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Erschienen in: Medical Oncology 4/2017

01.04.2017 | Original Paper

Intra-articular benign bone lesions treated with Magnetic Resonance-guided Focused Ultrasound (MRgFUS): imaging follow-up and clinical results

verfasst von: Francesco Arrigoni, Antonio Barile, Luigi Zugaro, Alessandra Splendiani, Ernesto Di Cesare, Ferdinando Caranci, Anna Maria Ierardi, Chiara Floridi, Alessio Salvatore Angileri, Alfonso Reginelli, Luca Brunese, Carlo Masciocchi

Erschienen in: Medical Oncology | Ausgabe 4/2017

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Abstract

Purpose of this study was to evaluate the employment of MRI-guided Focused Ultrasound (MRgFUS) for treatment of intra-articular benign bone lesions as alternative to surgery, and to monitor the success of the treatment on CT and MRI images. From March 2011 to August 2013, 14 intra-articular benign bone lesions were treated with MRgFUS. All patients were studied by CT and MR imaging. Pain was measured using the visual analogue scale (VAS) before and after treatment (6 and 12 months). All patients in our series demonstrated regression in painful symptomatology during screening. A significant drop in the mean VAS pain score (from 7.8 to 0.6) was observed at 12-month follow-up, and pain medication was no longer needed after treatment. No complications were observed. Three diagnostic imaging signs were found suggesting absence of biological activity and confirming the clinical findings: calcification of the treated lesion, lack of contrast enhancement and disappearance of bone oedema around the lesions. Conclusion: the employment of MRgFUS is safe and effective in the treatment of intra-articular benign bone lesions. The clinical outcome is satisfactory, and the success of the treatment is confirmed by diagnostic imaging.
Literatur
1.
Zurück zum Zitat Farfalli GL, Slullitel PA, Muscolo DL, Ayerza MA, Aponte-Tinao LA. What happens to the articular surface after curettage for epiphyseal chondroblastoma?. A Report on Functional Results: Arthritis, and Arthroplasty. Clin Orthop Relat Res; 2016. Farfalli GL, Slullitel PA, Muscolo DL, Ayerza MA, Aponte-Tinao LA. What happens to the articular surface after curettage for epiphyseal chondroblastoma?. A Report on Functional Results: Arthritis, and Arthroplasty. Clin Orthop Relat Res; 2016.
2.
Zurück zum Zitat Aponte-Tinao L, Ayerza MA, Muscolo DL, Farfalli GL. Survival, recurrence, and function after epiphyseal preservation and allograft reconstruction in osteosarcoma of the knee. Clin Orthop Relat Res. 2015;473(5):1789–96. doi:10.1007/s11999-014-4028-5.CrossRefPubMed Aponte-Tinao L, Ayerza MA, Muscolo DL, Farfalli GL. Survival, recurrence, and function after epiphyseal preservation and allograft reconstruction in osteosarcoma of the knee. Clin Orthop Relat Res. 2015;473(5):1789–96. doi:10.​1007/​s11999-014-4028-5.CrossRefPubMed
3.
Zurück zum Zitat Thawait SK, Thawait GK, Frassica FJ, Andreisek G, Carrino JA, Chhabra A. A systematic approach to magnetic resonance imaging evaluation of epiphyseal lesions. Magn Reson Imaging. 2013;31(3):418–31.CrossRefPubMed Thawait SK, Thawait GK, Frassica FJ, Andreisek G, Carrino JA, Chhabra A. A systematic approach to magnetic resonance imaging evaluation of epiphyseal lesions. Magn Reson Imaging. 2013;31(3):418–31.CrossRefPubMed
4.
Zurück zum Zitat Mellado JM, Bencardino JT, Pérez del Palomar L. Magnetic resonance imaging features of the discrete epiphyseal radiolucency: a problem-solving approach to differential diagnosis. Curr Probl Diagn Radiol. 2008;37(6):243–61.CrossRefPubMed Mellado JM, Bencardino JT, Pérez del Palomar L. Magnetic resonance imaging features of the discrete epiphyseal radiolucency: a problem-solving approach to differential diagnosis. Curr Probl Diagn Radiol. 2008;37(6):243–61.CrossRefPubMed
5.
