nach oben

Neurocritical Care

Erschienen in:

17.11.2017 | Translational research

Glibenclamide and Therapeutic Hypothermia Have Comparable Effect on Attenuating Global Cerebral Edema Following Experimental Cardiac Arrest

verfasst von: Shin Nakayama, Noriko Taguchi, Yumi Isaka, Takako Nakamura, Makoto Tanaka

Erschienen in: Neurocritical Care | Ausgabe 1/2018

Einloggen, um Zugang zu erhalten

Abstract

Background

Cerebral edema is one of the major causes of mortality following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). A subunit of the sulfonylurea receptor 1–transient receptor potential M4 (Sur1–TRPM4) channel has been implicated in the pathogenesis of ischemia-evoked cerebral edema. In this study, we examined whether glibenclamide (GBC), a Sur1–TRPM4 channel inhibitor, attenuates cerebral edema following CA/CPR and further examined the efficacy of GBC combined with therapeutic hypothermia.

Methods

Isoflurane-anesthetized adult male wild-type C57Bl/6 mice subjected to 7-min CA/CPR were randomized into five groups: sham operation, control with normothermia, GBC with normothermia, control with hypothermia, and GBC with hypothermia. The primary outcome was to evaluate regional brain water content; the secondary outcome was to measure blood glucose level, Sur1–TRPM4 expression, and pro-inflammatory factor expression.

Results

Compared with normothermia, GBC treatment or hypothermia significantly attenuated brain water content in mice subjected to CA/CPR. GBC combined with hypothermia had no additional effects on attenuating cerebral edema. Pro-inflammatory factor messenger RNA expression (TNF-α and IL-6), NFκβ activation, and SUR1–TRPM4 levels were upregulated after CA/CPR. Compared with normothermia, hypothermia, but not GBC, partly suppressed these factors’ expression.

Conclusions

GBC attenuated cerebral edema following CA/CPR by blocking Sur1–TRPM4 channels upregulated by CA insult. The effect of GBC was comparable with that of therapeutic hypothermia alone. These results suggest that GBC is an alternative approach for treating CA-evoked cerebral edema.

Morimoto Y, Kemmotsu O, Kitami K, Matsubara I, Tedo I. Acute brain swelling after out-of-hospital cardiac arrest: pathogenesis and outcome. Crit Care Med. 1993;21(1):104–10.CrossRefPubMed

Adrie C, Haouache H, Saleh M, Memain N, Laurent I, Thuong M, Darques L, Guerrini P, Monchi M. An underrecognized source of organ donors: patients with brain death after successfully resuscitated cardiac arrest. Intensive Care Med. 2008;34(1):132–7. https://doi.org/10.1007/s00134-007-0885-7.CrossRefPubMed

Callaway CW, Donnino MW, Fink EL, Geocadin RG, Golan E, Kern KB, Leary M, Meurer WJ, Peberdy MA, Thompson TM, Zimmerman JL. Part 8: post-cardiac arrest care: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2015;132(18 Suppl 2):S465–82. https://doi.org/10.1161/CIR.0000000000000262.CrossRefPubMedPubMedCentral

Filippidis AS, Carozza RB, Rekate HL. Aquaporins in brain edema and neuropathological conditions. Int J Mol Sci. 2016;. https://doi.org/10.3390/ijms18010055.PubMedPubMedCentralCrossRef

Fukuda AM, Badaut J. Aquaporin 4: a player in cerebral edema and neuroinflammation. J Neuroinflammation. 2012;9:279. https://doi.org/10.1186/1742-2094-9-279.CrossRefPubMedPubMedCentral

Stokum JA, Gerzanich V, Simard JM. Molecular pathophysiology of cerebral edema. J Cereb Blood Flow Metab. 2016;36(3):513–38. https://doi.org/10.1177/0271678X15617172.CrossRefPubMed

Simard JM, Chen M, Tarasov KV, Bhatta S, Ivanova S, Melnitchenko L, Tsymbalyuk N, West GA, Gerzanich V. Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke. Nat Med. 2006;12(4):433–40. https://doi.org/10.1038/nm1390.CrossRefPubMedPubMedCentral

Zweckberger K, Hackenberg K, Jung CS, Hertle DN, Kiening KL, Unterberg AW, Sakowitz OW. Glibenclamide reduces secondary brain damage after experimental traumatic brain injury. Neuroscience. 2014;272:199–206. https://doi.org/10.1016/j.neuroscience.2014.04.040.CrossRefPubMed

Simard JM, Geng Z, Woo SK, Ivanova S, Tosun C, Melnichenko L, Gerzanich V. Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2009;29(2):317–30. https://doi.org/10.1038/jcbfm.2008.120.CrossRefPubMed

10.

