMedCrossRef
204.
Zurück zum Zitat Karnad DR, Guntupalli KK. Neurologic disorders in pregnancy. Crit Care Med. 2005;33(10):S362–71.PubMedCrossRef Karnad DR, Guntupalli KK. Neurologic disorders in pregnancy. Crit Care Med. 2005;33(10):S362–71.PubMedCrossRef
205.
Zurück zum Zitat Molgaard-Nielsen D. Newer-generation antiepileptic drugs and the risk of major birth defects. J Am Med Assoc. 2011;305(19):1996–2002.CrossRef Molgaard-Nielsen D. Newer-generation antiepileptic drugs and the risk of major birth defects. J Am Med Assoc. 2011;305(19):1996–2002.CrossRef
206.
Zurück zum Zitat Duley L, Henderson-Smart DJ, Chou D: Magnesium sulphate versus phenytoin for eclampsia. Cochrane Database Syst Rev 2010(10):CD000128. Duley L, Henderson-Smart DJ, Chou D: Magnesium sulphate versus phenytoin for eclampsia. Cochrane Database Syst Rev 2010(10):CD000128.
207.
Zurück zum Zitat Appleton R, Choonara I, Martland T, Phillips B, Scott R, Whitehouse W. The treatment of convulsive status epilepticus in children. The status epilepticus working party, members of the status epilepticus working party. Arch Dis Child. 2000;83(5):415–9.PubMedCrossRef Appleton R, Choonara I, Martland T, Phillips B, Scott R, Whitehouse W. The treatment of convulsive status epilepticus in children. The status epilepticus working party, members of the status epilepticus working party. Arch Dis Child. 2000;83(5):415–9.PubMedCrossRef
208.
Zurück zum Zitat Singhi S, Banerjee S, Singhi P. Refractory status epilepticus in children: role of continuous diazepam infusion. J Child Neurol. 1998;13(1):23–6.PubMedCrossRef Singhi S, Banerjee S, Singhi P. Refractory status epilepticus in children: role of continuous diazepam infusion. J Child Neurol. 1998;13(1):23–6.PubMedCrossRef
209.
Zurück zum Zitat Vespa PM, Nuwer MR, Nenov V, Ronne-Engstrom E, Hovda DA, Bergsneider M, Kelly DF, Martin NA, Becker DP. Increased incidence and impact of nonconvulsive and convulsive seizures after traumatic brain injury as detected by continuous electroencephalographic monitoring. J Neurosurg. 1999;91(5):750–60.PubMedCrossRef Vespa PM, Nuwer MR, Nenov V, Ronne-Engstrom E, Hovda DA, Bergsneider M, Kelly DF, Martin NA, Becker DP. Increased incidence and impact of nonconvulsive and convulsive seizures after traumatic brain injury as detected by continuous electroencephalographic monitoring. J Neurosurg. 1999;91(5):750–60.PubMedCrossRef
210.
Zurück zum Zitat Claassen J, Mayer SA, Kowalski RG, Emerson RG, Hirsch LJ. Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology. 2004;62(10):1743–8.PubMedCrossRef Claassen J, Mayer SA, Kowalski RG, Emerson RG, Hirsch LJ. Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology. 2004;62(10):1743–8.PubMedCrossRef
211.
Zurück zum Zitat Pandian JD, Cascino GD, So EL, Manno E, Fulgham JR. Digital video-electroencephalographic monitoring in the neurological-neurosurgical intensive care unit: clinical features and outcome. Arch Neurol. 2004;61(7):1090–4.PubMedCrossRef Pandian JD, Cascino GD, So EL, Manno E, Fulgham JR. Digital video-electroencephalographic monitoring in the neurological-neurosurgical intensive care unit: clinical features and outcome. Arch Neurol. 2004;61(7):1090–4.PubMedCrossRef
212.