Zurück zum Zitat Nishio J, Arashiro Y, Mori S, Iwasaki H, Naito M. Periosteal chondroma of the distal tibia: computed tomography and magnetic resonance imaging characteristics and correlation with histological findings. Mol Clin Oncol. 2015;3(3):677–81. doi:10.3892/mco.2015.492.PubMedPubMedCentral Nishio J, Arashiro Y, Mori S, Iwasaki H, Naito M. Periosteal chondroma of the distal tibia: computed tomography and magnetic resonance imaging characteristics and correlation with histological findings. Mol Clin Oncol. 2015;3(3):677–81. doi:10.​3892/​mco.​2015.​492.PubMedPubMedCentral
6.
Zurück zum Zitat Ferrari F, Arrigoni F, Miccoli A, Mascaretti S, Fascetti E, Mascaretti G, Barile A, Masciocchi C. Effectiveness of magnetic resonance-guided focused ultrasound surgery (MRgFUS) in the uterine adenomyosis treatment: technical approach and MRI evaluation. Radiol Med. 2016;121(2):153–61. doi:10.1007/s11547-015-0580-7.CrossRefPubMed Ferrari F, Arrigoni F, Miccoli A, Mascaretti S, Fascetti E, Mascaretti G, Barile A, Masciocchi C. Effectiveness of magnetic resonance-guided focused ultrasound surgery (MRgFUS) in the uterine adenomyosis treatment: technical approach and MRI evaluation. Radiol Med. 2016;121(2):153–61. doi:10.​1007/​s11547-015-0580-7.CrossRefPubMed
7.
Zurück zum Zitat Masciocchi C, Zugaro L, Arrigoni F, Gravina GL, Mariani S, La Marra A, et al. Radiofrequency ablation versus magnetic resonance guided focused ultrasound surgery for minimally invasive treatment of osteoid osteoma: a propensity score matching study. Eur Radiol. 2016;26:2472–81. doi:10.1007/s00330-015-4111-7.CrossRefPubMed Masciocchi C, Zugaro L, Arrigoni F, Gravina GL, Mariani S, La Marra A, et al. Radiofrequency ablation versus magnetic resonance guided focused ultrasound surgery for minimally invasive treatment of osteoid osteoma: a propensity score matching study. Eur Radiol. 2016;26:2472–81. doi:10.​1007/​s00330-015-4111-7.CrossRefPubMed
8.
Zurück zum Zitat Masciocchi C, Conchiglia A, Gregori LM, Arrigoni F, Zugaro L, Barile A. Critical role of HIFU in musculoskeletal interventions. Radiol Med. 2014;119(7):470–5.CrossRefPubMed Masciocchi C, Conchiglia A, Gregori LM, Arrigoni F, Zugaro L, Barile A. Critical role of HIFU in musculoskeletal interventions. Radiol Med. 2014;119(7):470–5.CrossRefPubMed
9.
Zurück zum Zitat Arrigoni F, Gregori LM, Zugaro L, Barile A, Masciocchi C. MRgFUS in the treatment of MSK lesions: a review based on the experience of the University of L’Aquila. Italy Review article. Translational Cancer Research. 2014;. doi:10.3978/j.issn.2218-676X.2014.10.04. Arrigoni F, Gregori LM, Zugaro L, Barile A, Masciocchi C. MRgFUS in the treatment of MSK lesions: a review based on the experience of the University of L’Aquila. Italy Review article. Translational Cancer Research. 2014;. doi:10.​3978/​j.​issn.​2218-676X.​2014.​10.​04.
11.