Wu Z, Zhu SZ, Hu YF, Gu Y, Wang SN, Lin ZZ, Xie ZS, Pan SY. Glibenclamide enhances the effects of delayed hypothermia after experimental stroke in rats. Brain Res. 2016;1643:113–22. https://doi.org/10.1016/j.brainres.2016.04.067.CrossRefPubMed

11.

Huang K, Gu Y, Hu Y, Ji Z, Wang S, Lin Z, Li X, Xie Z, Pan S. Glibenclamide improves survival and neurologic outcome after cardiac arrest in rats. Crit Care Med. 2015;43(9):e341–9. https://doi.org/10.1097/CCM.0000000000001093.CrossRefPubMed

12.

Huang K, Wang Z, Gu Y, Hu Y, Ji Z, Wang S, Lin Z, Li X, Xie Z, Pan S. Glibenclamide is comparable to target temperature management in improving survival and neurological outcome after asphyxial cardiac arrest in rats. J Am Heart Assoc. 2016;. https://doi.org/10.1161/JAHA.116.003465.CrossRefPubMedPubMedCentral

13.

Nakayama S, Amiry-Moghaddam M, Ottersen OP, Bhardwaj A. Conivaptan, a selective arginine vasopressin V1a and V2 receptor antagonist attenuates global cerebral edema following experimental cardiac arrest via perivascular pool of aquaporin-4. Neurocrit Care. 2016;24(2):273–82. https://doi.org/10.1007/s12028-015-0236-4.CrossRefPubMed

14.

Kofler J, Hattori K, Sawada M, DeVries AC, Martin LJ, Hurn PD, Traystman RJ. Histopathological and behavioral characterization of a novel model of cardiac arrest and cardiopulmonary resuscitation in mice. J Neurosci Methods. 2004;136(1):33–44. https://doi.org/10.1016/j.jneumeth.2003.12.024.CrossRefPubMed

15.

Ye S, Weng Y, Sun S, Chen W, Wu X, Li Z, Weil MH, Tang W. Comparison of the durations of mild therapeutic hypothermia on outcome after cardiopulmonary resuscitation in the rat. Circulation. 2012;125(1):123–9. https://doi.org/10.1161/CIRCULATIONAHA.111.062257.CrossRefPubMed

16.

Zeynalov E, Chen CH, Froehner SC, Adams ME, Ottersen OP, Amiry-Moghaddam M, Bhardwaj A. The perivascular pool of aquaporin-4 mediates the effect of osmotherapy in postischemic cerebral edema. Crit Care Med. 2008;36(9):2634–40. https://doi.org/10.1097/CCM.0b013e3181847853.CrossRefPubMedPubMedCentral

17.

Chen CH, Toung TJ, Sapirstein A, Bhardwaj A. Effect of duration of osmotherapy on blood-brain barrier disruption and regional cerebral edema after experimental stroke. J Cereb Blood Flow Metab. 2006;26(7):951–8. https://doi.org/10.1038/sj.jcbfm.9600248.CrossRefPubMed

18.

Nakayama S, Vest R, Traystman RJ, Herson PS. Sexually dimorphic response of TRPM2 inhibition following cardiac arrest-induced global cerebral ischemia in mice. J Mol Neurosci. 2013;51(1):92–8. https://doi.org/10.1007/s12031-013-0005-9.CrossRefPubMedPubMedCentral

19.

