Erschienen in:
23.07.2020 | Original Article
Serum Survivin in Oral Submucosal Fibrosis and Squamous Cell Carcinoma
verfasst von:
Ramya Thota, Sadhna Aggarwal, Amit Singh Chirom, Alok Thakar, Siddhartha Dutta Gupta, Suresh C. Sharma, Satya N. Das
Erschienen in:
Indian Journal of Otolaryngology and Head & Neck Surgery
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Sonderheft 2/2022
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Abstract
Survivin, an inhibitor of apoptosis protein is a biomarker of significance in prognostication of many malignancies. In the current study we investigated the serum survivin levels in patients with oral submucosal fibrosis (OSMF) and squamous cell carcinoma (OSCC). Serum was isolated from, peripheral blood collected of clinically and histopathologically confirmed OSMF and OSCC patients. Circulating level of survivin was measured in patients and control subjects by ELISA and analyzed further using Kruskal–Wallis test and two-sample Wilcoxon rank-sum (Mann–Whitney) test. Serum Survivin levels were significantly reduced in the OSCC group as compared to the control group. No significant correlation was noted between the serum survivin level and various clinicopathological characteristics of OSCC and OSMF patients. Our study suggests that free, wild form of circulating survivin probably has no role in predicting the prognosis of oral cancer or the malignant transformation potential of oral submucosal fibrosis.