Zurück zum Zitat Liberman B, Gianfelice D, Inbar Y, Beck A, Rabin T, Shabshin N, et al. Pain palliation in patients with bone metastases using MR-guided focused ultrasound surgery: a multicenter study. Ann Surg Oncol. 2009;16(1):140–6.CrossRefPubMed Liberman B, Gianfelice D, Inbar Y, Beck A, Rabin T, Shabshin N, et al. Pain palliation in patients with bone metastases using MR-guided focused ultrasound surgery: a multicenter study. Ann Surg Oncol. 2009;16(1):140–6.CrossRefPubMed
12.
Zurück zum Zitat Rosenthal DI, Hornicek FJ, Torriani M, Gebhardt MC, Mankin HJ. Osteoid osteoma: percutaneous treatment with radiofrequency energy. Radiology. 2003;229(1):171–5.CrossRefPubMed Rosenthal DI, Hornicek FJ, Torriani M, Gebhardt MC, Mankin HJ. Osteoid osteoma: percutaneous treatment with radiofrequency energy. Radiology. 2003;229(1):171–5.CrossRefPubMed
13.
Zurück zum Zitat Murad M, Bari V, Rafique MZ, Ashraf K. Periosteal desmoid. JPMA. 2007;57:44–7. Murad M, Bari V, Rafique MZ, Ashraf K. Periosteal desmoid. JPMA. 2007;57:44–7.
15.
17.
Zurück zum Zitat Bauer TW, Dorfman HD. Intraosseous ganglion. A clinicopathologic study of 11 cases. Am J Surg Pathol. 1982;6:207–13.CrossRefPubMed Bauer TW, Dorfman HD. Intraosseous ganglion. A clinicopathologic study of 11 cases. Am J Surg Pathol. 1982;6:207–13.CrossRefPubMed
18.
Zurück zum Zitat Patel S, Agrawal A, Maheshwari R, Chauhan VD. Periosteal osteoblastoma of the pelvis: a rare case. Iran J Med Sci. 2015;40(1):77–80.PubMedPubMedCentral Patel S, Agrawal A, Maheshwari R, Chauhan VD. Periosteal osteoblastoma of the pelvis: a rare case. Iran J Med Sci. 2015;40(1):77–80.PubMedPubMedCentral
19.
Zurück zum Zitat Marsh BW, Bonfiglio M, Brady LP, Enneking WF. Benign osteoblastoma: range of manifestations. J Bone Jt Surg Ser A. 1975;57(1):1–9.CrossRef Marsh BW, Bonfiglio M, Brady LP, Enneking WF. Benign osteoblastoma: range of manifestations. J Bone Jt Surg Ser A. 1975;57(1):1–9.CrossRef
20.
Zurück zum Zitat Bufkin WJ. The avulsive cortical irregularity. Am J Roentgenol Radium Ther Nucl Med. 1971;112(3):487–92.CrossRefPubMed Bufkin WJ. The avulsive cortical irregularity. Am J Roentgenol Radium Ther Nucl Med. 1971;112(3):487–92.CrossRefPubMed
21.
Zurück zum Zitat Olvi Liliana G, Santini-Araujo E. Periosteal desmoid. In: Santini-Araujo E, Kalil RK, Bertoni F, Park Y-K, editors. Tumors and tumor-like lesions of bone. London: Springer; 2015. Olvi Liliana G, Santini-Araujo E. Periosteal desmoid. In: Santini-Araujo E, Kalil RK, Bertoni F, Park Y-K, editors. Tumors and tumor-like lesions of bone. London: Springer; 2015.
22.
Zurück zum Zitat Resnick D, Greenway G. Distal femoral cortical defects, irregularities and excavations. Radiology. 1982;143:345–54.CrossRefPubMed Resnick D, Greenway G. Distal femoral cortical defects, irregularities and excavations. Radiology. 1982;143:345–54.CrossRefPubMed
25.