Zurück zum Zitat Vespa PM, O’Phelan K, Shah M, Mirabelli J, Starkman S, Kidwell C, Saver J, Nuwer MR, Frazee JG, McArthur DA, et al. Acute seizures after intracerebral hemorrhage: a factor in progressive midline shift and outcome. Neurology. 2003;60(9):1441–6.PubMedCrossRef Vespa PM, O’Phelan K, Shah M, Mirabelli J, Starkman S, Kidwell C, Saver J, Nuwer MR, Frazee JG, McArthur DA, et al. Acute seizures after intracerebral hemorrhage: a factor in progressive midline shift and outcome. Neurology. 2003;60(9):1441–6.PubMedCrossRef
213.
Zurück zum Zitat Varelas PN, Hacein-Bey L, Hether T, Terranova B, Spanaki MV. Emergent electroencephalogram in the intensive care unit: indications and diagnostic yield. Clin EEG Neurosci. 2004;35(4):173–80.PubMed Varelas PN, Hacein-Bey L, Hether T, Terranova B, Spanaki MV. Emergent electroencephalogram in the intensive care unit: indications and diagnostic yield. Clin EEG Neurosci. 2004;35(4):173–80.PubMed
214.
Zurück zum Zitat Jordan KG. Neurophysiologic monitoring in the neuroscience intensive care unit. Neurol Clin. 1995;13(3):579–626.PubMed Jordan KG. Neurophysiologic monitoring in the neuroscience intensive care unit. Neurol Clin. 1995;13(3):579–626.PubMed
215.
Zurück zum Zitat Legriel S, Bruneel F, Sediri H, Hilly J, Abbosh N, Lagarrigue MH, Troche G, Guezennec P, Pico F, Bedos JP. Early EEG monitoring for detecting postanoxic status epilepticus during therapeutic hypothermia: a pilot study. Neurocrit Care. 2009;11(3):338–44.PubMedCrossRef Legriel S, Bruneel F, Sediri H, Hilly J, Abbosh N, Lagarrigue MH, Troche G, Guezennec P, Pico F, Bedos JP. Early EEG monitoring for detecting postanoxic status epilepticus during therapeutic hypothermia: a pilot study. Neurocrit Care. 2009;11(3):338–44.PubMedCrossRef
216.
Zurück zum Zitat Hirsch LJ. Continuous EEG monitoring in the intensive care unit: an overview. J Clin Neurophysiol. 2004;21(5):332–40.PubMed Hirsch LJ. Continuous EEG monitoring in the intensive care unit: an overview. J Clin Neurophysiol. 2004;21(5):332–40.PubMed
217.
Zurück zum Zitat Shahwan A, Bailey C, Shekerdemian L, Harvey AS. The prevalence of seizures in comatose children in the pediatric intensive care unit: a prospective video-EEG study. Epilepsia. 2010;51(7):1198–204.PubMedCrossRef Shahwan A, Bailey C, Shekerdemian L, Harvey AS. The prevalence of seizures in comatose children in the pediatric intensive care unit: a prospective video-EEG study. Epilepsia. 2010;51(7):1198–204.PubMedCrossRef
218.
Zurück zum Zitat Abend NS. Nonconvulsive seizures are common in critically ill children. Neurology. 2011;76(12):1071–7.PubMedCrossRef Abend NS. Nonconvulsive seizures are common in critically ill children. Neurology. 2011;76(12):1071–7.PubMedCrossRef
219.
Zurück zum Zitat Hahn CD. Nonconvulsive seizures among critically ill children: look and you shall find. Neurology. 2011;76(12):1036–7.PubMedCrossRef Hahn CD. Nonconvulsive seizures among critically ill children: look and you shall find. Neurology. 2011;76(12):1036–7.PubMedCrossRef
220.
Zurück zum Zitat Vespa PM, Miller C, McArthur D, Eliseo M, Etchepare M, Hirt D, Glenn TC, Martin N, Hovda D. Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis. Crit Care Med. 2007;36(7):2218–9. Vespa PM, Miller C, McArthur D, Eliseo M, Etchepare M, Hirt D, Glenn TC, Martin N, Hovda D. Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis. Crit Care Med. 2007;36(7):2218–9.