Vajda Z, Pedersen M, Fuchtbauer EM, Wertz K, Stodkilde-Jorgensen H, Sulyok E, Doczi T, Neely JD, Agre P, Frokiaer J, Nielsen S. Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice. Proc Natl Acad Sci USA. 2002;99(20):13131–6. https://doi.org/10.1073/pnas.192457099.CrossRefPubMed

20.

Amiry-Moghaddam M, Otsuka T, Hurn PD, Traystman RJ, Haug FM, Froehner SC, Adams ME, Neely JD, Agre P, Ottersen OP, Bhardwaj A. An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain. Proc Natl Acad Sci USA. 2003;100(4):2106–11. https://doi.org/10.1073/pnas.0437946100.CrossRefPubMed

21.

Frydenlund DS, Bhardwaj A, Otsuka T, Mylonakou MN, Yasumura T, Davidson KG, Zeynalov E, Skare O, Laake P, Haug FM, Rash JE, Agre P, Ottersen OP, Amiry-Moghaddam M. Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice. Proc Natl Acad Sci USA. 2006;103(36):13532–6. https://doi.org/10.1073/pnas.0605796103.CrossRefPubMed

22.

Papadopoulos MC, Manley GT, Krishna S, Verkman AS. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J. 2004;18(11):1291–3. https://doi.org/10.1096/fj.04-1723fje.CrossRefPubMed

23.

Verkman AS, Anderson MO, Papadopoulos MC. Aquaporins: important but elusive drug targets. Nat Rev Drug Discov. 2014;13(4):259–77. https://doi.org/10.1038/nrd4226.CrossRefPubMedPubMedCentral

24.

Sullivan HC, Harik SI. ATP-sensitive potassium channels are not expressed in brain microvessels. Brain Res. 1993;612(1–2):336–8.CrossRefPubMed

25.

Chen M, Simard JM. Cell swelling and a nonselective cation channel regulated by internal Ca²⁺ and ATP in native reactive astrocytes from adult rat brain. J Neurosci. 2001;21(17):6512–21.CrossRefPubMed

26.

Simard JM, Tsymbalyuk N, Tsymbalyuk O, Ivanova S, Yurovsky V, Gerzanich V. Glibenclamide is superior to decompressive craniectomy in a rat model of malignant stroke. Stroke. 2010;41(3):531–7. https://doi.org/10.1161/STROKEAHA.109.572644.CrossRefPubMedPubMedCentral

27.

Arrich J, Holzer M, Havel C, Mullner M, Herkner H. Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database syst Rev. 2012;. https://doi.org/10.1002/14651858.CD004128.pub3.PubMedCrossRef

28.

Janata A, Holzer M. Hypothermia after cardiac arrest. Prog Cardiovasc Dis. 2009;52(2):168–79. https://doi.org/10.1016/j.pcad.2009.07.001.CrossRefPubMed

29.

Xiao F, Zhang S, Arnold TC, Alexander JS, Huang J, Carden DL, Conrad SA. Mild hypothermia induced before cardiac arrest reduces brain edema formation in rats. Acad Emerg Med. 2002;9(2):105–14.CrossRefPubMed

30.

Zhao H, Li CS, Gong P, Tang ZR, Hua R, Mei X, Zhang MY, Cui J. Molecular mechanisms of therapeutic hypothermia on neurological function in a swine model of cardiopulmonary resuscitation. Resuscitation. 2012;83(7):913–20. https://doi.org/10.1016/j.resuscitation.2012.01.001.CrossRefPubMed

31.

Gong P, Hua R, Zhang Y, Zhao H, Tang Z, Mei X, Zhang M, Cui J, Li C. Hypothermia-induced neuroprotection is associated with reduced mitochondrial membrane permeability in a swine model of cardiac arrest. J Cereb Blood Flow Metab. 2013;33(6):928–34. https://doi.org/10.1038/jcbfm.2013.33.CrossRefPubMedPubMedCentral

32.

Han HS, Karabiyikoglu M, Kelly S, Sobel RA, Yenari MA. Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke. J Cereb Blood Flow Metab. 2003;23(5):589–98. https://doi.org/10.1097/01.wcb.0000059566.39780.8d.CrossRefPubMed

33.