Zurück zum Zitat Regini E, Mariscotti G, Durando M, Ghione G, Luparia A, Campanino PP, Bianchi CC, Bergamasco L, Fonio P, Gandini G. Radiological assessment of breast density by visual classification (BI-RADS) compared to automated volumetric digital software (Quantra): implications for clinical practice. Radiol Med. 2014;119(10):741–9. doi:10.1007/s11547-014-0390-3.CrossRefPubMed Regini E, Mariscotti G, Durando M, Ghione G, Luparia A, Campanino PP, Bianchi CC, Bergamasco L, Fonio P, Gandini G. Radiological assessment of breast density by visual classification (BI-RADS) compared to automated volumetric digital software (Quantra): implications for clinical practice. Radiol Med. 2014;119(10):741–9. doi:10.​1007/​s11547-014-0390-3.CrossRefPubMed
26.
Zurück zum Zitat Faletti R, Cassinis MC, Fonio P, Grasso A, Battisti G, Bergamasco L, Gandini G. Diffusion-weighted imaging and apparent diffusion coefficient values versus contrast-enhanced MR imaging in the identification and characterization of acute pyelonephritis. Eur Radiol. 2013;23(12):3501–8. doi:10.1007/s00330-013-2951-6.CrossRefPubMed Faletti R, Cassinis MC, Fonio P, Grasso A, Battisti G, Bergamasco L, Gandini G. Diffusion-weighted imaging and apparent diffusion coefficient values versus contrast-enhanced MR imaging in the identification and characterization of acute pyelonephritis. Eur Radiol. 2013;23(12):3501–8. doi:10.​1007/​s00330-013-2951-6.CrossRefPubMed
27.
Zurück zum Zitat Salvati F, Rossi F, Limbucci N, Pistoia ML, Barile A, Masciocchi C. Mucoid metaplastic-degeneration of anterior cruciate ligament. J Sports Med Phys Fitness. 2008;48(4):483–7.PubMed Salvati F, Rossi F, Limbucci N, Pistoia ML, Barile A, Masciocchi C. Mucoid metaplastic-degeneration of anterior cruciate ligament. J Sports Med Phys Fitness. 2008;48(4):483–7.PubMed
28.
Zurück zum Zitat Ripani M, Continenza MA, Cacchio A, Barile A, Parisi A, De Paulis F. The ischiatic region: normal and MRI anatomy. J Sports Med Phys Fitness. 2006;46(3):468–75.PubMed Ripani M, Continenza MA, Cacchio A, Barile A, Parisi A, De Paulis F. The ischiatic region: normal and MRI anatomy. J Sports Med Phys Fitness. 2006;46(3):468–75.PubMed
29.
30.
Zurück zum Zitat Splendiani A, Perri M, Grattacaso G, Di Tunno V, Marsecano C, Panebianco L, Gennarelli A, Felli V, Varrassi M, Barile A, Di Cesare E, Masciocchi C, Gallucci M. Magnetic resonance imaging (MRI) of the lumbar spine with dedicated G-scan machine in the upright position: a retrospective study and our experience in 10 years with 4305 patients. Radiol Med. 2016;121(1):38–44. doi:10.1007/s11547-015-0570-9.CrossRefPubMed Splendiani A, Perri M, Grattacaso G, Di Tunno V, Marsecano C, Panebianco L, Gennarelli A, Felli V, Varrassi M, Barile A, Di Cesare E, Masciocchi C, Gallucci M. Magnetic resonance imaging (MRI) of the lumbar spine with dedicated G-scan machine in the upright position: a retrospective study and our experience in 10 years with 4305 patients. Radiol Med. 2016;121(1):38–44. doi:10.​1007/​s11547-015-0570-9.CrossRefPubMed
31.
Zurück zum Zitat Splendiani A, Ferrari F, Barile A, Masciocchi C, Gallucci M. Occult neural foraminal stenosis caused by association between disc degeneration and facet joint osteoarthritis: demonstration with dedicated upright MRI system. Radiol Med. 2014;119(3):164–74. doi:10.1007/s11547-013-0330-7.CrossRefPubMed Splendiani A, Ferrari F, Barile A, Masciocchi C, Gallucci M. Occult neural foraminal stenosis caused by association between disc degeneration and facet joint osteoarthritis: demonstration with dedicated upright MRI system. Radiol Med. 2014;119(3):164–74. doi:10.​1007/​s11547-013-0330-7.CrossRefPubMed
32.
