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01.12.2010 | Original Article

Structural epicardial disease and microvascular function are determinants of an abnormal longitudinal myocardial blood flow difference in cardiovascular risk individuals as determined with PET/CT

verfasst von: Ines Valenta, MD, Alessandra Quercioli, MD, Gabriella Vincenti, MD, René Nkoulou, MD, Stephan Dewarrat, MSc, Olivier Rager, MD, Habib Zaidi, PhD, Yann Seimbille, PhD, Francois Mach, MD, Osman Ratib, MD, Thomas H. Schindler, MD, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 6/2010

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Abstract

Background

The aim of this study was to determine whether epicardial structural disease may affect the manifestation of a longitudinal decrease in myocardial blood flow (MBF) or MBF difference during hyperemia in cardiovascular risk individuals, and its dependency on the flow increase.

Methods and Results

In 54 cardiovascular risk individuals (at risk) and in 26 healthy controls, MBF was measured with ¹³N-ammonia and PET/CT in mL/g/min at rest and during dipyridamole stimulation. Computed tomography coronary angiography (CTA) was performed using a 64-slice CT of a PET/CT system. Absolute MBFs during dipyridamole stimulation were mildly lower in the mid-distal than in the mid-LV myocardium in controls (2.20 ± .51 vs 2.29 ± .51, P < .0001), while it was more pronounced in at risk with normal and abnormal CTA (1.56 ± .42 vs 1.91 ± .46 and 1.18 ± .34 vs 1.51 ± .40 mL/g/min, respectively, P < .0001), resulting in a longitudinal MBF difference that was highest in at risk with normal CTA, intermediate in at risk abnormal CTA, and lowest in controls (.35 ± .16 and .22 ± .09 vs .09 ± .04 mL/g/min, respectively, P < .0001). On multivariate analysis, log-CCS and mid-LV hyperemic MBF increase, indicative of microvascular function, were independent predictors of the observed longitudinal MBF difference (P ≤ .004 by ANOVA).

Conclusions

Epicardial structural disease and microvascular function are important determinants of an abnormal longitudinal MBF difference as determined with PET/CT.

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Titel: Structural epicardial disease and microvascular function are determinants of an abnormal longitudinal myocardial blood flow difference in cardiovascular risk individuals as determined with PET/CT
verfasst von: Ines Valenta, MD
Alessandra Quercioli, MD
Gabriella Vincenti, MD
René Nkoulou, MD
Stephan Dewarrat, MSc
Olivier Rager, MD
Habib Zaidi, PhD
Yann Seimbille, PhD
Francois Mach, MD
Osman Ratib, MD
Thomas H. Schindler, MD, PhD
Publikationsdatum: 01.12.2010
Verlag: Springer-Verlag
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 6/2010
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-010-9272-9

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Structural epicardial disease and microvascular function are determinants of an abnormal longitudinal myocardial blood flow difference in cardiovascular risk individuals as determined with PET/CT