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Neuroscience Bulletin
Erschienen in: Neuroscience Bulletin 3/2016

01.06.2016 | Review

Molecular, Functional, and Structural Imaging of Major Depressive Disorder

verfasst von: Kai Zhang, Yunqi Zhu, Yuankai Zhu, Shuang Wu, Hao Liu, Wei Zhang, Caiyun Xu, Hong Zhang, Takuya Hayashi, Mei Tian

Erschienen in: Neuroscience Bulletin | Ausgabe 3/2016

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Abstract

Major depressive disorder (MDD) is a significant cause of morbidity and mortality worldwide, correlating with genetic susceptibility and environmental risk factors. Molecular, functional, and structural imaging approaches have been increasingly used to detect neurobiological changes, analyze neurochemical correlates, and parse pathophysiological mechanisms underlying MDD. We reviewed recent neuroimaging publications on MDD in terms of molecular, functional, and structural alterations as detected mainly by magnetic resonance imaging (MRI) and positron emission tomography. Altered structure and function of brain regions involved in the cognitive control of affective state have been demonstrated. An abnormal default mode network, as revealed by resting-state functional MRI, is likely associated with aberrant metabolic and serotonergic function revealed by radionuclide imaging. Further multi-modal investigations are essential to clarify the characteristics of the cortical network and serotonergic system associated with behavioral and genetic variations in MDD.
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Metadaten
Titel
Molecular, Functional, and Structural Imaging of Major Depressive Disorder
verfasst von
Kai Zhang
Yunqi Zhu
Yuankai Zhu
Shuang Wu
Hao Liu
Wei Zhang
Caiyun Xu
Hong Zhang
Takuya Hayashi
Mei Tian
Publikationsdatum
01.06.2016
Verlag
Springer Singapore
Erschienen in
Neuroscience Bulletin / Ausgabe 3/2016
Print ISSN: 1673-7067
Elektronische ISSN: 1995-8218
DOI
https://doi.org/10.1007/s12264-016-0030-0

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