Zurück zum Zitat Barile A, Limbucci N, Splendiani A, Gallucci M, Masciocchi C. Spinal injury in sport. Eur J Radiol. 2007;62(1):68–78.CrossRefPubMed Barile A, Limbucci N, Splendiani A, Gallucci M, Masciocchi C. Spinal injury in sport. Eur J Radiol. 2007;62(1):68–78.CrossRefPubMed
33.
Zurück zum Zitat Barile A, Lanni G, Conti L, Mariani S, Calvisi V, Castagna A, Rossi F, Masciocchi C. Lesions of the biceps pulley as cause of anterosuperior impingement of the shoulder in the athlete: potentials and limits of MR arthrography compared with arthroscopy. Radiol Med. 2013;118(1):112–22.CrossRefPubMed Barile A, Lanni G, Conti L, Mariani S, Calvisi V, Castagna A, Rossi F, Masciocchi C. Lesions of the biceps pulley as cause of anterosuperior impingement of the shoulder in the athlete: potentials and limits of MR arthrography compared with arthroscopy. Radiol Med. 2013;118(1):112–22.CrossRefPubMed
35.
Zurück zum Zitat Masciocchi C, Barile A, Lelli S, Calvisi V. Magnetic Resonance Imaging (MRI) and arthro-MRI in the evaluation of the chondral pathology of the knee joint. Radiol Med. 2004;108(3):149–58.PubMed Masciocchi C, Barile A, Lelli S, Calvisi V. Magnetic Resonance Imaging (MRI) and arthro-MRI in the evaluation of the chondral pathology of the knee joint. Radiol Med. 2004;108(3):149–58.PubMed
36.
Zurück zum Zitat Barile A, Regis G, Masi R, Maggiori M, Gallo A, Faletti C, Masciocchi C. Musculoskeletal tumours: preliminary experience with perfusion MRI. RadiolMed. 2007;112(4):550–61. Barile A, Regis G, Masi R, Maggiori M, Gallo A, Faletti C, Masciocchi C. Musculoskeletal tumours: preliminary experience with perfusion MRI. RadiolMed. 2007;112(4):550–61.
37.
Zurück zum Zitat Masciocchi C, Lanni G, Conti L, Conchiglia A, Fascetti E, Flamini S, Coletti G, Barile A. Soft-tissue inflammatory myofibroblastic tumors (IMTs) of the limbs: potential and limits of diagnostic imaging. Skeletal Radiol. 2012;41(6):643–9.CrossRefPubMed Masciocchi C, Lanni G, Conti L, Conchiglia A, Fascetti E, Flamini S, Coletti G, Barile A. Soft-tissue inflammatory myofibroblastic tumors (IMTs) of the limbs: potential and limits of diagnostic imaging. Skeletal Radiol. 2012;41(6):643–9.CrossRefPubMed
38.
Zurück zum Zitat Cazzato RL, Garnon J, Ramamurthy N, Koch G, Tsoumakidou G, Caudrelier J, Arrigoni F, Zugaro L, Barile A, Masciocchi C, Gangi A. Percutaneous image-guided cryoablation: current applications and results in the oncologic field. Med Oncol. 2016;33(12):140. doi:10.1007/s12032-016-0848-3.CrossRefPubMed Cazzato RL, Garnon J, Ramamurthy N, Koch G, Tsoumakidou G, Caudrelier J, Arrigoni F, Zugaro L, Barile A, Masciocchi C, Gangi A. Percutaneous image-guided cryoablation: current applications and results in the oncologic field. Med Oncol. 2016;33(12):140. doi:10.​1007/​s12032-016-0848-3.CrossRefPubMed
39.