221.
Zurück zum Zitat Vulliemoz S, Perrig S, Pellise D, et al. Imaging compatible electrodes for continuous electroencephalogram monitoring in the intensive care unit. J Clin Neurophysiol. 2009;26(4):236–43.PubMedCrossRef Vulliemoz S, Perrig S, Pellise D, et al. Imaging compatible electrodes for continuous electroencephalogram monitoring in the intensive care unit. J Clin Neurophysiol. 2009;26(4):236–43.PubMedCrossRef
222.
Zurück zum Zitat Ives J. New chronic EEG electrode for critical/intensive care unit monitoring. J Clin Neurophysiol. 2005;22(2):119–23.PubMedCrossRef Ives J. New chronic EEG electrode for critical/intensive care unit monitoring. J Clin Neurophysiol. 2005;22(2):119–23.PubMedCrossRef
223.
Zurück zum Zitat Vespa P. Continuous EEG monitoring for the detection of seizures in traumatic brain injury, infarction, and intracerebral hemorrhage: “to detect and to protect”. J Clin Neurophysiol. 2005;22(2):99–106.PubMedCrossRef Vespa P. Continuous EEG monitoring for the detection of seizures in traumatic brain injury, infarction, and intracerebral hemorrhage: “to detect and to protect”. J Clin Neurophysiol. 2005;22(2):99–106.PubMedCrossRef
224.
Zurück zum Zitat Vespa P, Prins M, Ronne-Engstrom E, Caron M, Shalmon E, Hovda DA, Martin NA, Becker DP. Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: a microdialysis study. J Neurosurg. 1998;89(6):971–82.PubMedCrossRef Vespa P, Prins M, Ronne-Engstrom E, Caron M, Shalmon E, Hovda DA, Martin NA, Becker DP. Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: a microdialysis study. J Neurosurg. 1998;89(6):971–82.PubMedCrossRef
225.
Zurück zum Zitat Vespa PM, McArthur D, O’Phelan K, Glenn T, Etchepare M, Kelly D, Bergsneider M, Martin NA, Hovda DA. Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study. J Cereb Blood Flow Metab. 2003;23(7):865–77.PubMedCrossRef Vespa PM, McArthur D, O’Phelan K, Glenn T, Etchepare M, Kelly D, Bergsneider M, Martin NA, Hovda DA. Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study. J Cereb Blood Flow Metab. 2003;23(7):865–77.PubMedCrossRef
226.
Zurück zum Zitat Vespa P, McArthur DL, Glenn T, et al. Nonconvulsive seizures after traumatic brain injury are associated with hippocampal atrophy. Neurology. 2010;75(9):792–8.PubMedCrossRef Vespa P, McArthur DL, Glenn T, et al. Nonconvulsive seizures after traumatic brain injury are associated with hippocampal atrophy. Neurology. 2010;75(9):792–8.PubMedCrossRef
227.
Zurück zum Zitat Claassen J, Hirsch LJ, Mayer SA. Treatment of status epilepticus: a survey of neurologists. J Neurol Sci. 2003;211(1–2):37–41.PubMedCrossRef Claassen J, Hirsch LJ, Mayer SA. Treatment of status epilepticus: a survey of neurologists. J Neurol Sci. 2003;211(1–2):37–41.PubMedCrossRef
228.
Zurück zum Zitat Goodkin HP, Yeh JL, Kapur J. Status epilepticus increases the intracellular accumulation of GABAA receptors. J Neurosc: Off J Soc Neurosci. 2005;25(23):5511–20.CrossRef Goodkin HP, Yeh JL, Kapur J. Status epilepticus increases the intracellular accumulation of GABAA receptors. J Neurosc: Off J Soc Neurosci. 2005;25(23):5511–20.CrossRef
229.