Hoffmann A, Baltimore D. Circuitry of nuclear factor kappaB signaling. Immunol Rev. 2006;210:171–86. https://doi.org/10.1111/j.0105-2896.2006.00375.x.CrossRefPubMed

34.

Mortola JP. Implications of hypoxic hypometabolism during mammalian ontogenesis. Respir Physiol Neurobiol. 2004;141(3):345–56. https://doi.org/10.1016/j.resp.2004.01.011.CrossRefPubMed

35.

Colbourne F, Li H, Buchan AM. Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats. J Cereb Blood Flow Metab. 1999;19(7):742–9. https://doi.org/10.1097/00004647-199907000-00003.CrossRefPubMed

36.

Huh PW, Belayev L, Zhao W, Koch S, Busto R, Ginsberg MD. Comparative neuroprotective efficacy of prolonged moderate intraischemic and postischemic hypothermia in focal cerebral ischemia. J Neurosurg. 2000;92(1):91–9. https://doi.org/10.3171/jns.2000.92.1.0091.CrossRefPubMed

37.

Li J, Li C, Yuan W, Wu J, Li J, Li Z, Zhao Y. Mild hypothermia alleviates brain edema and blood-brain barrier disruption by attenuating tight junction and adherens junction breakdown in a swine model of cardiopulmonary resuscitation. PLoS ONE. 2017;12(3):e0174596. https://doi.org/10.1371/journal.pone.0174596.CrossRefPubMedPubMedCentral

38.

Xiao F, Arnold TC, Zhang S, Brown C, Alexander JS, Carden DL, Conrad SA. Cerebral cortical aquaporin-4 expression in brain edema following cardiac arrest in rats. Acad Emerg Med. 2004;11(10):1001–7. https://doi.org/10.1197/j.aem.2004.05.026.CrossRefPubMed

39.

Negroni JA, Lascano EC, del Valle HF. Glibenclamide action on myocardial function and arrhythmia incidence in the healthy and diabetic heart. Cardiovasc Hematol Agents Med Chem. 2007;5(1):43–53.CrossRefPubMed

40.

Munoz A, Nakazaki M, Goodman JC, Barrios R, Onetti CG, Bryan J, Aguilar-Bryan L. Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels. Stroke. 2003;34(1):164–70.CrossRefPubMed

Titel: Glibenclamide and Therapeutic Hypothermia Have Comparable Effect on Attenuating Global Cerebral Edema Following Experimental Cardiac Arrest
verfasst von: Shin Nakayama
Noriko Taguchi
Yumi Isaka
Takako Nakamura
Makoto Tanaka
Publikationsdatum: 17.11.2017
Verlag: Springer US
Erschienen in: Neurocritical Care / Ausgabe 1/2018
Print ISSN: 1541-6933
Elektronische ISSN: 1556-0961
DOI: https://doi.org/10.1007/s12028-017-0479-3

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Thrombektomie auch bei großen Infarkten von Vorteil

16.05.2024 Ischämischer Schlaganfall Nachrichten

Auch ein sehr ausgedehnter ischämischer Schlaganfall scheint an sich kein Grund zu sein, von einer mechanischen Thrombektomie abzusehen. Dafür spricht die LASTE-Studie, an der Patienten und Patientinnen mit einem ASPECTS von maximal 5 beteiligt waren.

Schwindelursache: Massagepistole lässt Otholiten tanzen

14.05.2024 Benigner Lagerungsschwindel Nachrichten

Wenn jüngere Menschen über ständig rezidivierenden Lagerungsschwindel klagen, könnte eine Massagepistole der Auslöser sein. In JAMA Otolaryngology warnt ein Team vor der Anwendung hochpotenter Geräte im Bereich des Nackens.

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Viertel reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2018

Practical Pearl: Use of MRI to Differentiate Pseudo-subarachnoid Hemorrhage from True Subarachnoid Hemorrhage

Bilateral Bow Hunter’s Syndrome Mimicking a Classic Seizure Semiology

How Harvard Defined Irreversible Coma

Critical West Nile Neuroinvasive Disease

Electroencephalographic Patterns in Neurocritical Care: Pathologic Contributors or Epiphenomena?