Zurück zum Zitat Barile A, La Marra A, Arrigoni F, Mariani S, Zugaro L, Splendiani A, Di Cesare E, Reginelli A, Zappia M, Brunese L, Duka E, Carrafiello G, Masciocchi C. Anaesthetics, steroids and platelet-rich plasma (PRP) in ultrasound-guided musculoskeletal procedures. Br J Radiol. 2016;89:20150355. doi:10.1259/bjr.20150355.CrossRefPubMed Barile A, La Marra A, Arrigoni F, Mariani S, Zugaro L, Splendiani A, Di Cesare E, Reginelli A, Zappia M, Brunese L, Duka E, Carrafiello G, Masciocchi C. Anaesthetics, steroids and platelet-rich plasma (PRP) in ultrasound-guided musculoskeletal procedures. Br J Radiol. 2016;89:20150355. doi:10.​1259/​bjr.​20150355.CrossRefPubMed
40.
Zurück zum Zitat Zoccali C, Rossi B, Zoccali G, Barbarino E, Gregori L, Barile A, Masciocchi C. A new technique for biopsy of soft tissue neoplasms: a preliminary experience using MRI to evaluate bleeding. Minerva Med. 2015;106(2):117–20.PubMed Zoccali C, Rossi B, Zoccali G, Barbarino E, Gregori L, Barile A, Masciocchi C. A new technique for biopsy of soft tissue neoplasms: a preliminary experience using MRI to evaluate bleeding. Minerva Med. 2015;106(2):117–20.PubMed
41.
Zurück zum Zitat Carrafiello G, Fontana F, Mangini M, Ierardi AM, Cotta E, Floridi C, Piacentino F, Fugazzola C. Initial experience with percutaneous biopsies of bone lesions using XperGuide cone-beam CT (CBCT): technical note. Radiol Med. 2012;117(8):1386–97.CrossRefPubMed Carrafiello G, Fontana F, Mangini M, Ierardi AM, Cotta E, Floridi C, Piacentino F, Fugazzola C. Initial experience with percutaneous biopsies of bone lesions using XperGuide cone-beam CT (CBCT): technical note. Radiol Med. 2012;117(8):1386–97.CrossRefPubMed
44.
Zurück zum Zitat Rehnitz C, Sprengel SD, Lehner B, Ludwig K, Omlor G, Merle C, et al. CT-guided radiofrequency ablation of osteoid osteoma: correlation of clinical outcome and imaging features. Diagn Interv Radiol. 2013;19(4):330.PubMed Rehnitz C, Sprengel SD, Lehner B, Ludwig K, Omlor G, Merle C, et al. CT-guided radiofrequency ablation of osteoid osteoma: correlation of clinical outcome and imaging features. Diagn Interv Radiol. 2013;19(4):330.PubMed
45.
Zurück zum Zitat Fuchs S, Gebauer B, Stelter L, Schäfer ML, Renz DM, Melcher I, et al. Postinterventional MRI findings following MRI-guided laser ablation of osteoid osteoma. Eur J Radiol. 2014;83(4):696–702.CrossRefPubMed Fuchs S, Gebauer B, Stelter L, Schäfer ML, Renz DM, Melcher I, et al. Postinterventional MRI findings following MRI-guided laser ablation of osteoid osteoma. Eur J Radiol. 2014;83(4):696–702.CrossRefPubMed
Metadaten
Titel
Intra-articular benign bone lesions treated with Magnetic Resonance-guided Focused Ultrasound (MRgFUS): imaging follow-up and clinical results
verfasst von
Francesco Arrigoni
Antonio Barile
Luigi Zugaro
Alessandra Splendiani
Ernesto Di Cesare
Ferdinando Caranci
Anna Maria Ierardi
Chiara Floridi
Alessio Salvatore Angileri
Alfonso Reginelli
Luca Brunese
Carlo Masciocchi
Publikationsdatum
01.04.2017
Verlag
Springer US
Erschienen in
Medical Oncology / Ausgabe 4/2017
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-017-0904-7

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