Zurück zum Zitat Naylor DE, Liu H, Wasterlain CG. Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J Neurosc: Off J Soc Neurosci. 2005;25(34):7724–33.CrossRef Naylor DE, Liu H, Wasterlain CG. Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J Neurosc: Off J Soc Neurosci. 2005;25(34):7724–33.CrossRef
230.
Zurück zum Zitat Goodkin HR, Joshi S, Kozhemyakin M, Kapur J. Impact of receptor changes on treatment of status epilepticus. Epilepsia. 2007;48(Suppl 8):14–5.PubMedCrossRef Goodkin HR, Joshi S, Kozhemyakin M, Kapur J. Impact of receptor changes on treatment of status epilepticus. Epilepsia. 2007;48(Suppl 8):14–5.PubMedCrossRef
231.
Zurück zum Zitat Goodkin HP, Buck ML. Still orphans: antiepileptic drug trials in children under 2 years of age. Neurology. 2008;70(22 Pt 2):2093–4.PubMedCrossRef Goodkin HP, Buck ML. Still orphans: antiepileptic drug trials in children under 2 years of age. Neurology. 2008;70(22 Pt 2):2093–4.PubMedCrossRef
232.
Zurück zum Zitat Meldrum BS. Excitatory amino acids in epilepsy and potential novel therapies. Epilepsy Res. 1992;12(2):189–96.PubMedCrossRef Meldrum BS. Excitatory amino acids in epilepsy and potential novel therapies. Epilepsy Res. 1992;12(2):189–96.PubMedCrossRef
233.
Zurück zum Zitat Yen W, Williamson J, Bertram EH, Kapur J. A comparison of three NMDA receptor antagonists in the treatment of prolonged status epilepticus. Epilepsy Res. 2004;59(1):43–50.PubMedCrossRef Yen W, Williamson J, Bertram EH, Kapur J. A comparison of three NMDA receptor antagonists in the treatment of prolonged status epilepticus. Epilepsy Res. 2004;59(1):43–50.PubMedCrossRef
234.
Zurück zum Zitat Lauritzen M. Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. J Cereb Blood Flow Metab. 2011;31(1):17–35.PubMedCrossRef Lauritzen M. Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. J Cereb Blood Flow Metab. 2011;31(1):17–35.PubMedCrossRef
235.
Zurück zum Zitat Hartings JA. Spreading depolarizations have prolonged direct current shifts and are associated with poor outcome in brain trauma. Brain. 2011;134(5):1529–40.PubMedCrossRef Hartings JA. Spreading depolarizations have prolonged direct current shifts and are associated with poor outcome in brain trauma. Brain. 2011;134(5):1529–40.PubMedCrossRef
236.
Zurück zum Zitat Dohmen C. Spreading depolarizations occur in human ischemic stroke with high incidence. Ann Neurol. 2008;63(6):720–8.PubMedCrossRef Dohmen C. Spreading depolarizations occur in human ischemic stroke with high incidence. Ann Neurol. 2008;63(6):720–8.PubMedCrossRef
237.
Zurück zum Zitat Dreier JP. Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations. Brain. 2006;129(12):3224–37.PubMedCrossRef Dreier JP. Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations. Brain. 2006;129(12):3224–37.PubMedCrossRef
238.
Zurück zum Zitat Dreier JP, Major S, Pannek HW, Woitzik J, Scheel M, Wiesenthal D, Martus P, Winkler MK, Hartings JA, Fabricius M, et al. Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex. Brain. 2012;135(Pt 1):259–75.PubMedCrossRef Dreier JP, Major S, Pannek HW, Woitzik J, Scheel M, Wiesenthal D, Martus P, Winkler MK, Hartings JA, Fabricius M, et al. Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex. Brain. 2012;135(Pt 1):259–75.PubMedCrossRef
239.
Zurück zum Zitat Fabricius M. Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain. Clin Neurophysiol. 2008;119(9):1973.PubMedCrossRef Fabricius M. Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain. Clin Neurophysiol. 2008;119(9):1973.PubMedCrossRef
240.
Zurück zum Zitat Waziri A. Intracortical electroencephalography in acute brain injury. Annals of neurology. 2009;66(3):366–77.PubMedCrossRef Waziri A. Intracortical electroencephalography in acute brain injury. Annals of neurology. 2009;66(3):366–77.PubMedCrossRef
241.
Zurück zum Zitat Treiman DM. The role of benzodiazepines in the management of status epilepticus. Neurology. 1990;40(5 Suppl 2):32–42.PubMed Treiman DM. The role of benzodiazepines in the management of status epilepticus. Neurology. 1990;40(5 Suppl 2):32–42.PubMed
242.
Zurück zum Zitat Nei M, Lee J-M, Shanker VL, Sperling MR. The EEG and prognosis in status epilepticus. Epilepsia. 1999;40(2):157–63.PubMedCrossRef Nei M, Lee J-M, Shanker VL, Sperling MR. The EEG and prognosis in status epilepticus. Epilepsia. 1999;40(2):157–63.PubMedCrossRef
243.
Zurück zum Zitat Chen DK, So YT, Fisher RS. Use of serum prolactin in diagnosing epileptic seizures: report of the therapeutics and technology assessment subcommittee of the American academy of neurology. Neurology. 2005;65(5):668–75.PubMedCrossRef Chen DK, So YT, Fisher RS. Use of serum prolactin in diagnosing epileptic seizures: report of the therapeutics and technology assessment subcommittee of the American academy of neurology. Neurology. 2005;65(5):668–75.PubMedCrossRef
244.
Zurück zum Zitat DeGiorgio CM, Heck CN, Rabinowicz AL, Gott PS, Smith T, Correale J. Serum neuron-specific enolase in the major subtypes of status epilepticus. Neurology. 1999;52(4):746–9.PubMedCrossRef DeGiorgio CM, Heck CN, Rabinowicz AL, Gott PS, Smith T, Correale J. Serum neuron-specific enolase in the major subtypes of status epilepticus. Neurology. 1999;52(4):746–9.PubMedCrossRef
245.
Zurück zum Zitat Treiman DMGL, Marsh ST. Characterization of experimental status epilepticus by nonlinear dynamical analysis of the EEG. Epilepsia. 2005;46(Suppl 8):304. Treiman DMGL, Marsh ST. Characterization of experimental status epilepticus by nonlinear dynamical analysis of the EEG. Epilepsia. 2005;46(Suppl 8):304.
246.
Zurück zum Zitat Hirsch LJ, Brenner RP, Drislane FW, So E, Kaplan PW, Jordan KG, Herman ST, LaRoche SM, Young B, Bleck TP, et al. The ACNS subcommittee on research terminology for continuous EEG monitoring: proposed standardized terminology for rhythmic and periodic EEG patterns encountered in critically ill patients. J Clin Neurophysiol. 2005;22(2):128–35.PubMedCrossRef Hirsch LJ, Brenner RP, Drislane FW, So E, Kaplan PW, Jordan KG, Herman ST, LaRoche SM, Young B, Bleck TP, et al. The ACNS subcommittee on research terminology for continuous EEG monitoring: proposed standardized terminology for rhythmic and periodic EEG patterns encountered in critically ill patients. J Clin Neurophysiol. 2005;22(2):128–35.PubMedCrossRef
Metadaten
Titel
Guidelines for the Evaluation and Management of Status Epilepticus
verfasst von
Gretchen M. Brophy
Rodney Bell
Jan Claassen
Brian Alldredge
Thomas P. Bleck
Tracy Glauser
Suzette M. LaRoche
James J. Riviello Jr.
Lori Shutter
Michael R. Sperling
David M. Treiman
Paul M. Vespa
Neurocritical Care Society Status Epilepticus Guideline Writing Committee
Publikationsdatum
01.08.2012
Verlag
Humana Press Inc
Erschienen in
Neurocritical Care / Ausgabe 1/2012
Print ISSN: 1541-6933
Elektronische ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-012-9695-z

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